Pages tagged with "Intervention"

843 pages, most important first (overviews, then meta-analyses, then RCTs, then newest). Combine with another topic

• Summary of Vitamin D trials - Grant
• National Standard summary and strength of evidence for vitamin D
• Overview Diabetes and vitamin D
• Overview Tuberculosis and Vitamin D
• Proof that Vitamin D Works
• Overview MS and vitamin D
• Overview of 8 Types of Supplementation Studies
• Overview of Vitamin D Meta-analysis and RCT for Caucasians
• Grade A recommendations for vitamin D
• Lack of vitamin D and Calcium a world problem – strength of evidence etc – 2009
• Evaluating the vitamin D evidence - Heaney
• COPD fought by Vitamin D - many studies
• Multiple Myeloma (blood cell cancer) treated by vitamin D - many studies
• Coimbra high-dose vitamin D protocol - many studies
• 60,000 IU of Vitamin D daily for 7 years treats many autoimmune diseases without toxicity (cofactors were used)
• Randomized Controlled Trials and Vitamin D - many studies
• Vertigo treated by Vitamin D - many studies
• ALS fought by vitamin D - many studies
• NAFLD and Vitamin D - many studies
• Sepsis is both prevented and treated by Vitamin D - many studies
• Knee osteoarthritis treated by Vitamin D - many studies
• Middle ear infection (Otitis Media) and Vitamin D – many studies
• Restless Legs Syndrome - Vitamin D, Iron, etc. - many studies
• Chronic Hives treated by Vitamin D - many studies
• Vitamin D and Vitamin K intervention trials - many studies
• Far fewer respiratory track infections in infants and children getting 400 IU of Vitamin D – many studies
• After COVID infection, Vitamin D helps - many studies
• UTI associated with low Vitamin D as well as treated - many studies
• Vitamin D prevents Hepatitis-C and helps treat it (many studies)
• Common cause of dizziness (BPPV) reduced 5 X by several doses of 50,000 IU of vitamin D – several studies
• Chikungunya virus and Vitamin D - several studies
• Preemies, Vitamin D, Omega-3, etc. - several studies
• 3X reduction in preemie Bronchopulmonary Dysplasia if add tiny amount of Vitamin D – meta-analysis
• Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015
• COVID fought by Vitamin D: 2.3X less likely to die of COVID if supplemented, 1.9 X less likely to become infected – meta-analysis
• COVID and Vitamin D: 2X more likely to die if low, 2X more likely to survive if supplement – umbrella meta-analysis
• COVID death rate in hospital halved if take any amount of vitamin D for any length of time – meta-analysis
• 5 X less COVID infection of health care workers who took lots of vitamin D – meta-analysis
• Vitamin D response independent of dosing interval – meta-analysis
• Vitamin D-disease associations vary with the type of study – RCT, Observational, MR
• RCTs probably not the future gold standard - CDC former head
• Eczema (Atopic Dermatitis) treated by 1600 IU of vitamin D – meta-analysis
• PMS reduced by Vitamin D intervention - meta-analysis
• Vitamin D and omega-3 are the only supplements which show benefit in meta-analysis
• PTH reduced 3.5 pmol by vitamin D intervention which added 22 ng – meta-analysis
• Brain (Alzheimer’s) worked better with Vitamin D intervention – meta-analysis
• Example of a vitamin D meta-analysis which ignored the data
• COVID-19 defeated 3x faster by 420,000 IU Vitamin D nanoemulsion – RCT
• Single 600,000 IU dose of nanoemulsion Vitamin D is safe and effective to fight COVID, even if delay until enter ICU – RCT
• RCTs: The Foundational Flaw of Modern Medicine? - Cheng
• Gave 1,000 IU of Vitamin D daily while pregnant (no surprise, no benefit) - RCT 2016
• 1,000 IU of Vitamin D while pregnant helped a little bit (4,000 IU helps a lot) – RCT 2016
• Endometriosis treated by Vitamin D (50,000 IU bi-weekly) – RCT
• BPH (PSA) decreased by Vitamin D (50,000 IU bi-weekly) – RCT
• Lupus treated again by daily Vitamin D - 4,000 IU or 8,000 IU (slightly better) - RCT
• Migraine headaches cut in half by 4,000 IU of vitamin D – RCT
• 2000 IU of vitamin D for just 2 weeks helped in many ways – RCT
• Infants getting an additional 800 IU of vitamin D for 2 years had 60% fewer psychiatric symptoms at age 7 – RCT
• 6,400 IU of Vitamin D is safe and effective during breastfeeding – RCT Dec, 2020
• Breastfeeding mother getting 6400 IU of Vitamin D is similar to infant getting 400 IU – RCT
• Raynaud's pain decreased with 600,000 IU monthly vitamin D – RCT
• Half as much AFIB after bypass if 600,000 IU of vitamin D before surgery – RCT
• COVID deaths cut in half by a single dose of 600,000 IU of Vitamin D - RCT
• Vitamin D3 has been extensively studied: ~4,000 Randomized Trials
• LDL Cholesterol reduced by Vitamin D plus Calcium – RCT
• Smokers helped by Vitamin D (100,000 IU monthly) - RCT
• Swine flu not prevented by 2,000 IU of vitamin D daily (the upper limit at the time) – RCT 2014
• 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT
• 50,000 IU of vitamin D weekly for 8 weeks of pregnancy raised most above 30 nanograms - RCT
• 300,000 IU of Vitamin D total is not enough during pregnancy – RCT
• While in labor, preterm birth delayed 6 days by Vitamin D (single dose of 50,000 IU) - RCT
• Vitamin D and RCTs (Randomized Controlled Trials)
• Less weight gain if add Vitamin D, even if have a high fat diet (in rats) – RCT
• Atopic dermatitis reduced by at least half if take 2800 IU Vitamin D while pregnant - RCT
• Autistics have half of the response to Vitamin D – RCT
• Vitamin D cut in half CIS resulting in MS lesions - RCT
• Supplement preterm infants with vitamin D if less than 80 ng – RCT
• Major Depressive Disorder RCTs often use Vitamin D: 50,000 IU weekly or single 300,000 IU - Review
• Sunburning reduced by 200,000 IU of Vitamin D – RCT
• Birth rates doubled with Vitamin D - 300,000 IU for infertile men – RCT
• TB treatment helped by the addition of Vitamin D (100,000 IU bi-weekly) – RCT
• Breast Cancer cure rate by chemotherapy increased 2.3 X by Vitamin D (50,000 IU weekly) - RCT
• ICU patients 6X more likely to die if poor response to 570,000 IU of Vitamin D – RCT
• CIS (MS) reduced 36% by two capsules of 50,000 IU of Vitamin D taken biweekly – RCT
• Asthma reduced by 4,400 IU of Vitamin D while pregnant - RCT and video Weiss
• Asthma reduced by weekly 50,000 IU of vitamin D – RCT
• Rickets prevented by single injection of vitamin D or weekly supplementation – RCT
• Over 48 Virus studies have RCT in the title
• Smoking depression, etc. reduced by Vitamin D (bi-weekly, 50,000 IU) - RCT
• Vitamin D and Calcium do not increase bone density (also need exercise, Mg, K2, protein etc.) – RCT
• Resulting childhood Asthma cut in half if 4,400 IU Vitamin D daily while pregnant - RCT
• 430 genes changed when 3,800 IU Vitamin D added in late second trimester – RCT
• Dysmenorrhea substantially reduced by Ginger, just 1,000 IU Vitamin D also helped – RCT
• 44 percent of successful RCTs in VitaminDWiki used non-daily dosing
• Sleep disorders nicely treated by Vitamin D (50,000 IU twice a month) – RCT
• Non-RCTs may over-estimate benefits by 19%. by confounding, etc.
