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Vitamin D fights treatment-resistant cancers (petrie dish) – June 2019

VitaminDWiki Summary

Vitamin D may be able to treat many multidrug-resistant diseases
Cells which pump drugs out of them have the protein MRP1
Calcitriol kills cells with MRP1 (in Petrie dish)
This may be the reason that Vitamin D helps Chemo, etc.

How vitamin D helps fight treatment-resistant cancer Medical News Today

“The researchers showed that calcitriol and calcipotriol can selectively hone in on cancer cells that have too much MRP1 and destroy them”
“… multidrug resistance-associated protein 1 (MRP1). The protein sits in the cell wall and drives a pump that ejects cancer drugs out of the cell.”
“Cancer cells that develop resistance to chemotherapy drugs often overexpress, or overproduce, transporter proteins. This abundance is the primary cause of chemoresistance”
“MRP1 doesn't just reduce the effectiveness of cancer drugs, it can also weaken the effect of antibiotics, antivirals, anti-inflammatories, antidepressants, and drugs that treat HIV.”

Reference

Calcitriol and Calcipotriol Modulate Transport Activity of ABC Transporters and Exhibit Selective Cytotoxicity in MRP1-overexpressing Cells
Kee W. Tan, Angelina Sampson, Bremansu Osa-Andrews and Surtaj H. Iram
Drug Metabolism and Disposition December 2018, 46 (12) 1856-1866; DOI: https://doi.org/10.1124/dmd.118.081612
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VitaminDWiki

MRP1 connection may explain many of the following

Calcitriol in VitaminDWiki

Calcitriol category listing has 62 items along with related searches
Active vitamin D appears to treat cancer – more studies needed – June 2018

Quick Chemo look on the web

Known	Half of late-stage cancer patients get chemotherapy
Unknown	% of Cancers which are now Chemo resistant

Vitamin D fights treatment-resistant cancers (petrie dish) – June 2019

5689 visitors, last modified 20 Jun, 2019,

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- Chemotherapy drugs often reduce Vitamin D levels, restoring levels helps– Aug 2018 Chemotherapy might be augmented with Vitamin D – Jan 2017 Breast Cancer chemotherapy 2.7 X more likely to be successful if not vitamin D deficient – Dec 2017 Chemotheraphy not work as well with low Vitamin D (colon cancer this time) – Aug 2018

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Cancer - after diagnosis 108 Top news 911

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12162	Calcitriol MRP1.pdf	PDF 2018	admin 19 Jun, 2019	1.13 Mb	647

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