Neurological Sciences, pp 1–4 , https://doi.org/10.1007/s10072-018-3440-0
L. Ferre’F. ClarelliG. SferruzzaM. A. RoccaE. MasciaM. RadaelliF. SangalliG. Dalla CostaL. MoiolaM. AboulwafaF. Martinelli BoneschiG. ComiM. FilippiV. MartinelliF. Esposito
This study noticed fewer lesions in patients which happen to have > 40 ng of Vitamin D
90% of MSers have become disease-free when they added enough vitamin D to get Vitamin D > 150 ng
Background: Several studies have shown an association between 25-hydroxyvitamin D (25[OH]D) levels and multiple sclerosis (MS) susceptibility and/or level of disease activity in patients treated with first line drugs.
Aims: To investigate whether baseline 25[OH]D values could influence disease activity also during treatment with the second-line drug fingolimod (FTY).
Patients and methods
We enrolled 176 MS patients who started FTY at the San Raffaele Hospital (OSR) MS center with available 25[OH]D measurement at the time of treatment start. We then prospectively followed them for 2 years with periodic clinical examinations and MRI scans.
We found no linear correlation between baseline 25[OH]D levels and annualized relapse rate (ARR) or time to first relapse.
However, we observed that patients with serum 25[OH]D ≥ 100 nmol/l showed a lower number of Gd+ and combined unique activity (CUA) lesions at baseline compared to patients with the lowest 25[OH]D levels (less than 50 nmol/l, p value < 0.05). Moreover, they showed fewer CUA lesions at 2-year follow-up also when accounting for baseline level of disease activity (p value < 0.05).
In patients treated with FTY, those with the highest baseline 25(OH)D levels had a significantly lower number of active lesions at baseline; the same effect, even if weaker, was observed also at 2-year follow-up when adjusting for baseline disease activity. Given Vitamin D supplementation safety profile, also if a causal effect has not yet been shown, most of MS patients could probably benefit from 25[OH]D levels above those currently considered to be sufficient.
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