Pages tagged with "Meta-analysis"

798 pages, most important first (overviews, then meta-analyses, then RCTs, then newest). Combine with another topic

• Overview Meta-analysis of Vitamin D
• Overview Epileptic children and Vitamin D
• Overview of 8 Types of Supplementation Studies
• Overview of Vitamin D Meta-analysis and RCT for Caucasians
• Vitamin D may prevent falls and fractures without Calcium – an overview of 9 meta-analysis
• Vitamin D trials, studies, and meta-analysis
• Vitamin D is not a vitamin nor an anti-oxidant
• Why single medical articles should not be trusted
• Heart Failure and Vitamin D meta-analyses - many studies
• Diabetic Foot Ulcers helped by Vitamin D - meta-analyses many studies
• Pregnancy, offspring health, and Vitamin D - umbrella of 250,000 pregnancies - meta-analysis
• Diabetes and Vitamin D meta-analyses - many studies
• Stroke and Vitamin D meta-analyses - many studies
• Dementia is associated with low vitamin D - many studies
• Melanoma might be suppressed by Vitamin D - many studies
• After COVID infection, Vitamin D helps - many studies
• Anorexia nervosa and Vitamin D - several studies
• Low Calcium associated with severe COVID-19 – several studies
• Obese are 3.4 X more likely to be Vitamin D deficient – meta-analysis
• Blood pressure reduced if take more than 4.5 grams of Omega-3 daily– umbrella meta-analysis
• Temporomandibular Disorders (superset of TMJ) - 3.8 X more likely to be vitamin D deficient – meta-analysis
• Colorectal cancer 14 percent less likely if 10 ng more Vitamin D – 22nd meta-analysis
• Colon Cancer is not treated by small amounts of Vitamin D - meta-analysis Aug 2026
• Observational evidence, not RCTs, is the right test for a nutrient like vitamin D - review
• 45% less Autism in offspring if 20 ng/mL more maternal Vitamin D - meta-analysis
• Total Testosterone increased if take more than 4,000 IU vitamin D daily – meta-analysis
• 300+ mg of magnesium daily improved 10 cardiometabolic measures - meta-analysis
• Asian men often smoke then die of lung cancer (if you must smoke, take Vitamin D) – meta-analysis
• Cancer risk weakly associated with vitamin D-binding protein – meta-analysis
• COPD in Asians twice as likely if poor Vitamin D Binding Protein – meta-analysis
• COPD strongly associated with Vitamin D Binding Protein problems – meta-analysis
• C-reactive protein (heart disease marker) reduced by vitamin D – meta-analysis 2014, 2019
• The worse the sleep apnea, the lower the vitamin D levels – meta-analysis 2017, 2020
• Testosterone meta-analysis (not give vitamin D for long enough or gave to unhealthy persons)
• Critically ill patients who received 300,000 IU of Vitamin D were 40% less likely to die within a month - meta-analysis
• Depression is especially reduced by large intermittent doses of vitamin D – meta-analysis
• Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data
• Depression reduced if take more than 5,000 IU of vitamin D daily – umbrella meta-analysis
• Preterm birth extended by 2 weeks with Omega-3 – Meta-analysis
• Inflammatory biomarkers reduced by Vitamin D - umbrella analysis of 97 RCTs
• Inflammation markers reduced by Vitamin D - umbrella meta-analysis
• Colorectal cancer deaths 26-32% lower with higher Vitamin D – meta-analysis
• Vitamin D3 better than D2, especially if non-daily or high dose - meta-analysis
• Incidence Autism and ADHD reduced 18 percent per 10 ng of Vitamin D during pregnancy – meta-analysis
• Vitamin D3 is 40% better than D2 if normal weight, no difference if overweight –Meta-analysis
• Vitamin D dosing efficacy: weekly is similar to daily - meta-analysis
• Psoriasis not treated by monthly Vitamin D -meta-analysis
• Diabetic foot complications - Vitamin D is the only changeable factor - umbrella of meta-analyses
• Vitamin D also significantly helps standard Multiple Sclerosis Therapy - meta-analysis
• Drug-Resistant Epilepsy is more common if lower level of vitamin D - meta-analysis
• Bladder cancer 25 percent less likely if have high vitamin D – meta-analysis
• Bladder cancer 60 percent less likely if have high vitamin D – meta-analysis
• Liver problems, including hepatitis, are associated with low Vitamin D - Meta-analysis 2025
• Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis
• CPAP 2X more likely if very low Vitamin D 2 years before - Meta-analysis
• T2 Diabetes and associated CVD problems fought by Vitamin D (weekly 50,000 IU)
• Enveloped virus infection (RSV, coronavirus, HIV, etc.) 1.5X more likely if poor Vitamin D Receptor – meta-analysis
• Need at least 6,000 IU of Vitamin D daily during pregnancy and breastfeeding (Wagner) – meta-analysis
• Depression reduced by 8,000 IU of Vitamin D daily – meta-analysis
• Depression decreased the most with 7,000 IU daily Vitamin D - meta-analysis
• Respiratory Track Infection Network Meta-Analysis (ignores 5+ factors)
• High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis
• Sepsis is treated by Vitamin D if you are low - meta-analysis 2025
• Thyroid Cancer 1.4 X higher risk if low vitamin D– meta-analysis
• Thyroid Cancer 1.3X higher risk if low vitamin D (yet again) – meta-analysis
• Graphs of Vitamin D and Cancer – meta-analysis
• Pancreatic Cancer survival 2.3 X more likely if good level of Vitamin D – meta-analysis
• ICU trials typically use 300,000 IU of Vitamin D - meta-analysis
• Active TB 3.5 X more likely if low Vitamin D - 15th meta-analysis
• Getational Diabetes treated by Vitamin D - meta-analysis April 2026
• Fertility was not improved in men when Vitamin D was only given for a few months - meta-analysis - April 2026
• Ulcerative Colitis treated 4X better when Vitamin D was added – Meta-Analysis
• Colorectal Cancer Fought by Vitamin D – 25th meta-analysis
• Fertility improvement -Vitamin D is the best supplement - meta-analysis
• Chronic Rhinosinusitis is treated with Vitamin D, but the benefits stop 3 months after supplementation stops (no surprise) - meta-analysis
• Hearing Loss 39% more likely if low Vitamin D - meta-analysis
• Risk of AFib after Cardiac surgery cut in half by 200,000+ IU Vitamin D meta-analysis
• Sepsis is ~2X more likely if Vitamin D deficient - meta-analysis
• Back pain relief – low evidence that drugs or NSAIDS help – Meta-analysis
• Vitamin D cut dental caries in half in 1930's – RCT meta-analysis
• After Spinal Fusion, Vitamin D is better than Bisphosphonate Therapy at 1 year - meta-analysis
• MASLD (NAFLD, Non-Alcoholic Liver Disease) and Vitamin D - meta-analysis
• 2,980 Vitamin D meta-analyses as of Feb 2026
• Vitamin D meta-analyses for different health problems
• Burn patients with higher levels of Vitamin D do better in 6 ways - meta-analysis Dec 2025
• Treat 10 people with Vitamin D in the winter to prevent 1 Acute Respiratory Infection - meta-analysis 2026
• Cystic Fibrosis patients have low vitamin D (need different dosing) – meta-analysis
• Tooth transplant - best success if Vitamin D level under 70 ng - meta-analysis Nov 2025
• Autism associated with low Vitamin D (again) – Meta-Analysis
• 70% of pregnancies have less than 30 ng of Vitamin D - meta-analysis
• Vitamin D2 lowers the levels of Vitamin D3 in the blood - meta-analysis
• Multiple Sclerosis 5.1 X more likely if poor sun and poor HLA-DRB1×15:01 - meta-analysis
• Multiple Sclerosis 2X-3X more likely if poor Vitamin D Receptor – Meta-analysis
• Yet another meta-analysis ignores vitamin D dose and serum level – Autoimmune disease
• 2 X survival of cancer immotherapy if high level of Vitamin D - meta-analysis
• Vitamin D fights many health problems – an umbrella review of 508 studies
• Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis
• Prenatal vitamin D deficiency increases risk of dental cavities by 35% - meta-analysis
• Multiple Sclerosis - network meta-analysis
