Higher vit D associated with less pancreatic cancer in 118,000 people April 2010
Br J Cancer. 2010 Apr 13. Epub ahead of print
Bao Y, Ng K, Wolpin BM, Michaud DS, Giovannucci E, Fuchs CS.
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
Background:Studies evaluating vitamin D status in relation to pancreatic cancer risk have yielded inconsistent results.Methods:We prospectively followed 118 597 participants in the Nurses' Health Study and Health Professionals Follow-up Study from 1986 to 2006. We calculated a 25-hydroxyvitamin D (25(OH)D) score from known predictors of vitamin D status for each individual and then examined the predicted 25(OH)D levels in relation to pancreatic cancer risk. Relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards models adjusted for age, sex, race, height, smoking, and diabetes. We then further adjusted for body mass index (BMI) and physical activity in a sensitivity analysis.
Results:During 20 years of follow-up, we identified 575 incident pancreatic cancer cases. Higher 25(OH)D score was associated with a significant reduction in pancreatic cancer risk; compared with the lowest quintile, participants in the highest quintile of 25(OH)D score had an adjusted RR of 0.65 (95% CI=0.50-0.86; P(trend)=0.001). Results were similar when we further adjusted for BMI and physical activity.
Conclusions:Higher 25(OH)D score was associated with a lower risk of pancreatic cancer in these two prospective cohort studies.British Journal of Cancer advance online publication, 13 April 2010; doi:10.1038/sj.bjc.6605658 www.bjcancer.com. PMID: 20389298