Nigella sativa (black cumin) fights many health problems and is associated with Vitamin D

Quantitative Effects of Nigella Sativa on Health Problems: A Research Review
Health Benefits of Nigella Sativa: A Comprehensive Review
The Association Between Nigella Sativa (Black Cumin) and Vitamin D
Nigella sativa reduces Diabetic cardio problems in 4 ways - meta-analysis June 2025
Nigella sativa 4.6X more likely than placebo to treat skin diseases - meta-analysis Dec 2022
ConsumerLab reviewed Nigella sativa: Prime Natural has 28X more thymoquinoine than the least

Quantitative Effects of Nigella Sativa on Health Problems: A Research Review

Nigella sativa (black seed) has been extensively studied for its therapeutic potential across various health conditions. This report examines the quantitative evidence documenting the extent to which Nigella sativa reduces specific health problems, based on clinical trials and research studies.

Diabetes Management

Clinical studies have demonstrated significant improvements in glycemic control with Nigella sativa supplementation:
A clinical trial showed that 2 grams of Nigella sativa daily for 12 weeks reduced fasting blood glucose by 45 mg/dl, 62 mg/dl, and 56 mg/dl at 4, 8, and 12 weeks respectively, while HbA1c decreased by 1.52% after 12 weeks of treatment 1.
Administration of 2 grams/day of Nigella sativa for 12 weeks alongside regular antidiabetic medications significantly reduced fasting blood glucose, 2-hour postprandial blood glucose, and glycosylated hemoglobin (HbA1c) 2.
Patients with metabolic syndrome and poor glycemic control (HbA1c >7%) showed significant reductions in HbA1c, fasting blood glucose, and postprandial blood glucose after 8 weeks of Nigella sativa supplementation 2.
A randomized, double-blind, placebo-controlled trial with 70 type 2 diabetes patients found that 2.5 ml of Nigella sativa oil twice daily for 3 months significantly decreased HbA1c, fasting blood glucose, and postprandial blood glucose compared to the control group 2.

Lipid Profile Improvement

Nigella sativa has shown considerable effects on improving lipid profiles:
A meta-analysis of 34 studies with 2,278 participants revealed that Nigella sativa supplementation significantly reduced total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C), while increasing high-density lipoprotein cholesterol (HDL-C) 3.
In a one-year study of patients with type 2 diabetes, Nigella sativa supplementation significantly lowered total cholesterol at 6, 9, and 12 months, and LDL-C at 3 and 6 months compared to the control group 4.
A placebo-controlled study showed that Nigella sativa (Kalonji) decreased LDL-cholesterol by 12.93 mg/dl and increased HDL-cholesterol by 3.38 mg/dl after six weeks of treatment 5.
Supplementation with Nigella sativa for one year in patients with type 2 diabetes was effective in lowering total cholesterol, LDL, and blood pressure while improving HDL levels 4.

Blood Pressure Reduction

Several studies have documented the antihypertensive effects of Nigella sativa:
A randomized, double-blind, placebo-controlled clinical trial reported a significant reduction of systolic and diastolic blood pressure in a dose-dependent manner in individuals with mild hypertension who received 100 and 200 mg of Nigella sativa extract twice daily for 8 weeks 6.
A single-blind, nonrandomized controlled trial of 57 patients with type 2 diabetes demonstrated that 2 g daily supplementation of Nigella sativa for 1 year resulted in significant reductions in systolic blood pressure, diastolic blood pressure, mean arterial pressure, and heart rate 6.
In a study of hypertensive patients, 5 ml/day of Nigella sativa seeds oil for 8 weeks decreased systolic and diastolic blood pressure, fasting plasma glucose, total cholesterol, and LDL-C, while also reducing malondialdehyde (MDA) and increasing glutathione reductase 7.

