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The role of vitamin D in prevention and treatment of infection – Aug 2013

Inflamm Allergy Drug Targets. 2013 Aug;12(4):239-45.
Gunville CF1, Mourani PM, Ginde AA.
1Section of Critical Care, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA. cameron.gunville at childrenscolorado.org

Vitamin D is well known for its classic role in the maintenance of bone mineral density. However, vitamin D also has an important "non-classic" influence on the body's immune system by modulating the innate and adaptive immune system, influencing the production of important endogenous antimicrobial peptides such as cathelicidin, and regulating the inflammatory cascade. Multiple epidemiological studies in adults and children have demonstrated that vitamin D deficiency is associated with increased risk and greater severity of infection, particularly of the respiratory tract. Although the exact mechanisms by which vitamin D may improve immune responses to infection continue to be evaluated, vitamin D supplementation trials of prevention and adjunct therapy for infection are underway. Given its influence on the immune system and inflammatory cascade, vitamin D may have an important future role in the prevention and treatment of infection.

PMID: 23782205

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The role of vitamin D in prevention and treatment of infection – Aug 2013

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- Infectious Disease typically not treated if use less than 4000 IU vitamin D daily– review Oct 2014 Inflammation, infection, active vitamin D, and Olmesartan - Sept 2014 STD not decreased by metronidazole plus increasing the vitamin D levels to 30 ng – June 2014 One issue of Inflammation and Allergy-Drug Targets has vitamin D items behind paywall– June 2013

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