Rethinking corticosteroids use in oncology - March 2025
Front Pharmacol. 2025 Mar 26:16:1551111. doi: 10.3389/fphar.2025.1551111
Pierrick Martinez 1, Jean-Marc Sabatier 2
Corticosteroids (CSs), widely used in oncology for their anti-inflammatory and immunosuppressive properties, help manage cancer-related symptoms and side effects. However, their long-term use may negatively affect patient survival and exacerbate tumor progression.
- Elevated glucose and glutamine metabolism,
- disruption of vitamin D levels, and
- alterations in the microbiome
are some of the key factors contributing to these adverse outcomes.
Approaches such as ketogenic diets, fasting, sartans, and vitamin D supplementation have shown promise in providing similar benefits to CSs while mitigating the risks associated with the mechanisms identified as contributing to tumor progression. This perspective underscores the necessity for a reevaluation of CSs use in cancer care and advocates for further research into safer, more effective therapeutic strategies.
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Under what circumstances are corticosteroids used in oncology?
Under what circumstances are corticosteroids used with asthma?
Corticosteroids reduce Vitamin D in 4 ways
Perplexity AI - April 2025
1 of the ways: Corticosteroids stimulate the enzyme 24-hydroxylase CYP24A1
7+ VitaminDWiki pages have Corticosteroids in the title
The list is automatically updated
If you must take Corticosteroids, consider also increasing Vitamin D
- Vitamin D can safely reduce asthma exacerbations among corticosteroid-using children and adults with asthma: a systematic review and meta-analysis of randomized controlled trials
- https://doi.org/10.1016/j.nutres.2021.05.010 Aug 2021 PDF is behind a paywall