• Prisoners given Omega-3 for 3 months before release were 16% less likely to return in 3 years – RCT
• Seniors with Heart Failure helped by daily 4,000 IU of vitamin D (increase 16 ng) – RCT
• Chronic Heart Failure reduced by 4,000 IU daily for a year – RCT
• Children had a better response to Vitamin D given every 2 weeks than daily – RCT
• Viral infections reduced 40% by monthly 100,000 IU Vitamin D – RCT review
• Treatment of HIV in youths helped by 7,000 IU of vitamin D for 1 year – RCT
• 7000 IU vitamin D was not enough to reduce obese tissue – RCT
• APOE-04 Alzheimer’s progression slowed up by Omega-3 – RCT
• Long-COVID fatigue, anxiety, and cognition treated by 60,000 IU of vitamin D weekly – RCT
• 15.3 X fewer COVID deaths in those getting Vitamin D injections in ICU – RCT
• 5,000 IU of Vitamin D daily resulted in far fewer hospitalizations - RCT
• Risk of going from pre-MS to MS reduced 68 percent with 7100 IU vitamin D – RCT
• 4,000 IU of daily Vitamin D during pregnancy is good (Mongolia this time) – RCT
• Children with ADHD again helped by 50,000 IU weekly Vitamin D – RCT
• Chinese women in tropics needed 50,000 IU of Vitamin D monthly to keep above 30 ng – RCT
• Sepsis (with mechanical ventilation) treated by 5days of 50,000 IU of Vitamin D – RCT
• Military gave Vitamin D but only 40% got above 30 ng, no benefit was noticed for the entire group – RCT
• Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006
• Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT
• Ischaemic stroke – Vitamin D doubled survival (Injection followed by monthly 60,000 IU) – RCT
• Response to infant 2,000 IU Vitamin D daily was in 194 ng, monthly dosing was 20% less – RCT
• Immune systems of overweight black women improved by monthly 60,000 IU Vitamin D – RCT
• 100,000 IU of Vitamin D3 monthly for 4 months to diabetics (D2 bombed) – RCT
• Monthly 120,000 IU of Vitamin D while breastfeeding was good – RCT
• Asthma and COPD in a few seniors greatly decreased by monthly 100,000 IU Vitamin D – RCT
• Individualized – RCT
• Muscles improved in women with 50,000 IU vitamin D weekly (8 weeks) plus daily Magnesium – RCT
• Anxiety and Depression decreased in senior prediabetics with weekly 25,000 IU of Vitamin D – RCT
• Half of infants had less than 20 ng of Vitamin D with 800 IU (need more) – RCT
• Preeclampsia risk reduced 7X by 4,000 IU of Vitamin D daily – RCT
• Risk of Frailty reduced 4X by 4,000 IU of vitamin D – RCT
• Respiratory infections reduced by 63 percent with 4000 IU vitamin D daily - RCT
• PMS reduced by 50,000 IU every two weeks - RCT
• COVID-19 outpatients getting Quercetin nanoemulsion had excellent outcomes (Q increased Vitamin D in cells) – RCT
• Vitamin D loading dose of 30,000 IU twice a week is safe and effective – RCT
• Bone fractures of children not reduced if given little vitamin D, no Calcium etc. – RCT
• Dieters lost 5 more pounds if achieved more than 32 ng of vitamin D – RCT
• Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT
• Vitamin D 100,000 IU loading dose and stem cell transplants – RCT
• 5000 IU Vitamin D daily resulted in lower health care costs - RCT
• 2.5 X reduced risk of cancer in 70 year-olds by a small amount of Vitamin D, Omega-3 and exercise – RCT
• Multiple Sclerosis treated equally by UVB and weekly 50,000 IU of Vitamin D – RCT
• Infant infection reduced by half with vitamin D supplementation – RCT
• Respiratory Tract Infection visits 2.5 less likely with vitamin D: Pregnancy 2000 IU, Infant 800 IU – RCT
• COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT
• Venous ulcers healed 4X faster with weekly 50,000 IU vitamin D – RCT
• Chronic Periodontitis reduced by Vitamin D (60,000 IU weekly for 8 weeks) – RCT
• Breast Cancer survival: 44% with just 10,000 IU of vitamin D per week, 33% with placebo – RCT
• NAFLD in children nicely treated by combination of Vitamin D and Omega-3 – RCT
• Depression decreased after vitamin D (50,000 IU weekly to elderly in the case) – RCT
• Obese lost more weight on diet if added 50,000 IU of vitamin D weekly – many RCTs
• Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT
• Omega-3 did not prevent depression (they failed to reduce Omega-6, which blocks Omega-3) – RCT
• Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT
• Chronic tonsillitis virtually eliminated in children by Vitamin D (50,000 IU weekly) – RCT
• 50,000 IU of Vitamin D every 2 weeks reduced gestational diabetes – RCT
• COVID in hospital stopped by Vitamin D Receptor activators (curcumin, quercetin) – RCT
• Fracture 4X less likely following kidney transplant if high-dose Vitamin D (100,000 every 2 weeks) – RCT
• Attention-Deficit Hyperactivity Disorder treated by weekly 50,000 IU of vitamin D – RCT
• Tuberculosis not treated by lots of vitamin D for 16 weeks – RCT
• Tuberculosis not prevented by a tiny amount of vitamin D (equiv to 1,400 IU daily) – RCT
• TB not treated by vitamin D given for only 2 months – RCT
• Autism problems reduced by Vitamin D, Omega-3 – RCT
• Multiple Sclerosis is again not fought by 5,000 IU vitamin D daily (need at least 10X more) – RCT
• Vitamin D treatment of Chronic Kidney Disease: monthly better than daily – RCT
• Psoriasis reduced for those getting Vitamin D levels above 50 ng – RCT
• Half as many problems if take Vitamin D (300,000 IU) before thyroidectomy – RCT
• Weekly 50,000 IU of vitamin D is again found to be good – RCT
• Lupus: 60,000 IU Vitamin D monthly got to only 34 ng, not enough to help – RCT
• After Colorectal Cancer Surgery the immune system was maintained by Vitamin D (8,000 IU daily) – RCT
• Uterine Fibroids cut in half in group taking 1,000 IU of Vitamin D - RCT
• 1 in 3 died after hip fracture but only 1 in 14 if add Vitamin D and exercise – RCT
• Hip fracture recovery best with home exercise plus Vitamin D – RCT
• Early COVID treatments rarely work 7 days after symptoms, this trial gave Vitamin D on 7th day – RCT
• Hyperparathyroidism resulting from CKD eliminated by 8,000 IU of vitamin D daily for 12 weeks– RCT 2018
• Vitamin D once during pregnancy reduced infant health care costs (300 times ROI) – RCT
• COVID children helped by Vitamin D, trial terminated: unethical to not give Vitamin D to all: – RCT
• Vitamin D depression RCT canceled: too many were taking Vitamin D supplements, etc.
• Depression decreased by Vitamin D (12th study in VitaminDWiki) – RCT
• Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT
• COVID hospital deaths reduced 2X by 8 days of UVB – pilot RCT
• COVID-19 defeated by calcifediol form of Vitamin D in Spain - pilot RCT
• COVID-19 ICU survival rate increased 7X by daily Omega-3 – RCT
• Vitamin D not help 10 days after COVID-19 symptoms - RCT
• COVID-19 appears reduced by Resveratrol plus 100K IU of vitamin D – Small RCT
• Nursing home vaccinated against Influenza, 800 IU of vitamin D daily cut infection rate in half – small RCT
• Tested positive for COVID, taking probiotics stopped symptoms 5 days sooner - RCT
• COVID in hospital fought by Vitamin D (25,000 IU daily for 4 days, then 25K weekly) - RCT
• Vitamin D does not help when most are not deficient (cataract surgery in this case) – RCT
• 3,200 IU of daily not help much in population already having 30 ng of Vitamin D – RCT
• Small Vitamin D doses for a short time never help (not improve vaccination in this case) – RCT
• The challenges of a Vitamin D RCT – too many already taking it, etc. – Martineau
• One day of 12,000 IU of sublingual Vitamin D raised levels by 8.6 ng in 5 days – RCT
• Risk of COVID not reduced by 3,200 IU of vitamin D during 6 months (no surprise) – RCT
• Atrial Fibrillation risk reduced by 0.84 in those raising Vitamin D levels above 30 ng – RCT
• Overweight needed more EPA (4 grams) to fight depression – RCT
• Faster growth in infants getting 1200 IU of Vitamin D – RCT
• Breastfed Infants need more than an daily average of 800 IU of Vitamin D – RCT
• Children need 2000 IU of Vitamin D (India) - RCT
• Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT
• Diabetic hypertension reduced with Vitamin D and Calcium – RCT
• Gestational diabetes treated by Vitamin D plus Omega-3 – RCT
• Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT
• Hypertension (both systolic and diastolic) reduced with 2,000 IU of vitamin D – RCT