Inflammation Markers

Nigella sativa has demonstrated potent anti-inflammatory effects:
A meta-analysis of 20 randomized controlled trials with 1,086 participants found that Nigella sativa supplementation significantly reduced serum C-reactive protein (CRP), tumor necrosis factor α (TNFα), and malondialdehyde (MDA) levels 8.
The same meta-analysis showed that Nigella sativa significantly improved total antioxidant capacity (TAC), glutathione peroxidase (GPx), and superoxide dismutase (SOD) levels 8.
In patients with non-alcoholic fatty liver disease (NAFLD), 2 g/day of Nigella sativa seeds for 12 weeks significantly reduced high-sensitivity C-reactive protein (hs-CRP), nuclear factor-κB (NF-κB), and tumor necrosis factor-α (TNF-α) compared to baseline and placebo 7.

Respiratory Health

Asthma Improvement

Clinical trials have shown Nigella sativa's beneficial effects on respiratory function:
A single-blind, placebo-controlled, randomized study found that 2 g/day of Nigella sativa for 3 months significantly increased FEF25-75% and FEV1 (% predicted) at both 6 and 12 weeks in asthmatic patients 9.
Peak expiratory flow (PEF) variability significantly improved in patients receiving both 1 g/day and 2 g/day of Nigella sativa at 6 and 12 weeks compared to controls 9.
Fractional exhaled nitric oxide (FeNO) and serum IgE decreased significantly after 12 weeks in patients receiving Nigella sativa supplementation 9.
Both 1 g/day and 2 g/day doses of Nigella sativa produced significant improvements in Asthma Control Test (ACT) scores at 6 and 12 weeks compared to baseline, and significantly fewer patients experienced asthma exacerbations in the group receiving 1 g/day of Nigella sativa 10 9.

Immune Cell Parameters

Nigella sativa has shown immunomodulatory effects in clinical studies:
A double-blind, randomized, placebo-controlled clinical trial found that 1 g dose of Nigella sativa produced a significant elevation in total lymphocyte count (from 1850±0.24 to 2170±0.26, p=0.008), CD3+ (from 1184.4±75.60 to 1424±114.51, p=0.009), and CD4+ counts (from 665.6±141.66 to 841±143.36, p=0.002) 11.
Treatment with Nigella sativa seed methanol extract was found to increase the total leukocyte count up to 1.2 × 10
4 cells/mm3 and significantly increase the activity of bone marrow cells 12.

Nigella sativa supplementation at levels of 4% or 5% positively enhanced immunity against Newcastle disease virus in experimental studies 11.

Body Composition Effects

Research has documented Nigella sativa's impact on weight and body composition:
A crossover, double-blind, placebo-controlled, randomized clinical trial found that supplementation with 2000 mg of Nigella sativa oil led to significant decreases in body mass index (p<0.001), body weight (p<0.001), and waist circumference (p=0.020) 13.
The same study showed significant decreases in body fat mass (p=0.019), body fat percent (p<0.001), and visceral fat area (p=0.011) 13.
Consumption of Nigella sativa powder at 1 g/day in 30 postmenopausal women for 2 months caused a significant decrease in body weight (p=0.012) and BMI (p=0.011) compared to baseline 7.

Cognitive Function

Studies have shown Nigella sativa's effects on neurological health:
Administration of Nigella sativa extract affected memory improvement by decreasing the expression of amyloid-beta (Aβ), neurofibrillary tangles (NFT), and glycogen synthase kinase 3β (GSK3β) in experimental models of Alzheimer's disease 14.
Nigella sativa increased the plasma ratio of Aβ42/40, which is considered beneficial for cognitive function 14

Skin Conditions

Clinical studies have documented Nigella sativa's efficacy in treating skin disorders:
A meta-analysis of clinical trials found that Nigella sativa supplementation can potentially be effective in the treatment of different skin problems including atopic dermatitis, eczema, warts, keratosis, psoriasis, vitiligo, and acne, with an odds ratio of 4.59 (95% CI: 2.02, 10.39) 15.
The efficacy of Nigella sativa essential oil and extract has been demonstrated in most clinical studies for skin conditions, with oil supplements in topical form being more commonly reported and effective 15.

Digestive System Benefits

Research has shown Nigella sativa's positive effects on gastrointestinal health:
In an animal study, 20 rats with stomach ulcers treated with Nigella sativa showed an 83% recovery rate, comparable to common medications used to treat stomach ulcers but without side effects 16.
A 2010 study found that Nigella sativa oil was effective in overcoming Helicobacter pylori infections, which are known to contribute to stomach ulcers 16.
Thymoquinone administration was shown to prevent and improve colitis in experimental models, suggesting potential therapeutic benefits for individuals with inflammatory bowel disease 16.

