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Responses by healthy individuals to 2,000 IU vitamin D daily – Feb 2022


Monthly Increase in Vitamin D Levels upon Supplementation with 2000 IU/Day in Healthy Volunteers: Result from “Integriamoci”, a Pilot Pharmacokinetic Study

Molecules 2022, 27(3), 1042; https://doi.org/10.3390/molecules27031042
by Valeria Avataneo 1ORCID,Alice Palermiti 1ORCID,Amedeo De Nicolò 1,*ORCID,Jessica Cusato 1ORCID,Gloria Giussani 2,Andrea Calcagno 3ORCID andAntonio D’Avolio 1ORCID
1 Laboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, Amedeo di Savoia Hospital, University of Turin, 10126 Turin, Italy
2 Witt Italia S.p.A., 10046 Poirino, Italy
3 Unit of Infectious Diseases, Department of Medical Sciences, University of Turin, 10124 Turin, Italy

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Vitamin D (VD) is a calcium- and phosphate-controlling hormone used to treat bone disorders; yet, several other effects are progressively emerging. VD deficiency is highly prevalent worldwide, with suboptimal exposure to sunlight listed among the leading causes: oral supplementation with either cholecalciferol or calcitriol is used. However, there is a scarcity of clinical studies investigating how quickly VD concentrations can increase after supplementation. In this pilot study, the commercial supplement ImmuD3 (by Erboristeria Magentina®) was chosen as the source of VD and 2000 IU/day was administered for one month to 21 healthy volunteers that had not taken any other VD supplements in the previous 30 days. Plasma VD levels were measured through liquid chromatography coupled to tandem mass spectrometry after 7, 14, and 28 days of supplementation. We found that 95% of the participants had insufficient VD levels at baseline (<30 ng/mL; median 23.72 ng/mL; IQR 18.10–26.15), but after 28 days of supplementation, this percentage dropped to 62% (median 28.35 ng/mL; IQR 25.78–35.20). The median increase in VD level was 3.09 ng/mL (IQR 1.60–5.68) after 7 days and 8.85 ng/mL (IQR 2.85–13.97F) after 28 days. This study suggests the need for continuing VD supplementation and for measuring target level attainment.
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Created by admin. Last Modification: Thursday February 3, 2022 18:47:37 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
16995 Supplementary Table 1.pdf admin 03 Feb, 2022 48.08 Kb 182
16994 2000 IU table.jpg admin 03 Feb, 2022 57.52 Kb 178
16993 2000 IU table.jpg admin 03 Feb, 2022 57.52 Kb 54
16992 Responses to 2,000 IU daily.jpg admin 03 Feb, 2022 90.72 Kb 162
16991 response to 2000 IU.pdf admin 03 Feb, 2022 762.09 Kb 217