• Hypertension reduced by Magnesium plus 3,000 IU of vitamin D for 12 weeks – RCT
• 4X less likely to get COVID following 4,000 IU daily for a month – RCT
• Vitamin D for infants – 100,000 IU monthly is better than 400 IU daily – RCT
• Short-term response to 1,000 IU of Vitamin D tripled in obese when Magnesium was added – RCT
• 21 fewer days in hospital with ARDS (COVID) if 10,000 IU of Vitamin D daily after enter hospital – RCT April, 2022
• Breast Cancer not prevented by 1,000 IU of Vitamin D (no surprise) – RCT
• 10,000 IU of Vitamin D for 3 years found to help bone by two measurement methods – RCT
• Influenza vaccine antibodies not change with Vitamin D – 21 ng or 44 ng – RCT
• Response to Vitamin D varies with genes (3,000 IU, weight loss in this RCT)
• Stroke patients need more than 2,000 IU of vitamin D (found this time in Japan) – RCT
• Monthly vitamin D helped hearts with low vitamin D a bit (need it more frequently) – RCT
• Sleep not helped when half got to 35 ng of Vitamin D (may need 60 ng) – RCT
• Tuberculosis treatment helped a bit by a bit of Vitamin D - RCT
• Group achieving 30 ng (vs 26 ng) were 2X less likely to get COVID symptoms - RCT
• NAFLD not reduced by 1680 IU of vitamin D plus Omega-3 (no surprise) – RCT
• Yet another study confirms Depression is treated by weekly Vitamin D (50,000 IU)– RCT
• Diabetes helped somewhat by weekly 50,000 IU of vitamin D (5 ways to improve) – RCT
• 50,000 IU of vitamin D monthly in winter gets most above 20 ng – RCT
• Off Topic: EDTA similar reduction in heart attack as Vitamin C, aspirin and Mg – RCT
• Most Diabetics getting 40,000 IU of vitamin D weekly did not get to 30 ng (needed gut-friendly form) - RCT
• 2,000 IU of vitamin D and Omega-3 reduced Cancer death rate bv 40% (normal weight) – VITAL RCT
• Stoss (loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT
• Additional Vitamin D not help – infants previously had 35 ng of vitamin D – RCT
• Added 1 lb of muscle to sarcopenia adults in 13 weeks with just 800 IU vitamin D and protein – RCT
• A small amount of Vitamin D for a short time does not help (2800 IU, 8 weeks) – RCT
• Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT
• Non-Alcoholic Fatty Liver Disease (NAFLD) treated by Vitamin D (20,000 IU weekly after loading dose) – RCT
• 18 fewer hospital days if given 500,000 IU of vitamin D while ventilated in ICU – RCT
• TB not prevented by a small amount of Vitamin D (2,000 IU daily average, Mongolia) – RCT
• RTI – Feel much better if increase vitamin D level above 40 ng (4000 IU) – RCT
• Respiratory infections (RTI) cut in half by 20,000 IU weekly vitamin D if initially deficient – RCT
• Menstrual Pain (PMS) reduced by vitamin D – RCT 2012, 2014, 2016
• PMS again significantly reduced by 50,000 IU of vitamin D (This time, every two weeks) – RCT
• Tuberculosis recovery speeded up by single 450,000 IU dose of vitamin D – RCT
• ADHD 1.5X less likely if 4,400 IU Vitamin D daily during pregnancy - RCT
• 400 IU of Vitamin D helped breastfed infants, need more – RCT
• Mother got 100,000 IU of vitamin D monthly, breastfeeding infant got a little – RCT
• Daily, monthly Vitamin D had similar great benefits, more than 6 months needed – RCT
• Antibiotic use cut in half by elderly (over 70) after monthly 60,000 IU of vitamin D – RCT
• 40,000 IU vitamin D weekly reduced depression in many obese subjects – RCT 2008
• Sublingual vitamin D gave similar response as oral for most, and better for some – RCT
• Rectal Cancer genes down-regulated by Vitamin D (3,200 IU only helped some) – RCT
• Falls not decreased by 60,000 IU Vitamin D monthly (not a news item) – RCT
• Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016
• IBS not helped by daily 3,000 IU Vitamin D (but non-daily and gut-friendly help) – RCT
• Colorectal Cancer treatment aided by omega-3 plus weekly Vitamin D – RCT
• 5,000 U daily raised Vitamin D a bit and helped COVID-19 a bit – RCT
• Hay Fever treated by Vitamin D (50,000 IU weekly) – RCT
• Athletes helped by weekly 50,000 IU Vitamin D – RCT
• Hashimoto's thyroiditis helped by weekly 50,000 IU of vitamin D – RCT
• Infant Respiratory Infections not reduced by mothers taking small amount of vitamin D (28,000 weekly)– RCT
• Digestive Tract Cancer survival increased 3X if 2,000 IU of vitamin D and have high level of PD-L1 – RCT
• 400 IU of Vitamin D provided no benefit to children (not a surprise) – RCT
• Monthly 100,000 IU of vitamin D is safe (and may be better than daily) – RCT
• Sperm not improved enough by Vitamin D - 50,000 IU weekly for 8 weeks - RCT
• Every TB patient benefited from 2 doses of 600,000 IU of vitamin D – RCT
• Inflammation reduced by a single dose of Vitamin D (200,000 IU) – RCT
• 5X less likely to enter ICU with COVID-19 if get Calcifediol (semi-activated vitamin D) - RCT
• Overweight elderly respond well to 3600 IU Vitamin D daily for a year – RCT
• 50,000 IU of Vitamin D once every 2 weeks achieved 40 ng in 3 months – RCT
• Weekly response to semi-activated vitamin D slightly better than standard – RCT
• Vitamin D every 25 days may be BETTER than daily – RCT
• Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT
• Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT
• Recurrence of child pneumonia delayed by 100000 IU of vitamin D – RCT
• Crohn’s disease helped when vitamin D level raised above 30 ng – RCT
• Diverticular disease:12X reduction if low Vitamin D and given 100,000 IU monthly – RCT
• Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT
• Crohn's Disease relapse rate of 3 in 8 with 1,000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT
• Anti-inflamatory cytokines increased when vitamin D levels were raised above 30 ng – RCT
• Far more Vitamin D in breast milk from a 150,000 IU dose than from daily 5,000 IU – RCT
• Upper Respiratory Tract Infections in adults reduced by just 400 IU of vitamin D – RCT
• Migraine headaches reduced with 50,000 IU vitamin D weekly – RCT
• Mild cognitive decline reversed by a year of just 800 IU Vitamin D daily – RCT
• 9,000 dollar prize for RCT which found cognition improved after taking 4,000 IU of Vitamin D for 18 weeks
• Those getting an injection of 300,000 IU Vitamin D got out of the ICU a week sooner – RCT
• Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT
• Toddlers with more than 48 ng of vitamin D weighted less and were thinner – RCT
• 500,000 IU of vitamin D cut in half the hospital days following a lung failure – RCT 2015
• 4,000 IU of vitamin D for 1 month does not help (muscles in this case) – RCT
• Vitamin D injection is far better than oral for diabetics (poor gut) – RCT
• HIV patients helped by monthly 120,000 IU of Vitamin D – RCT
• College swimmers helped by daily 5,000 IU of Vitamin D in the fall – RCT
• Vitamin D needed to get children to just 20 ng in winter 800 IU white skin, 1100 IU dark (Sweden) – RCT
• Ventilator-associated pneumonia death rate cut in half by Vitamin D injection (300,000 IU) – RCT
• Pregnancies helped a lot by Vitamin D (injection then 50,000 IU monthly) – RCT
• Weekly oral Vitamin D recommended before surgery (Bariatric in this case) – RCT
• 300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT
• 5 days of 100,000 IU of Vitamin D increased hemoglobin in critical illness – RCT
• Newborn Vitamin D - single 50,000 IU is better than daily – RCT
• Several Diabetic pains reduced by injection of 300,000 IU of Vitamin D – RCT
• 24 ng lower response to Vitamin D due to obesity, low initial Vitamin D, and genetics – RCT
• Childhood colds reduced 25 percent by weekly Vitamin D – RCT
• Monthly 100,000 IU of Vitamin D adds about 25 ng - RCT
• Response to 150,000 IU vitamin D once vs 5,000 IU daily – RCT
• Diabetic inflammation reduced by Vitamin D (30,000 IU weekly) – RCT
• Diabetes (Type II) reduced by single injection of 300,000 IU of vitamin D3 – RCT
• Ulcerative colitis treated by injection of 300,000 IU of vitamin D – RCT
• Vitamin D levels in children optimized with six Vitamin D biscuits – RCT
• Lupus flareups cut in half by just 2,000 IU of vitamin D – RCT
• Little weight loss in obese children from very small amount of vitamin D (1200 IU) – RCT
• Monthly vitamin D dosing had higher response than 3 per month – RCT
