Muscular Dystrophy probably treated by high-dose Vitamin D plus muscle rehab

Muscular Dystrophies – low vitamin D might be associated with all 9 types – Aug 2018

Table of contents


Muscular Dystrophy treated by high-dose Coimbra Protocol (Facebook Aug 2019)

Facebooktranslated
" hi good people!
I almost don't enter facebook anymore, but as I started to report on the treatment with vitamin D (Coimbra Protocol), for muscular dystrophy, I couldn't help but report the results of the
I've been doing this treatment for EXACTLY 7 months, and as reported before, some enzymes in my body (CPK) were high, causing my muscles to become inflamed, consequently losing strength (this is the process of the disease)
But yesterday I got the results of the exams I did end of July, and guess
Below are the words of my doctor (Dr. Lucia Schaedler):
"your cpk and dhl that are muscle enzymes, are practically normal, indicating that thank god the inflammatory activity of your disease is stopped"

Imagine, lose strength for 17 years and receive such a news, that the disease is stabilized
Only God knows how happy I am with this, and I wanted to share with you this news, that were people who gave me so many words of support and love since I decided to report about this disease I

PS. With The Disease Stabilized, it does not mean that I will have the muscle strength I had before, and yes that I will not continue to lose, now is to do the next step: Physiotherapy to keep the muscles I have, and continue with the treatment But as for God, nothing is impossible, I will not stop believing that one day I can make my moves again


Fracture in Duchenne Muscular Dystrophy: Natural History and Vitamin D Deficiency – 2016

J Child Neurol. 2016 Aug;31(9):1181-7. doi: 10.1177/0883073816650034
Perera N1, Sampaio H2, Woodhead H3, Farrar M4.
1 Discipline of Paediatrics, School of Women's and Children's Health, UNSW Medicine, University of New South Wales, Sydney, Australia.
2 Department of Neurology, Sydney Children's Hospital, Randwick, Australia.
3 Discipline of Paediatrics, School of Women's and Children's Health, UNSW Medicine, University of New South Wales, Sydney, Australia Department of Endocrinology, Sydney Children's Hospital, Randwick, Australia.
4 Discipline of Paediatrics, School of Women's and Children's Health, UNSW Medicine, University of New South Wales, Sydney, Australia Department of Neurology, Sydney Children's Hospital, Randwick, Australia m.farrar@unsw.edu.au.

The present study examined the natural history of fracture and vitamin D levels in Duchenne muscular dystrophy patients, who are vulnerable to osteoporosis and fractures. Retrospective analysis of a cohort of 48 Duchenne muscular dystrophy patients revealed that 43% of patients experienced ≥1 fracture. Fracture probabilities at ages 6, 9, 12, and 15 years were 4%, 9%, 31%, and 60% respectively, accelerating around the time of ambulation loss (mean age 11.8 ± 2.7 years). Chronic corticosteroid therapy was utilized in 69% of patients and was associated with all vertebral fractures. A history of vitamin D deficiency occurred in 84%, and 35% were currently deficient. Despite chronic vitamin D supplementation, 38% remained deficient. These results demonstrate that osteoporosis and fracture remain major concerns in Duchenne muscular dystrophy. Bone health should be optimized well before loss of ambulation, however current levels of vitamin D supplementation may be inadequate given high levels of deficiency.
 Download the PDF from VitaminDWiki


People with DMD need more Vitamin D - meta-analysis Oct 2023

A systematic literature review and meta-analysis of the effectiveness of vitamin D supplementation for patients with Duchenne muscular dystrophy
Neuromuscular Disorders https://doi.org/10.1016/j.nmd.2023.10.008

Highlights

  • Vitamin D insufficiency or deficiency is prevalent in Duchenne muscular dystrophy
  • We looked at the effectiveness of vitamin D supplementation across multiple studies
  • Current doses prevent severe deficiency but are not as effective as intended
  • No significant link between supplement dose and serum vitamin D levels was found
  • About 20% of people with Duchenne taking vitamin D supplements are still deficient

