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Vitamin K guidelines for neonates need to be reconsidered – March 2018

Vitamin K deficiency: a case report and review of current guidelines.

Ital J Pediatr. 2018 Mar 14;44(1):36. doi: 10.1186/s13052-018-0474-0.
Marchili MR1, Santoro E2, Marchesi A3, Bianchi S3, Rotondi Aufiero L3, Villani A3.

VitaminDWiki
  • To prevent Vitamin K Deficiency Bleeding many countries inject or give Vitamin K orally to all newborns
  • Total doses range from 1 to 6 mg over several days - depend on country

  • I wonder why ALL infants get Vitamin K injections/oral
  • I wonder if this started when Vitamin K levels in maternal blood decreased ~40 years ago
    • due to decreased Vitamin K in dairy products (low-fat, etc.)
  • I wonder if K1 or K2 is used
  • I wonder why they do not continue to look at Vitamin K levels in infants/toddlers
  • I wonder why Vitamin K is given at birth to stop bleeding but Vitamin K is restricgted in elderly to prevent bleeding
  • I wonder why Vitamin D is not also given to infants
    • similar to East Germany 600,000 IU injections for many decades
    • Henry Lahore - founder of VitaminDWiki

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BACKGROUND:
Vitamin K, a fat soluble vitamin, is a necessary cofactor for the activation of coagulation factors II, VII, IX, X, and protein C and S. In neonatal period, vitamin K deficiency may lead to Vitamin K Deficiency Bleeding (VKDB).

CASE PRESENTATION:
We present the case of a 2 months and 20 days Caucasian male, presented for bleeding from the injections sites of vaccines. At birth oral vitamin K prophylaxis was administered. Neonatal period was normal. He was exclusively breastfed and received a daily oral supplementation with 25 μg of vitamin K. A late onset vitamin K deficiency bleeding was suspected. Intravenous Vitamin K was administered with complete recovery.

CONCLUSIONS:
Nevertheless the oral prophylaxis, our case developed a VKDB: it is necessary to revise the current guidelines in order to standardize timing and dosage in different clinical conditions.

PMID: 29540231 DOI: 10.1186/s13052-018-0474-0

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Created by admin. Last Modification: Tuesday March 20, 2018 18:35:14 GMT-0000 by admin. (Version 7)

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9559 K T2.jpg admin 20 Mar, 2018 18:03 72.68 Kb 255
9558 Vit K Guidelines.pdf PDF 2018 admin 20 Mar, 2018 18:03 349.28 Kb 126
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