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Neuromyelitis optica (Devic's Disease is not MS) is also associated with low vitamin D – April 2015

Reduced serum vitamin D levels in neuromyelitis optica

Neurological Sciences, April 2015 https://doi.org/10.1007/s10072-015-2229-7
Erdem Tüzün drerdem at yahoo.com (1), Özlem Küçükhüseyin (2), Murat Kürtüncü (3)
Recai Türkoğlu (4), İlhan Yaylım (2)
1. Department of Neuroscience, Institute for Experimental Medical Research (DETAE), Istanbul University, Vakif Gureba Street, Capa, 34390, Istanbul, Turkey
2. Department of Molecular Medicine, Institute for Experimental Medical Research (DETAE), Istanbul University, Istanbul, Turkey
3. Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
4. Department of Neurology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey

Dear Sir,
Vitamin D deficiency has been associated with several autoimmune disorders and increased autoimmune responses in healthy individuals. One of many potential factors underlying this association is the well-established anti-inflammatory action of vitamin D administration resulting in reduced proinflammatory cytokine production and enhanced regulatory T cell activity [1]. Although vitamin D deficiency is well known in multiple sclerosis (MS) [2], its significance in neuromyelitis optica (NMO), another autoimmune disease of the central nervous system (CNS), is less well understood. NMO, NMO spectrum disorder and recurrent transverse myelitis patients have been recently shown to display reduced vitamin D levels [3, 4]. Although, these studies have shed some light on the impact of vitamin D on NMO pathogenesis, associations between vitamin D levels and clinical–demographic features of NMO patients are yet to be characterized. . . . End of free text by publisher

PDF is available free at Sci-Hub   10.1007/s10072-015-2229-7


  1. Ritterhouse, LL, Crowe, SR, Niewold, TB, Kamen, DL, Macwana, SR, Roberts, VC, Dedeke, AB, Harley, JB, Scofield, RH, Guthridge, JM, James, JA (2011) Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus. Ann Rheum Dis 70: pp. 1569-1574 CrossRef
  2. Lin, CH, Kadakia, S, Frieri, M (2014) New insights into an autoimmune mechanism, pharmacological treatment and relationship between multiple sclerosis and inflammatory bowel disease. Autoimmun Rev 13: pp. 114-116 CrossRef
  3. Mealy, MA, Newsome, S, Greenberg, BM, Wingerchuk, D, Calabresi, P, Levy, M (2012) Low serum vitamin D levels and recurrent inflammatory spinal cord disease. Arch Neurol 69: pp. 352-356 CrossRef
  4. Min, JH, Waters, P, Vincent, A, Cho, HJ, Joo, BE, Woo, SY, Lee, SY, Shin, HY, Lee, KH, Kim, BJ (2014) Low levels of vitamin D in neuromyelitis optica spectrum disorder: association with disease disability. PLoS ONE 9: pp. e107274 CrossRef
     Download the PDF from VitaminDWiki
  5. Wingerchuk, DM, Lennon, VA, Pittock, SJ, Lucchinetti, CF, Weinshenker, BG (2006) Revised diagnostic criteria for neuromyelitis optica. Neurology 66: pp. 1485-1489 CrossRef
  6. Grau-López, L, Granada, ML, Raïch-Regué, D, Naranjo-Gómez, M, Borràs-Serres, FE, Martínez-Cáceres, E, Ramo-Tello, C (2012) Regulatory role of vitamin D in T-cell reactivity against myelin peptides in relapsing-remitting multiple sclerosis patients. BMC Neurol 12: pp. 103 CrossRef

Neuromyelitis optica Wikipedia

  • “Neuromyelitis optica (NMO), also known as Devic's disease or Devic's syndrome, is a heterogeneous condition consisting of recurrent and simultaneous inflammation and demyelination of the optic nerve (optic neuritis) and the spinal cord (myelitis).”
  • “35% of African Americans are often misdiagnosed with MS when they really have NMO”


  • The Incidence and Prevalence of Neuromyelitis Optica - A Systematic Review - 2013
    "the prevalence per 100,000 population ranged from 0.52 to 4.4. "
    doi: 10.7224/1537-2073.2012-048 free text and PDF
  • Association between Sun Exposure, Vitamin D Intake, Serum Vitamin D Level, and Immunoglobulin G Level in Patients with Neuromyelitis Optica Spectrum Disorder. Aug 2018
    doi: 10.4103/ijpvm.IJPVM_45_16    free PDF online
  • Low levels of vitamin D in neuromyelitis optica spectrum disorder: association with disease disability - Sept 2014
    doi: 10.1371/journal.pone.0107274    free PDF online
    The worse the disease, the lower the Vitamin D

Devic's Disease treated by Coimbra Protocol

Created by admin. Last Modification: Sunday September 9, 2018 13:52:36 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
10507 NMO EDSS.jpg admin 09 Sep, 2018 13:49 28.65 Kb 735
10506 NMO PLOS.jpg admin 09 Sep, 2018 13:49 17.90 Kb 742
10505 NMO.jpg admin 09 Sep, 2018 13:48 18.68 Kb 901
5372 neuromyelitis optica Sept 2014.pdf PDF 2014 admin 25 Apr, 2015 12:28 390.52 Kb 1022