We conducted a systematic literature review and meta-analysis on the effectiveness of vitamin D supplementation in maintaining or restoring vitamin D levels in Duchenne muscular dystrophy. Due to a lack of randomised controlled trials, cross-sectional and retrospective and prospective cohort studies were taken as the best available evidence. Inclusion criteria included reporting mean serum vitamin D levels in a supplement-taking group. After screening 102 records; 13 were included in a narrative synthesis and eight of these in a meta-analysis.
We show that current dosing regimens are preventing severe deficiency but are not effective at maintaining sufficient vitamin D levels within the Duchenne population.
Despite high levels of daily vitamin D supplementation (>1000 International Units), at least 20% of people with Duchenne remain vitamin D deficient.
No significant association between dose and serum vitamin D levels was found (r2 = 0.3, p = 0.237). A meta-analysis of mean serum vitamin D levels across eight studies also revealed substantial variability in response to vitamin D supplementation and high heterogeneity (I2 = 99.59 %). These data could impact on an individual's risk and severity of osteoporosis and vertebral fractures.
 Download the PDF from VitaminDWiki


Need 3X more vitamin D if DMD - 2019

Increased Rates of Vitamin D Insufficiency in Boys With Duchenne Muscular Dystrophy Despite Higher Vitamin D3 Supplementation – 2019
Glob Pediatr Health. 2019 Mar 15;6:2333794X19835661. doi: 10.1177/2333794X19835661
Bian Q1, McAdam L2, Grynpas M3, Mitchell J1, Harrington J4.
 Download the PDF from VitaminDWiki

Vitamin D supplementation is important for many chronic pediatric conditions to help maintain bone health; however, there is little evidence about how disease-related factors affect vitamin D status. The objective was to compare 25-hydroxyvitamin D (25(OH)D) concentrations in 3 pediatric cohorts (Duchenne muscular dystrophy [DMD], systemic lupus erythematosus SLE, and osteogenesis imperfecta [OI]). In a retrospective study of 367 subjects, children with DMD had increased prevalence of vitamin D insufficiency (25% vs 14% [SLE] and 10% [OI], P = .002), despite higher vitamin D3 supplementation doses. Boys with DMD also had higher weight, fat mass, and lower lean mass percentage Z scores. DMD was associated with having higher rates of vitamin D insufficiency than other comparable pediatric chronic disease cohorts, the effect of which may be modulated by clinical factors such as increased adiposity. While corroboration of these results is needed given baseline differences between the patient groups, greater vitamin D supplementation doses may be required to achieve optimal serum 25(OH)D concentrations in boys with DMD.
Image

DMD - 3X lower response to ~1600 IU Vitamin D supplementation
Image
DMD, Duchenne muscular dystrophy;
OI, osteogenesis imperfecta;
SLE, systemic lupus erythematosus


This study was cited 24 times as of Oct 2023

Google Scholar


Since MD is associated with GI problems, they might just need Gut-Friendly D

Half of MD people have Gastrointestional problems

Overview Gut and vitamin D contains gut-friendly information

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart
Image

Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
   you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be usefulit is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
Long
10 Sun/UVBSlowLong
10Topical
(skin patch/cream, vagina)
Slow
Fast nano
Normal
9Nanoemulsion -mucosal
perhaps activates VDR
FastNormal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
4Sublingual/spray
(some goes into gut)
FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months


Perhaps poor gut ==> low vitamin D ==> MD

The GI problems often precede MD symptoms

  • "Digestive symptoms can be the first sign of muscular dystrophy. For example, in myotonic muscular dystrophy, digestive symptoms can precede musculoskeletal features. "
    • Gastrointestinal manifestations in myotonic muscular dystrophy - 2006 doi: 10.3748/wjg.v12.i12.1821

The risk inheriting MD might be reduced if use gut-friendly Vitamin D

Limb-girdle muscular dystrophy - perhaps caused by a poor gene - a treatment in 2023

The Atlantic Magazine July 2023
The enzyme is known as HMG-CoA reductase halts cholesterol production
Dysfunction in this enzyme causes muscle weakness from both limb-girdle muscular dystrophy and statins.