• COPD trial to use 80,000 IU of vitamin D weekly – RCT 2021
• Traumatic Brain Injury – 120,000 IU of Vitamin D resulted in 3 fewer days on ventilators – RCT
• Depression in psychiatric youths reduced 28 percent after just 1 month of vitamin D – RCT
• Diabetes not helped by increasing Vitamin D levels to 20 ng (proven again) – RCT
• Vitamin D intervention for 8 weeks of pregnancy: infants taller, heavier and bigger heads – RCT
• Dengue virus prevented by a small amount of Vitamin D – RCT
• Respiratory tract infection eliminated in 36 percent of people by 4000 IU of Vitamin D – RCT
• Irritable Bowel Syndrome treated by weekly 50,000 IU Vitamin D – RCT
• Lower back pain treated by 600,000 IU of Vitamin D – RCT
• Diabetes helped by 5,000 IU of Vitamin D – RCT
• Less response to 800 IU of Vitamin D by Africans than natives in Finland – RCT
• Obese responded to weekly vitamin D better than non-obese – RCT
• Vitamin D changed microbiota in gut and airway, might reduce cystic fibrosis – RCT
• Prostate Cancer treatment (Vitamin D, Omega-3, Tumeric) RCT ending
• Multiple Sclerosis treated by 50,000 IU Vitamin D bi-weekly plus Omega-3 – RCT
• Lymphoid cancer deaths cut in half with 400 IU of vitamin D and 1 gram of Calcium (WHI) – RCT
• Salmon dinners (400 IU Vitamin D daily) not enough to stop winter decline (Norway) – RCT
• 10,000 IU of Vitamin D taken daily for 3 years is safe – RCT
• Influenza A: 5X reduction in first month (only) with 2,000 IU of vitamin D– RCT
• Muscle strength of Judo athletes increased 13 percent following single dose of 150,000 IU vitamin D – RCT
• Exercise plus vitamin D increases elderly muscles (Nordic walking in this case) – RCT
• Cystic Fibrosis not helped by 50,000 IU of Vitamin D taken twice a month – RCT
• Bones of white children not helped by 1,000 IU of vitamin D (Northern latitudes) – RCT
• Vitamin D – monthly dosing was better than daily with Calcium – RCT
• 50,000 IU of vitamin D every two weeks – Jordan conclusion - RCT
• 50,000 IU Vitamin D one time after birth helped – RCT
• 1700 IU vitamin D (50000 monthly) helped antarctic explorers – RCT
• Taekwondo athletes helped by just 1 month of Vitamin D (longer would be better) - RCT
• 5,000 IU Vitamin D daily resulted in many benefits after 3 months (US soldiers) – RCT
• Parkinson's disease stabilized with just 1200 IU of vitamin D – RCT
• Severely Obese not helped much by 50,000 IU of vitamin D weekly for 8 weeks – RCT
• Can burn pain be relieved by 4 g of Omega-3 and 2,000 IU of vitamin D – RCT due 2021
• Atopic dermatitis dramatically reduced in Iran with 1600 IU of vitamin D – RCT
• Diabetics and prediabetics helped by 5,000 IU of Vitamin D for 6 months– RCT
• Preemie immunity (Treg) vastly improved by 800 IU of Vitamin D daily – RCT
• Third study found that Infants needed 1600 IU of vitamin D – JAMA RCT
• Allergic Rhinitis (hay fever) reduced by just 1,000 IU of vitamin D for 30 days – RCT
• Depression reduced in Diabetics with 3 months of 4,000 IU of vitamin D – RCT
• Urgency Urinary Incontinence in senior black women decreased 40 percent by weekly 50,000 IU vitamin D – RCT
• Less bone loss if take 100,000 IU vitamin D monthly – RCT
• Type 2 Diabetes inflammation reduced by 50,000 IU of Vitamin D bi-weekly and resistance training – RCT
• Diabetic inflammation reduced by Calcium and 50,000 IU of vitamin D in 8 weeks – RCT 2014
• Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT
• Treatment of neonate sepsis greatly aided by Vitamin D – RCT
• Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT
• Methadone cognition improved by 50,000 IU of vitamin D every 2 weeks – RCT
• Risk of Metabolic syndrome for senior women reduced 42 percent by 1,000 IU of vitamin D – RCT
• Autism in children reduced by Vitamin D (used 300 IU per kg per day) – RCT
• Digestive tract cancer death rates reduced a bit by a bit of vitamin D – RCT
• Advanced Colorectal Cancer survival is increased somewhat with 4,000 IU of vitamin D – RCT
• 25 minutes of daily sun provided less than half of the response as 500 IU of vitamin D (Korea) – RCT
• Bacterial vaginosis reduced 10 times by 2,000 IU of vitamin D – RCT
• Fetal bones helped a bit by 1,000 IU of vitamin D – RCT
• Adding 1,000 IU vitamin D while pregnant did not help much (no surprise) – RCT
• Schizophrenia reduced by biweekly 50,000 IU Vitamin D and probiotics – RCT
• Preeclampsia risk reduced by higher levels of vitamin D (VDAART 4,400 IU) - RCT
• Cognition of Alzheimer’s patients improved by daily 4,000 IU of vitamin D – RCT
• 2000 IU vitamin D during pregnancy and 800 IU to infant resulted in less use of antibiotics – RCT
• 100,000 IU of vitamin D monthly decreases use of NASIDs by 13 percent if low vitamin D – RCT
• 4000 IU Vitamin D Safe and Effective For Healthy Pregnant Women – RCT
• PMS reduced by half in girls who had low levels of vitamin D – RCT
• IBS – 82 percent had low vitamin D, 3,000 IU spray helped a lot – RCT
• Physical performance of black senior women not improved with 30 ng of Vitamin D – RCT
• 50,000 IU of vitamin D weekly following cardiac failure helps – RCT 2014
• Senior quality of life not helped by 800 IU of Vitamin D (not nearly enough) – RCT
• Nordic Walking and 4,000 IU of vitamin D lowered cholesterol, fat, weight, and lipids (senior women) – RCT
• Gestational Diabetes reduce 3 times by 5,000 IU of Vitamin D – RCT
• Diabetes treated if given enough vitamin D (example: 50,000 IU weekly) – review of RCT
• Cognition improved a tiny amount with 400 IU of vitamin D (not a surprise) – RCT
• 100000 IU vitamin D monthly helps COPD patients – 3 RCT
• Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT
• Knee Osteoarthritis benefited by 20 ng of Vitamin D for 5 years – RCT
• Cardiovascular risk markers not helped by 20,000 IU of vitamin D weekly – RCT
• Lung cancer treated by Vitamin D (1200 IU early stage) – RCT
• 5,000 IU daily or 50,000 IU Vitamin D weekly repleted many dark skinned adolescents – RCT
• Vitamin D RCT using 100,000 IU monthly for a variety of health problems – results of ViDA due in 2016
• Knee replacement not helped by 2,000 IU of vitamin D (both too late and too little) – RCT
• 1200 IU vs 400 IU of vitamin D did not improve bone health or immunity of children who were sufficient – RCT
• Fibromyalgia pain reduced with vitamin D intervention that achieved 30-48 ng – RCT
• Insulin sensitivity in obese adolescents greatly improved with 4000 IU of vitamin D - RCT
• Multiple sclerosis helped some by 10,000 IU of vitamin D daily avg. for 3 months – RCT
• IBS quality of life improved by vitamin D (50,000 IU every two weeks) – RCT
• Cystic fibrosis treatment by vitamin D improved quality of life and breathing (8200 IU daily)– RCT
• Gestational Diabetes treated with 50,000 IU every two weeks – RCT
• No genetic response to 4,000 IU of Vitamin D (other studies disagree) – RCT
• Urinary sepsis – a single Vitamin D injection reduced hospital days by 40 percent – RCT
• ADHD reduced by just 3,000 IU of Vitamin D and methylphenidate for just 12 weeks – RCT
• 35,000 IU vitamin D weekly during 3rd quarter pregnancy – RCT
• Elite Athletes do well with weekly 35,000 IU of Vitamin D – RCT
• Prostate cancer reduced when 4000 IU vitamin D was added– Hollis RCT
• Breathing by ever-smokers improved by monthly Vitamin D – RCT 2017
• Arterial stiffness reduced by a single dose of 100,000 IU of vitamin D – RCT
• Lupus reduced when half of participants got to 38 ng of Vitamin D (not statistically significant) – RCT
• Prostate Cancer might be treated by 4,000 IU of vitamin D and aspirin – RCT 2021
• Colon Cancer proven again to not be treated by just 1000 IU of vitamin D – RCT
• Senior cognition improved somewhat by 4,000 IU of Vitamin D (if initially less than 30 ng) – RCT
• Hypertension not controlled by 26 ng of Vitamin D (50,000 IU bi-weekly A-A) – RCT
• Atopic Dermatitis (Eczema) in Mongolian children reduced with 1,000 IU of vitamin D – RCT
• Blood pressure reduced by monthly 100,000 IU of vitamin D in those who were deficient – RCT
• Leg bone (tibia) grew thicker with 4,000 IU of vitamin D and Calcium – RCT
• Probably Fractures of the Tibia can be healed with 100,000 IU of vitamin D weekly – RCT 2023
• Vitamin D taken daily (4,000 IU) vs weekly (50,000 IU) – RCT 2019
