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Air pollution while pregnant associated with lower vitamin D (perhaps indoors more) – March 2019

Particulate Air Pollution Exposure and Plasma Vitamin D Levels in Pregnant Women: A Longitudinal Cohort Study.

J Clin Endocrinol Metab. 2019 Mar 21. pii: jc.2018-02713. doi: 10.1210/jc.2018-02713.
Zhao Y1, Wang L2, Liu H3, Cao Z1, Su X1, Cai J4, Hua J1.

VitaminDWiki


CONTEXT: No studies have assessed the associations between air pollution exposure and vitamin D status in pregnant women.

OBJECTIVE: To examine the association between particulate air pollution exposure and circulating 25-hydroxyvitamin 25(OH)D levels in pregnant women.

DESIGN: A longitudinal cohort study.

PARTICIPANTS: A total of 3285 pregnant women were recruited at a Maternal and Child Health Hospital.

INTERVENTIONS: None.

MAIN OUTCOME MEASURES: Serum 25(OH)D levels.

RESULTS: We observed trimester-specific associations between particulate air pollution exposure and circulating 25(OH)D levels. The associations were most pronounced for the periods of third trimester and the entire pregnancy. A 10 μg/m3 increase in PM2.5 and PM10 exposure during the entire pregnancy was associated with a 4.62% (95% CI, -6.31% to -2.93%) and 5.06% (95% CI, -6.50% to -3.62%) decrease in 25(OH)D levels, respectively. Particulate air pollution exposure was also associated with elevated odds of maternal vitamin D deficiency. A 10 μg/m3 increase in PM2.5 and PM10 exposure during the entire pregnancy was associated with a 45% (OR=1.45, 95% CI, 1.29 to 1.63) and 48% (OR=1.48, 95% CI, 1.33 to 1.64) increase in the odds of maternal vitamin D deficiency. Mediation analysis estimated that decreased solar UVB radiation mediated 69.5% and 66.4% of the inverse association between PM2.5 and PM10 exposure and circulating 25(OH)D levels.

CONCLUSION: Our results suggest that prenatal exposure to particulate air pollution may play an independent role in maternal vitamin D deficiency. The role of air pollution should be incorporated into future guidelines for the prevention of maternal vitamin D deficiency.

Created by admin. Last Modification: Friday March 22, 2019 10:52:49 GMT-0000 by admin. (Version 2)
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