What Are the Different Types of Muscular Dystrophy? May 2021
Image


Muscular Dystrophy and genes

MD and genes

Reduced response to Vitamin D is often due to poor vitamin D genes, such as:
CYP27A1, CYP2R1 or VDBP
Possibly: Poor Genes ==> Low Vitamin D ==> muscular dystrophy
Unaware of if genes can be changed
The solution might be just give 2X more vitamin D - similar to obese

Sometimes a reduced response to Vitamin D is due to a drug being taken to treat a disease
Wonder if a child with poor MD genes would be less likely to get MD if they had lots of Vitamin D

MD describes a set of 30+ similar problems due to poor inherited genes - WikiPedia

  • "The word "dystrophy" comes from the Greek dys, meaning "no, un-" and troph- meaning "nourish""

People with DMD have poor response to Vitamin D - 2017 thesis

 Download the PDF from VitaminDWiki
DMD had far less response to Vitamin D
Image

DMD insufficient but not deficient
Image


Mechanisms in Sarcopenia and Muscular Dystrophy - Aug 2015

Editorial: Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach
 Download the PDF from VitaminDWiki


Suspect that if MD is treated, that muscle growth will be helped by Sarcopenia techniques

VitaminDWiki - Multiple Sclerosis and Vitamin D ~ 50,000 Facebook members in 13 languages – Jan 2017


Life Extension Magazine Overview of Muscular Dystrophy - Dec 2020

Nutrients that help
Coenzyme Q10 (anti-oxidant - sometimes combined with Vitamin D)
Resveratrol (ncreases Vitamin D in cells),
Creatine (builds muscles)
Omega-3 (builds muscles)
Vitamin D
Glutamine
L-Carnitine
Green tea
Vitamin E and Selenium (anti-oxidants)
N-acetylcysteine (antioxidant which decreases muscle damage)


VitaminDwiki – Overview Muscles and Vitamin D contains

To build muscles you need more than just Vitamin D
   also need Exercise, Protein, Magnesium, Omega-3, and activated Vitamin D Receptors
     In fact, Vitamin D monotherapy sometimes DECREASES muscles.

Notes on Vitamin D Receptor:
Vitamin D Receptors get vitamin D in the blood to the muscle cells
Approximately 20% of people have poor vitamin D receptors
As people age, their Vitamin D receptors also become less activated
There are 12+ low-cost activators for the Vitamin D Receptor
122+ VitaminDWiki pages have MUSCLE in the title
Dr. Greger on Vitamin D and Muscles - May 2020
Vitamin D Supplements for Increasing Aging Muscle Strength

  • "We have known for more than 400 years that muscle weakness is a common presenting symptom of vitamin D deficiency"
  • conservative "U.S. Preventive Services Task Force, the official prevention guideline setting body, and the American Geriatric Society to “recommend vitamin D supplementation for persons who are at high risk of falls.”
  • AGS recommends 4,000 IU to capture 92 percent of the population"