• Delay onset of Multiple Sclerosis with 100,000 IU of vitamin D every two weeks – RCT 2020
• Perhaps fewer bone non-unions with 100,000 IU weekly of vitamin D – RCT 2018
• Hypertension not reduced by adding vitamin D to patients who had enough vitamin D – RCT
• Preemies need 1,000 IU of vitamin D – RCT
• Vitamin D aided progesterone in reducing traumatic brain injury – RCT
• 2000 IU of vitamin D should improve toddlers health in winter – RCT almost completed
• Monthly 120,000 IU Vitamin D plus daily Calcium was great during pregnancies – RCT
• Reduced depression with single 300,000 IU injection of vitamin D – RCT
• Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT
• Near the end of pregnancy 50,000 IU vitamin D weekly was great – RCT
• Hives treatment augmented by 60,000 IU Vitamin D weekly – RCT
• Vitamin D daily or weekly dosing resulted in similar response -RCT
• Prenatal Vitamin D (35,000 weekly, 3rd trimester) resulted in 1 cm taller infants at age 1 year – RCT
• 50,000 IU of vitamin D weekly (D3 or D2) got two thirds of cystic fibrosis patients to 30 nanograms – RCT
• Juvenile Lupus fatigue reduced by vitamin D ( 50,000 IU weekly for 6 months) – RCT
• Non-alcoholic fatty liver disease (NAFLD) reduced somewhat by 50,000 IU vitamin D every 2 weeks – RCT
• No multiple sclerosis relapses during pregnancy if 50,000 IU of Vitamin D weekly – RCT
• 2X fewer Senior falls in group getting 100,000 IU vitamin D monthly via Meals-on-Wheels – RCT
• Weekly pizza fortified with 28,000 IU raised Vitamin D by 30 nanograms – RCT
• Pregnancy – adding 35,000 IU Vitamin D weekly was nice, but not enough – RCT
• Many benefits of 50,000 IU vitamin D every two weeks (methadone treatment) – RCT
• Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT
• Preeclampsia recurrence reduced 2 X by 50,000 IU of vitamin D every two weeks – RCT
• Heart Failure not helped by Vitamin D (several strange things about the trial) – RCT
• Single dose (up to 60,000 IU) vitamin D raised levels in 87 percent of Cystic fibrosis patients – RCT
• Bone mineral density somewhat better with 3750 IU vs 600 IU Vitamin D (1 year, with Calcium) – RCT
• Tuberculosis treatment greatly helped by injection of 200,000 IU of vitamin D – RCT
• Visual memory improved a bit by vitamin D if start with less than 30 ng – RCT
• Fatigue reduced by a single dose of vitamin D (100,000 IU) – RCT
• Crohn's disease treated by 2000 IU Vitamin D - RCT
• Multiple Sclerosis Relapsing-Remitting rate reduced 30 percent by addition of 14,000 IU vitamin D daily – RCT
• Vitamin D intervention increased by 20 percent the survival of critically ill patients- RCT
• 3,800 IU Vitamin D during pregnancy did not help much – RCT
• Overweight and obese lost 12 lbs with vitamin D in 6 months– RCT
• Elderly falls reduced 3.6 times by 900 IU of vitamin D and simple exercise – RCT
• Winter youths need at least 1200 IU of vitamin D to maintain 20 nanograms – RCT 2016
• Improved muscle function in postmenopausal women with just 1,000 IU of vitamin D daily – RCT
• COPD reduced by 40 percent with monthly 100,000 IU of vitamin D – RCT
• Gestational Diabetes reduced 40 percent by 5,000 IU of vitamin D – RCT
• Perinatal depression decreased 40 percent with just a few weeks of 2,000 IU of vitamin D – RCT
• Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT
• Just 1500 IU of Vitamin D significantly helps Prozac – RCT
• Vitamin D improved child muscle mass even without varying dose with weight – RCT
• Five times less mite allergy when vitamin D added in mid pregnancy and to infant – RCT
• Infant much healthier if Gestational Diabetic mother got 2 doses of vitamin D – RCT
• 800 IU vitamin D for infant and 2000 IU for mother is good, not great – RCT
• More calcium in bones in those teenage girls getting 2,000 IUs daily – RCT
• Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT
• Inflammation in African Americans not reduced with 3 months of 4000 IU of vitamin D – RCT
• Improved births with 2,000 IU vitamin D during pregnancy in India - RCT
• Musculoskeletal pain reduced with 4,000 IU of vitamin D – RCT
• Congestive heart failure in infants virtually cured by 1000 IU of vitamin D – RCT
• 5,000 IU Vitamin D was not enough to reduce preeclampsia but did help future infant – RCT
• Respiratory diseases helped by vitamin D if initially have low level – RCT review
• Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT
• Post menopausal vaginal dryness treated with vitamin D vaginal suppositories – RCT
• Monthly 100,000 IU vitamin D supplementation got virtually all vitamin D deficient subjects above 20 ng – RCT
• Rate of injuries from falls cut in half by just 800 IU of vitamin D and exercise – RCT
• 39% fewer falls with 2000 IU than 800 IU – RCT
• Monthly vitamin D (120,000 IU) got most overweight African Americans about 35 ng – RCT
• COPD reduced by vitamin D taken once every 60 days – RCT
• Breast Cancer medicine pain reduced with 4300 IU vitamin D – RCT
• Age-related cognitive decline in rats mitigated by Vitamin D intervention – RCT
• Probability of getting TB reduced 60 percent with just 800 IU of vitamin D – RCT
• Heart failure markers reduced by 400 IU of vitamin D and Calcium (surprise) – RCT
• Death due to cystic fibrosis reduced about 4X due to 250000 IU of vitamin D – RCT
• Cystic fibrosis helped with single dose of 250,000 IU of vitamin D – RCT
• 3000 IU reduced hypertension for the vitamin D insufficient – RCT
• MS helped by average daily 2800 IU vitamin D – RCT
• 1600 IU vitamin D was enough to get all (white, non-obese) elderly to 20 ng – RCT
• Hip bone loss stopped with 1000 IU of vitamin D, while 400 IU similar to placebo – RCT
• Many preemies need at least 800 IU of vitamin D – RCT
• Hip fracture reduced 38 percent with Calcium and just 400 IU of vitamin D – RCT
• More blood was pumped by those getting 800,000 IU of vitamin D after heart failure – RCT
• Calcium and 4,000 IU Vitamin D in Postmenopausal Women – RCT
• Bronchial Asthma reduced with 60,000 IU monthly vitamin D – RCT
• Hip fractures reduced 2X to 6X with just 10 minutes of sunlight daily – RCT 2003-2010
• 6 percent less likely to die by taking just a little vitamin D for 3 plus years – RCT
• 2800 IU of vitamin D before and after parathyroid surgery helped a lot – RCT
• 4000 IU vitamin D daily for just 5 days reduced inflammation after heart attack – RCT
• Hypertension reduced 6.8 mmHg with 3,000 IU of vitamin D daily – RCT
• Infants getting 1400 IU vitamin D weekly grew better – RCT
• Women taking 4,000 IU reduced pregnancy risks in half RCT
• TB treatment helped with Vitamin D – RCT
• Pregnancy helped by single dose of 60,000 IU of Vitamin D – RCT
• Adding 4,000 IU of vitamin D daily at 20 weeks pregnancy not help much – RCT
• Muscle increased 17 percent in vitamin D insufficient elderly getting 4,000 IU for 4 months – RCT
• People with old burns improved muscle strength with 2200 IU average vitamin D – RCT
• Just 300 IU daily of vitamin D reduced respiratory infections by 50% – RCT
• Recent Diabetics treated by supplementation which achieved 60 ng of vitamin D – RCT
• Allergy to House dust mite greatly reduced by adding just 600 IU of vitamin D – RCT
• 1700 IU vitamin D for a year provided no cardiovascular benefit (no surprise) – RCT
• 4000 IU RCT reduces type 2 diabetes HOMA by 24% and CRP by 64%
• Diabetes prevention RCT kicked off: adding 4,000 IU vitamin D
• Chronic Kidney Disease reduced with 3600 IU vitamin D (50000 twice a month)– RCT
• Bones better after pregnancy with just 200 IU of vitamin D plus 600 Calcium – RCT
• Mayo clinic starting Cancer RCT using grossly inadequate 2,000 IU of vitamin D
• Girls in India grew much faster when given Vitamin D, Ca, Zn, multi. – RCT
• 1000 IU of vitamin D not enough to increase teen blood levels – RCT
• Chronic Heart Failure helped with 2,000 IU of vitamin D (PRA reduced) – RCT
• Insulin improvement in obese teens with 4000 IU of vitamin D – RCT
• Just 500 IU of vitamin D helped reduce rheumatoid arthritis pain - RCT
• Preterm birth rate reduced 60% by Vitamin D (40 ng)
• 2,000 IU of vitamin D reduced schizophrenia chance by 77 percent (male infants) - 2004
• Inhaled liposomal Glutathione might fight COPD, CF, COVID, Pulmonary Fibrosis , smoke, etc.
