Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts — Feb 2019
JNCI: Journal of the National Cancer Institute, Vol 111, Issue 2, 1 Feb 2019, Pages 158–169, https://doi.org/10.1093/jnci/djy087
Marjorie L McCullough Emilie S Zoltick Stephanie J Weinstein Veronika Fedirko Molin Wang Nancy R Cook A Heather Eliassen Anne Zeleniuch-Jacquotte Claudia Agnoli Demetrius Albanes ...
- Cancer - Colon category listing has
144 items along with related searches - Overview Cancer-Colon and vitamin D
- Overview Cancer and vitamin D
- Colorectal cancer is associated with Vitamin D (17 meta-analyses so far) – July 2018
- Increased incidence of 7 cancers if live far from equator (if not take vitamin D) – March 2019
- Colon cancer 25 percent less likely if consume Calcium, Magnesium, Zinc, etc.– Nov 2018
- Death from Colon Cancer 8 X less likely if good level of vitamin D – Nov 2018
 Download the PDF from Sci-Hub via VitaminDWiki
Background
Experimental and epidemiological studies suggest a protective role for vitamin D in colorectal carcinogenesis, but evidence is inconclusive. Circulating 25-hydroxyvitamin D (25(OH)D) concentrations that minimize risk are unknown. Current Institute of Medicine (IOM) vitamin D guidance is based solely on bone health.Methods
We pooled participant-level data from 17 cohorts, comprising 5706 colorectal cancer case participants and 7107 control participants with a wide range of circulating 25(OH)D concentrations. For 30.1% of participants, 25(OH)D was newly measured. Previously measured 25(OH)D was calibrated to the same assay to permit estimating risk by absolute concentrations. Study-specific relative risks (RRs) for prediagnostic season-standardized 25(OH)D concentrations were calculated using conditional logistic regression and pooled using random effects models.Results
Compared with the lower range of sufficiency for bone health (50–<62.5 nmol/L), deficient 25(OH)D (<30 nmol/L) was associated with 31% higher colorectal cancer risk (RR = 1.31, 95% confidence interval CI = 1.05 to 1.62); 25(OH)D above sufficiency (75–<87.5 and 87.5–<100 nmol/L) was associated with 19% (RR = 0.81, 95% CI = 0.67 to 0.99) and 27% (RR = 0.73, 95% CI = 0.59 to 0.91) lower risk, respectively. At 25(OH)D of 100 nmol/L or greater, risk did not continue to decline and was not statistically significantly reduced (RR = 0.91, 95% CI = 0.67 to 1.24, 3.5% of control participants). Associations were minimally affected when adjusting for body mass index, physical activity, or other risk factors.
For each 25 nmol/L increment in circulating 25(OH)D, colorectal cancer risk was- 19% lower in women (RR = 0.81, 95% CI = 0.75 to 0.87) and
- 7% lower in men (RR = 0.93, 95% CI = 0.86 to 1.00)
(two-sided Pheterogeneity by sex = .008). Associations were inverse in all subgroups, including colorectal subsite, geographic region, and season of blood collection.
Conclusions
Higher circulating 25(OH)D was related to a statistically significant, substantially lower colorectal cancer risk in women and non–statistically significant lower risk in men. Optimal 25(OH)D concentrations for colorectal cancer risk reduction, 75-100 nmol/L, appear higher than current IOM recommendations.
2X more likely to survive if >20 ng of vitamin D after CC surgery - April 2019
Higher Post-Operative Serum Vitamin D Level is Associated with Better Survival Outcome in Colorectal Cancer Patients.
Nutr Cancer. 2019 Apr 4:1-8. doi: 10.1080/01635581.2019.1597135.
Markotic A1,2, Langer S3, Kelava T2,4, Vucic K5, Turcic P6, Tokic T7, Stefancic L8, Radetic E7, Farrington S9, Timofeeva M9, Rudan I10, Campbell H10, Dunlop M9, Kirac I11, Zgaga L12.25-Hydroxyvitamin D (25-OHD) may have a prognostic value in colorectal cancer (CRC) patients. However, as 25-OHD concentration is strongly impacted by surgery, it is uncertain what is the most reliable time-point for 25-OHD assessment, pre- or post-operative. Therefore, we examined 515 CRC patients (AJCC I-III) who underwent surgery. Blood samples were collected either pre-operatively (n = 286; median = 1 day before surgery) or post-operatively (n = 229; median = 8 days). Serum 25-OHD concentration was determined by liquid chromatography-tandem mass spectrometry. Association between 25-OHD and survival was tested in the whole cohort, followed by stratified analyses in pre- and post-operatively sampled. Median 25-OHD in the cohort was 36.7 nmol/L and median follow-up time was 5.9 years. There were no differences between pre- and post-operative cohort in age, sex, 25-OHD, AJCC stage, or localization of tumor.
After adjustment, higher 25-OHD (>50 nmol/L) was associated with better overall survival only in post-operative (HR = 0.53; 95% CI: 0.33-0.84; P = 0.006), but not in pre-operative cohort (HR = 1.13; 95% CI: 0.77-1.65; P = 0.53). In conclusion, higher post-operative 25-OHD levels were associated with better survival outcome in CRC patients, while no such association was found for pre-operative levels. Time-point of blood collection should be addressed carefully in future research as it might affect the prognostic value of 25-OHD in CRC.Colon Cancer 30 percent higher risk if low vitamin D (optimally need ~40 ng) – Feb 20195871 visitors, last modified 05 Apr, 2019, This page is in the following categories (# of items in each category)Attached files
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