• Multiple Sclerosis risk is increased 50% if low Vitamin D - 19 study meta-analysis
• 4,000 IU Vitamin D while pregnant does not decrease infant respiratory problems (no surprise) - meta-analysis
• Oral cancer risk from smoking: 3X less if good CYP24A1 gene, 3X higher if poor Receptor gene - meta-analysis
• Vitamin D before surgery helped again (Thyroid in this case) - meta-analysis
• Vitamin D levels needed to protect against various diseases - meta-analysis
• Small vitamin D doses provide small benefits for acute respiratory infections – Meta-analysis
• Type II Diabetics: Most common deficiency is Vitamin D (2nd is Magnesium) – meta-analysis
• Food allergy 4 X more likely in 2 year-old children with low Vitamin D – meta-analysis
• Rheumatoid arthritis fought by Vitamin D (by single large dose or long enough time) – meta-analysis
• Postmenopausal sexual arousal improved 44% by topical vitamin D (not oral) – meta-analysis
• If low vitamin D before orthopedic surgery, then 1.5 X increased risk of cardiac event (MACE) – meta-analysis
• Breast Cancer Chemo 35% more likely to be successful if more than 20 ng of Vitamin D – meta-analysis
• 3X reduction in preemie Bronchopulmonary Dysplasia if add tiny amount of Vitamin D – meta-analysis
• Protein aids muscle gain – meta-analysis
• Protein after resistance training increased senior walking speed – meta-analysis
• Non-cancer colon growths 7 % less likely per 10 ng increase in Vitamin D
• Osteoporosis synergistically treated by bisphosphonates and Vitamin D - meta-analysis
• Vitamin D gene (CYP24A1) changes decrease breast and pancreatic cancers – meta-analysis
• Pancreatic cancer mortality 28% more likely if low vitamin D – meta-analysis
• Vitamin D (especially topical) reduces Chronic Pruritus (itchy skin) – meta-analysis
• Chronically Itchy skin treated by topical Vitamin D – meta-analysis
• Lupus patients are 5 X more likely to have low vitamin D – many meta-analyses
• Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015
• Low Back Pain not helped by vitamin D if low dose or short duration (loading dose does help however) - meta-analysis
• Hives (Urticaria) 7X more likely if vitamin D deficient, supplementation helps – meta-analysis
• After bariatric surgery all of the fat-soluble vitamins are lacking (Note: other forms of the vitamins are much better) – meta-analysis
• Weekly Vitamin D better than daily – lower cost, less pill burden, perhaps 1.5X better response – meta-analysis
• Preterm birth 30 percent more likely if low vitamin D – meta-analysis
• Body weight not reduced by small doses of calcitriol – meta-analysis
• COVID ICU use reduced by 42% if take more than 100,000 IU of vitamin D over two weeks – meta-analysis
• Poor Vitamin D Receptor does not increase the risk of Breast Cancer (but the opposite is true) – umbrella meta-analysis
• Risk of bleeding in the eye (RVO) is 14 X more likely if low vitamin D – meta-analysis
• Athletic strength improved by Vitamin D – meta-analysis
• Chronic Heart Failure helped by Vitamin D – meta-analysis
• Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis
• Infant respiratory distress reduced by Vitamin D – meta-analysis
• Vaccinations did not stop COVID (68 studies) – meta-analysis
• Vitamin D reduces many Cardiovascular risk factors (provided doses are personalized) – meta-analysis
• Analysis of 280 Breast Cancer meta-analyses: having low vitamin D was highly suggestive – umbrella
• COVID fought by Vitamin D: 2.3X less likely to die of COVID if supplemented, 1.9 X less likely to become infected – meta-analysis
• COVID and Vitamin D: 2X more likely to die if low, 2X more likely to survive if supplement – umbrella meta-analysis
• COVID death rate in hospital halved if take any amount of vitamin D for any length of time – meta-analysis
• Rickets risk reduced by more than 11 ng of Vitamin D - meta-analysis
• In vitro fertilization not helped by vitamin D if ignore high levels and male levels – meta
• No increase in falls, fractures or all-cause mortality when Vitamin D is given monthly or less often– meta-analysis
• Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis
• Influenza risk cut in half by the only trial giving enough vitamin D for body weight – meta-analysis
• Depression 1.6 X more likely if low Vitamin D, taking Vitamin D reduces depression – umbrella of meta-analyses
• Depression in seniors greatly reduced by Vitamin D (50,000 IU weekly) – meta-analysis
• Getting more than 1,000 IU of Vitamin D cut in half childhood risk of influenza, coughs and fevers – Meta-analysis
• Bladder cancer 25 percent less likely if have high vitamin D – meta-analysis
• Bladder cancer modifiable risk factors include low vitamin D – meta-analysis
• Bladder cancer in muscles 2.7 times more-likely if vitamin D less than 20 ng -meta-analysis
• Women have conception problems when vitamin D levels are less than 24 ng – meta-analysis
• Adults with eating disorders consumed less than 400 IU of vitamin D – meta-analysis
• Breast Cancer risk - meta-analysis of 50 studies
• Increased risk of ADHD (28 pct.) and Autism (58 pct.) if low vitamin D during pregnancy – meta-analysis
• Autism 2X more likely if poor Vitamin D Receptor (yet again) – meta-analysis
• Shift work associated with lower Vitamin D in 12 of 13 studies – meta-analysis
• 100,000 IU of Vitamin D monthly (27 ng) is not enough to reduce fractures and falls – meta-analysis
• Menstrual pain reduced by Vitamin D (50,000 weekly or 300,000 monthly) – meta-analyses
• Non-Hodgkin Lymphoma 20 percent more likely if low UV – meta-analysis
• Omega-3 increases Vitamin D levels – Meta-analysis
• Ischemic Stroke risk reduced by 2.5 if have good level of vitamin D – meta-analysis
• Insulin resistance in overweight youths treated Vitamin D (such as 50K IU weekly) – meta-analysis
• Vitamin D given daily, weekly, or monthly has similar response (116 RCTs) – meta-analysis
• Celiac Disease 2.2X higher risk if low vitamin D, Gluten Free Diet slightly increases D – meta-analysis
• 1.5X more likely to die of Prostate Cancer if low vitamin D when initially diagnosed – meta-analysis
• 16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis
• 5 X less COVID infection of health care workers who took lots of vitamin D – meta-analysis
• Vitamin D deficiency increases risk of Dementia by 1.4 X and Alzheimer’s by 1.5 X – Meta-analysis
• Vitamin D reduces: pre-eclampia 1.6 X, postpartum dep. 3.6 X, autism 1.5X etc. - meta-analysis
• Vitamin D supplementation decreased the risk of preeclampsia by 39% – meta-analysis
• Muscle strength improved with Calfidediol (a form of vitamin D) - meta-analysis
• Muscle Inflammation (idiopathic inflammatory myopathy) 3.2 X more likely if low Vitamin D – meta-analysis
• Patients on Hemodialysis 3X more likely if die of heart failure if low Magnesium – meta-analysis
• Dialysis patients 23 percent more likely to live if had just 10 ng more Vitamin D – meta-analysis
• Anxiety severity reduced if more than 2 grams of Omega-3 – meta-analysis
• Overactive bladder 4.4 X more likely if low vitamin D – meta-analysis
• Little Vitamin D does not reduce risk of CVD – RCT meta-analysis
• Vitamin D is the best Vitamin to prevent a stroke - meta-analysis
• Early Childhood Caries 1.4 times more likely if 20-30 ng of Vitamin D – meta-analysis
• COVID and Vitamin D: any amount of D, at any time, for any duration reduced ICU - meta-analysis
• COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis
• Diabetes helped by daily 4,000 IU of Vitamin D – meta-analysis
• Bone loss reduced in women by vitamin D supplementation - Meta-analysis
• T1 Diabetes increased by 27% by second year of COVID – meta-analysis
• High-dose Vitamin D reduced inflammation and insulin resistance (obese children)
• Multiple Sclerosis treatment not helped by small doses of vitamin D (yet again) – meta-analysis
