Reduced serum vitamin D levels in neuromyelitis optica
Neurological Sciences, April 2015 https://doi.org/10.1007/s10072-015-2229-7
Erdem Tüzün drerdem at yahoo.com (1), Özlem Küçükhüseyin (2), Murat Kürtüncü (3)
Recai Türkoğlu (4), İlhan Yaylım (2)
1. Department of Neuroscience, Institute for Experimental Medical Research (DETAE), Istanbul University, Vakif Gureba Street, Capa, 34390, Istanbul, Turkey
2. Department of Molecular Medicine, Institute for Experimental Medical Research (DETAE), Istanbul University, Istanbul, Turkey
3. Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
4. Department of Neurology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
Dear Sir,
Vitamin D deficiency has been associated with several autoimmune disorders and increased autoimmune responses in healthy individuals. One of many potential factors underlying this association is the well-established anti-inflammatory action of vitamin D administration resulting in reduced proinflammatory cytokine production and enhanced regulatory T cell activity [1]. Although vitamin D deficiency is well known in multiple sclerosis (MS) [2], its significance in neuromyelitis optica (NMO), another autoimmune disease of the central nervous system (CNS), is less well understood. NMO, NMO spectrum disorder and recurrent transverse myelitis patients have been recently shown to display reduced vitamin D levels [3, 4]. Although, these studies have shed some light on the impact of vitamin D on NMO pathogenesis, associations between vitamin D levels and clinical–demographic features of NMO patients are yet to be characterized. . . . End of free text by publisher
PDF is available free at Sci-Hub 10.1007/s10072-015-2229-7
References
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Neuromyelitis optica Wikipedia
- “Neuromyelitis optica (NMO), also known as Devic's disease or Devic's syndrome, is a heterogeneous condition consisting of recurrent and simultaneous inflammation and demyelination of the optic nerve (optic neuritis) and the spinal cord (myelitis).”
- “35% of African Americans are often misdiagnosed with MS when they really have NMO”
PubMed
- The Incidence and Prevalence of Neuromyelitis Optica - A Systematic Review - 2013
"the prevalence per 100,000 population ranged from 0.52 to 4.4. "
doi: 10.7224/1537-2073.2012-048 free text and PDF - Association between Sun Exposure, Vitamin D Intake, Serum Vitamin D Level, and Immunoglobulin G Level in Patients with Neuromyelitis Optica Spectrum Disorder. Aug 2018
doi: 10.4103/ijpvm.IJPVM_45_16 free PDF online - Low levels of vitamin D in neuromyelitis optica spectrum disorder: association with disease disability - Sept 2014
doi: 10.1371/journal.pone.0107274 free PDF online
The worse the disease, the lower the Vitamin D
Devic's Disease treated by Coimbra Protocol
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