Integrative Approaches to the Treatment of Cancer - Nov 2022
Cancers 2022, 14(23), 5933; https://doi.org/10.3390/cancers14235933
Kylie O’Brien 1 , Karin Ried 2, Taufiq Binjemain 2 and Avni Sali 2,asali@niim.com.au
1 NICM Health Research Institute, Western Sydney University, Westmead, NSW 2145, Australia
2 National Institute of Integrative Medicine, Hawthorn, VIC 3122, Australia
PDF Table of Contents
Simple Summary
A significant proportion of people with cancer use forms of complementary medicine. Many factors contribute to cancer including some which are modifiable by the patient, such as stress, poor nutrition, vitamin D deficiency, poor sleep and lack of physical activity. This paper discusses why it is important that oncologists help cancer patients to address such factors, and why an integrative approach which combines evidence-based complementary medicines or therapies with orthodox treatment might lead to better outcomes for cancer patients.
Abstract
A significant proportion of cancer patients use forms of complementary medicine or therapies. An integrative approach to cancer management combines conventional medicine with evidence-based complementary medicines/therapies and lifestyle interventions, for the treatment and prevention of disease and the optimisation of health. Its basis is a holistic one; to treat the whole person, not just the disease. It makes use of adjunct technologies which may assist the clinician in diagnosis of early carcinogenesis and monitoring of treatment effectiveness. Many factors contribute to the development of cancer including some which are largely modifiable by the patient and which oncologists may be in a position to advise on, such as
- stress,
- poor nutrition,
- lack of physical activity,
- poor sleep, and
- Vitamin D deficiency
An integrative approach to addressing these factors may contribute to better overall health of the patient and better outcomes. Evidence-based complementary medicine approaches include the use of supplements, herbal medicine, various practices that reduce stress, and physical therapies. Individualised to the patient, these can also help address the symptoms and signs associated with cancer and its orthodox treatment
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VitaminDWiki - Cancer category contains
- Cancer
293 |
items Overview Cancer and vitamin D
- Cancer and Vitamin D - many studies
- After Cancer Diagnosis
113 |
items
- Bladder Cancer
28 |
items
- Breast Cancer
259 |
items Overview Breast Cancer and Vitamin D
- Colon Cancer
144 |
items Overview Cancer-Colon and vitamin D
- Leukemia
19 |
items
- Liver Cancer
17 |
items
- Lung Cancer
55 |
items Overview Lung cancer and vitamin D
- Lymphoma Cancer
26 |
items
- Other Cancer
66 |
items
- Ovarian Cancer
26 |
items
- Pancreatic Cancer
57 |
items
- Prostate Cancer
103 |
items Overview Prostate Cancer and Vitamin D
- Skin Cancer
121 |
items Overview Suntan, melanoma and vitamin D
- Childhood Cancers - Vitamin D can help - many studies
- Easiest way to treat cancer – take Vitamin D – Nov 2022
- 13 Cancers are helped by Vitamin D – Biobank July 2023
- 2X increase of 14 cancers in non-seniors in 20 years (low vitamin D) – Sept 2022
- Vitamin D prevents and treats cancer in many ways – May 2021
- Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
- 8 ways that Cancer might be prevented by Vitamin D - June 2019
- Cancer stem cells and Vitamin D - many studies
- Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
- Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
- Melanoma 25 X more likely if low vitamin D – Feb 2018
- Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018
Cancers get less Vitamin D when there is a poor Vitamin D Receptor
- Vitamin D Receptor pages in VitaminDWiki with CANCER in title 86 as of July 2023
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Vitamin D Receptor (Cancers OR Viruses) - many studies
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer (general) and VDR
23 |
articles
- Breast Cancer and VDR
24 |
articles
- Colon Cancer and VDR
13 |
articles
- Prostate Cancer and VDR
7 |
articles
- Skin Cancer and VDR
10 |
articles
- Note some Health problems, such as some Cancers, protect themselves
by actively reducing Receptor activation
Vitamin D needed to TREAT Health problems 30 ng rickets, 150 ng MS
* Evolution of experiments with patients, often also need co-factors
29+ Interventions with CANCER in title
This list is automatically updated
Items found: 31
Title |
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Modified |
Breast Cancer survival: 44% with just 10,000 IU of vitamin D per week, 33% with placebo – RCT Dec 2023 |
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13 Aug, 2023 |
Breast Cancer trial using 50,000 IU Vitamin D weekly cancelled (no funding) |
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18 Apr, 2023 |
After Colorectal Cancer Surgery the immune system was maintained by Vitamin D (8,000 IU daily) – RCT Jan 2023 |
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03 Jan, 2023 |
Cancer risk reduced 65 percent by vitamin D levels greater than 40 nanograms – April 2016 |
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31 Dec, 2022 |
2.5 X reduced risk of cancer in 70 year-olds by a small amount of Vitamin D, Omega-3 and exercise – RCT April 2022 |
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25 Apr, 2022 |
Breast Cancer not prevented by 1,000 IU of Vitamin D (no surprise) – RCT Aug 2021 |
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14 Apr, 2022 |