• Acne 3X more likely if low Vitamin D – meta-analysis
• Vitamin D has successfully fortified milk products, bread, orange juice, etc. – meta-analysis
• Omega-3 helped periodontal treatment (details behind paywall) - meta-analysis
• Neuromyelitis optica spectrum disorder (a rare nerve inflammation) 24X more likely to be vitamin D deficient – meta-analysis
• 1.77 nmol response to 100 IU of Vitamin D (46 RCTs) – meta-analysis
• IBS - Vitamin D was the only micronutrient under DRV - meta-analysis
• Vitamin D response independent of dosing interval – meta-analysis
• Vitamin D and the Critically Ill - meta-analysis
• Even after a Cancer diagnosis Vitamin D improves survival – meta-analysis
• Meta-analysis of Vitamin D
• Vitamin D and Age-Related Macular Degeneration (and 2 AMD meta-analyses)
• Morbid Obesity is associated with low Vitamin D around the globe - meta-analysis
• An eye infection (non-infectious uveitis) 2X more likely if low vitamin D a year before – Meta-analysis
• Small doses for a short time rarely help (Omega-3, post surgery this time) – meta-analysis
• Chronic Kidney not helped much by little vitamin D (none got to a 75 nmol level) – meta-analysis
• Bariatric Surgery in Adolescents: 41% vitamin D deficient - meta-analysis
• Omega-3 improves elderly muscles – 2 meta-analyses
• Dental caries 1.22 X more likely if Vitamin D Deficient – meta-analysis
• Infections in children reduced a bit by 2,000 IU of vitamin D - meta-analysis
• Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis
• COVID ICU 3X less-likely if take any amount and type of Vitamin D – meta-analysis
• Vitamin D and fractures – 24 meta-analyses and counting
• Sepsis 2X-3X more likely if poor Vitamin D Receptor – meta-analysis
• High Selenium intake cuts risk of Osteoporosis in half - meta-analysis
• Magnesium reduces inflammation (CRP) and increases nitric oxide – meta-analysis
• COVID Vaccinations increased risk of cardiac deaths in youths by 19%
• Myocarditis, Pericarditis 2X more likely if had COVID vaccination in previous 30 days - meta-analysis
• Childhood BMI decreased when add a little Vitamin D – meta-analysis
• Indoor athletes have 4.5 ng less Vitamin D (Asia in this case) – meta-analysis
• Yet another reason to take Vitamin D while pregnant – fight COVID - meta-analysis
• NAFLD weakly associated with low vitamin D – meta-analysis 2013
• Knee Osteoarthritis treated by vitamin D if use more than 2,000 IU daily or non-daily high dose – meta-analysis
• IBS reduced by 50,000 IU of Vitamin D (weekly or bi-weekly) – Meta-analysis
• Asthma has been treated by 40 ng of vitamin D, but not this time – meta-analysis
• Osteoporotic bone fractures predicted by 12 risk factors - taking little Vitamin D is one of them – meta-analysis
• Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis
• ICU patients 30 % less likely to die if have enough vitamin D – meta-analysis
• Prostate Cancer Survivors are 2.3 X more likely to have high levels of Vitamin D – meta-analysis
• 4 cups of coffee increases risk of fracture - meta-analysis 2014
• Alzheimer’s 1.6X more likely if vitamin D is less than 25 ng – meta-analysis
• Mental disorders fought by Omega-3 etc. - meta-meta-analysis
• Rheumatoid Arthritis pain is reduced by Vitamin D, high doses also reduced inflammation (CRP) – Meta-analysis
• T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies
• 77% of Asians have less than 30 ng of Vitamin D – meta-analysis
• Sunscreen use is no longer associated with reduced skin cancer – meta-analysis
• Low vitamin D while pregnant – a health emergency (Indonesia in this case) – meta-analysis
• Malaria death 3X less likely in mice given vitamin D (looks good for humans too) – meta-analysis
• Better Cognition needs at least 25 ng of Vitamin D (38 studies)– meta-analysis
• Vitamin D-disease associations vary with the type of study – RCT, Observational, MR
• Inflammation associated with Cancer reduced by Vitamin D – meta-analysis
• Afib 40% less likely after heart by-pass if have enough Vitamin D – meta-analysis
• ADHD in children 2.6 X more likely if low vitamin D – meta-analysis
• Melanoma is 1.4X more-likely if low Vitamin D – meta-analysis
• Breast Cancer not prevented by vitamin D when use small doses or for just a short time – Meta-analysis
• Vitamin D during pregnancy increased child’s bone mineral density – meta-analysis
• COVID death 1.5 X less likely if high vitamin D, emergency D (50K to 100K) is great – meta-analysis
• Ovarian Cancer 37 percent less likely if high vitamin D – meta-analysis
• Vitamin D Deficiency in South America - meta-analysis
• Fractures 1.5 X more-likely if low serum Magnesium – meta-analysis
• Eating Fish – 17 health benefits (Omega-3 and perhaps Vitamin D) – umbrella review
• Preeclampsia reduced by 33 percent if high vitamin D – meta-analysis
• Sjögren's Disease ( dry eye, dry mouth, etc.) associated with low vitamin D - Meta-analysis
• Recurrent Stroke 5X more-likely if very low vitamin D - meta-analysis
• Infertile patients 1.7X more-likely to become pregnant if take Vitamin D – meta-analysis
• COVID-19 treated by Vitamin D (reduce ICU by 3X) - 22nd meta-analysis
• COVID-19 death increased 2X if low Vitamin D (less than 10 to less than 30 ng) – 21st meta-analysis
• COVID-19 risk reduced by vitamin D supplementation – umbrella review of 7 meta-analysis
• COVID-19 treated by Vitamin D (example: ICU reduced by 5X) – 20th meta-analysis
• Severe COVID-19 2.5 X more likely if low vitamin D (23 studies) – 19th meta-analysis
• Vitamin D fights COVID (54 studies of 1,400,000 people) – 23rd meta-analysis
• COVID Long-Haul prevalence increases with time: 50% at 4 months - meta
• Severe COVID 2.6 X less likely if supplement with Vitamin D – 26th meta-analysis
• Worse COVID during 3Q pregnancy if 2.5 ng lower Vitamin D – meta-analysis
• COVID test positive is about half as likely if have Vitamin D – 24th meta-analysis
• Dialysis patients who added Vitamin D were 41 percent less likely to get infection – Meta-analysis
• Multiple Sclerosis treated when use high doses of vitamin D – meta-analysis
• IBD treated in children by Vitamin D, especially if use more than 2,000 IU daily for 12 weeks – meta-analysis
• Childhood and youth obesity – more than 4,000 IU vitamin D average daily would help – meta-analysis
• Colorectal Cancer 10 percent more likely if poor Vitamin D Receptor – meta-analysis
• Risk of heart failure increased 1.4X if low vitamin D – meta-analysis
• Hip fracture 58 percent more likely if low vitamin D – meta-analysis
• Hip fractures greatly reduced by sunshine, vitamin D, and vitamin K – meta-analysis
• ICU Vitamin D supplementation not help (study ignored level achieved) – meta-analysis 2022
• Low vitamin D in Malaysia (85 percent less than 30 ng) – meta-analysis
• Maternal pregnancy problems if Vitamin D is less than 40 ng – meta-analysis
• Vitamin D, by itself, does not decrease BMI – meta-analysis
• Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis
• Vitamin D loading doses quickly and safely raise levels – meta-analysis
• Depression is treated by 2,000 IU of Vitamin D – 2 meta-analyses
• Risk of Cardiac failure reduced 20 percent by 800 IU of vitamin D and Calcium – meta-analysis
• Some measures of metabolic syndrome are decreased by Vitamin D (may need Mg) – meta-analysis
• Small doses of Vitamin D do not reduce childhood breathing allergies – meta-analysis
• COVID-19 death 1.6 X more likely if low vitamin D (24 studies) – 17th meta-analysis
• Depression treated by 50K IU Vitamin D weekly (but not 1,000 IU daily) – meta-analysis
• Best psoriasis treatment was combo of Vitamin D, UVA, and Calcium – meta-analysis
• Many ear problems are strongly associated with low vitamin D – meta-analysis
• Vitamin D reduces BMI and waist circumference – umbrella meta-analysis
