Loading...
 
Toggle Health Problems and D

3000 IU of vitamin D minimum to reduce parathyroid hormone (PTH) – meta-analysis Sept 2015

Determinants of parathyroid hormone response to vitamin D supplementation: a systematic review and meta-analysis of randomised controlled trials.

Br J Nutr. 2015 Sep 4:1-15.
Moslehi N1, Shab-Bidar S2, Mirmiran P3, Hosseinpanah F4, Azizi F5.

PTH response to Vitamin D intervention
Image

This systematic review aimed to assess the determinants of the parathyroid hormone (PTH) level response to vitamin D supplementation. We searched Medline, Google Scholar and the reference lists of previous reviews. All randomised controlled trials (RCT) on vitamin D supplementation that involved apparently healthy human subjects with a report of PTH were selected. Potential studies were screened independently and in duplicate. Results are summarised as mean differences with 95 % confidence intervals. Quality assessment, subgroup analysis, meta-analysis and meta-regression analysis were carried out. Thirty-three vitamin D supplementation RCT were included. Vitamin D supplementation significantly raised circulating 25-hydroxyvitamin D (25(OH)D) with significant heterogeneity among studies with a pooled mean difference (PMD) of 15.5 ng/ml (test for heterogeneity: P<0·001 and I 2=97·3 %). Vitamin D supplementation significantly reduced PTH level with PMD of -8·0 pg/ml, with significant heterogeneity ( (test for heterogeneity: P<0·001) and the I 2 value was 97·3 %). In the subgroup analyses, the optimum treatment effect for PTH was observed with Ca doses of 600-1200 mg/d (-22·48 pg/ml), after the duration of a >12-month trial (-18·36 pg/ml), with low baseline 25(OH)D concentration of <20 ng/ml (-16·70 pg/ml) and in those who were overweight and obese (-18·11 pg/ml).
Despite the present meta-analysis being hindered by some limitations, it provided some interesting evidence, suggesting that suppression of PTH level needs higher vitamin D intake (75 μg/d) than the current recommendations and longer durations (12 months), which should be taken into account for nutritional recommendations.

 Download the PDF from VitaminDWiki


See also VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
15595 PTH response meta.jpg admin 17 May, 2021 12:43 66.15 Kb 72
15594 PTH meta 2015.pdf admin 17 May, 2021 12:37 1.44 Mb 41
See any problem with this page? Report it (FINALLY WORKS)