Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis

The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis.

Biomed Res Int. 2016;2016:5305282. Epub 2016 Nov 6.

Zhang Y1, Xia W1, Lu P1, Yuan H1.

1Department of Endocrinology, Henan Provincial People's Hospital and Zhengzhou University People's Hospital, Zhengzhou, Henan, China.

Items in both categories Diabetes and Vitamin D Receptor are listed here: {category} * Diabetic Retinopathy twice as likely if a T2 Diabetic has low level of vitamin D – meta-analysis March 2017 Vitamin D Receptor category has the following {include} Items in both categories Diabetes and Vision are listed here: {category} See also web * Wikipedia * "also known as diabetic eye disease, is when damage occurs to the retina due to diabetes. It can eventually lead to blindness" * "affects up to 80 percent of all patients who have had diabetes for 20 years or more" * " It is also the leading cause of blindness for people aged 20 to 64 years."

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Aims. Studies on the associations of vitamin D receptor (VDR) gene polymorphisms with diabetic retinopathy (DR) susceptibility reported conflicting results. A systematic meta-analysis was undertaken to clarify this topic.

Methods. A systematic search of electronic databases (PubMed, EMBASE, and CNKI) was carried out until March 31, 2016. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association.

Results. A total of 7 studies fulfilling the inclusion criteria were included in this meta-analysis (649 cases and 707 controls). Pooled ORs showed a significant association between FokI polymorphism and DR risk in all the four genetic models (

  • OR = 1.612 (1.354~1.921),

  • 1.988 (1.481~2.668),

  • 1.889 (1.424~2.505), and

  • 2.674 (1.493~4.790)

in allelic, dominant, recessive, and additive models, resp., PZ < 0.01), but not for TaqI or BsmI polymorphism (PZ > 0.05). Similar results were found in the subgroup analysis. Sensitivity analysis indicated that the results were relatively stable and reliable. Results of Begg's and Egger's tests suggested a lack of publication bias.

Conclusions. Our meta-analysis demonstrated that DR was significantly associated with VDR gene FokI polymorphism. However, due to the relatively small sample size in this meta-analysis, further studies with a larger sample size should be done to confirm the findings.

PMID: 27891515 DOI: 10.1155/2016/5305282