Rectal Cancer genes down-regulated by Vitamin D (3,200 IU only helped some) – RCT Aug 2021 |
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03 Aug, 2021 |
Colorectal Cancer treatment aided by omega-3 plus weekly Vitamin D – RCT Sept 2019 |
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25 Jul, 2021 |
Digestive Tract Cancer survival increased 3X if 2,000 IU of vitamin D and have high level of PD-L1 – RCT June 2021 |
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29 Jun, 2021 |
Prostate Cancer PSA reduced by 60 ng of Vitamin D, Vitamin B complex, Omega-3, Curcumin and diet – June 2021 |
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20 Jun, 2021 |
2,000 IU of vitamin D and Omega-3 reduced Cancer death rate bv 40% (normal weight) – VITAL RCT Nov 2020 |
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03 Dec, 2020 |
Breast Cancer chemo reduces Bone Mineral Density, injecting Vitamin D increases it – Sept 2019 |
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07 Sep, 2019 |
Multiple Myeloma (blood cell cancer) treated by vitamin D - many studies |
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14 Jun, 2019 |
After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019 |
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04 Jun, 2019 |
Digestive tract cancer death rates reduced a bit by a bit of vitamin D – RCT April 2019 |
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10 Apr, 2019 |
Advanced Colorectal Cancer survival is increased somewhat with 4,000 IU of vitamin D – RCT April 2019 |
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10 Apr, 2019 |
Vitamin D and Omega-3 Ineffective for Preventing Cancer and Heart Disease (too little was used) – Nov 2018 |
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21 Nov, 2018 |
Lung cancer treated by Vitamin D (1200 IU early stage) – RCT July 2018 |
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04 Sep, 2018 |
Liver cancer nicely treated by high dose vitamin D for 16 weeks (early stage, in rats) – April 2018 |
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23 Apr, 2018 |
Prostate Cancer might be treated by 4,000 IU of vitamin D and aspirin – RCT 2021 |
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28 Nov, 2017 |
Lymphoid cancer deaths cut in half with 400 IU of vitamin D and 1 gram of Calcium (WHI) – RCT Nov 2017 |
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04 Nov, 2017 |
Prostate Cancer treatment (Vitamin D, Omega-3, Tumeric) RCT ending Dec 2018 |
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26 Sep, 2017 |
Palliative cancer benefit of 4,000 IU of Vitamin D – less opioids, infection, and CRP – Aug 2017 |
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01 Sep, 2017 |
Low risk Prostate Cancer decreased with 4,000 IU of vitamin D – July 2012 |
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21 Dec, 2015 |
Colon Cancer proven again to not be treated by just 1000 IU of vitamin D – RCT Oct 2015 |
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20 Oct, 2015 |
Breast Cancer medicine pain reduced with 4300 IU vitamin D – RCT June 2012 |
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24 May, 2015 |
Prostate cancer reduced when 4000 IU vitamin D was added– Hollis RCT April 2015 |
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02 Apr, 2015 |
Active form of vitamin D appears to help prevent and treat some cancers – Feb 2011 |
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16 Mar, 2015 |
Not enough women willing to stop taking vitamin D to permit breast cancer clinical trial – June 2012 |
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14 Mar, 2015 |
Breast Cancer reduced 20 percent by just 400 IU of vitamin D plus Calcium – 2011 |
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15 Nov, 2014 |
Mayo clinic starting Cancer RCT using grossly inadequate 2,000 IU of vitamin D – Sept 2013 |
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04 Dec, 2013 |
This list is automatically updated
Items found: 84
Title |
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Modified |
Analysis of 280 Breast Cancer meta-analyses: having low vitamin D was highly suggestive – umbrella July 2024 |
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28 Jul, 2024 |
Bladder cancer in muscles 2.7 times more-likely if vitamin D less than 20 ng -meta-analysis May 2024 |
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23 May, 2024 |
1.5X more likely to die of Prostate Cancer if low vitamin D when initially diagnosed – meta-analysis March 2024 |
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13 Mar, 2024 |
Pancreatic Cancer survival 2.3 X more likely if good level of Vitamin D – meta-analysis Sept 2023 |
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15 Sep, 2023 |
Thyroid Cancer 1.4 X higher risk if low vitamin D– meta-analysis Feb 2018 |
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29 Aug, 2023 |
Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013 |
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31 Jul, 2023 |
16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis May 2023 |
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22 May, 2023 |
Breast Cancer not prevented by vitamin D when use small doses or for just a short time – Meta-analysis April 2023 |
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11 May, 2023 |
Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018 |
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30 Apr, 2023 |
Breast Cancer risk - meta-analysis of 50 studies - Dec 2019 |
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25 Mar, 2023 |
