Colon Cancer is not treated by small amounts of Vitamin D - meta-analysis Aug 2026
Impact of Vitamin D Supplementation on Levels of Serum Cholecalciferol and Cytokines in Individuals with Colorectal Cancer: A Systematic Review and Meta-Analysis of Relevant Clinical Trials
International Journal of Preventive Medicine 17, August 2026. | DOI: 10.4103/ijpvm.ijpvm7325
Background: This study assesses the impact of vitamin D supplementation on serum cholecalciferol levels and some cytokines in colorectal cancer (CRC) patients.
Methods: We conducted a thorough search for relevant RCTs in PubMed, Scopus, and Google Scholar using appropriate keywords until December 2024. We calculated weighted mean differences (WMDs) and 95% confidence intervals (CIs) through random-effects analysis.
Results: Five studies were included. Combining data from four studies showed a significant increase in serum 25 (OH) cholecalciferol levels after supplementation (WMD: 23.72; 95% CI: 12.92, 34.52). However, results from two studies indicated no significant changes in serum CRP (WMD: -2.48; 95% CI: -7.42, 2.46) and IL-6 (WMD: -2.49; 95% CI: -6.89, 1.92) levels. Conversely, TNF-α significantly decreased after administration (WMD: -0.81; 95% CI: -1.18, -0.45). There were no significant changes in anti-inflammatory cytokine IL-10 levels (WMD: 0.29; 95% CI: -0.43, 1.01).
Conclusions: This study demonstrates a significant rise in serum 25 (OH) cholecalciferol and a significant decrease in TNF-α, with no notable changes in serum CRP, IL-6, and IL-10 levels in CRC patients after vitamin D treatment.
26 meta-analyses agreed that CRC is treated when enough vitamin D is given - as of Sept 2026__
Related in VitaminDWiki
- Colorectal cancer deaths 26-32% lower with higher Vitamin D – meta-analysis
- 16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis
- Colon Cancer - perhaps prevent it and many others with $40/year supplements
- Colorectal cancer still reduced 6 years after taking Berberine - Sept 2025
- Colon Cancer survival increases with vitamin D, up to 50 ng
- Colorectal Cancer – vitamin D did not help (too small of a response) – RCT
Vitamin D Receptor and CRC
- Colorectal Cancer risk can increase 3X to 30 X (VDR mutations)
- Colon Cancer protects itself by changing the VDR and CYP3A4 genes,
CRC is probably like many other health problems: ~1/2 as much Vitamin D is needed to prevent than to treat - Cancer and the Vitamin D Receptor, a primerCancer and the Vitamin D Receptor, a primer