138+ VitaminDWiki pages with MUSCLE, etc in the title

This list is automatically updated

Items found: 139
Title Modified
Bladder cancer in muscles 2.7 times more-likely if vitamin D less than 20 ng -meta-analysis May 2024 23 May, 2024
Muscle strength improved with Calfidediol (a form of vitamin D) - meta-analysis May 2022 29 Feb, 2024
Muscle Inflammation (idiopathic inflammatory myopathy) 3.2 X more likely if low Vitamin D – meta-analysis Feb 2024 29 Feb, 2024
Handgrip and Vitamin D - many studies 20 Feb, 2024
Female preemies become women with low hand grip strength - Dec 2023 24 Dec, 2023
Omega-3 helps muscles - many studies 16 Nov, 2023
Fatigue reduced by Vitamin D (Cancer, muscle, MS, age, etc) - many studies 12 Nov, 2023
Skeletal Muscles regenerated with Vitamin D supplementation – review Oct 2023 29 Oct, 2023
Pelvic Organ Prolapse after menopause 5.6 X more likely if low Vitamin D (weak muscles) – Oct 2023 02 Oct, 2023
Muscles improved in women with 50,000 IU vitamin D weekly (8 weeks) plus daily Magnesium – RCT Sept 2020 16 Sep, 2023
Muscle pain in obese women reduced by aerobic exercise plus 50,000 IU Vitamin D - RCT May 2021 27 Aug, 2023
Sarcopenia (muscle loss) is reduced by vitamin D and many other supplements - July 2023 27 Aug, 2023
Vitamin D Receptors in muscles decrease with age in those with Osteoporosis - 2018 20 Aug, 2023
Sarcopenia (muscle loss) fought by Vitamin D, exercise and protein - many studies 11 Jul, 2023
Some excess calories diverted to muscle growth if high level vitamin D (exercising mice) – preprint May 2022 02 Jun, 2023
Muscular Dystrophy probably treated by high-dose Vitamin D plus muscle rehab 23 Mar, 2023
Off topic: back muscle pain quickly treated by TENS - Jan 2023 25 Jan, 2023
More muscle strength 80 years after being born in warm season (no surprise) – Nov 2022 26 Nov, 2022
Grip strength of children not improved by 800 IU Vitamin D daily (not nearly enough) – RCT Feb 2018 31 Oct, 2022
Exercise-induced muscle damage fought when enough vitamin D used for long enough – review Sept 2022 24 Sep, 2022
Frailty and low muscle mass both associated with low vitamin D – Aug 2013 14 Sep, 2022
Statin muscle problems decreased in 4 out of 5 patients when vitamin D was added – June 2022 30 Jun, 2022
Omega-3 improves elderly muscles – 2 meta-analyses 06 Jun, 2022
Overview Muscles and Vitamin D 20 May, 2022
High-Dose Vitamin D puts surplus calories into muscles instead of fat (mice) – May 2022 20 May, 2022
3X less muscle atrophy after ACL surgery if more than 40 ng of vitamin D – May 2022 14 May, 2022
Better handgrip strength if some good vitamin D genes (or if supplement) – April 2022 09 Apr, 2022
Handgrip strength increased 9 percent in college athletes with 8 weeks of Omega-3 – RCT Feb 2022 18 Mar, 2022
Muscle Strength improved 1.4 to 19 percent by vitamin D3 (not D2) – systematic review June 2016 13 Feb, 2022
Role of Vitamin K in Bones and Muscles - Feb 2022 13 Feb, 2022
Some vitamin D is stored in skeletal muscles – multiple studies 27 Dec, 2021
Severe sarcopenia (loss of muscle) 6 X more likely in women with rheumatoid arthritis having low vitamin D – Oct 2021 16 Oct, 2021
Loss of muscle strength –sarcopenia – one of the suspects is vitamin D – Aug 2012 16 Oct, 2021
Less muscle inflammation after exercise if high level of Vitamin D (50 ng) -July 2021 08 Jul, 2021
Low muscle strength predicts low vitamin D level in elderly – March 2021 06 May, 2021
Adding just a little vitamin D does not help (muscle mass in this case) – meta-analysis Jan 2021 06 Feb, 2021
Low muscle mass at least 2X more likely if low Vitamin D (Korea, all ages) – Dec 2020 04 Jan, 2021
4,000 IU of vitamin D for 1 month does not help (muscles in this case) – RCT Jan 2020 21 Sep, 2020
Sarcopenia (muscle loss) is 1.6X more likely if poor Vitamin D receptor – July 2020 23 Jul, 2020
Less muscle loss associated with eating more fish (Omega-3, Vitamin D, Magnesium, etc) – Jan 2020 30 Jan, 2020
2X less muscle soreness after exercise if Omega-3 index higher than 4 – RCT 2014 23 Dec, 2019
Muscles not improved by just Vitamin D weekly (also need exercise) – Dec 2019 17 Dec, 2019
Low vitamin D resulted in reduced genes to make muscles (in rats) – Nov 2019 11 Nov, 2019
Active muscles store vitamin D in the winter - Oct 2019 11 Oct, 2019
Omega-3 helps muscles – Aug 2019 24 Aug, 2019
Muscles of senior women not helped by just vitamin D (also need exercise) – Aug 2019 10 Aug, 2019
8 Signs of Low Vitamin D - sweating, bones ache, muscle pain, poor immune, fatigue, slow healing etc. – YouTube Dec 2018 05 Aug, 2019
