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LL-37 (Cathelicidin, increased by Vitamin D) fights COVID and Diabetes – May 2022

Upregulating Human Cathelicidin Antimicrobial Peptide LL-37 Expression May Prevent Severe COVID-19 Inflammatory Responses and Reduce Microthrombosis

Front Immunol. 2022 May 12;13:880961. doi: 10.3389/fimmu.2022.880961
Karim M Aloul 1, Josefine Eilsø Nielsen 1 2, Erwin B Defensor 3, Jennifer S Lin 1, John A Fortkort 1, Mehrdad Shamloo 3, Jeffrey D Cirillo 4, Adrian F Gombart 5 6, Annelise E Barron 1

LL-37 Diabetes


LL-37 Brain-Blood-Barrier


LL-37 Roles


COVID-19 is characterized by hyperactivation by inflammatory cytokines and recruitment of macrophages, neutrophils, and other immune cells, all hallmarks of a strong inflammatory response that can lead to severe complications and multi-organ damage. Mortality in COVID-19 patients is associated with a high prevalence of neutrophil extracellular trap (NET) formation and microthrombosis that are exacerbated by hyperglycemia, diabetes, and old age. SARS-CoV-2 infection in humans and non-human primates have revealed long-term neurological consequences of COVID-19, possibly concomitant with the formation of Lewy bodies in the brain and invasion of the nervous system via the olfactory bulb. In this paper, we review the relevance of the human cathelicidin LL-37 in SARS-CoV-2 infections. LL-37 is an immunomodulatory, host defense peptide with direct anti-SARS-CoV-2 activity, and pleiotropic effects on the inflammatory response, neovascularization, Lewy body formation, and pancreatic islet cell function. The bioactive form of vitamin D and a number of other compounds induce LL-37 expression and one might predict its upregulation, could reduce the prevalence of severe COVID-19. We hypothesize upregulation of LL-37 will act therapeutically, facilitating efficient NET clearance by macrophages, speeding endothelial repair after inflammatory tissue damage, preventing α-synuclein aggregation, and supporting blood-glucose level stabilization by facilitating insulin release and islet β-cell neogenesis. In addition, it has been postulated that LL-37 can directly bind the S1 domain of SARS-CoV-2, mask angiotensin converting enzyme 2 (ACE2) receptors, and limit SARS-CoV-2 infection. Purposeful upregulation of LL-37 could also serve as a preventative and therapeutic strategy for SARS-CoV-2 infections.

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Cathelicidin - Wikipedia

  • Cathelicidin antimicrobial peptide (CAMP) is a polypeptide that is primarily stored in the lysosomes of macrophages and polymorphonuclear leukocytes (PMNs); in humans, the CAMP gene encodes the peptide precursor CAP-18 (18 kDa), which is processed by proteinase 3-mediated extracellular cleavage into the active form LL-37.[1][2] LL-37 is the only peptide in the Cathelicidin family found in the human body.[3]


Google Scholar LL-37 62,000 hits , LL-37 covid 2,500 hits

Created by admin. Last Modification: Wednesday June 1, 2022 02:52:28 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
17704 LL-37 wikipedia.png admin 01 Jun, 2022 00:59 160.38 Kb 50
17703 LL-37 roles.jpg admin 31 May, 2022 22:58 195.00 Kb 53
17702 LL-37_CompressPdf.pdf admin 31 May, 2022 22:58 447.21 Kb 55
17701 LL-37 BBB.jpg admin 31 May, 2022 22:56 54.34 Kb 60
17700 LL-37 diabetes.jpg admin 31 May, 2022 22:56 87.18 Kb 109
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