Impact of vitamin D correction on circulating irisin: a 12 month interventional study
Int J Clin Exp Med 2016;9(7):13086-13092 www.iicem.com /ISSN:1940-5901/IJCEM0021873
Nasser M Al-Daghri1,2, Shakilur Rahman1, Shaun Sabico1, Osama E Amer1, Kaiser Wani1, Omar S Al-Attas1,2, Majed S Alokail1,2
1 Biomarkers Research Program, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia;
2 Prince Mutaib Chair for Biomarkers of Osteoporosis, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
19% increase in Irisin over a year - probably due to increased Vitamin D level
- Large increase in Irisin hormone by just increasing vitamin D to 20 nanograms (over a year)
- This intervention study did not use any vitamin D supplement, just sunshine and food
- Wonder how much increase there would have been if Vitamin D levels had gotten to 30 or 40 nanograms
See also VitaminDWiki
See also Web
- How 'Exercise Hormone' Helps Improve Your Weight and Health Mercola Oct 2016
- https://en.wikipedia.org/wiki/FNDC5 = Irisin
- First reported in 2012
- Irisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Training
March 2015 Download the PDF from VitaminDWiki has the following chart
"CON" exercise had 25% increase at 1 hour falling back to 18% at 6 hour
18% is similar to that of 1 year of added Vitamin D (19%)
Download the PDF from VitaminDWiki
Irisin, a novel myokine secreted by skeletal muscle, promotes browning of white fat and influences glucose and energy homeostasis. Irisin and vitamin D are also known for their roles in the musculoskeletal system. In this study, we examined the impact of vitamin D correction on circulating irisin in Saudi subjects. For this, vitamin D deficient subjects (<50 nmol/l) were advised to receive adequate sunlight, eat vitamin D enriched foods and retain normal physical activity for correction/improvement in vitamin D status. Seventy-eight (30 male and 48 female) subjects, who responded to vitamin D intervention, were selected for further analyses. Anthropometry and routine biochemical assay were performed. Serum 25 (OH) D was analyzed using electrochemiluminiscence. Irisin levels were analyzed at baseline and after 12-month of intervention. Serum 25 (OH) D levels were significantly increased at post-intervention compared to baseline value (51.0±4.0 vs. 27.8±2.3 in males and 69.1±4.5 vs. 27.1±1.8 in females). With an increase in the levels of vitamin D adjusted for age and BMI, a corresponding increase in irisin level was observed in males (P=0.026) and to a lesser extent in females (P=0.093). Thus, vitamin D correction had a significant impact on irisin levels in male Saudi subjects but in females it failed to reach at significance. Further studies are needed in other ethnic population to better understand the influence of vitamin D on irisin regulation and secretion.