Conclusion

The quantitative evidence from numerous clinical trials and research studies demonstrates that Nigella sativa provides significant health benefits across multiple systems. The most substantial and well-documented effects include reductions in blood glucose (45-62 mg/dl), HbA1c (1.52%), LDL cholesterol (12.93 mg/dl), blood pressure, and inflammatory markers, along with improvements in immune function, respiratory parameters, and skin conditions. These findings support the traditional use of Nigella sativa as a therapeutic agent and suggest its potential as an adjunctive treatment for various health conditions 17 18 7.

Health Benefits of Nigella Sativa: A Comprehensive Review

Nigella sativa, commonly known as black seed, black cumin, or kalonji, is a flowering plant native to the eastern Mediterranean, northern Africa, the Indian subcontinent, and Southwest Asia 1 2. This medicinal herb has been used for centuries in traditional medicine systems such as Ayurveda, Unani, Siddha, and Tibb, with evidence of its use dating back to ancient Egypt 1. Often referred to as "the herb from heaven" due to its wide range of therapeutic applications, Nigella sativa has gained significant attention in modern research for its numerous health benefits 2 3.

Bioactive Components

The therapeutic properties of Nigella sativa are primarily attributed to its bioactive compounds, with thymoquinone (TQ) being the major active component of its essential oil 2 4. Other beneficial compounds include:
Thymol, carvacrol, and p-cymene 4 5
Nigellidine and nigellicine 4
Alpha-hederin 4
Essential fatty acids, amino acids, vitamins, and minerals 4 6
These compounds contribute to the herb's potent antioxidant, anti-inflammatory, and immunomodulatory effects that underlie many of its health benefits 4 7.

Anti-inflammatory Properties

One of the most well-documented benefits of Nigella sativa is its powerful anti-inflammatory action, which makes it beneficial for various inflammatory conditions:
Reduces production of pro-inflammatory cytokines such as IL-6, IL-1β, and TNF-α 4 8
Inhibits cyclooxygenase-2 (COX-2) and nitric oxide synthase (iNOS) 4
Modulates inflammatory pathways including NF-κB signaling 4
Helps manage inflammatory conditions like arthritis, asthma, and inflammatory bowel disorders 9 6
Research shows that both fresh and stored extracts of Nigella sativa oil can modulate different inflammatory markers, with fresh extract significantly reducing IL-6 levels and stored extract inhibiting IL-1β 8.

Antioxidant Effects

Nigella sativa possesses remarkable antioxidant properties that help combat oxidative stress and protect cells from damage:
Increases levels of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), and glutathione 2 10
Reduces levels of thiobarbituric acid reactive substances (TBARS), a marker of lipid peroxidation 10 11
Enhances total antioxidant capacity (TAC) in the body 10 5
Protects against oxidative damage in various organs including the liver, kidneys, and brain 7 11
These antioxidant effects contribute to Nigella sativa's ability to prevent and treat various chronic diseases associated with oxidative stress 1 7.

Diabetes Management

Nigella sativa shows promising effects on glycemic control and diabetes management:
Improves glucose homeostasis and insulin sensitivity 10
Reduces fasting blood glucose and HbA1c levels in type 2 diabetic patients 10
Decreases insulin resistance while enhancing β-cell activity 10
Regulates key enzymes involved in carbohydrate metabolism 2
Protects pancreatic β-cells from damage and preserves their integrity 2 9
Long-term supplementation with Nigella sativa has been shown to not only improve glucose control but also enhance antioxidant defense systems in diabetic patients 10.

Cardiovascular Protection

Nigella sativa offers several benefits for heart health and the cardiovascular system:
Helps lower blood pressure in hypertensive individuals 9 12
Improves lipid profiles by reducing LDL ("bad") cholesterol and increasing HDL ("good") cholesterol 6 12
Prevents atherosclerosis development through anti-inflammatory and antioxidant actions 12
Protects against cardiotoxicity from various agents 12
May help reduce the risk of heart disease through multiple mechanisms 1 12
These cardiovascular benefits are attributed to the antioxidant and anti-inflammatory properties of Nigella sativa and its constituents, particularly thymoquinone 12.

