Vitamin D supplementation for the management of knee osteoarthritis: a systematic review of randomized controlled trials
Hussain, S., Singh, A., Akhtar, M. et al. Rheumatol Int (2017). doi:10.1007/s00296-017-3719-0
This study, like a majority of meta-analyses and reviews, ignores the vitamin D levels achieved.
- Overview Osteoarthritis and Vitamin D
- Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013
- Vitamin D increasing muscle strength may reduce knee pain – Feb 2016
- I needed more than Vitamin D to treat my knee osteoarthritis
- Severe Osteoarthritis not helped by vitamin D if not vitamin D deficient 2013-2015
- Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015
- Search VitaminDWiki for "Knee Osteoarthritis" 148 items as of April 2017
Conflicting evidence exists concerning the supplementation of vitamin D in knee osteoarthritis condition. This systematic literature review was done to explore the effects of vitamin D supplementation in the management of knee osteoarthritis. Electronic literature search was done in databases like PubMed®, Embase®, and Cochrane CENTRAL from inception to 6th July 2016. The quality of included Randomized Controlled Trials (RCTs) was assessed using Cochrane risk of bias tool. We considered change in Western Ontario and McMaster Universities (WOMAC) index, Visual Analog Scale (VAS) and Functional Pain Score (FPS) as the primary outcome measure. Change in tibial cartilage thickness, joint space width and safety profile was considered as secondary outcomes. Participants were randomized either to treatment or placebo group. Participants received cholecalciferol as an intervention through oral route in the dose range of 800–60,000 IU except in the one study where participants received ergocalciferol. All included RCTs showed a significant increase in serum vitamin D level in the treatment group compared to the placebo group at the end point. No significant reduction in pain and function was reported on WOMAC scale except in one study. No significant difference was reported for WOMAC stiffness in any study. VAS was assessed in three studies in which two showed statistically significant improvement in knee pain. Three of the RCTs reported safety data with one incidence of calculus ureteric and hip fracture found to be related to the drug. The study found evidence from RCTs to be insufficient to support the use of vitamin D supplementation for patients with knee osteoarthritis.