• Risk of Dementia and Alzheimer's reduced by higher levels of Vitamin D – meta-analysis
• Meta-analyses of vitamin D, etc, sorted by associated category
• Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis
• Glycemic control of type 2 diabetes – only Vitamin D had high quality studies – meta-analysis
• Atrial fibrillation sometimes treated by Omega-3 – meta-analysis
• USPSTF says no evidence that Vitamins prevent CVD or Cancer (data disagrees)
• Ignoring dose size etc, meta-analysis concludes that Vitamin D does not help (stroke risk in this case)
• Chance of dying increases by 25 percent in seniors if low vitamin D – Meta-analysis
• CAD patients with low vitamin D were 1.6 X more likely to die – 27th meta-analysis
• Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis
• Graves Disease is 2.2X more likely with low vitamin D – meta-analysis
• Depression reduced if use more than 2,800 IU of vitamin D – meta-analysis
• Recurrent Miscarriage 4X more likely if low vitamin D – meta-analysis
• Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies
• Vitamin D fortification of food provides no bone benefit (typically a tiny amount of D) - meta-analysis
• Psoriasis severity associated with low vitamin D (10 studies) – meta-analysis
• Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
• Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis
• Asthma treated by Vitamin D - 13th Meta-analysis
• IBS helped by vitamin D (virtually ignoring dose size, type and duration) – meta-analysis
• 2X increase risk of Asthma if a particular Vitamin D Receptor mutation – meta-analysis
• Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis
• Breast Cancer again associated with low vitamin D – 15th meta-analysis
• Omega-3 improves pregnancies – Meta-analysis
• Miscarriage 1.6 X more likely if low vitamin D – meta-analysis
• Magnesium helps bones a bit – meta-analysis
• More hip fractures if low vitamin D (2.1X in case-controlled studies) – meta-analysis
• Vitamin D reduces preeclampsia, gestational diabetes and hypertension - 38th meta-analysis
• Diabetic Retinopathy 27 percent more likely if low vitamin D – meta-analysis
• Magnesium fights diabetes (yet again)– meta-analysis
• Asthma reduced by Vitamin D, even for those using corticosteroids - meta-analysis 2021
• Diabetic Neuropathy 2.8X higher risk if low vitamin D – meta-analysis
• Alzheimer’s patients have less Magnesium – meta-analysis
• BPH increased risk if poor Vitamin D Receptor in Asians – meta-analysis
• RCTs probably not the future gold standard - CDC former head
• Low Vitamin D associated with preeclampsia - meta-analysis
• Pregnancy problems (LBW, PTB, SGA) associated with low vitamin D, 42nd meta-analysis
• Two thirds of South Asians have low Vitamin D (less than 20 ng) – meta-analysis
• COPD treated by Vitamin D – meta-analysis
• Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis
• Delirium or cognitive problems after surgery 1.5X more likely if low vitamin D –meta-analysis
• Sleep improved a bit by adding a bit of vitamin D – meta-anaysis
• Arterial Stiffness and Vitamins – only Vitamin D was found to help – meta-analysis
• Acute viral respiratory infections (RTI) reduced by Vitamin D - 20 reviews
• Small doses of vitamin D do not reduce risk of Acute Respiratory Infection - meta-analysis
• Preterm births 12 X more likely if poor Vitamin D Receptor (white infants in Italy) – meta-analysis
• Vitamin D3 but not D2 reduces mortality – meta-analysis
• Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis
• Small vitamin D doses while pregnant do not decrease infant allergies – meta-analysis
• White Matter Hyperintensities (brain) 1.8X more likely if 10 ng less vitamin D - meta-analysis
• Latent Tuberculosis 44 percent less likely if Vitamin D more than 30 ng - 14th meta-analysis
• Small amounts of Vitamin D reduce Influenza risk by 22 percent (loading dose is far better) – meta-analysis
• Poor Vitamin D receptor reduced vitamin D levels -meta-analysis
• Vitamin D3 levels decreased by consumption of UV mushrooms – meta-analysis
• Melanoma 2.1 X more likely if low vitamin D – meta-analysis
• Anemia 1.6 X more likely during pregnancy if low Vitamin D – meta-analysis
• Review of meta-analyses of non-skeletal benefits of vitamin D (Mortality, RTI, etc)
• Migraine headaches treated by Vitamin D – meta-analysis
• Pregnancies helped by Vitamin D (insulin and birth weight in this case) – meta-analysis
• 3.3 X more likely to die if infected with SARS-Cov-2 plus a second pathogen – meta-analysis
• Influenza Vaccination not benefited by lowish levels of vitamin D – meta-analysis
• Osteoporosis Risk varies with Vitamin D Receptor – three meta-analyses in 2020
• Health problems prevented by eating nuts (perhaps due to Magnesium and or Omega-3) – meta-analysis
• Need at least 6,000 IU daily while breastfeeding to eliminate Vitamin D deficiency – meta-analysis
• Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis
• Colorectal cancer 40 percent less likely if 1000 IU more Vitamin D – 21st meta-analysis
• Prostate cancer risk increase with Vitamin D (other studies disagree) – meta-analysis
• Those with TB were 3.2 X more likely to have low vitamin D – 13th meta-analysis
• Recurrrent Cardiovascular deaths cut in half if 10 ng more Vitamin D – meta-analysis
• Viral respiratory infections reduced by both Vitamin D and Zinc – meta-analysis
• Non-Alcoholic Fatty Liver Disease treated by Omega-3 – three meta-analysis 2016-2017
• NAFLD associated with low vitamin D (in children too) – meta-analysis
• Severe COVID-19 5X more likely if low vitamin D (23 studies) – 16th meta-analysis
• Acute respiratory tract infections prevented by vitamin D (even when ignoring the dose size – Meta-analysis
• Respiratory Tract Infection risk reduced 2X by Vitamin D loading doses – meta-analysis
• Catching Tuberculosis from family member 2 X more likely if low vitamin D – meta-analysis
• 2X higher risk of Alzheimer’s if poor Vitamin D Receptor – Meta-analysis
• 4 fewer days in hospital after hip or knee replacement if good level of vitamin D
• Metabolic Syndrome far less likely if high Vitamin D – 3 meta-analyses 2021
• Vitamin D reduces risk of cause specific death, unless it is D2 – meta-analysis BMJ
• Daily aspirin reduced chance of heart problems by 0.4 percent (but 50X more reduction if Vitamin D) – Meta-analysis
• Urinary Tract Infection in children 4.8 X more likely if low Vitamin D – meta-analysis
• Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis
• Stroke 22 percent more likely if low Vitamin D – meta-analysis
• Stroke risks increased if low Vitamin D: Death 3.6 X, recurrence 5.5 X – Meta-analysis
• Most Chinese have less than 20 ng level of Vitamin D - meta-analysis
• Atrial Fibrillation 1.3 times more likely if low vitamin D – meta-analysis
• Statin pain reduces Vitamin D levels by 4 ng ( 9 studies) - Meta-analysis
• Severe COVID-19 3.5 more likely if low vitamin D (30 studies) – meta-analysis
• It appears that 40 percent of African-Caribbeans in the Caribbean have less than 30 ng of Vitamin D – meta-analysis
• Chronic Pain reported 38 percent less often if supplemented with Vitamin D – meta-analysis
• Metabolic syndrome risk in children decreased 12 percent for each 10 ng increase in Vitamin D – meta-analysis
• Colorectal cancer 25 percent less likely if good level of Vitamin D – 20th meta-analysis
• Insulin Resistance is associated with low Vitamin D (both diabetic and non-diabetic) – meta-analysis
• Very low Vitamin D in Indian pregnancies– 1 in 3 women not even have 20 ng – meta-analysis
• COVID-19 patients who had supplemented with Vitamin D were 3X less likely to enter ICU
• Low back pain – 72 percent have low vitamin D – meta-analysis
• Obesity causes 20 percent of all cancer, low vitamin D may be the connection – meta-analysis
• COVID-19 was 2.6X more severe if very low Vitamin D (43 studies) – meta-analysis
