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Spinal curvature (Idiopathic Scoliosis) associated with low vitamin D

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Prevalence of 25-OH-Vitamin D and Calcium Deficiency in Adolescent Idiopathic Scoliosis

J Med Life. Apr-Jun 2020;13(2):260-264. doi: 10.25122/jml-2020-0101.
Alexandru Herdea 1 2, Adham Charkaoui 3 4, Alexandru Ulici 1 2
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Several etiologies have been proposed as a basis and evolution theory for the development of adolescent idiopathic scoliosis, but limited data were published until now that link vitamin D and calcium deficiency to this condition. The present study aims to evaluate the relationship between 25-OH-Vitamin D, total calcium, and the following data: Cobb angle, age, and patient sex. The seasonal variation for vitamin D will also be taken into consideration. A total of 101 patients with a mean age of 11.61 ± 2.33 years had vitamin D and calcium levels tested. The mean Cobb angle was 26.21o ± 12.37. The level of vitamin D was, on average, 24 ng/mL ± 9.64. Calcium values were within the normal range, with an average of 9.82 mg/dL ± 0.42. The male group showed lower levels of vitamin D compared to the female group (19.6 vs. 25.45 ng/mL) (p = 0.02). Seasonal variations showed significant differences for vitamin D (p=.0001). Vitamin D level was positively correlated with the calcium level (p=0.01, r=0.973), but also with the patient's age (p <0.001, r=0.158).
The Cobb angle was negatively correlated with serum vitamin D levels (p<0.01, r=-0.472). Patients included in this study had low vitamin D levels, significant differences being observed between boys and girls, boys being more affected. The positive correlation between vitamin D and calcium, together with the negative correlation with the Cobb angle, is yet another proof that patients with idiopathic scoliosis should be investigated regularly for these pathologies.


The Role of Vitamin D in the Pathogenesis of Adolescent Idiopathic Scoliosis - Oct 2018

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Created by admin. Last Modification: Saturday August 1, 2020 12:22:54 GMT-0000 by admin. (Version 6)

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ID Name Comment Uploaded Size Downloads
14108 The Role of Vitamin D in the Pathogenesis of Adolescent Idiopathic Scoliosis.pdf admin 01 Aug, 2020 12:18 991.11 Kb 1
14107 Idiopathic Scoliosis.pdf admin 01 Aug, 2020 12:12 215.61 Kb 0
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