Vitamin D stored in muscle via Vitamin D Binding Protein – July 2019 30 Jul, 2019
Mechanisms of vitamin D action in skeletal muscle – June 2019 22 Jun, 2019
Grip strength following wrist fracture increased by 50,000 IU Vitamin D monthly – May 2019 09 May, 2019
Vitamin D supplementation increases strength of lower muscles – Meta-analysis April 2019 01 May, 2019
Vitamin D does not help gain muscle mass (when only use small doses) – March 2019 03 Mar, 2019
Muscle loss (sarcopenia) may be both prevented and treated by Omega-3 – Feb 2019 23 Feb, 2019
Calcium supplements go to muscle, not bone, unless have enough Vitamin K – Feb 2019 12 Feb, 2019
Protein aids muscle gain – meta-analysis March 2018 02 Jan, 2019
Vitamin D and muscle – April 2019 07 Dec, 2018
Exercise plus vitamin D increases elderly muscles (Nordic walking in this case) – RCT Sept 2018 14 Sep, 2018
Postmenopausal women need Vitamin D, protein and exercise to prevent loss of muscle and bone – Aug 2018 21 Aug, 2018
Dietary Protein, Muscle and Physical Function in the Very Old – July 2018 17 Aug, 2018
Disability was 1.9 X more likely if weak muscles and low vitamin D two years before – Aug 2018 06 Aug, 2018
Muscle fatigue 4X less likely in rugby players getting Omega-3 and protein – July 2018 14 Jul, 2018
Seniors can restore lost muscle (Sarcopenia) – first restore vitamin D, then exercise – July 2018 13 Jul, 2018
Muscle problems are both treated and avoided by Vitamin D – April 2018 03 Jul, 2018
Seniors getting Vitamin D (but no exercise) for 3 months failed to increase muscle strength – RCT June 2018 03 Jul, 2018
Muscle, etc. problems if consume little vitamin D (mice) – June 2018 27 Jun, 2018
Poor handgrip strength in 5-year-old girls 3X more likely if low vitamin D – May 2018 24 May, 2018
Vitamin D weekly supplementation (Spinal Cord Injury athletes) increased handgrip strength – May 2018 15 May, 2018
Muscle pain (Low Magnesium) plus Low Vitamin D associated with 10X more Cancer, etc (San Francisco) – Aug 2017 13 Apr, 2018
Widespread pain, arthritis pain and muscle pain are associated with low vitamin D – meta-analysis March 2018 08 Apr, 2018
Fewer Breast Cancer deaths if more muscle (probably due to less fat, more Vitamin D) – April 2018 07 Apr, 2018
Omega-3 helps muscles and reduces inflammation, lipids, and insulin – Nov 2015 03 Mar, 2018
Osteoporosis and low grip strength both associated with low vitamin D – Feb 2018 13 Feb, 2018
Headaches (chronic tension) 3X more likely to have low vitamin D – also muscle weakness and bone tenderness – May 2017 25 Jan, 2018
Weaker hand grip if poor Vitamin D Receptor (15 percent) – Nov 2016 12 Nov, 2017
Seniors gained 0.3 kg of muscle in 6 weeks with 800 IU and Leucine protein – Aug 2017 29 Aug, 2017
Vitamin D improves muscle strength, reduces falling, and reduces frailty – review March 2015 27 Jul, 2017
Muscle strength not increased by Vitamin D - 96 percent were not deficient – RCT April 2017 20 Jul, 2017
Infant muscle development best with 400 IU of vitamin D (not 800) – Sept 2015 13 Jul, 2017
Fast twitch muscles increased by Vitamin D in athletes and seniors (reduce falling) – Oct 2016 08 Jun, 2017
Muscle strength not increased by Vitamin D when 96 percent already had enough – RCT April 2017 30 Apr, 2017
Muscle strength of senior women increased 25 percent with vitamin D, decreased 6 percent with placebo – Oct 2016 08 Mar, 2017
More fast twitch muscles (IIA) are associated with higher levels of Vitamin D – Feb 2017 02 Mar, 2017
Handgrip strength dropped by 20 percent in the last generation (perhaps due to lower vitamin D) - Feb 2017 02 Mar, 2017
Severely burned children recovered muscle capability much faster with daily 1000 IU of vitamin D – RCT March 2017 01 Mar, 2017
Hypothesis: Less severe muscle damage if vitamin D level had been normalized – July 2013 21 Feb, 2017
Large single-dose of Omega-3 reduced expected muscle damage – Feb 2017 21 Feb, 2017
Added 1 lb of muscle to sarcopenia adults in 13 weeks with just 800 IU vitamin D and protein – RCT Jan 2017 31 Jan, 2017
Sarcopenic added 1 lb of muscle in 13 weeks with just 800 IU vitamin D and protein – RCT Jan 2017 31 Jan, 2017
Osteosarcopenic obesity (obese with low bone and muscle mass) twice as likely if low vitamin D – Oct 2016 31 Jan, 2017
More muscle torque associated with higher vitamin D – Jan 2017 05 Jan, 2017
Vitamin D increased muscle strength by 1% to 19% (varied with dose and duration) – review June 2016 22 Nov, 2016