Ovarian Cancer 37 percent less likely if high vitamin D – meta-analysis March 2023 |
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20 Mar, 2023 |
Colorectal Cancer 10 percent more likely if poor Vitamin D Receptor – meta-analysis Jan 2023 |
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08 Jan, 2023 |
Colorectal cancer 14 percent less likely if 10 ng more Vitamin D – 22nd meta-analysis – Sept 2022 |
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13 Sep, 2022 |
USPSTF says no evidence that Vitamins prevent CVD or Cancer (data disagrees) Aug 2022 |
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05 Sep, 2022 |
Even after a Cancer diagnosis Vitamin D improves survival – meta-analysis Aug 2022 |
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19 Aug, 2022 |
Colorectal cancer 40 percent less likely if 1000 IU more Vitamin D – 21st meta-analysis – Oct 2021 |
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29 Oct, 2021 |
Colorectal cancer 25 percent less likely if good level of Vitamin D – 20th meta-analysis – June 2021 |
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02 Jul, 2021 |
Lung Cancer death 40 percent less likely if high level of Vitamin D – meta-analysis Nov 2020 |
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24 Nov, 2020 |
Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020 |
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09 Nov, 2020 |
Vitamin D fights 13 cancers – review of 35 meta-analyses – Oct 2020 |
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06 Oct, 2020 |
Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020 |
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02 Oct, 2020 |
Colorectal cancer treated by Vitamin D – 19th meta-analysis – Sept 2020 |
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17 Sep, 2020 |
3X less risk of Liver cancer if more than 30 ng of vitamin D – meta-analysis July 2020 |
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28 Jul, 2020 |
Liver Cancer 8 percent less likely for every 4 ng higher level of vitamin D – Meta-analysis April 2020 |
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02 Apr, 2020 |
Breast Cancer risk reduced 17 percent by 1 hour of daily summer sun – meta-analysis Jan 2020 |
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07 Jan, 2020 |
Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019 |
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14 Dec, 2019 |
Colon cancer both prevented and treated by Vitamin D – meta-analysis Dec 2019 |
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04 Dec, 2019 |
Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016 |
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09 Nov, 2019 |
Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019 |
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05 Jul, 2019 |
People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019 |
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05 Jul, 2019 |
Breast Cancer rate reduced by 40 percent with Omega-3 – meta-analysis June 2013 |
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16 Jun, 2019 |
Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019 |
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13 Jun, 2019 |
Variety of Vitamin D forms treat Prostate Cancer – RCT Review April 2019 |
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01 May, 2019 |
Pancreatic cancer risk of death reduced 19 percent by Vitamin D – meta-analysis June 2017 |
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20 Mar, 2019 |
Breast Cancer reduced 20 percent by fish (Omega-3) – meta-analysis Feb 2019 |
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05 Mar, 2019 |
16 percent less Prostate Cancer sometimes for each 10 ng vitamin D increase - meta-analysis Jan 2011 |
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13 Oct, 2018 |
Lung Cancer risk decreased 2.4 percent with every 100 IU Vitamin D extra intake – meta-analysis Sept 2018 |
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15 Sep, 2018 |
Colorectal cancer is associated with Vitamin D (17 meta-analyses so far) – July 2018 |
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18 Jul, 2018 |
Thyroid Cancer 1.3X higher risk if low vitamin D (yet again) – meta-analysis June 2018 |
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02 Jun, 2018 |
Cancer not treated by Vitamin D when ignore dose size, type, and length of trial – meta-analysis April 2018 |
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09 Apr, 2018 |
Pancreatic cancer risk reduced 25 percent by just 10 micrograms of Vitamin D or Vitamin B12 – meta-analysis March 2018 |
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30 Mar, 2018 |
Prostate cancer risk increase with Vitamin D (other studies disagree) – meta-analysis Jan 2018 |
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11 Jan, 2018 |
Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017 |
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29 Dec, 2017 |
Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017 |
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14 Dec, 2017 |
Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017 |
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27 Jul, 2017 |
Lung Cancer less likely if vitamin D (higher level or supplement) – meta-analysis May 2015 |
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06 Jul, 2017 |
Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017 |
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13 Jun, 2017 |