Respiratory Health

Nigella sativa has shown significant benefits for respiratory conditions:
Improves lung function parameters in patients with asthma and chronic obstructive pulmonary disease (COPD) 11
Reduces airway inflammation and bronchial hyperresponsiveness 13 11
Helps expand tracheal muscles and reduces shortness of breath 13
Decreases frequency and severity of asthma attacks 11
Maintains oxidant-antioxidant balance in the respiratory system 11
Clinical studies have demonstrated that Nigella sativa oil supplementation can significantly improve lung function tests, including forced vital capacity (FVC) and peak expiratory flow (PEF), in patients with respiratory disorders 11.

Immune System Support

Nigella sativa has immunomodulatory properties that help strengthen the immune system:
Contains immune-boosting nutrients including potassium, iron, zinc, magnesium, and calcium 6 14
Enhances both innate and acquired immune function 14
Helps regulate excessive immune responses in autoimmune conditions 9
Possesses antimicrobial properties against bacteria, viruses, and fungi 1 13
May help fight against antibiotic-resistant bacteria like MRSA 13
The immunomodulatory effects of Nigella sativa make it valuable for both enhancing immune function during infections and regulating overactive immune responses in inflammatory conditions 14.

Gastrointestinal Health

Nigella sativa offers several benefits for digestive health:
Protects against gastric ulcers and mucosal damage 15
Exhibits gastroprotective effects against ischemia/reperfusion injury 15
Helps manage digestive disorders like indigestion, bloating, and irritable bowel syndrome 9 15
Possesses antibacterial activity against Helicobacter pylori, which causes peptic ulcers 13 15
Reduces inflammation in the gut and improves digestion 9 15
These effects are attributed to the anti-inflammatory, antioxidant, and antimicrobial properties of Nigella sativa and its constituents 15

Neurological Benefits

Research has revealed several neuroprotective effects of Nigella sativa:
Improves learning and memory through anti-inflammatory, antioxidant, and anti-cholinesterase properties 3 16
Shows potential in preventing or treating neurodegenerative diseases like Alzheimer's and Parkinson's 3 17
Exhibits anticonvulsant effects that may help manage epilepsy 3 18
Possesses analgesic properties that help alleviate pain 3
Protects against neurotoxicity from various agents 16
The neuroprotective effects of Nigella sativa are primarily attributed to thymoquinone, which can cross the blood-brain barrier and exert its beneficial effects on the central nervous system 3 17.

Anticancer Potential

Nigella sativa and thymoquinone have shown promising anticancer properties:
Inhibits cancer cell proliferation and induces apoptosis (programmed cell death) 19
Targets epigenetic regulators including UHRF1, DNMT1, and HDAC1 19
Shows activity against various cancer types including breast, colon, and lung cancers 19
Enhances the effectiveness of conventional cancer treatments 4 19
Possesses chemopreventive properties that may help prevent cancer development 7 19
The anticancer effects of Nigella sativa are attributed to its ability to modulate multiple cellular pathways involved in cancer development and progression 19.

Skin Health

Nigella sativa oil has several benefits for skin health:
Helps manage skin conditions like eczema, psoriasis, and acne 20 9
Promotes wound healing through anti-inflammatory and antimicrobial effects 20
Increases collagen production and has moisturizing effects beneficial for skin health 20
May help with skin pigmentation problems like vitiligo 20
Protects against skin infections due to its antimicrobial properties 20
Clinical studies have shown that topical application of black seed extract can significantly reduce acne severity and improve skin lesions in psoriasis 20.

Traditional Uses and Historical Significance

Nigella sativa has a rich history of traditional use across different cultures:
Used in ancient Egypt, with evidence found in pharaoh tombs 1
Mentioned in Islamic literature as one of the greatest forms of healing medicine 3
Recommended by Pliny the Elder in the 1st century A.D. as a digestive aid and antidote for snake bites and scorpion stings 21
Used in traditional medicine of India, Bangladesh, Algeria, and many other countries for various ailments 21
Employed in Ayurvedic medicine for digestive issues, respiratory problems, and skin disorders 2 21
The widespread traditional use of Nigella sativa across different regions and time periods attests to its significant therapeutic potential 1 21.

