Pregnancy helped by single dose of 60,000 IU of Vitamin D – RCT

Supplementation of vitamin D in pregnancy and its correlation with feto-maternal outcome.

Clin Endocrinol (Oxf). 2015 Feb 14. doi: 10.1111/cen.12751. [Epub ahead of print]

Sablok A1 aanchalsablok54@gmail.com, Batra A, Thariani K, Batra A, Bharti R, Aggarwal AR, Kabi BC, Chellani H.

1Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

(A) 60,000 IU
Vitamin D (B)
Women 60 120
Vitamin D Level mother 18 ng 32 ng
Cord blood level 17 ng 23 ng
Birthweight 2,4 kg 2.6 kg
preterm labour
or pre-eclampsia
or gestational diabetes.		 44% 22%

CONTEXT: Vitamin D deficiency is widely prevalent throughout the world. Pregnant women, neonates and infants form most vulnerable groups for vitamin D deficiency.

OBJECTIVE: (1) To find prevalence of vitamin D deficiency in pregnant women. (2) To evaluate the effect of supplementation with cholecalciferol in improving vitamin D levels in pregnant women and evaluate its correlation with feto-maternal outcome.

DESIGN: Randomized control trial from years 2010 to 2012.

SETTING: Tertiary care centre, Delhi, India.

PARTICIPANTS: One-hundred and eighty pregnant women. Study population divided randomly into two groups: group A: nonintervention (60 women) and group B: intervention (120 women).

INTERVENTION: The intervention group received supplementation of vitamin D in dosages depending upon 25(OH)-D levels.

MAIN OUTCOME MEASURES: Risk of maternal complications such as preterm labour, pre-eclampsia and gestational diabetes associated with vitamin D deficiency and risk of low birthweight and poor Apgar score in infants of mothers with vitamin D deficiency.

RESULTS: Adjusted serum 25(OH)-D concentration was lower in group A as compared to group B (mean 46·11 ± 74·21 nmol/l vs 80 ± 51·53 nmol/l). Forty-four percent patients in group A and 20·3% patients in group B developed preterm labour/pre-eclampsia/gestational diabetes. Newborns of mothers in group A had lower cord blood levels of 25(OH)-D levels as compared to group B (mean 43·11 ± 81·32 nmol/l vs 56·8 ± 47·52 nmol/l). They also had lower birthweight of mean 2·4 ± 0·38 kg as compared to group B 2·6 ± 0·33 kg.

CONCLUSIONS: Vitamin D supplementation reduces risk of maternal comorbidities and helps improve neonatal outcomes.

PMID 25683660

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RCT: Are vitamin D levels associated with pregnancy outcomes? Report on study at Vitamin D Council

Given large doses of vitamin D ( not daily) depending on deficiency level

   Sufficient (> 20 ng) 60,000 IU vitamin D at 20 weeks - not much left after 19 weeks!!

   Insufficient: 120,000 IU at 20 and 24 weeks

   Deficient:120,000 IU of vitamin D at 20, 24, 28, and 32 weeks.(about only half had > 20 ng at birth)

Vitamin D None
Complications 20% 44%
Small for gestational age 8% 19%
Pre-eclampsia 11% 21% (p = 0.08).

See also VitaminDWiki

The articles in Pregnancy AND Intervention are here:

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