Relation of Severe Deficiency of Vitamin D to Cardiovascular Mortality During Acute Coronary Syndromes.
Am J Cardiol. 2012 Nov 20. pii: S0002-9149(12)02282-5. doi: 10.1016/j.amjcard.2012.10.006. Correia LC, Sodré F, Garcia G, Sabino M, Brito M, Kalil F, Barreto B, Lima JC, Noya-Rabelo MM.
Medical School of Bahia, Salvador, Brazil; Cardiology Division, San Rafael Hospital, Monte Tabor, Salvador, Brazil. Electronic address: lccorreia at terra.com.br.
Vitamin D deficiency is associated with risk for a first cardiovascular event in the general population, possibly because of inflammation, insulin resistance, and neurohumoral activation. However, its relation with outcomes in acute coronary syndromes has not been reported.
To test the hypothesis that severe deficiency of vitamin D is independently associated with cardiovascular mortality during ACS, 206 patients admitted for
- unstable angina,
- non-ST-segment elevation myocardial infarction, or
- ST-segment elevation acute myocardial infarction
had 25-hydroxyvitamin D serum levels measured at admission. Severe vitamin D deficiency was defined a priori as a value ≤10 ng/ml. The average concentration of vitamin D was 20 ± 8.2 ng/ml, and 10% of patients were severely deficient (95% confidence interval 6.6% to 15%).
Cardiovascular mortality during hospitalization took place in 14 patients, an incidence of 6.8%. Patients with severe vitamin D deficiency had in-hospital cardiovascular mortality of 24%, significantly higher than the 4.9% observed in the remaining patients (relative risk 4.3, 95% confidence interval 1.8 to 10, p = 0.001).
After adjustment for Global Registry of Acute Coronary Events (GRACE) score, Gensini angiographic score, and potential confounding variables, severe deficiency of vitamin D remained an independent predictor of in-hospital cardiovascular mortality (odds ratio 14, 95% confidence interval 1.2 to 158, p = 0.03).
In conclusion, severe vitamin D deficiency is independently associated with in-hospital cardiovascular mortality in patients with acute coronary syndromes.
Copyright © 2012 Elsevier Inc. All rights reserved. PMID: 23174181
- Overview Cardiovascular and vitamin D
- Half as many heart deaths for those with high levels of vitamin D – meta-analysis Sept 2012
- Cardiovascular disease 50 % more likely if low vitamin D – meta-analysis Nov 2012
- Vitamin D intervention reduced death due the heart failure by 32 percent – Feb 2012
- All items in Cardiovascular and Vitamin D
- Echocardiograms confirm problems with low vitamin D – May 2012
- 30 ng perhaps best for cardiovascular - graphs from many countries - 2011.pdf file
14X more likely to die after first cardiovascular event if vitamin D deficient – Nov 2012
- Interventional Clinical Trials for (heart OR cardiovascular) and "vitamin D" 230 as of Nov 2012
3688 visitors, last modified 09 Dec, 2012,This page is in the following categories (# of items in each category)