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Migraine headaches treated by Vitamin D – meta-analysis Jan 2021

The Efficacy of Vitamin D Supplementation for Migraine: A Meta-Analysis of Randomized Controlled Studies

Clin Neuropharmacol. 2021 Jan-Feb 01;44(1):5-8. doi: 10.1097/WNF.0000000000000419.
Yuan-Feng Zhang 1, Zhi-Qiang Xu, Hong-Jie Zhou, Ya-Zhen Liu, Xiao-Jiang Jiang


Headache has the following on metals and migraines
Compared blood levels of 25 people with migraines to 25 people without GreenMedInfo

Metal MigraineNo Migraine Migraine Ratio
Cadmium 0.36 ug0.09 ug 4X MORE if increase
Iron0.97 ug0.48 ug2X MORE if increase
Lead1.48 ug0.78 ug 2X MORE if increase
Magnesium10.6 ug34.5 ug 3.5X LESS if increase
Zinc *0.24 ug 5.77 ug 24X LESS if increase

 * Note: Zinc increases the activation of the Vitamin D Receptor, which allows more vitamin D into cells


  • Zinc somewhat reduced Migraine in RCT - Sept 2020

Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial https://doi.org/10.1186/s12937-020-00618-9 FREE PDF

Migraines have low vitamin D, Migraines plus Restless Leg have far lower vitamin D (no surprise) – Dec 2021

Introduction: The efficacy of vitamin D for migraine remains controversial. We conduct a systematic review and meta-analysis to explore the influence of vitamin D versus placebo on treatment in migraine patients.

Methods: We search PubMed, EMbase, Web of Science, EBSCO, and Cochrane library databases through April 2020 for randomized controlled trials assessing the effect of vitamin D versus placebo on treatment efficacy in migraine patients. This meta-analysis is performed using the random-effect model.

Results: Five randomized controlled trials are included in the meta-analysis. Overall, compared with control group in migraine patients, vitamin D treatment is associated with

  • substantially reduced number of headache days
    • (standard mean difference [SMD], -0.53; 95% confidence interval [CI], -0.83 to -0.23; P = 0.0006),
  • frequency of headache attacks (SMD, -1.09; 95% CI, -1.86 to -0.32; P = 0.006),
  • headache severity (SMD, -0.55; 95% CI, -0.91 to -0.19; P = 0.0003), and
  • Migraine Disability Assessment score (SMD, -0.76; 95% CI, -1.11 to -0.40; P < 0.0001).

Conclusions: Vitamin D treatment is effective to alleviate migraine.


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  • Mattle HP, Nedeltchev K, Schankin C, et al. Migraine Headache: Clinical Association With PFO and Observational Studies, Patent Foramen Ovale Closure for Stroke, Myocardial Infarction, Peripheral Embolism, Migraine, and Hypoxemia. Elsevier; 2020:117–127.

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