Oral Cholecalciferol versus Ultraviolet Radiation B: Effect on Vitamin D Metabolites in Patients with Chronic Pancreatitis and Fat Malabsorption
- A Randomized Clinical Trial.
Pancreatology. 2011 Aug 30;11(4):376-382.
Bang UC, Matzen P, Benfield T, Beck Jensen JE.
Department of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark.
Background: Patients with chronic pancreatitis (CP) often develop fat malabsorption and are susceptible to hypovitaminosis D. Aim: We wanted to evaluate the intestinal uptake of cholecalciferol in patients with CP and fat malabsorption.
Methods: We did a prospective placebo-controlled study including patients with verified CP and fat malabsorption. They were randomized to 10 weeks of (A) ultraviolet radiation B (UVB) 6 min weekly in a commercial tanning bed, (B) vitamin D supplement 1,520 IU/daily, or (C) placebo. The vitamin D metabolites 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (calcitriol) were quantified at the start and end of the study.
Results: In total 30 patients were randomized and 27 completed the study. Compliance to tablets and tanning sessions was >80%. The changes in 25OHD levels in group B (32.3 nmol/l; 95% CI 15-50) were significantly greater than changes in group A (p < 0.001) and group C (p < 0.001). Changes in group A (1.1 nmol/l) did not differ from the placebo group (p = 0.9). Changes in calcitriol levels were identical between groups.
Conclusions: Daily vitamin D supplements increased 25OHD in patients with CP compared to placebo whereas weekly tanning bed sessions did not. and IAP.
Copyright © 2011 S. Karger AG, Basel.
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