Association Between Vitamin D and Risk of Colorectal Cancer: A Systematic Review of Prospective Studies.
J Clin Oncol. 2011 Aug 29.
Ma Y, Zhang P, Wang F, Yang J, Liu Z, Qin H.
The Sixth People's Hospital affiliated with Shanghai Jiao Tong University, Shanghai, People's Republic of China.
PURPOSE To conduct a systematic review of prospective studies assessing the association of vitamin D intake or blood levels of 25-hydroxyvitamin D [25(OH)D] with the risk of colorectal cancer using meta-analysis.
METHODS Relevant studies were identified by a search of MEDLINE and EMBASE databases before October 2010 with no restrictions.
We included prospective studies that reported relative risk (RR) estimates with 95% CIs for the association between vitamin D intake or blood 25(OH)D levels and the risk of colorectal, colon, or rectal cancer.
Approximately 1,000,000 participants from several countries were included in this analysis.
Results Nine studies on vitamin D intake and nine studies on blood 25(OH)D levels were included in the meta-analysis.
The pooled RRs of colorectal cancer for the highest versus lowest categories of vitamin D intake and blood 25(OH)D levels were 0.88 (95% CI, 0.80 to 0.96) and 0.67 (95% CI, 0.54 to 0.80), respectively.
There was no heterogeneity among studies of vitamin D intake (P = .19) or among studies of blood 25(OH)D levels (P = .96).
10 ng/mL increment in blood 25(OH)D level conferred an RR of 0.74 (95% CI, 0.63 to 0.89).
CONCLUSION Vitamin D intake and blood 25(OH)D levels were inversely associated with the risk of colorectal cancer in this meta-analysis.
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