• Intervention - non daily
• Preeclampsia reduced by Vitamin D (50,000 IU bi-weekly) and Calcium
• 400,000 IU barely raised liver transplant candidate vitamin D levels (no surprise)
• Low risk Prostate Cancer decreased with 4,000 IU of vitamin D
• Antibiotic use decreased after supplementing with 1500 IU of Vitamin D
• 7100 IU (50000 weekly) got most women to 30 ng of vitamin D
• Tinnitus reduced by Vitamin D (60,000 IU weekly for 12 weeks)
• 19 of the reasons that Vitamin D trials fail
• Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants
• 53 Multiple Sclerosis patients somewhat helped by 10,000 IU of vitamin D (vs. many virtually cured by 100,000 IU)
• Vitamin D2 substantially reduced lumbar degenerative disease
• High-dose Vitamin D reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis
• Video by Dr. Coimbra – 95 % of autoimmune diseases cured with Vitamin D in high doses
• Tick disorder reduced by Vitamin D supplementation
• Autism decreased in 8 out of 10 children supplemented with vitamin D
• 100 years since Vitamin D discovery, proof that supplementation works
• Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection
• Diabetic neuropathy reduced by injection of 600,000 IU of vitamin D
• Vitamin D toxicity problems from 600,000 IU weekly for 6 weeks
• In Vitro Fertilization clinical trial using 50,000 IU of Vitamin D bi-weekly
• Intervention - Vitamin D
• Influenza prevented by 40 ng levels or treated with vitamin D hammer (50,000 IU)
• Vitamin D and exercise after hip fracture surgery – far fewer deaths
• Quality of Life
• Massive improvement in vaginal microbiome during pregnancy with Vitamin D
• 14000 IU vitamin D (50000 twice a week) often stops Sickle Cell pain
• Vitamin D and Liposomal Glutathione restore the immune system
• Polymyalgia Rheumatica treated by raising Vitamin D above 40 ng
• Many symptoms vanquished by Vitamin D (50,000 IU weekly)
• Rheumatoid Arthritis pain reduced by vitamin D (monthly or daily)
• The many problems with Vitamin D trials (such as VITAL) - Sunil
• Problems with the VITAL study
• Multiple Sclerosis slowed by bi-weekly 100,000 IU of Vitamin D (Note: Same amount daily reverses MS)
• Dental caries cut in half by vitamin D, review of 24 old clinical trials
• Coimbra Protocol (using Vitamin D) is safe and effective for Multiple Sclerosis and Autoimmune diseases
• Obese have a slow, decreased response to 700 IU of Vitamin D
• 50,000 IU of Vitamin D monthly is safe for 1 year, levels still rising
• Asthma treated by daily 50,000 IU of Vitamin D
• Rickets: Vitamin D safe and effective - ten doses of 60,000 IU or 1 injection of 600,000 IU
• Type 1 Diabetic inflammation reduced by 50 ng of Vitamin D
• HbA1c levels (Diabetes) reduced by monthly 50,000 IU of vitamin D
• Depression cost-effectively reduced by 50,000 IU of Vitamin D monthly (Iranian teens)
• Spinal TB surgery now includes Vitamin D as the standard of care (5,000 IU daily)
• Vitamin D Has No Effect on Cardiovascular Health (20 studies disagree)
• Vitamin D intervention reduces preterm births and low birth weight by 60 percent – Cochrane Reviews
• Vitamin D and Glutamine reduced Trauma Center deaths by half – Matthews
• Monthly vitamin D dosing better for children than daily (again)
• Several rheumatic diseases treated by high-dose vitamin D, but made worse if Calcium was added
• Have getting 50000 IU Vitamin D weekly for 8 weeks got to 30 ng level
• 54,000 IU of vitamin D daily with no Calcium (1,000 IU per kg: Coimbra protocol)
• Pesticides 8 X less likely to result in female infertility if take vitamin D
• Post-stroke Vitamin D supplementation helped in 11 ways
• Hospital ICU added high dose vitamin D - malpractice lawsuit costs dropped from 26 million dollars to ZERO
• Autoimmune risk decreased 30 percent by small amount of vitamin D and or Omega-3 – ViTAL
• Diabetes prevented by 50,000 IU vitamin D monthly (Iran)
• Bone biomarkers increased equally by daily, weekly, or monthly Vitamin D (CKD in children in this case)
• Vitamin D levels in teens restored with 150,000 IU monthly for 3 months (mean 33 ng)
• Pain reduced by Vitamin D (60K weekly, then monthly) plus daily Calcium in 3 months
• Prostate Cancer PSA reduced by 60 ng of Vitamin D, Vitamin B complex, Omega-3, Curcumin and diet
• Muscles not improved by just Vitamin D weekly (also need exercise)
• Mild Obstructive Sleep Apnea decreased by 50,000 IU weekly vitamin D
• Wheezing reduced 35 percent if vitamin D added during pregnancy
• Salmon intervention (vitamin D and Omega-3) improved heart rate variability and reduced anxiety
• Those with Asthma or COPD had half the response to Vitamin D
• Increase life expectancy by 2 years if double Vitamin D levels – Grant
• 2,000 IU of Vitamin D per kg of food – best growth, bone strength, etc. (pig trial)
• Less morphine recall if preceded by twice a week Vitamin D (400 IU per kg in rats, human weights 80 kg)
• UVB added in classroom reduced cavities, increased height, increased academics. etc
• More than 16 reasons why Vitamin D trials fail
• Propensity Scores are useful if there are no hidden biases
• More than 700 Intervention Trials in VitaminDWiki since the IoM decision
• Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks
• Fibromyalgia pain, fatigue, etc. reduced by 50,000 IU of Vitamin D for 12 weeks
• Acute respiratory tract infections not reduced by Vitamin D if already have a good level
• Cluster headaches virtually eliminated in 7,000 people with high-dose vitamin D and cofactors
• How often might 50,000 IU vitamin D be taken - results of clinical trials
• Senior cognition improved in 4 ways by Vitamin D (50,000 IU weekly for 8 weeks)
• Breast-feeding mothers need 2000 IU of vitamin D to get infants to even 12 ng
• Personalized Lifestyle Intervention reduced cognitive decline (Alzheimer's)
• Every schizophrenia measure was improved when vitamin D levels were normalized
• 35,000 IU vitamin D daily for 6 months helped ALL psoriasis suffers (106 ng) – Brazil
• Weight loss on low-calorie diet: 7 lbs more lost if got lots of Vitamin D
• Cardiovascular events – need more than monthly 60,000 IU vitamin D to prevent other than infarction
• Kidney patients who happened to be getting high-dose Calcitriol were 9X less likely to die of COVID-19
• Children getting 60,000 IU monthly got to vitamin D level of 33 ng
• 5,000 or 10,000 IU Vitamin D for 7 years both safe and effective (4700 patients, 8 months to plateau)
• Breast Cancer trial using 50,000 IU Vitamin D weekly cancelled (no funding)
• Women had better sexual desire, orgasm and satisfaction after Vitamin D supplementation
• 7 improvements in lives of veterans with chronic pain with 50,000 IU vitamin D weekly
• 2000 IU daily raised vitamin D levels by 5 nanograms while on submarine patrol
• Hemodialysis patients (CKD) helped by weekly 50,000 IU of vitamin D
• Kidney disease helped by active or high dose Vitamin D