• COVID-19 mortality 3X more likely if low vitamin D (999,179 people) – meta-analysis
• Low vitamin D - anemia 2.2X more likely (no surprise) – meta-analysis
• Tuberculosis still associated with low vitamin D – 12th meta-analysis
• Sports benefits from up to 50 ng of Vitamin – meta-analysis
• Jaundice associated with 7 ng less vitamin D – Meta-analysis
• ICU mortality reduced by non-oral vitamin D – meta-analysis
• Increased pregnancy problems with COVID-19 – meta-analysis and letter to editor
• 3000 IU of vitamin D minimum to reduce parathyroid hormone (PTH) – meta-analysis
• Low Vitamin D if little UVB, supplementation helps (Antarctica) – meta-analysis
• Kidney stone risk varies a lot with both genetics and race – meta-analysis
• Stress fractures in basic training associated with 2.5 ng less vitamin D – meta-analysis
• 3X less risk of Liver cancer if more than 30 ng of vitamin D – meta-analysis
• Vitiligo associated with low vitamin D (Note: Vit. D and UV has treated it for over a decade) – meta-analysis
• Vitiligo (spotty skin coloring) is 4 X more likely if poor Vitamin D Receptor – meta-analysis
• Prediabetes treated by Vitamin D (34 ng, 3500 IU per day) – meta-analysis
• Vitamin D levels needed and importance - meta-analysis
• Miscarriage 2 times more likely if low vitamin D – meta-analysis
• Colorectal cancer is associated with Vitamin D (17 meta-analyses so far)
• Colorectal cancer treated by Vitamin D – 19th meta-analysis
• 3.7 X less likely to die of COVID-19 if supplemented with Vitamin D - meta-analysis
• Low Vitamin D associated with 2.7X more severe COVID-19 – 12th MA
• Vitamin C sometimes reduces mechanical ventilation duration – meta-analysis
• Vitamin D supplementation and fewer kidney stones – meta-analysis of RCT
• Adding just a little vitamin D does not help (muscle mass in this case) – meta-analysis
• Less obese child if supplemented with Vitamin D as an infant– meta-analysis
• Vitamin D supplementation fights COVID-19 – 11th meta-analysis
• Sleep improved by Vitamin D, Melatonin, amino acids, etc. -Meta-analysis
• Vitamin D reduces COVID-19 by 80 percent - anonymous meta-analysis
• Less likely to test positive for COVID-19 if higher Vitamin D – meta-analysis
• Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses
• Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis
• Spot Baldness (Alopecia Areata) 4.1 X more likely if low vitamin D – meta-analysis
• Small vitamin D doses given during pregnancy do not reduce childhood asthma – meta-analysis
• T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis
• Hyperglycemia associated with low vitamin D – type II diabetics and healthy people – meta-analysis
• COVID-19 1.7X more likely to be severe if low Vitamin D - meta-analysis
• Increased risk of fracture if high level of Vitamin D (if continue to take Calcium) – umbrella analysis of meta-analyses
• Lung Cancer death 40 percent less likely if high level of Vitamin D – meta-analysis
• Low Vitamin D associated 1.8X increased risk of COVID-19 death in hospital – meta-analysis
• 2311 Systematic Reviews or Meta-Analyses of Vitamin D in PubMed
• Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis
• COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis
• Vitamin D fights 13 cancers – review of 35 meta-analyses
• Colon cancer both prevented and treated by Vitamin D – meta-analysis
• Spinal disc degeneration 1.8X more likely if poor Vitamin D Receptor – mata-analysis
• Diabetics helped by vitamin D in 5 ways – meta-analysis
• Fewer days in ICU after 300,000 IU of vitamin D, but not 540,000 – meta-analysis
• Vitamin D RDA of 600 IU is not enough - global RCT meta-analysis
• Recurrent Tonsillitis 4 X more likely if low vitamin D – meta-analysis
• Live birth 1.7 X more likely after IVF if good level of vitamin D – meta-analysis
• Acute Lower Respiratory Infections in Children - associated with low vitamin D – meta-analysis
• Alzheimer’s Disease risk is 1.3X higher if Vitamin D deficient – meta-analysis
• Prudent to consider that Vitamin D has a role in COVID-19 – meta-analysis
• Frailty risk increases 12 percent for every 10 ng less vitamin D – meta-analysis
• Liver Cancer 8 percent less likely for every 4 ng higher level of vitamin D – Meta-analysis
• Vitamin D loading doses reduce ICU mortality by 30 percent – meta-analysis
• Seniors 2.2 X more likely to walk slowly if very low vitamin D – meta-analysis
• Vitamin D loading doses of up to 400,000 IU OK for adolescents – meta-analysis
• Fatty Fish in diet increases vitamin D level a few nanograms – meta-analysis
• Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis
• Infant wheezing 40 percent less likely if mother supplemented with vitamin D, vitamin E, or Zinc – meta-analysis
• Endometriosis: 2.7 X more likely if with low vitamin D (trend of 9 studies)– meta-analysis
• Dry eyes associated with low Vitamin D – meta-analysis
• Small doses of vitamin D do not reduce the risk of Breast Cancer – meta-analysis
• Bone quality improved 2X by Vitamin D plus Vitamin K2 (trend) – meta-analysis
• Cardiovascular disease associated with postmenopausal non-human primates – meta-analysis
• Vitamin D reduces respiratory tract infections by 40 percent– meta-analysis
• Multiple Sclerosis: 10 percent fewer relapses for each 10 ng higher level of vitamin D – Meta-analysis
• Alzheimer’s Disease risk is 1.9 X higher if Vitamin D deficient- meta-analysis
• Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis
• Lung Cancer risk decreased 2.4 percent with every 100 IU Vitamin D extra intake – meta-analysis
• Small for gestational age is 1.6 X more likely if mother was vitamin D deficient – meta-analysis
• Parkinson’s disease 20 percent more likely in Asians if poor Vitamin D Receptor – meta-analysis
• Parkinson’s disease 1.6X more likely if a poor Vitamin D Receptor – meta-analysis
• Vitamin D does not reduce blood pressure in healthy people (no hypertension, etc) – Meta-analysis
• Glyphosate (Roundup) increases risk of NH lymphoma by 41 percent – meta-analysis
• Breast Cancer risk reduced 17 percent by 1 hour of daily summer sun – meta-analysis
• Multiple Sclerosis 40 percent more likely if mother had low vitamin D – meta-analysis
• Risk of Multiple Sclerosis varies with the Vitamin D Receptor – meta-analysis
• Alopecia areata (spot baldness) associated with 8.5 ng lower levels of vitamin D – meta-analysis
• Hip fractures not prevented by Vitamin D (800 IU daily or large quarterly or annual doses) – meta-analysis
• Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT
• Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015
• Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis
• Kidney failure 1.1 X more likely if poor Vitamin D Receptor – meta-analysis
• Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis
• Arterial stiffness reduced if use at least 2,000 IU of Vitamin D for 4 months – meta-analysis
• COPD severity is associated with Vitamin D deficiency – meta-analyses 2015, 2019
• Multiple Sclerosis: number needed to treat with vitamin D may be as low as 1.3 – Meta-analysis
• Vitamin K (across all dose sizes and types) decrease Vascular Stiffness – meta-analysis
• Hypertension not reduced much if use less than 5,000 IU of Vitamin D – meta-analysis
• Psorasis treatment helped by Vitamin D – Cochrane
• Psoriasis is associated with 6 ng less vitamin D – meta-analysis
• Vitamin D supplementation increases strength of lower muscles – Meta-analysis
• Blood vessels not helped by small vitamin D doses – meta-analysis
• African Vitamin D - 60% have less than 30 ng – Meta-analysis
• Inflammatory Bowel Disease 1.5 X more likely if low vitamin D – meta-analysis
• Asthmatics less able to breathe if low vitamin D – meta-analysis
• Vitamin D supplementation improves muscle strength in healthy adults – meta-analysis of 6 RCT