Safety and Side Effects

While Nigella sativa is generally considered safe for most people when used appropriately, some potential side effects and precautions should be noted:
Common side effects may include nausea, bloating, and digestive discomfort 22
May cause hypoglycemia (low blood sugar) in some individuals, especially when combined with diabetes medications 22
Could potentially affect kidney function with long-term use at high doses 22
Should be avoided during pregnancy, before surgery, and by those on anticoagulant therapy 22
May interact with medications for diabetes, hypertension, and blood thinning 22
It's important to consult with a healthcare provider before using Nigella sativa, especially for those with existing health conditions or those taking medications 22.

Conclusion

Nigella sativa offers a remarkable array of health benefits supported by both traditional knowledge and modern scientific research. From its powerful anti-inflammatory and antioxidant properties to its specific effects on metabolic, cardiovascular, respiratory, neurological, and immune health, this medicinal herb shows promise in preventing and treating various health conditions 1 2 4. As research continues to validate its traditional uses and uncover new therapeutic applications, Nigella sativa stands as a valuable natural remedy with significant potential in complementary and integrative medicine 7 3 21.
References

The Association Between Nigella Sativa (Black Cumin) and Vitamin D

Nigella sativa, commonly known as black cumin or black seed, has been used in traditional medicine for centuries across various cultures. Recent scientific research has begun to explore potential connections between this medicinal plant and vitamin D metabolism, function, and supplementation effects. This report examines the current evidence regarding the association between Nigella sativa and vitamin D.

Thymoquinone and Vitamin D Metabolism

Thymoquinone (TQ), the primary bioactive compound in Nigella sativa, has been found to influence vitamin D metabolism in several ways:
Recent research indicates that thymoquinone may affect vitamin D metabolism, particularly in conditions involving insulin resistance 1 2.
Studies have demonstrated that TQ administration can impact serum vitamin D levels, which appears to be directly related to the expression of several genes involved in vitamin D metabolism in the liver 1 2.
Specifically, thymoquinone has been shown to influence the expression of the Vitamin D Receptor (VDR) gene, which may be responsible for some of TQ's therapeutic effects on insulin resistance and related metabolic conditions 1 2.

Synergistic Effects of Nigella Sativa and Vitamin D

Several clinical studies have investigated the combined effects of Nigella sativa and vitamin D supplementation:
A randomized controlled clinical trial published in 2022 found promising therapeutic benefits when Nigella sativa and vitamin D3 were administered in combination to COVID-19 patients with mild to moderate symptoms 3 4.
This combination therapy showed superior results compared to either supplement alone, particularly in viral clearance rates and symptom alleviation 3 4 5.
The Nigella sativa-vitamin D3 combination significantly contributed to the reduction of COVID-19 symptoms, with 50% of patients becoming free of cough after 7 days, 70% showing absence of fatigue after 4 days, and improvements in other symptoms 3.

Mechanisms of Interaction

The interaction between Nigella sativa components and vitamin D appears to operate through several mechanisms:
Research suggests that when combined with vitamin D3, ThymoQuin (a standardized black seed oil extract) reduced inflammatory biomarkers and upregulated immune response 6 7.
In vitro studies have shown that the combination of ThymoQuin and vitamin D3 dramatically reduced average lipid droplet size and effectively increased small lipid droplet area in mesenchymal stem cells 7 8.
This combination also demonstrated a recognizable increase in mitochondrial activity and healthy regulation of inflammatory cytokines 7 8.
The synergistic effect may be attributed to the unique properties of black seed oil standardized to 3% thymoquinone with very low free fatty acids 7 8.

Effects on Vitamin D Receptor (VDR)

Nigella sativa appears to have specific effects on vitamin D receptor expression and function:
Studies have shown that thymoquinone from Nigella sativa can influence the expression of the VDR gene, which plays a crucial role in vitamin D metabolism and function 1 2.
This interaction with VDR may explain some of the observed effects of Nigella sativa on conditions where vitamin D metabolism is important, such as insulin resistance 1 2.
The modulation of VDR expression by Nigella sativa components could potentially enhance the body's response to vitamin D, though more research is needed to fully understand this mechanism 1 2.