• ICU cost reduced by at least 27,000 dollars if get high dose vitamin D in first week
• HIV treatment augmented by high-dose vitamin D, daily or weekly
• High dose vitamin D fights Folate gene changes by COVID, autoimmune, CVD, ALZ
• Hypothyroidism risk reduced 32 percent in those getting vitamin D levels above 50 ng
• 54 genes significantly affected by Vitamin D (50,000 IU weekly for 12 weeks)
• Cancer risk reduced 65 percent by vitamin D levels greater than 40 nanograms
• 2.3 X more weight loss in those who had low vitamin D levels and took some
• Immune systems not improved with 1,000 IU of vitamin D daily (not a surprise)
• Angina dramatically reduced by injections of vitamin D twice a month (300,000 IU)
• Better Surgical outcomes if preceded by Vitamin D loading dose
• Vitamin D Supplements Don’t Reduce COVID-19 Risk (used only 3,200 IU daily)
• Optic neuritis progession into Multiple Sclerosis reduced 68 percent by 50,000 IU of vitamin D weekly
• Better response to shingles virus after 6,400 IU Vitamin D raised above 40 ng
• Response and adverse effects of 20,000 and 30,000 IU Vitamin D weekly
• Peripheral diabetic neuropathy helped by weekly 50,000 IU vitamin D
• Vitamin D not help when not give enough (Graves Disease in this case – 26 ng)
• Growing pains reduced 57 percent by vitamin D therapy
• Vitamin D Random Controlled Trials are becoming impossible
• Malaria in mice brains, and associated inflammation, prevented by Vitamin D intervention
• Promising Vitamin D Clinical Trials - 2017
• Vitamin D should improve oral heath in adults (no intervention got to 30 ng) – Review
• Rickets reduced 60X - lessons learned by Turkey 2011
• Infants have gotten free 400 IU of vitamin D in Turkey since 2005, More for longer would be even better
• Reduction of infant asthma may require good vitamin D when lung development starts (4 weeks)
• Responses by healthy individuals to 2,000 IU vitamin D daily
• Fibromyalgia pain substantially reduced by weekly Vitamin D (50,000 IU)
• Diseases arising from depletion are cured by repletion - Hippocrates 400 BC
• Post-stroke fatigue cut in half by Vitamin D (just 600 IU daily in 3 months)
• Gingivitis inflammation (retracted)
• Vitamin D given slowly in hospital did not fight COVID-19 much
• Stroke not prevented by just 2,000 IU of vitamin D plus 840 mg Omega-3 (VITAL)
• Vitamin D and Omega-3 Ineffective for Preventing Cancer and Heart Disease (too little was used)
• Vitamin D restored in teens by doses totalling 300,000 IU
• 450,000 IU of vitamin D over 9 weeks given to 100,000 teenage Iranian girls helped their livers
• Those with HIV who doubled their vitamin D levels reduced their chance of death by 47 percent
• Breast Cancer chemo reduces Bone Mineral Density, injecting Vitamin D increases it
• PMS in teens reduced 3X by 50,000 IU vitamin D weekly
• PMS decreased when Vitamin D was added
• 1,000 IU of vitamin D provides little benefit (Kidney transplant in this case)
• Vitamin D trial for COVID-19 – using their patented slow-release form
• Lost 19 lbs more if add vitamin D to calorie restriction and walking program
• All asthma problems reduced after 1 year of Vitamin D
• Weekly Vitamin D plus daily Magnesium is great (reduced depression in obese women in this case)
• Mental health intervention trials using enough vitamin D for long enough found benefits
• Palliative cancer benefit of 4,000 IU of Vitamin D – less opioids, infection, and CRP
• COVID-19 mortality reduced 4X (chart looks like 2X) by large, infrequent doses of Vitamin D in France
• Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019
• Cognitive function of adult women improved in 3 months of 50,000 IU weekly Vitamin D
• Immune systems helped by 50,000 IU of vitamin D (weekly for 3 months)
• Ulcerative Colitis inflammation treated by weekly vitamin D (40,000 IU)
• T-cells increased with monthly doses of 140,000 IU vitamin D
• Many Infectious diseases (virus) treated and prevented by Vitamin D – review
• Bipolar Spectrum Disorder decreased with 2,000 IU of vitamin D
• Prediabetes both prevented and treated by monthly Vitamin D, etc.
• 6,000 IU of vitamin D for 6 weeks helped soccer players somewhat
• 5000 IU of vitamin D in daily bread resulted in 50 ng and improved quality of life
• Stroke patients getting weekly 50,000 IU Vitamin D did better – trial
• Little Vitamin D benefit if not achieve a good level (T1D in this cases)
• Gut bacteria of Crohn's disease patients improved by Vitamin D
• Peritoneal Dialysis nicely treated by active vitamin D
• Crohn's Disease patients normalizing their Vitamin D levels decreased risk of surgery by 44 percent
• Colds substantially reduced by Vitamin D or UV during military training
• Half of obese black teens achieved at least 30 ng of Vitamin D with 5,000 IU daily
• 2,000 IU of vitamin D daily helped 80 percent of adolescents
• Sublingual Vitamin D sometimes is better than tablet
• 50,000 IU of Vitamin D weekly for 9 weeks did not improve CVD
• 400,000 IU of vitamin D reduced adult pain and improved quality of life
• Let the Sun shine on you - Gillie
• Knee osteoarthritis treated with vitamin D, weekly 50,000 IU
• Increasing Vitamin D in aged care facilities to more than 800 IUs did not reduce falls
• Vitamin D injections of a total of 1,800,000 IU reduced shinbone tenderness
• Lupus flares totally eliminated by loading dose then 100000 IU of vitamin D each month
• Only 1 NCAA basketball player getting 10,000 IU vitamin D daily achieved 50 ng goal
• Fewer injuries and higher ballet jumps with 2,000 IU of vitamin D
• Assisted Reproduction – 5 studies concluded vitamin D repletion helps – Review
• Improved health due to vitamin D fortification in Finland
• Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily
• Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China)
• Vitamin D 100,000 IU daily was OK for Dr. Cannell for 6 months
• Vitamin D during pregnancy – single 200,000 IU similar to daily 5,000 IU
• Sickle cell Vitamin D deficiency corrected with 160 K IU loading dose
• Fell more often with higher doses of vitamin D (not statistically significant)
• Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome
• Rheumatoid arthritis reduced by 440,000 IU of Vitamin D over 4 months
• ICU death rate reduced 3X when a vitamin D injection changed the PTH
• Response by obese to weekly 50,000 IU of Vitamin D
• Pulmonary hypertension reduced in some people with weekly 50,000 IU vitamin D for 3 months – 2016
• Pulmonary Hypertension deaths prevented by 80 ng of Vitamin D (in rats)
• Autism and Vitamin D massive review – latitude, season, migration, VitD levels and intervention
• Autism treated by Vitamin D (monthly injection of 150,000 IU)
• Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic)
• 5000 IU vitamin D3 added daily to bread raised blood levels to 50 ng – 2009
• Heart attack ICU costs cut in half by Vitamin D
• NAFLD is treated by Vitamin D, Omega-3, Curcumin, Silymarinm, etc.