• Vitamin D supplementation help muscles of seniors who are vitamin D deficient – meta-analysis
• Vitamin D trials by military – all 4 found benefit – review
• Multiple Sclerosis and the Vitamin D Receptor – meta-analysis
• Fracture risk reduced somewhat by 800 IU of vitamin D and Calcium – meta-analysis
• How to read a medical study (with notes on Vitamin D studies)
• Migrants from Middle East are slightly more vitamin D deficient than those from Africa - meta-analysis
• Vitamin D fortification of yogurt – meta-analysis
• Pneumonia 6X more likely if very low vitamin D – meta-analysis
• Psoriasis risk in Caucasians is 1.3 X higher if poor Vitamin D Receptor – meta-analysis
• Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis
• Pneumonia patients 3 X more likely to die if low vitamin D – meta-analysis
• COPD exacerbations 2X less often if low vitamin D then supplemented – meta-analysis
• Omega-3 reduces heart problems by ~5 percent – meta-analysis by Heart Association
• Tuberculosis 3X more likely if less than 12 ng of Vitamin D - meta-analysis
• Fertility (sperm) associated with vitamin D – meta-analysis
• Crohn’s Disease associated with lower Vitamin D - meta-analysis
• IVF 50 percent more likely to result in pregnancy if high vitamin D – meta-analysis
• Preeclampsia 2.7 X less likely if 50,000 IU of Vitamin D every 2 weeks – meta-analysis
• BMI decreased by Vitamin D (none of the trials used enough D for long enough) – meta-analysis
• Autism risk increased 30 percent by Cesareans (both low vitamin D) – meta-analysis
• Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis
• Attention-Deficit Hyperactivity Disorder helped by Vitamin D, need more data – meta-analysis
• Multiple Sclerosis 23 percent more likely if born in April vs. Oct – meta-analysis
• Low Magnesium associated with diabetes, etc. – meta-analysis 2016
• Depression treated by Omega-3 (again) – meta-analysis
• Eczema (Atopic Dermatitis) treated by 1600 IU of vitamin D – meta-analysis
• Eczema (Atopic Dermatitis) treated by 1,600 IU Vitamin D (again) – Meta-analysis
• Septic children have low Vitamin D (54 studies, ignored Vitamin D Receptor) – meta-analysis
• Depression less likely if more Vitamin D (12 percent per 10 ng) – meta-analysis
• Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene
• Variety of Vitamin D forms treat Prostate Cancer – RCT Review
• People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT
• Low-dose vitamin D does not help cardiovascular (many were 100-1,000 IU) – meta-analysis
• Low back pain 2X more likely if very low Vitamin D – meta-analysis
• Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – meta-analysis
• Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis
• Tuberculosis increased risk if poor Vitamin D receptor varies by race – meta-analysis
• Active form of vitamin D (calcitriol) cut in half the fractures following organ transplant – meta-analysis
• Breast Cancer rate reduced by 40 percent with Omega-3 – meta-analysis
• Hepatitis B patients have 2 ng lower level of Vitamin D – meta-analysis
• Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis
• Vitamin D helps Diabetic Nephropathy kidneys – meta-analysis
• Vitamin K (any amount and any kind) reduced bone fractures by 24 percent – meta-analysis
• Diabetics are 2.7 X more likely to get peripheral neuropathy if low vitamin D – meta-analysis
• Hashimoto's thyroiditis 3.2 X more likely if low vitamin D – meta-analysis
• High Blood Pressure reduced by Vitamin D supplementation in seniors and obese – meta-analysis
• Vitamin D reduced only the systolic blood pressure in T2DM – Meta-analysis
• PMS reduced by Vitamin D intervention - meta-analysis
• Asthma supplementation by Vitamin D (any amount) reduced attacks by 25 percent – meta-analysis
• Parkinson’s patients 50X less likely to get even a little sun– meta-analysis
• Diabetic inflammation reduced by Vitamin D – meta-analysis
• Inflammatory bowel diseases are associated with Vitamin D etc. – meta-meta-analysis
• Asthma risk reduced by 67 percent with Vitamin D supplementation if level was initially low– meta-analysis
• Global sperm count dropped by 59 percent in 40 years – meta-analysis
• Hypertension associated with genes which reduce vitamin D – meta-analysis
• Gestational diabetes 60 percent more likely below 20 ng of vitamin D – meta-analysis
• Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis
• Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis
• Alzheimer’s (1.2X) and Parkenson’s (1.3X) more likely if poor Vitamin D Receptor – meta-analysis
• Pancreatic cancer risk of death reduced 19 percent by Vitamin D – meta-analysis
• Tuberculosis (multi-drug resistant) was 13.4 X more likely to be quickly cleared with Vitamin D - Meta-analysis
• Breast Cancer reduced 20 percent by fish (Omega-3) – meta-analysis
• Chronic Kidney Disease mortality is 60 percent less likely if good vitamin D – meta-analysis
• Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis
• More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis
• Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis
• Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis
• Crohn’s disease associated with vitamin D and latitude – meta-analysis
• Preeclampsia 2.7X more frequent if low vitamin D – meta-analysis
• Preeclampsia rate cut in half by high level of vitamin D – meta-analysis
• Birth size and weight increased by Vitamin D – meta-analysis
• Infants need 400 IU of vitamin D to prevent rickets – meta-analysis
• ADHD associated with low vitamin D in all 8 trials – meta-analysis
• Pregnancies helped by Vitamin D in many ways – 27th meta-analysis
• Respiratory infections reduced only 20 percent by Vitamin D (ignored dose size, duration, type, etc) – meta-analysis
• Premature or low birth weight resulted in children 3X more likely to be anxious – meta-analysis
• APS (a rare disease) is 3X more likely if low vitamin D – meta-analysis
• Lupus associated with low vitamin D – Caucasian 2.2 X, Arab 4.6 X – meta-analysis
• Metabolic Syndrome in children is associated with low vitamin D – review
• Multiple Sclerosis increases risk of Psoriasis by 1.9X (both associated with low vitamin D) – meta-analysis
• Osteoporosis 15 percent more likely if poor Vitamin D receptor – meta-analysis
• Parkinson's Disease 2.1 X more likely if low Vitamin D – Meta-analysis
• Alzheimer's risk increased 7 percent for every 4 ng decrease in Vitamin D– meta-analysis
• IBD relapse rate reduced by low Vitamin D - meta-analysis
• Small or infrequent doses of vitamin D do not reduce heart failure much – meta-analysis
• Preventing Falls in Older Adults – Vitamin D combination is the best - JAMA Meta-analysis
• Vitamin D decreases oxidative stress – meta-analysis
• Depression is associated with low Magnesium – meta-analysis
• Juvenile Rheumatoid Arthritis associated with low vitamin D, but how low – meta-analysis
• Vitamin D not help fractures and falls if not vitamin D deficient – meta-analysis
• 16 percent less Prostate Cancer sometimes for each 10 ng vitamin D increase - meta-analysis
• Knee joint space narrowing (Osteoarthritis) 1.5X worse with low vitamin D – meta-analysis
• COPD 2.8 times more likely to be severe if low vitamin D – meta-analysis
• Tuberculosis in children 1.7 X more likely if low vitamin D – meta-analysis
• Less depression in seniors taking enough Omega-3 – meta-analysis
• Late stage AMD 2.2 more likely if low vitamin D – meta-analysis
• Colorectal cancer 60 percent less likely: high vs low Vitamin D level – meta-analysis
• ICU length of stay reduced when supplement with Omega-3 – meta-analysis
• Myopia in adults is 8 percent more likely for every 4 ng less Vitamin D – meta-analysis
• Vitiligo is associated with low vitamin D (nothing about treatment) – meta-analysis
