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Cancer 4 times more likely if low vitamin D (in dogs) – 2016

Serum 25-hydroxyvitamin D concentrations in dogs - correlation with health and cancer risk.

Vet Comp Oncol. 2016 Sep;14(3):295-305. doi: 10.1111/vco.12101. Epub 2014 Jul 8.
Selting KA1, Sharp CR2, Ringold R3, Thamm DH4, Backus R1.
1 Veterinary Medical Teaching Hospital, University of Missouri, Columbia, MO, USA.
2 Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.
3 Veterinary Diagnostics Institute, Simi Valley, CA, USA.
4 Department of Clinical Sciences, Animal Cancer Center, Colorado State University, Fort Collins, CO, USA.

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Relative risk of the disease group compared with that of the control group

25-hydroxyvitamin D (25(OH)D) is important in bone health as well as many diseases including cancer. Supplementation may increase responsiveness of cancer cells to chemotherapy. Serum 25(OH)D, intact parathyroid hormone (iPTH) and canine C-reactive protein (c-CRP) were measured in healthy dogs and dogs with haemoabdomen. Regression analysis determined optimal 25(OH)D concentrations. In healthy dogs (n = 282), mean iPTH concentrations correlated inversely (r(2) = 0.88, P < 0.001) to 25(OH)D concentrations. Variation in both iPTH and c-CRP plateaued at 25(OH)D concentrations of 100-120 ng mL(-1) . Haemoabdomen dogs (n = 63, 43 malignant and 20 benign) had 25(OH)D concentrations ranging from 19.4 to >150 ng mL(-1) .
Relative risk of cancer increased with decreasing 25(OH)D concentrations [RR = 3.9 for 25(OH)D below 40 ng mL(-1) (P = 0.0001)]. Serum 25(OH)D concentrations in dogs vary widely, and are influenced by dietary VitD content. Serum vitD measurement can identify dogs for which supplementation may improve health and response to cancer therapy.

PMID: 25041357 DOI: 10.1111/vco.12101

Clips from the study

  • “This data has been previously presented at the American College of Veterinary Internal Medicine Forum, June 2013, Seattle, WA, USA”
  • “It should be noted that dogs with insufficient vitamin D, despite a 6–12 month follow-up period, should still be considered at risk for the development of disease such as cardiac disease, inflammatory bowel disease and cancer as previously published.42– 46”
  • As the majority of these dogs eat commercial dog food diets, our data likely reflect the level of vitamin D supplementation that exists today, rather than what should be considered adequate. “
    Note by VitaminDWiki: Many farm-animal and zoo-animal vets have found that they need to give 3X the amount of vitamin D to keep the animals healthy than what the US govt recommends. Suspect that the pets also need more, but pet vets get more income when if there is poor health, thus they have a negative incentive to keep the pets healthy

Attached files

ID Name Comment Uploaded Size Downloads
7920 Dog cancer T2.jpg admin 18 Apr, 2017 25.77 Kb 1154
7919 Dogs Cancer.pdf admin 18 Apr, 2017 504.10 Kb 926