Lung Cancer risk decreases 5 percent for every 2.5 nanogram increase in Vitamin D – meta-analysis Sept 2015 |
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22 Feb, 2017 |
Colorectal cancer 60 percent less likely: high vs low Vitamin D level – meta-analysis Dec 2016 |
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22 Dec, 2016 |
Colorectal Cancer recurrence not prevented by 1,000 IU of vitamin D – meta-analysis Dec 2016 |
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09 Dec, 2016 |
Bladder cancer modifiable risk factors include low vitamin D – meta-analysis March 2016 |
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08 Dec, 2016 |
Bladder cancer 60 percent less likely if have high vitamin D – meta-analysis Dec 2015 |
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08 Dec, 2016 |
Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014 |
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12 Nov, 2016 |
10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012 |
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23 Sep, 2016 |
Kidney cancer 22 percent less likely if high vitamin D – meta-analysis Nov 2015 |
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30 Mar, 2016 |
Bladder cancer 25 percent less likely if have high vitamin D – meta-analysis April 2015 |
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24 Dec, 2015 |
Bladder cancer 25 percent less likely if have high vitamin D – meta-analysis Oct 2014 |
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24 Dec, 2015 |
Non-cancer colon growths 7 percent less likely with each 10 ng increase in vitamin D – Oct 2011 |
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31 Oct, 2015 |
Cancer risk weakly associated with vitamin D-binding protein – meta-analysis Sept 2015 |
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15 Oct, 2015 |
Meta-graphs of vitamin D and Cancer – Dec 2011 |
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20 Sep, 2015 |
Colon cancer 30 percent more likely if low vitamin D – 12th meta-analysis Aug 2015 |
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14 Aug, 2015 |
Obesity causes 20 percent of all cancer, low vitamin D may be the connection – meta-analysis - Sept 2014 |
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31 May, 2015 |
Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015 |
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03 May, 2015 |
Colon cancer risk reduced by many vitamins – 13 percent reduction by Vitamin D – meta-analysis Jan 2015 |
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11 Dec, 2014 |
Breast Cancer – review of 2 RCT did not find association with 1000 IU of Vitamin D – July 2013 |
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16 Nov, 2014 |
Cancer (colon, breast, lymph) survival about 2X better with high level vitamin D – meta-analysis July 2014 |
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30 Sep, 2014 |
Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014 |
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30 Sep, 2014 |
Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 |
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12 May, 2014 |
More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014 |
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08 May, 2014 |
Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014 |
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08 Apr, 2014 |
Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 |
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06 Mar, 2014 |
Breast Cancer post menopause down 12 percent for every 5 ng of vitamin D – meta-analysis May 2013 |
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28 Oct, 2013 |
Probably need more than 1000 IU of vitamin D to prevent cancer – meta-analysis Aug 2013 |
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20 Aug, 2013 |
3.2 percent less Breast Cancer for 2.4 ng more vitamin D – meta-analysis June 2013 |
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08 Jul, 2013 |
Colorectal cancer 26 percent less likely for every 10 ng of vitamin D – meta-analysis Aug 2011 |
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10 Nov, 2012 |
Breast cancer association with low vitamin D suggested by Meta-analysis -April 2010 |
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19 Jul, 2012 |
Colon cancer probability increases with decreased vitamin D – Meta-analysis July 2011 |
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23 Jun, 2012 |
Vitamin D has a complex relationship with Cancer – meta-analysis July 2011 |
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30 Sep, 2011 |
Meta-analysis of 3 cancers - 10 ng more vitamin D decrease colorectal by 15 percent– May 2010 |
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31 Aug, 2011 |
Risk of Prostate Cancer weakly associated with vitamin D - meta-analysis March 2011 |
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11 Aug, 2011 |
Meta-analysis found vitamin D association with colon but not prostate nor breast cancer May 2010 |
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17 Jan, 2011 |
Meta-analysis not find low vitamin D years before breast cancer – Aug 2010 |
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10 Sep, 2010 |
Meta-analysis confirmed that vitamin D and calcium prevents breast cancer – June 2010 |
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30 Aug, 2010 |
Meta-analysis did not find strong association between vitamin D and breast cancer risk -April 2010 |
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12 May, 2010 |