Acute viral respiratory infections (RTI) reduced by Vitamin D - 20 reviews

The effects of Vitamin D on acute viral respiratory infections: a rapid review - Aug 2020

Ryan Bradley bradley@nunm.edu 1, Janet Schloss* 3,4, Danielle Brown' Deisy Celis2/ John Finnell' Rita Hedol Vladyslav Honcharov2/ Traci Pantuso' Hilda Pena2, Romy Lauche3' Amie Steel3 1Helfg Ott Research Institute,

Clinical significance:

Despite several positive systematic reviews and meta-analyses, the available experimental evidence related to the effects of vitamin D on acute respiratory tract infection (ARTI) is plagued with heterogeneity and mixed quality, and therefore is insufficient to recommend vitamin D supplementation to the general population as a protective agent against ARTI. However, based on the evidence identified in this rapid review (including a high margin of clinical safety), combined with strong mechanistic rationale, the following recommendations can be made for those at risk of ARTI:

  • 1. vitamin D status should be tested for those at risk of ARTI;

  • 2. patients identified with deficiency or insufficiency should be supplemented with vitamin D until their status is normalized; and

  • 3. daily dosing of vitamin D3 is preferred to achieve serum concentrations > 30 nmol/L in a timely manner.

Clinical trials support vitamin D doses of 800 IU/day up to 10,000 lU/day with 1,000 - 2,000 lU/day being a common dosing strategy in clinical trials, and potentially more effective then lower daily or bolus dosing strategies.

VitaminDWiki comments on study

Download the PDF from VitaminDWiki

Huge range of amount of Vitamin D given: as low as 40 IU

image

  • Sorry, unable to extract text from this PDF without lots of errors

    • Perhaps the watermark was too intense

  • PDF is extremely conservative: the goal of >13 ng

    • Most health studies conclude that people need > 30ng,

    • Some studies conclude that the goal should be > 50 ng

  • They incorrectly assume that the common dosing strategy is a good dosing strategy

  • This study, like many previous studies, found that a single large (bolus) dose when not followed up with maintenance dosing, does not help.

Respiratory Tract Infection risk reduced 2X by Vitamin D loading doses – meta-analysis Jan 2021

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