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Review of clinical trials for Multiple Sclerosis with Vitamin D intervention – 2013

Can we prevent or treat multiple sclerosis by individualised vitamin D supply?

EPMA Journal 2013, 4:4 doi:10.1186/1878-5085-4-4
Jan Dörr 12 jan-markus.doerr at charite.de, Andrea Döring 123 and Friedemann Paul 12
1 NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany
2 Clinical and Experimental Research Center for Multiple Sclerosis, Charité - Universitätsmedizin Berlin, Berlin, Germany
3 Current address: Department of Neurology, DIAKO, Flensburg, Germany

Apart from its principal role in bone metabolism and calcium homeostasis, vitamin D has been attributed additional effects including an immunomodulatory, anti-inflammatory, and possibly even neuroprotective capacity which implicates a possible role of vitamin D in autoimmune diseases like multiple sclerosis (MS). Indeed, several lines of evidence including epidemiologic, preclinical, and clinical data suggest that reduced vitamin D levels and/or dysregulation of vitamin D homeostasis is a risk factor for the development of multiple sclerosis on the one hand, and that vitamin D serum levels are inversely associated with disease activity and progression on the other hand. However, these data are not undisputable, and many questions regarding the preventive and therapeutic capacity of vitamin D in multiple sclerosis remain to be answered. In particular, available clinical data derived from interventional trials using vitamin D supplementation as a therapeutic approach in MS are inconclusive and partly contradictory. In this review, we summarise and critically evaluate the existing data on the possible link between vitamin D and multiple sclerosis in light of the crucial question whether optimization of vitamin D status may impact the risk and/or the course of multiple sclerosis.


First clinical trial of 3 pages in the PDF

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PDF is attached at the bottom of this page

See also VitaminDWiki

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Attached files

ID Name Comment Uploaded Size Downloads
3331 MS T2.gif admin 29 Nov, 2013 02:13 51.69 Kb 1015
3330 MS individualized.pdf PDF - 2013 admin 29 Nov, 2013 02:13 622.62 Kb 706
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