Clinical Applications

The emerging research on Nigella sativa and vitamin D has led to several potential clinical applications:
Commercial products combining black seed oil with vitamin D3 have been developed, suggesting recognition of their potential synergistic benefits 9 10 11.
These combination supplements are marketed for supporting immune system function, bone and joint health, and skin health 9 10 11.
In a clinical trial, the combination of Nigella sativa and vitamin D3 showed significant improvements in laboratory parameters, including decreased ferritin levels, increased lymphocyte counts, and reduced body temperature in COVID-19 patients 3 4 5.

Cholesterol and Metabolic Effects

Both Nigella sativa and vitamin D have been studied for their effects on cholesterol and metabolic health:
Recent research suggests that Nigella sativa supplementation may lower LDL cholesterol and create an inverse relationship with vitamin D levels, though the exact mechanism requires further investigation 12 13.
Black seed oil has been shown to reduce total cholesterol, LDL cholesterol, and triglycerides while modestly increasing HDL cholesterol, which may complement vitamin D's metabolic effects 13.
The combination of thymoquinone from Nigella sativa and vitamin D3 has demonstrated beneficial effects on metabolic parameters in animal studies, including improvements in insulin resistance metrics 1 2.

Cancer Research

Some promising research has explored the combined effects of Nigella sativa components and vitamin D in cancer prevention:
A study published in 2017 found that thymoquinone potentiates the chemoprotective effect of vitamin D3 against colon cancer in an animal model 14.
The combined supplementation of vitamin D and thymoquinone showed a more prominent anti-tumor effect than either supplement alone, manifested by significant reduction in the numbers of grown tumors 14.
Mechanistically, the combination induced significant reduction of pro-cancerous molecules (including Wnt, β-catenin, NF-κB) and increased anti-tumorigenesis biomarkers 14.

Conclusion

The current scientific evidence suggests several meaningful associations between Nigella sativa (black cumin) and vitamin D:
Thymoquinone from Nigella sativa appears to influence vitamin D metabolism and VDR gene expression 1 2.
Synergistic effects have been observed when Nigella sativa components are combined with vitamin D supplementation, particularly in immune function and inflammatory response 3 6 7.
The combination may offer enhanced benefits for metabolic health, cholesterol management, and potentially cancer prevention compared to either substance alone 12 13 14.
However, while these findings are promising, more comprehensive human clinical trials are needed to fully understand the relationship between Nigella sativa and vitamin D, as well as to establish optimal dosing and specific indications for combined supplementation 1
References

Nigella sativa reduces Diabetic cardio problems in 4 ways - meta-analysis June 2025

Effects of black seed (Nigella sativa L.) on cardiometabolic indices in type 2 diabetic patients: A systematic review and meta-analysis of RCTs
Complementary Therapies in Medicine Volume 90, June 2025, https://doi.org/10.1016/j.ctim.2025.103174

Background
Black seed is known for its health benefits in traditional medicine. While recent studies suggest it may improve cardiometabolic health, its impact on type 2 diabetes mellitus (T2DM) remains unclear. This study aims to meta-analysis randomized controlled trials (RCTs) to assess the effects of black seed supplementation on cardiometabolic indices in T2DM patients.

Methods
Following PRISMA guidelines, a comprehensive database search was conducted up to January 2025, and data were extracted from relevant RCTs. Mean differences (MD) and standard deviations (SD) were analyzed using a random-effects model, heterogeneity was assessed, and publication bias was evaluated.

Results
The pooled meta-analysis of 16 RCTs showed that black seed supplementation significantly reduced

fasting blood glucose	(FBG) (MD: −21.43 mg/dL; p = 0.005),
hemoglobin A1c	(HbA1c) (MD: −0.44; p = 0.01),
total cholesterol	(TC) (MD: −18.80 mg/dL; p = 0.04) and
low-density lipoprotein	(LDL) (MD: −19.53 mg/dL; p = 0.003)

No significant effects were observed for 2-hour postprandial glucose (2-hpp), fasting insulin, homeostatic model assessment (HOMA), triglycerides (TG), high-density lipoprotein (HDL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, and body weight, or body mass index (BMI).
Subgroup analyses revealed that black seed supplementation effectively reduced FBG for longer than 8 weeks; additionally, HbA1c, HOMA, and LDL in higher doses (>1 g/day), shorter durations (≤8 weeks), and use of the oil form.

