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Death from Coronary Heart Disease related to low Magnesium intake – March 2013

Dietary and plasma magnesium and risk of coronary heart disease among women.

J Am Heart Assoc. 2013 Mar 18;2(2):e000114. Doi: 10.1161/JAHA.113.000114.
Chiuve SE, Sun Q, Curhan GC, Taylor EN, Spiegelman D, Willett WC, Manson JE, Rexrode KM, Albert CM.
Center for Arrhythmia Prevention, Department of Medicine Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

BACKGROUND: Magnesium is associated with lower risk of sudden cardiac death, possibly through antiarrhythmic mechanisms. Magnesium influences endothelial function, inflammation, blood pressure, and diabetes, but a direct relation with coronary heart disease (CHD) risk has not been established.

METHODS AND RESULTS: We prospectively examined the association between dietary and plasma magnesium and risk of CHD among women in the Nurses' Health Study. The association for magnesium intake was examined among 86 323 women free of disease in 1980. Information on magnesium intake and lifestyle factors was ascertained every 2 to 4 years through questionnaires.
Through 2008, 3614 cases of CHD (2511 nonfatal/1103 fatal) were documented.
For plasma magnesium, we conducted a nested case-control analysis, with 458 cases of incident CHD (400 nonfatal/58 fatal) matched to controls (1:1) on age, smoking, fasting status, and date of blood sampling.

Higher magnesium intake was not {quite} associated with lower risk of total CHD (P-linear trend=0.12) or nonfatal CHD (P-linear trend=0.88) in multivariable models.

However, magnesium intake was inversely associated with risk of fatal CHD.
The RR comparing quintile 5 to quintile 1 of magnesium intake was 0.61 (95% CI, 0.45 to 0.84; P-linear trend=0.003). The association between magnesium intake and risk of fatal CHD appeared to be mediated partially by hypertension. Plasma magnesium levels above 2.0 mg/dL were associated with lower risk of CHD, although not independent of other cardiovascular biomarkers (RR, 0.67; 95% CI, 0.44 to 1.04).

CONCLUSIONS: Dietary and plasma magnesium were not associated with total CHD incidence in this population of women. Dietary magnesium intake was inversely associated with fatal CHD, which may be mediated in part by hypertension.

PMID: 23537810

CHD vs plasma Magnesium

virtually all data points are within the dashed lines

PDF is attached at the bottom of this page

Possible reasons by VitaminDWiki

  1. Magnesium directly reduces coranary heart disease
  2. Magnesium reduces Calcium deposits in the blood vessels
  3. Magnesium required to get the benefits of vitamin D

See also VitaminDWiki

Magnesium and Vitamin D are synergistic, that is, increasing one helps the other.

Magnesium not Magnesium
Vitamin D Magnesium or Vitamin D
Aging, Amytrophic Lateral Sclerosis, Alzheimer's Disease;
Asthma, Attention Deficit Disorder; Autism, Cancer, Cerebrovascular,
Chronic Fatigue, Diabetes, Hearing Loss, Heart Disease. Heart Attack, Atherosclerosis,
Cardiovascular Disease, HIV, AIDS; Hypertension; Kidney Stones,
Migraine Headache, Multiple Sclerosis, Obesity, Osteoporosis; Peripheral vascular disease;
Pregnancy-related problems,Rheumatoid Arthritis; Sports-related problems,
Vitamin D only
Acne, Allergy, Autoimmune, Bone, Breathing,
Celiac, Cognition, Colds and Flu, Cystic Fibrosis,
Dental, Fertility, Hyperparathyroid, Immunity, Kidney,
Liver, Lupus, Osteoarthritis, P in - chronic, Parkinson,
Psoriasis, Rickets, Strokes, Sarcoidosis, Thyroid, Parathyroid,
Tuberculosis, Vision, Hair, Skin, Sports
Not Vitamin D Magnesium only
Aggressive Behavior, Alcoholism, Arrhythmia, Cerebral Palsy,
Chemical Sensitivity, Cluster Headaches; Cocaine-related Stroke; Constipation,
Cramps, Fluoride Toxicity; Head Injuries, Central Nervous System Injuries,
Magnesium Deficiency; Menopause, Mitral Valve Prolapsee,
Nystagmus, Psychiatric Disorders; Repetitive Strain Injury, Sickle Cell Disease, SIDS,
Stress, Stuttering, Tetanus; Tinnitis, Sound Sensitivity; TMJ; Toxic Shock; Violence

Attached files

ID Name Comment Uploaded Size Downloads
2270 Magnesiun and Heart.pdf admin 01 Apr, 2013 785.65 Kb 1170
2269 Plasma Mg and CHD.jpg admin 01 Apr, 2013 15.10 Kb 1488