• Vitamin D supplementation reduced SGA, fetal mortality, infant mortality – JAMA Meta
• Back pain not helped by Vitamin D (if ignore amount and type) – meta-analysis
• Fractures not reduced by small amounts of vitamin D - meta-analysis
• Metabolic Syndrome risk decreases 12 percent with 150 mg of Magnesium – meta-analysis
• MS not treated by Vitamin D (a few old studies using small doses) – Meta-analysis
• Diabetes treated and prevented by more than 2,000 IU of vitamin D (need more and gut-friendly) - meta-analyses 2018
• Chronic Pancreatitis associated with painful bones (vitamin D) – meta-analysis
• Clinical Trials of vitamin D can have “biological flaws”
• Tuberculosis 1.3 times more likely if poor Vitamin D Receptor – meta-analysis
• Much more than 2,000 IU of vitamin D is needed daily (Middle East studies agree) – meta-analysis
• Cancer not treated by Vitamin D when ignore dose size, type, and length of trial – meta-analysis
• Widespread pain, arthritis pain and muscle pain are associated with low vitamin D – meta-analysis
• Autism is associated with low vitamin D – meta-analysis
• Pancreatic cancer risk reduced 25 percent by just 10 micrograms of Vitamin D or Vitamin B12 – meta-analysis
• Peripheral Arterial Disease patients have low vitamin D levels – meta-analysis
• 137 health problems associated with low vitamin D – meta-meta-analysis
• Breath better if higher level of Vitamin D – meta-analysis
• Vitamin D improves muscle strength if deficient – meta-analysis
• Elderly lower limb muscle strength improved with Vitamin D supplementation - Meta-analysis
• 50 percent fewer strokes with vitamin D, even though ignored dose size – meta-analysis
• Cerebrovascular disease 40 percent less likely if high level of vitamin D – meta-analysis
• Vitamin D associated with 50 percent less ischemic stroke – meta-analysis
• Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis
• Diabetic Retinopathy twice as likely if a T2 Diabetic has low level of vitamin D – meta-analysis
• Fractures reduced with any amount of vitamin D and some Calcium - Cochraine
• Fibromyalgia associated with lower Vitamin D – meta-analysis
• Omega-3 Cardiovascular meta-analysis has at least 5 major problems
• Disc Degeneration in women is 1.7X more likely if poor Vitamin D Receptor – meta-analysis
• Atopic Dermatitis risk is 55 percent higher if low vitamin D – Meta-analysis
• Cesarean (associated with low Vitamin D) increased asthma, obesity, miscarriage and stillbirth – meta-analysis
• Vitamin D and Respiratory Tract Infections – meta-analysis with charts
• Type 1 Diabetes (T1DM) 1.6 X more likely if low vitamin D – meta-analysis
• Parkinson’s Disease and the “Sunshine” Vitamin (vitamin D)
• ADHD 2 times more likely if poor Omega-6 to Omega-3 ratio – meta-analysis
• Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017
• First-Episode Psychosis associated with low Vitamin D, Vitamin C and Folate – meta-analysis
• Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis
• Calcium increased risk of side effects in trials (no problems with just Vitamin D) – meta-analysis
• The Misuse of Meta-analysis in Nutrition Research (and vitamin D) – JAMA
• Influenza vaccine meta-analysis found moderate protection – Lancet
• Critically ill children with low vitamin D: 2.5 X more likely to die or stay 2 days longer - meta-analysis
• Vitamin D during pregnancy reduces risk of childhood asthma by 13 percent – meta-analysis
• Bacterial vaginosis in pregnancy increased prematurity risk by 60 percent - meta-analysis 1999
• Fewer than half of pregnancies will get even 20 ng of vitamin D with 800 IU daily dose – meta-analysis
• 2.7 fewer days in hospital after surgery if had taken Omega-3 (19 RCT) – meta-analysis
• Resistance exercise combined with Vitamin D is great for seniors – meta-analysis
• Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis
• Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis
• Preeclampsia reduced 2X by Vitamin D, by 5X if also add Calcium – meta-analysis
• Bone formation in the lab is aided by Vitamin D, Vitamin K1, and Vitamin K2 – meta-analysis
• Magnesium treats diabetes and cardiovascular problems – meta-analysis
• Vitamin D and omega-3 are the only supplements which show benefit in meta-analysis
• Preeclampsia risk reduced 60 percent if supplement with Vitamin D (they ignored dose size) – meta-analysis
• Chronic widespread pain reduced a bit by vitamin D ignored dose sizes - meta-analysis
• Vitamin D helps during pregnancy – meta-analysis
• Lymphoma, leukemia etc, survival poor if low vitamin D – meta-analysis
• Lung Cancer less likely if vitamin D (higher level or supplement) – meta-analysis
• Rheumatic diseases not helped by Vitamin D – if you ignore what and how much was given – meta-analysis
• Surgical outcomes are better for higher levels of Vitamin D – systematic review
• Fewer Multiple Sclerosis lesions when supplemented with Vitamin D – meta-analysis
• Depression might be reduced by vitamin D – meta-analysis
• Inflammation reduced when vitamin D supplementation raised level higher than 32 ng – meta-analysis
• Systematic Reviews of Vitamin D underway as of
• Autism risk factors – many are associated with low vitamin D – meta-meta-analysis
• Autoimmune Thyroid Disease 3X more likely if low vitamin D – meta-analysis
• Low Vitamin D results in adverse pregnancy and birth outcomes – Wagner meta-analysis
• Adding Calcium does NOT cause cardiovascular problems (reverses their meta-analysis)
• Preterm birth rate reduced by 43 percent with adequate Vitamin D supplementation – meta-analysis
• Lung Cancer risk decreases 5 percent for every 2.5 nanogram increase in Vitamin D – meta-analysis
• Chronic Kidney disease not helped much by vitamin D provided you ignore dose size – meta-analysis
• Vitamin D deficiency diseases in dark skinned people living far from equator – Meta-analysis
• Multiple Sclerosis and small doses of Vitamin D – meta-review
• Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis
• Asthma exacerbations in children decrease by 60 percent with vitamin D supplementation – meta-analysis – 2015
• Dementia risk factor is increased by 1.5 if low vitamin D – meta-analysis
• Vitamin D prevents falls – majority of meta-analyses conclude – meta-meta analysis
• Asthma not helped by less than 2,000 IU of vitamin D - meta-analysis
• Tuberculosis, genes and vitamin D – Meta-Analysis
• Tuberculosis 4.5X more likely if vitamin D less than 10 nanogram – meta-analysis
• Low vitamin D is a risk factor for tuberculosis – meta-analysis
• Birth weight and length increased with high levels of vitamin D – meta-analysis
• Low vitamin D increased probability of low birth weight by 60 percent – meta-analysis
• Hypertension reduced by Omega-3, especially if previously untreated – meta-analysis
• Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis
• Obese of all ages have lower levels of vitamin D – meta-analysis
• Slipped upper femoral epiphysis (hip pain in teen) associated with vitamin D – meta-analysis
• Cognitive decline in elderly slowed by Omega-3 – meta-analysis
• Kidney cancer 22 percent less likely if high vitamin D – meta-analysis
• Kidney stones associated with higher vitamin D (but not agree how much 20-100 ng) – meta-analysis
• Omega-3 helps childhood cognition – meta-analysis
• Asthma medicines not helped by vitamin D (if only a small amount of D is taken) – meta-analysis
• Migraine headaches quickly reduced with Magnesium – Meta-analysis
• Colorectal Cancer recurrence not prevented by 1,000 IU of vitamin D – meta-analysis
• Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis
• Rheumatoid Arthritis strongly associated with low vitamin D – meta-analysis
• Parkinson’s Disease systematic review finds association with low vitamin D
• Several more Vitamin D analyses fail to consider dose size, duration, etc.
