The relationship between vitamin D deficiency and pulmonary hypertension – 2013

Prague Med Rep. 2013;114(3):154-61.
Demir M 1, Uyan U, Keçeoçlu S, Demir C.
1Department of Cardiology, Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey.

Vitamin D deficiency actives renin-angiotensin-aldosterone system (RAAS) which affects cardiovascular system. Activation of RAAS is associated with pulmonary hypertension (PHT). Relation between vitamin D deficiency and PHT could be therefore suggested. In our study we compared pulmonary artery pressure between vitamin D deficiency and control groups. 115 consecutive patients (average age: 61.86 ± 5.86) who have detected very low vitamin D (vitamin D levels < 10 ng/ml) were enrolled. 117 age matched persons (average age: 61.74 ± 5.99) were selected as the control group. All groups underwent transthoracic echocardiography. Routine biochemical measurement of 25-OH vitamin D and parathormon (PTH) levels were performed. Baseline characteristics of the study groups were comparable. Systolic pulmonary artery pressure (SPAP) of patients in the low vitamin D group was higher than the control groups. As a result our study, a relation between vitamin D deficiency and pulmonary artery hypertension was revealed.

PMID: 24093815
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pulmonary hypertension Wikipedia March 2014

Clipped from introduction
Pulmonary hypertension (PH) is an increase of blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, together known as the lung vasculature, leading to shortness of breath, dizziness, fainting, leg swelling and other symptoms. Pulmonary hypertension can be a severe disease with a markedly decreased exercise tolerance and heart failure.

Clipped from Epidemiology
In scleroderma the incidence has been estimated to be 6 to 60% of all patients,
in rheumatoid arthritis up to 21%,
in systemic lupus erythematosus 4 to 14%,
in portal hypertension between 2 to 5%,
in HIV about 0.5%, and
in sickle cell disease ranging from 20 to 40%.