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Vitamin D is synergistic with many Cancer therapies (radiation in this case) – Aug 2021

Vitamin D Enhances Radiosensitivity of Colorectal Cancer by Reversing Epithelial-Mesenchymal Transition

Front Cell Dev Biol. 2021 Aug 4;9:684855. doi: 10.3389/fcell.2021.684855
Xinyue Yu 1, Qian Wang 1, Baocai Liu 1, Ning Zhang 1, Guanghui Cheng 1

VitaminDWiki

If have a high level of Vitamin D, sometimes the doctor can use less radio/chemo therapy
   Less therapy ==> potentially decreased: hair loss, pain, appetite loss, gut problems, sleep loss, fatigue, etc.
Some chemotherapies also lower the vitamin D levels, so vitamin D levels need to be restored
Warning: Not reducing some cancer therapies when having a high level of vitamin D can be DEADLY
see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=396
         click on chart for details

Breast Cancer specific

Vitamin D Receptor is also important

 Download the PDF from VitaminDWiki

Table of contents
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Abstract
Colorectal cancer (CRC) is often resistant to conventional therapies. Previous studies have reported the anticancer effects of vitamin D in several cancers, its role in radiotherapy (RT) remains unknown. We found that 1α, 25-dihydroxyvitamin D3 (VD3), the biologically active form of vitamin D, had antitumor effect on CRC and sensitized CRC cells to ionizing radiation (IR). VD3 demonstrated synergistic effect in combination with IR, which were detected by colony formation and cell proliferation assay. Radiosensitivity restoration induced by VD3 was associated with a series of phenotypes, including apoptosis, autophagy, and epithelial-mesenchymal transition (EMT). Using proteomics, "regulation of cell migration" and "cadherin" were found to be obviously enriched GO terms. Moreover, cystatin D and plasminogen activator inhibitor-1 (PAI-1), the differentially expressed proteins, were associated with EMT. Next, we confirmed the contributions of these two genes in enhancing IR sensitivity of CRC cells upon inhibition of EMT. As determined by proteomics, the mechanism underlying such sensitivity involved partially block of JAK/STAT3 signaling pathway. Furthermore, VD3 also elicited sensitization to RT in xenograft CRC models without additional toxicity.

Our study revealed that VD3 was able to act in synergy with IR both in vitro and in vivo and could also confer radiosensitivity by regulating EMT, thereby providing a novel insight for elevating the efficacy of therapeutic regimens.

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Created by admin. Last Modification: Monday October 4, 2021 19:29:39 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
16123 Radiosensitivy ToC.jpg admin 23 Aug, 2021 17:18 55.80 Kb 143
16122 Vitamin D Enhances Radiosensitivity_compressed.pdf PDF 2021 admin 23 Aug, 2021 16:53 796.68 Kb 115
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