• 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis
• 800 IU Vitamin D does not help heart – meta-analysis
• Cognitive Impairment 2.4X more likely if low vitamin D – meta-analysis
• 10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis
• Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis
• Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis
• More vitamin D needed during pregnancy – meta-analysis
• Diabetes not prevented by Vitamin D (when you ignore how much vitamin D was taken)
• Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
• Blood pressure is reduced by more than 800 IU of vitamin D – meta-analysis
• Lower respiratory tract infections in children associated with Low Vitamin D – meta-analysis
• 40 ng Vitamin D perhaps optimal for reduced mortality – Meta-analysis
• 3X variation in response to dose of vitamin D – meta-analysis
• Poor cognition associated with low vitamin D in elderly (Asians now too) – meta-analysis
• 2X more preeclampsia when vitamin D less than 30 ng, etc. - meta-analysis
• Rheumatoid Arthritis associated with lower vitamin D and higher latitude – meta-analysis
• Alzheimer's Disease more likely with low vitamin D – meta-analysis
• Does vitamin D treat pain – still not absolutely, positively sure – meta-analysis
• Chronic Widespread Pain associated with Vitamin D under 10 ng – meta-analysis
• Vitamin D response reduced if taken with Calcium – meta-analysis
• Shift workers 23 percent more likely to have cardiovascular events – meta-analysis
• Gene makes COPD 2.6X more likely unless get more vitamin D – meta-analysis
• Gut problems more likely if low vitamin D (IBD: 1.6, UC: 2.3) – meta-analysis
• Chronic Heart Failure not treated by Vitamin D, if dose size is ignored – meta-analysis
• 1.5X increased infection, sepsis, and death if in ICU with low vitamin D - Meta-analysis
• Acute fracture patients – 70 percent were vitamin D deficient – meta-analysis
• Vitamin D meta-analyses often disagree due to selection of: trial, data extraction, statistics, etc.
• Colon cancer 30 percent more likely if low vitamin D – 12th meta-analysis
• Low density lipoprotein cholesterol is predictable from vitamin D levels – meta-analysis
• Alzheimer’s disease 21 percent more likely if low vitamin D – meta-analysis
• Cochrane review finds that Vitamin D and Calcium treat osteoporosis
• Hip fractures reduced 30 percent with 800 IU of vitamin D – meta-analysis
• Hypertension is associated with low vitamin D in some groups – meta-analysis
• Pregnancy and Vitamin D – meta-analysis
• Low vitamin D and depression - Study and meta-analysis,
• Falls not prevented by vitamin D given every 3 months or less often – meta-analysis
• Probiotics reduces blood pressure, but not as much as vitamin D does – meta-analysis
• Fallers often had less than 20 ng of vitamin D – meta-analysis
• Parkinson’s Disease – no association found with changes in Vitamin D genes – meta-analysis
• Statin pain associated with 10 ng less vitamin D – meta-analysis
• Slight depression not reduced by adding vitamin D if already had enough (no surprise) – meta-analysis
• PTH reduced 3.5 pmol by vitamin D intervention which added 22 ng – meta-analysis
• Less likely to die if have enough vitamin D - Meta-analysis
• Multiple sclerosis patients have 15 ng lower levels of vitamin D – meta-analysis
• Colon cancer risk reduced by many vitamins – 13 percent reduction by Vitamin D – meta-analysis
• Breast Cancer – review of 2 RCT did not find association with 1000 IU of Vitamin D
• Cancer (colon, breast, lymph) survival about 2X better with high level vitamin D – meta-analysis
• Half as many heart deaths for those with high levels of vitamin D – meta-analysis
• Cardiovascular disease 50 % more likely if low vitamin D - meta-analysis
• Diabetes not prevented or treated if give only modest amount of vitamin D or for short period of time – meta-analysis
• Different amounts of vitamin D needed to prevent different diseases
• Bone fractures reduced by a minimum of 800 IU vitamin D and Calcium – meta-meta-analysis
• Parkinson’s disease 2X more likely if low Vitamin D – meta-analysis
• Brain (Alzheimer’s) worked better with Vitamin D intervention – meta-analysis
• Systematic Reviews and Vitamin D - Vitamin D Council
• Vitamin A increases risk of fracture if too much or too little – meta-analysis
• Asthma is strongly associated with low vitamin D (but not COPD) – meta-analysis
• 2X more likely to have preeclampsia if less than 20 ng of vitamin D – Meta-analysis
• Metabolic Syndrome 13 percent more likely for every 10 ng less vitamin D – Meta-analysis
• 20 ng is enough vitamin D for healthy Nordic Caucasians: 5th Nordic meta-analysis
• No weight loss when average over trials lasting 6 weeks and only 200 IU of vitamin D – meta-analysis
• Breast Cancer post menopause down 12 percent for every 5 ng of vitamin D – meta-analysis
• Vitamin D reduced risk of death of Chronic Kidney Disease by 30 percent: Meta-analysis
• Magnesium prevents cardiovascular events – Meta-analysis
• Standard and artificial vitamin D both help Chronic Kidney Disease – meta-analysis
• Probably need more than 1000 IU of vitamin D to prevent cancer – meta-analysis
• Food fortified by 440 IU increased vitamin D levels by 8 ng – meta-analysis
• 3.2 percent less Breast Cancer for 2.4 ng more vitamin D – meta-analysis
• Vitamin D with Calcium reduces mortality by 7 percent – meta-analysis
• Type 2 diabetes 1.5X more likely if low vs high vitamin D – meta-analysis
• No association between Multiple Sclerosis relapses and being treated with vitamin D–meta-analysis
• Alzheimer’s and Parkinson’s diseases associated with low vitamin D – meta-analysis
• 4 percent less type 2 diabetes for every 4 ng more vitamin D – meta-analysis
• Meta-analysis of 3 cancers - 10 ng more vitamin D decrease colorectal by 15 percent
• 2X more likely to be depressed if low vitamin D (cohort studies) - Meta-analysis
• Hypertension 30 percent more likely if low vitamin D – meta-analysis
• Pregnancy and vitamin D meta-analysis
• Hypertension 2X more likely when vitamin D levels lower than 14 ng – meta-analysis
• Rheumatoid arthritis 24 percent more likely if low vitamin D consumption– meta-analysis
• Alzheimer disease associated with 2.5 ng less vitamin D – meta-analysis
• Omega-3 does not help heart patients – meta-analysis
• Colorectal cancer 26 percent less likely for every 10 ng of vitamin D – meta-analysis
• Death rate reduced 8 percent for 8 nanogram more vitamin D – meta-analysis
• Psoriasis best treated by combinations such as vitamin D and UVB – meta-analysis
• Vitamin D plus steroids helps psoriasis 2X more than vitamin D – meta-analysis
• Vitamin D3 is much better than D2, especially if not taken daily – meta-analysis
• Breast cancer association with low vitamin D suggested by Meta-analysis
• Hip fractures in India - editorial with recommendation
• Vitamin D reduces falls – meta-analysis
• Meta-analysis of falls and 800+ IU of vitamin D found good results
• 800 IU vitamin D reduces falls
• 1000 IU minimum to decrease falls and fractures Swiss - 2009
• Vitamin D for elderly 800 to 2000 IU - Osteoporosis Canada
• Colon cancer probability increases with decreased vitamin D – Meta-analysis
• Bone fracture meta-analysis – vitamin D and Calcium are OK
• Vitamin D3 much better than D2 for loading doses– meta-analysis
• Example of a vitamin D meta-analysis which ignored the data
• Meta-analysis found hypertension reduced with vitamin D
• 20 year review concludes that Vitamin D reduce ageing
• Diabetes down 13 percent if more than 500 IU of vitamin D – meta-analysis
• Each 10 ng increase in vitamin D decreased kidney disease death by 14 percent
• Vitamin D has a complex relationship with Cancer – meta-analysis
• Chronic Kidney Disease meta-analysis of vitamin D
• Risk of Prostate Cancer weakly associated with vitamin D - meta-analysis
• Colon polyps reduced 15 percent by increasing vitamin D by 20 ng – meta-analysis
• Calcium without vitamin D increased heart risk by 30 percent
• Meta-analysis found vitamin D association with colon but not prostate nor breast cancer
• Meta-analysis finds vitamin D helps chronic kidney disease
• Meta-analysis unsure if vitamin D can prevent cardiovascular disease
• Meta-analysis of RCT – vitamin D might increase senior muscle function
• Meta-analysis not find low vitamin D years before breast cancer
• Meta-analysis confirmed that vitamin D and calcium prevents breast cancer
• TB associated with low vitamin D in a review and meta-analysis – 2008
• TB and vitamin D updated review and meta-analysis – plays a role
• Vitamin D and mortality a meta-analysis of RCT - 2008
• Effectiveness and Safety of Vitamin D in Relation to Bone Health - 2007
• Random Controlled Trials and Meta-Analysis in PubMed
• Meta-analysis did not find strong association between vitamin D and breast cancer risk