• Chronic Kidney Disease (stage 3) slowed by 30 ng of Vitamin D and Calcitriol
• HIV therapy reduces Vitamin D levels, supplementation helps
• Vitamin D fails to prevent Type 2 Diabetes (unaware of 8 proven ways)
• Vitamin D - no cure for depression (when you use only 1200 IU)
• Premature infants (30 weeks) who got 800-1000 IU of vitamin D were much healthier
• Optimal vitamin D supplementation strategies (D3 - weekly or monthly)
• Vitamin D given weekly better than daily (Nursing home, 5,600 IU weekly)
• Liver cancer nicely treated by high dose vitamin D for 16 weeks (early stage, in rats)
• Migraines in youths with low Vitamin D wonderfully treated by Vitamin D
• 50,000 IU Vitamin D weekly Improves Mood, Lowers Blood Pressure in Type 2 Diabetics
• Gut genes related to important disease changed in Obese with 2,000 IU for 12 weeks
• 400 IU of Vitamin D in food provided virtually no benefit to children
• After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor
• Growing pains reduced 60 percent by monthly Vitamin D
• Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT
• Grip strength following wrist fracture increased by 50,000 IU Vitamin D monthly
• Warts eliminated by vitamin D injections
• ALS reduction far more likely if take Curcumin, Luteolin, CBD, Omega-3, or Vitamin D etc
• Periodontitis treated by 4,000 IU of Vitamin D (pilot study)
• Common problems with Vitamin D clinical trials – Grassroots Health – 2019
• T1 diabetes in children helped with two doses of 150,000 IU of vitamin D and Calcium
• Prediabetics 60 percent less likely to become diabetic if given some vitamin D
• Vitamin D every 14 weeks is not often enough (asthma in this case)
• 70,000 IU of vitamin D had about 30 day half-life
• Congestive Heart Failure patients helped with Vitamin D intervention
• Preterm babies have low vitamin D, but recover in 6 weeks with 800 IU supplementation
• Amyloid brain plaque both prevented and removed by high vitamin D (in mice)
• Dr. Coimbra explains his treatment with high dose vitamin D for multiple sclerosis
• Vitamin D clinical trials should be based on Vitamin D tests
• Reasons to disqualify a Vitamin D trial
• Spinal Cord Injury wheelchair athletes helped by 12 weeks of Vitamin D
• Vitamin D weekly supplementation (Spinal Cord Injury athletes) increased handgrip strength
• Diabetes treated by vitamin D when levels exceeded 61 ng
• 6400 IU vitamin D is effective during breastfeeding
• Viral infection reduced 90 percent with 2000 IU of vitamin D
• Alcoholic liver cirrhosis treated by 1,000 IU of vitamin D
• Childhood Respiratory Health hardly improved with 600 IU of vitamin D (need much more)
• Clinical trials for pregnancy with Vitamin D intervention – 51 as of
• Heart Attack ICU costs reduced $37,000 by $20 of Vitamin D
• Vitamin D supplementation improved quality of life
• Vitamin D intervention – 1204 clinical trials
• Vitamin D intervention -100 active clinical trials as of
• Clinical trials using a LOT of vitamin D intervention
• Pure North (Calgary) improves health by raising vitamin D to 60 ng
• Quality of life increased with increased levels of vitamin D
• Sleep disorders cured by 60-80 ng of vitamin D and some B vitamins
• Weekly dosing of vitamin D is far better than single large dose (chronic liver, children)
• Vitamin D trials ethics is questioned again (in addition to not giving some D to all)
• Influenza risk reduced 2X by 2,000 IU of Vitamin D (vs 400), RTI reduced 3X by 400 or more IU
• Muscle fatigue reduced with 10,000 IU of vitamin D
• 200,000 IU restored levels in HIV children having low vitamin D
• HIV – recommend 100,000 IU vitamin D monthly to get levels 30 ng
• Gestational diabetes 30 percent less likely if consumed more than 400 IU of vitamin D daily
• Increased Testosterone and Erectile function, decreased weight with Vitamin D
• Depression in adolescent girls reduced somewhat by 50,000 IU weekly for 9 weeks
• Vitamin D – 91 percent safely got above 30 ng in 2 months with weekly 30,000 IU
• Monthly 80,000 IU of vitamin D safely got half above 40 ng in 6 months
• People with metastatic melanoma and initially Vitamin D deficient had 4.7 times worse outcome if not get enough D
• Chronic Back Pain relieved by weekly 60,000 IU of vitamin D
• 50,000 IU vitamin D 1-3 times per week helped obese patients in rehab.
• Muscle strength in youth increased with 60,000 IU vitamin D per week and 1 g Calcium
• Statin-induced Myalgias corrected with 100000 weekly Vitamin D2
• Vitamin D levels of HIV and non HIV equally restored with 50,000 IU twice a week
• Vitamin D loading dose then weekly 50,000 IU not help (COPD) if very deficient
• 50,000 IU vitamin D weekly is safe and effective for Primary Hyperparathyroidism
• Nursing home residents need Vitamin D 4,000 IU daily or 50,000 IU weekly
• 7100 IU (50000 weekly) restored vitamin D levels for those with Chronic Kidney Disease
• Only a select group of women will get a modest benefit from 800 IU of vitamin D
• Pregnancy complications reduced with 4000 IU of vitamin D - 2RCT
• Severe Alzheimer's delayed by 1 year with vitamin D intervention
• Preterm birth rate reduced 57 percent by Vitamin D
• Chance of death after heart failure reduced by 1000 IU of vitamin D
• Cardiovascular death reduction in dark skin migrants by just 1,000 IU of vitamin D
• Monthly 100,000 IU of vitamin D decreased respiratory infection but increased falls
• Autism cured in a child with Vitamin D, Dr. Cannell comments and cofactor recommendations
• Less use of musculoskeletal pain drugs if get vitamin D
• Neonate loading dose of 30,000 IU vitamin D helped a lot
• Irisin (exercise hormone) increased in men by increasing sunshine and vitamin D foods
• Autoimmune disorder patients in Brazil helped by vitamin D – video and Facebook
• Severe tooth decay in children unless supplemented with Vitamin D drops
• Infection fighting ability increased with 5,000 IU Vitamin D daily
• Vitamin D given to ALL high schools girls in Iran – 75 percent deficiency dropped to 6 percent
• Evidence for vitamin D – Holick
• Prediabetics not helped by 50,000 IU of vitamin D weekly and Calcium
• Athletic performance and recovery benefits of Vitamin D (4000-5000 IU and Vitamin K)
• Vitamin D has already cleared 100 percent of lesions from over 1,000 MS patients in Brazil
• Dental health improved with more than 800 IU of vitamin D
• Vitamin D non-skeletal trials – review
• Asthma exacerbations with colds reduced by 40 percent with vitamin D supplementation
• Pregnancy supplemented with 2,000 IU vitamin D got most infants to more than 12 nanograms
• Benefits of supplements (vitamin D is not snake oil)
• Metabolic Syndrome risk reduced 44 percent when vitamin D levels increased by 30 nanograms
• Infliximab reduction of inflammation (Crohn’s) greatly aided by Vitamin D
• 5700 IU vitamin D improved various growth factors in overweight people
• Pregnancies - Vitamin D intervention benefits not seen for 6 reasons
• Seniors need at least 4,000 IU vitamin D, no test needed – Consensus
• Obesity not reduced with 7,000 IU vitamin D daily
• Childhood migraine in Vitamin D deficient children reduced 6X by addition of daily 5,000 IU and amitriptyline
• Pain reduced when enough vitamin D was given – review
• 4,000 IU raised vitamin D levels during pregnancy
• Diabetes decreased in aged mice supplemented with vitamin D
• Better memory if take lots of vitamin D (senior rats)
• Skin damaged by sun helped by vitamin D supplementation - pilot study
• Pregnant mothers in Quatar needed more than weekly 50,000 IU Vitamin D
• Breast Cancer reduced 20 percent by just 400 IU of vitamin D plus Calcium – 2011
• Active form of vitamin D appears to help prevent and treat some cancers
• Yet again - more than 10000 IU of vitamin D treats MS
• 1000 IU per kg Vitamin D for autoimmune diseases – Coimbra
• Not enough women willing to stop taking vitamin D to permit breast cancer clinical trial
• Crohn’s helped by 5000 IU vitamin D
• No clear evidence that 800 IU of vitamin D will prevent chronic disease (no surprise)
• Lupus reduced with vitamin D intervention
• 100,000 IU of vitamin D monthly was not enough for 30 percent of the women
• African Americans need vitamin D intervention as well as education
• 800 IU vitamin D in capsule form (but not drops) helped nursing home residents
• Vitamin D intervention trials - a long list
• Vitamin D Intervention Clinical Trials
• 140,000 IU vitamin D monthly reduced probability of diabetes
• Collegiate Swimmers getting 4000 IU of vitamin D had fewer injuries
• Insulin resistance helped with 50000 IU of vitamin D weekly
• 60,000 IU vitamin D weekly for 3 months lasts for another 3 months
• 50,000 IU vitamin D weekly increased levels by 52 ng normally, but only 28 ng if obese
• Hearts responded to stress better after 5,000 IU of vitamin D for a month
• Over 1000 Clinical Trials with Vitamin D INTERVENTION
• Levels of evidence for levels of vitamin D
• Evidence that the minimum vitamin D blood level is 30 ng – Grant
• CureTogether Vitamin D symptoms, treatments, and causes
• Review of clinical trials for Multiple Sclerosis with Vitamin D intervention – 2013
• Chronic Fatigue Syndrome reduced with 25,000 IU of vitamin D weekly
• Off topic: For proof: Random Controlled and Observational Trials should agree
• Global vitamin D clinical trials, table of contents of commercial report
• Vitamin D intervention stopped bone loss in those mice getting too much alcohol
• Can Observational Studies be as good as Random Controlled Trials for Vitamin D
• Review of Vitamin D trials - Grant
• Vitamin D2 intervention increased elderly muscle strength
• 95 new vitamin D INTERVENTION trials added during 2012
• Why randomized controlled trials of calcium and vitamin D sometimes fail
• Off topic: Review of the Nocebo Effect on Medical Trials
• Evidence for vitamin D - details 2010
• Intervention of 400 IU of vitamin D raised infant blood levels 14 ng
• Crohn's disease kids are 2X more likely to have low vitamin D, intervention helps
• NLM Vitamin D recommendations and interactions
• Evidence for Vitamin D - Grant
• National Institute of Health - Strength of Vitamin D Evidence
• Vitamin D in the prevention of disease - what evidence do we still need
• Evidence for Vitamin D - 2009
• Evidence based medical information - GreenMedinfo
• 4000 IU Vitamin D intervention helped elderly bones