Vitamin D increased muscle strength by 1 to 19 percent – review June 2016 22 Nov, 2016
Vitamin D increasing muscle strength may reduce knee pain – Feb 2016 22 Nov, 2016
Myotonic dystrophy a (rare genetic muscle problem) associated with low vitamin D – Nov 2016 18 Nov, 2016
Myotonic dystrophy (a rare genetic muscle problem) associated with low vitamin D – Nov 2016 18 Nov, 2016
Muscle strength is associated with vitamin D receptor gene variants – March 2016 12 Nov, 2016
Improved muscle function in postmenopausal women with just 1,000 IU of vitamin D daily – RCT May 2015 31 Oct, 2016
Vitamin D supplementation improves muscle strength in healthy adults – meta-analysis of 6 RCT Aug 2014 31 Oct, 2016
Vitamin D improved child muscle mass even without varying dose with weight – RCT Feb 2016 06 May, 2016
Less muscle and insulin resistance for children of vitamin D deficient mothers – Jan 2011 05 May, 2016
Sunshine is a cure for “weak and soft muscles” – 425 BC 22 Apr, 2016
Senior muscles increased somewhat with Omega-3 – RCT July 2015 18 Jan, 2016
Muscle strength of Judo athletes increased 13 percent following single dose of 150,000 IU vitamin D – RCT Nov 2015 05 Nov, 2015
More muscle response when have adequate vitamin D 27 Jul, 2015
Pelvic floor muscle strength is low after giving birth if vitamin D deficient – March 2015 20 Mar, 2015
Weight loss includes muscle loss unless add vitamin D, whey and leucine – RCT Feb 2015 07 Feb, 2015
Elderly lost extra half pound of leg and arm muscle mass if low vitamin D (6 years) – Oct 2014 27 Jan, 2015
Vitamin D and bicarbonate perhaps synergistically reduce muscle loss – June 2013 27 Jan, 2015
Muscle increased 17 percent in vitamin D insufficient elderly getting 4,000 IU for 4 months – RCT Oct 2013 27 Jan, 2015
Low Vitamin D breaks down muscle by interferring with protein - Editorial Nov 2013 27 Jan, 2015
People with old burns improved muscle strength with 2200 IU average vitamin D – RCT Sept 2014 20 Dec, 2014
Vitamin D supplementation help muscles of seniors who are vitamin D deficient – meta-analysis July 2014 18 Jul, 2014
Muscle fatigue reduced with 10,000 IU of vitamin D – March 2013 05 May, 2014
MRI of elderly skeletal muscle lacking vitamin D – April 2014 30 Apr, 2014
Muscle cells differentiate into fat cells if there is low vitamin D in petrie dish – April 2013 30 Apr, 2014
Skeletal muscles helped by vitamin D – Review Feb 2014 08 Feb, 2014
Higher vitamin D during pregnancy associated with stronger hand grip at age 4 – Oct 2013 03 Jan, 2014
Elderly lower limb muscle strength improved with Vitamin D supplementation - Meta-analysis Oct 2013 23 Dec, 2013
Vitamin D improves muscle strength if deficient – meta-analysis - Oct 2010 19 Dec, 2013
Muscle strength not increased by raising vitamin D to only 30 ng – RCT Aug 2012 19 Dec, 2013
Vitamin D provides faster recovery after muscle overuse – April 2013 18 Dec, 2013
Type 2 muscles, not all muscles, get benefit from Vitamin D - Dec 2012 23 Oct, 2013
Evidence that vitamin D is also stored in muscle cells – Sept 2013 26 Sep, 2013
Muscle strength in youth increased with 60,000 IU vitamin D per week and 1 g Calcium – April 2010 10 Aug, 2013
Hypothesis: Low vitamin D is one of the causes of muscle weakness in alcoholics – Dec 2012 31 Jul, 2013
More muscle injuries in NFL players who were low on vitamin D – July 2011 13 Jul, 2013
Muscle inflammation 17X more probable if vitamin D deficient – Feb 2013 13 Jul, 2013
Muscle improved by increasing vitamin D if previously less than 24 ng – June 2013 02 Jul, 2013
Most immigrant women in Sweden had little vitamin D and lots of muscle pain – May 2013 22 May, 2013
Deadly amount of vitamin D speeds up recovery of crushed muscles in rats – Dec 2012 19 Apr, 2013
Relevance of Vitamin D in Bone and Muscle Health of Cancer Patients - Jan 2013 06 Dec, 2012
Vitamin D2 intervention increased elderly muscle strength – Nov 2010 10 Nov, 2012
Higher vitamin D helps regain muscle strength after knee surgery – July 2011 01 Sep, 2011
Meta-analysis of RCT – vitamin D might increase senior muscle function – Sept 2010 14 Sep, 2010
Skeletal Muscle weakness from lack of vitamin D fixed by adding Calcium and phosphorus – Aug 2010 11 Aug, 2010
Vitamin D, Muscle Function, and Exercise Performance in kids – June 2010 09 Jun, 2010
Vitamin D improving muscles may be due to improving phosphate levels – June 2010 03 Jun, 2010
Vit D associated with less muscle fat 11 Apr, 2010
Reduced muscle function in mice lacking Vitamin D Receptors in muscles – June 2019 No value for 'modification_date_major'