Conclusion
Black seed supplementation appears to significantly improve FBG, HbA1c, TC, and LDL levels in patients with T2DM. However, no significant effects were observed on other metabolic parameters, including insulin, TG, liver enzymes, kidney function, or body weight. These findings suggest that black seed may be a beneficial adjunct therapy for glycemic and lipid control in T2DM patients but require further research to confirm its broader metabolic effects.
Download the PDF from VitaminDWiki

Nigella sativa 4.6X more likely than placebo to treat skin diseases - meta-analysis Dec 2022

The Therapeutic Effects of Nigella sativa on Skin Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Evidence-Based Complementary and Alternative Medicine 05 December 2022 https://doi.org/10.1155/2022/7993579
Naser Nasiri, Mozhde Ilaghi Nezhad, Fariba Sharififar, Mahdieh Khazaneha, Mohammad Javad Najafzadeh, Neda Mohamadi

The aim of this systematic review was to identify randomized controlled trials that looked at the effects of Nigella sativa in any form on different skin diseases. Up to March 2022, the online databases of Scopus, Web of Science, PubMed, Embase, Google Scholar, and Cochrane trials were searched. This study included 14 records of people who had experienced different types of skin disease including atopic dermatitis, vulgaris, arsenical keratosis, psoriasis, vitiligo, acute cutaneous leishmaniasis, warts, eczema, and acne. The mean SD age of the patients was 28.86 (4.49); range: 18.3–51.4, with females accounting for 69% (506 out of 732) of the total. The follow-up mean SD was 8.16 (1.3) (ranged: 4 days to 24 weeks).
The odds ratio (OR) was found to be 4.59 in a meta-analysis (95% CI: 2.02, 10.39). Whereas the null hypothesis in this systematic review was that lotion had no impact, OR 4.59 indicated that lotion could be effective. The efficacy of N. sativa essential oil and extract has been demonstrated in most clinical studies. However, more research is needed to completely evaluate and validate the efficacy or inadequacy of therapy with N. sativa, although it appears that it can be used as an alternative treatment to help people cope with skin problems.
Download the PDF from VitaminDWiki

ConsumerLab reviewed Nigella sativa: Prime Natural has 28X more thymoquinoine than the least

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Nigella sativa (black cumin) fights many health problems and is associated with Vitamin D

Quantitative Effects of Nigella Sativa on Health Problems: A Research Review

Diabetes Management

Lipid Profile Improvement

Blood Pressure Reduction

Inflammation Markers

Respiratory Health

Asthma Improvement

Immune Cell Parameters

Body Composition Effects

Cognitive Function

Skin Conditions

Digestive System Benefits

Conclusion

Health Benefits of Nigella Sativa: A Comprehensive Review

Bioactive Components

Anti-inflammatory Properties

Antioxidant Effects

Diabetes Management

Cardiovascular Protection

Respiratory Health

Immune System Support

Gastrointestinal Health

Neurological Benefits

Anticancer Potential

Skin Health

Traditional Uses and Historical Significance

Safety and Side Effects

Conclusion

The Association Between Nigella Sativa (Black Cumin) and Vitamin D

Thymoquinone and Vitamin D Metabolism

Synergistic Effects of Nigella Sativa and Vitamin D

Mechanisms of Interaction

Effects on Vitamin D Receptor (VDR)

Clinical Applications

Cholesterol and Metabolic Effects

Cancer Research

Conclusion

Nigella sativa reduces Diabetic cardio problems in 4 ways - meta-analysis June 2025

Nigella sativa 4.6X more likely than placebo to treat skin diseases - meta-analysis Dec 2022

ConsumerLab reviewed Nigella sativa: Prime Natural has 28X more thymoquinoine than the least

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