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If parents exposed to pesticides, genes changed. will need more vitamin D to avoid Prostate Cancer – July 2013

Pesticide exposure and inherited variants in vitamin D pathway genes in relation to prostate cancer

Sara Karami1, karamis at mail.nih.gov; Gabriella Andreotti 2; Stella Koutros 2,
Kathryn Hughes Barry 3; Lee E. Moore 4; Summer S Han 2,
Jane A Hoppin 5; Dale P. Sandler 6; Jay H Lubin 3,
Laurie Burdette 3; Jeffrey Yuenger 7; Meredith Yeager 8,
Laura Beane Freeman 2; Aaron Blair 3, and Michael C.R. Alavanja3
1DCEG, National Cancer Institute
2Division of Cancer Epidemiology and Genetics, National Cancer Institute
3National Cancer Institute
4OEEB, National Cancer Institute
5Epidemiology Branch, NIEHS
6National National Cancer Institute
7SAIC-Frederick, Inc., National Cancer Institute
8Core Genotyping Facility, National Cancer Institute

Background: Vitamin D and its metabolites are believed to impede carcinogenesis by stimulating cell differentiation, inhibiting cell proliferation, and inducing apoptosis. Certain pesticides have been shown to deregulate vitamin D's anti-carcinogenic properties. We hypothesize that certain pesticides may be linked to prostate cancer via an interaction with vitamin D genetic variants.

Methods: We evaluated interactions between 41 pesticides and 152 single nucleotide polymorphisms (SNPs) in nine vitamin D pathway genes among 776 prostate cancer cases and 1,444 male controls in a nested case-control study of Caucasian pesticide applicators within the Agricultural Health Study. We assessed interaction P-values using likelihood ratio tests from unconditional logistic regression and a False Discovery Rate (FDR) to account for multiple comparisons.

Results: Five significant interactions (P<0.01) displayed a monotonic increase in prostate cancer risk with individual pesticide use in one genotype and no association in the other.

These interactions involved parathion and terbufos use and three vitamin D genes (VDR, RXRB and GC). The exposure-response pattern among participants with increasing parathion use with the homozygous CC genotype for GC rs7041 compared to unexposed participants was noteworthy (

  • low versus no exposure: odds ratio (OR)=2.58, 95% confidence interval (CI)=1.07-6.25;
  • high versus no exposure: OR=3.09, 95%CI=1.10-8.68; P-interaction=3.8x10-3).

Conclusions: In this study, genetic variations in vitamin D pathway genes, particularly GC rs7041, a SNP previously linked to lower circulating vitamin D levels modified pesticide associations with prostate cancer risk. Impact: Because our study is the first to examine this relationship, additional studies are needed to rule out chance findings.

Received December 31, 2012; Revision received June 5, 2013; Accepted June 13, 2013.
Copyright © 2013, American Association for Cancer Research.
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Comment: Apparently the presence of this genetic variation can be detected my measuring the vitamin D blood levels.
There would be a lower response to a dose of vitamin D by people carring this variation.

See also VitaminDWiki

See also web

  • Rs7041 at SNP pedia; has links to 40+ PubMed articles with Rs7041 - 1 the papers follows
    A study of 414 (ex)-smokers older than 50 years concluded that vitamin D levels were reduced by 25% in [rs7041](T;T) homozygotes
    they were also at increased risk for chronic obstructive pulmonary disease (COPD; odds ratio 2.11

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5899 Pesticide and PC.pdf PDF admin 08 Sep, 2015 12:31 78.66 Kb 418
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