95% of MD patients had low Vitamin D - 2019

Vitamin D in Patients With Duchenne Muscular Dystrophy   Free PDF
Question: Low D ==> MD,   MD ==> Low D,   or X ==> Low D and MD


10X increase in DMD in 16 years - 2020

Patient demographics and characteristics from an ambispective, observational study of patients with duchenne muscular dystrophy in Saudi Arabia - Sept 2020
Image
 Download the PDF from VitaminDWiki


Vitamin K2: A Cure for Muscular Dystrophy?- Video July 2022

MD results from too much Calcium in the muscles.
Vitamin K2 proven to reduce calcium in soft tissue


Overview of muscular dystrophies (Glucocorticoids decrease Vitamin D getting to cells) - Sept 2023

Great summary
 Download the PDF from VitaminDWiki
Note: Glucocorticoids are often used to Treat MD.
Glucocorticoids decrease active Vitamin D (not blood level) by changing activation of the CYP24A1 gene

Perplexity AI - March 2024
"Glucocorticoids are widely used in the treatment of Duchenne Muscular Dystrophy (DMD)... They are considered a standard part of care for most patients with DMD, with clinics often prescribing these medications as soon as patients are diagnosed"


New $$$ Duchenne MD drug - fewer side effects than Corticosteroids - Oct 2023

MD Edge - Vamorolone
2-6 mg/kg/d for a period of up to 48 months. Assuming 4 mg and 10 kg child ==> 40 mg/day
10 mg costs $140 (research $), so it might be EXTREMELY EXPENSIVE


FDA approved Duvyzat (it reduced the decline of speed of MD children to climb stairs over 18 months) - March 2024

Duvyzat approved by the US FDA

  • take twice a day for life
  • "The most common side effects of Duvyzat are diarrhea, abdominal pain, a decrease in platelets—which can lead to increased bleeding—nausea/vomiting, an increase in triglycerides (a type of fat in the body) and fever"

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