Muscle strength improved with Calfidediol (a form of vitamin D) - meta-analysis May 2022

Effect of Calcifediol on Physical Performance and Muscle Strength Parameters: A Systematic Review and Meta-Analysis

Nutrients 2022,14, 1860. https://doi.org/ 10.3390/nu14091860
Mario Barbagallo 1 , Nicola Veronese 1 , Agnese Di Prazza 1 , Francesco Pollicino 1, Luca Carruba 1,
Anna La Carrubba 1 and Ligia J. Dominguez *


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There is general agreement that optimal vitamin D status is necessary for bones, muscles, and general health, particularly in older adults, who are at higher risk of negative consequences of vitamin D deficiency, including sarcopenia; vitamin D supplementation is proposed as a potential intervention to mitigate sarcopenia. Several RCTs have reported that calcifediol (25(OH)D) was more potent than cholecalciferol in increasing plasma 25(OH)D. The present systematic review and meta-analysis aimed to summarize the effects of calcifediol on physical performance and muscle strength. We searched databases from inception to 1 January 2022 for studies investigating calcifediol on physical performance or muscle strength parameters. We calculated the difference between the means of follow-up vs. baseline data using standardized mean differences (SMD) and their 95% confidence intervals (CIs); a random-effect model was considered for all of the analyses. Seven RCTs were included in the meta-analysis. Calcifediol significantly improved gait speed (SMD = 2.500; 95%CI = 1.768-3.223; p < 0.0001); handgrip strength (n = 5446 participants, SMD = 0.532; 95%CI: 0.305-0.758; p < 0.0001; I2 = 20.2%); and leg extension (n = 4318 participants, SMD = 0.641; 95%CI: 0.346 to 0.935; p < 0.0001; I2 = 18.8% ;) vs. baseline values. In conclusion, in this systematic review and meta-analysis, we observed that calcifediol may have a positive effect on muscle strength parameters, with less evidence on physical performance. These data further indicate the importance of vitamin D and, in particular, of calcifediol, not only on bone metabolism but also on muscle parameters and sarcopenia.

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VitaminDWiki - Calcidiol (Calcifediol) contains

48 items in Calcidiol category

Calcidiol = Calcifediol = 25-hydroxyvitamin D3 = 25(OH)D = semi-activated Vitamin D
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VitaminDWiki -Getting Vitamin D into your body contains

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138+ VitaminDWiki pages with MUSCLE, etc in the title

This list is automatically updated

Items found: 140
Title Modified
Magnesium helps muscles in more than 10 ways - Dec 2023 18 Oct, 2024
Muscles and Vitamin D - many studies 13 Aug, 2024
Bladder cancer in muscles 2.7 times more-likely if vitamin D less than 20 ng -meta-analysis May 2024 23 May, 2024
Muscle strength improved with Calfidediol (a form of vitamin D) - meta-analysis May 2022 29 Feb, 2024
Muscle Inflammation (idiopathic inflammatory myopathy) 3.2 X more likely if low Vitamin D – meta-analysis Feb 2024 29 Feb, 2024
Handgrip and Vitamin D - many studies 20 Feb, 2024
Female preemies become women with low hand grip strength - Dec 2023 24 Dec, 2023
Omega-3 helps muscles - many studies 16 Nov, 2023
Fatigue reduced by Vitamin D (Cancer, muscle, MS, age, etc) - many studies 12 Nov, 2023
Skeletal Muscles regenerated with Vitamin D supplementation – review Oct 2023 29 Oct, 2023
Pelvic Organ Prolapse after menopause 5.6 X more likely if low Vitamin D (weak muscles) – Oct 2023 02 Oct, 2023
Muscles improved in women with 50,000 IU vitamin D weekly (8 weeks) plus daily Magnesium – RCT Sept 2020 16 Sep, 2023
Muscle pain in obese women reduced by aerobic exercise plus 50,000 IU Vitamin D - RCT May 2021 27 Aug, 2023
Sarcopenia (muscle loss) is reduced by vitamin D and many other supplements - July 2023 27 Aug, 2023
Vitamin D Receptors in muscles decrease with age in those with Osteoporosis - 2018 20 Aug, 2023
Sarcopenia (muscle loss) fought by Vitamin D, exercise and protein - many studies 11 Jul, 2023
Some excess calories diverted to muscle growth if high level vitamin D (exercising mice) – preprint May 2022 02 Jun, 2023
Muscular Dystrophy probably treated by high-dose Vitamin D plus muscle rehab 23 Mar, 2023
Off topic: back muscle pain quickly treated by TENS - Jan 2023 25 Jan, 2023
More muscle strength 80 years after being born in warm season (no surprise) – Nov 2022 26 Nov, 2022
Grip strength of children not improved by 800 IU Vitamin D daily (not nearly enough) – RCT Feb 2018 31 Oct, 2022
Exercise-induced muscle damage fought when enough vitamin D used for long enough – review Sept 2022 24 Sep, 2022
Frailty and low muscle mass both associated with low vitamin D – Aug 2013 14 Sep, 2022
Statin muscle problems decreased in 4 out of 5 patients when vitamin D was added – June 2022 30 Jun, 2022
Omega-3 improves elderly muscles – 2 meta-analyses 06 Jun, 2022
High-Dose Vitamin D puts surplus calories into muscles instead of fat (mice) – May 2022 20 May, 2022
3X less muscle atrophy after ACL surgery if more than 40 ng of vitamin D – May 2022 14 May, 2022
Better handgrip strength if some good vitamin D genes (or if supplement) – April 2022 09 Apr, 2022
Handgrip strength increased 9 percent in college athletes with 8 weeks of Omega-3 – RCT Feb 2022 18 Mar, 2022
Muscle Strength improved 1.4 to 19 percent by vitamin D3 (not D2) – systematic review June 2016 13 Feb, 2022
Role of Vitamin K in Bones and Muscles - Feb 2022 13 Feb, 2022
Some vitamin D is stored in skeletal muscles – multiple studies 27 Dec, 2021
Severe sarcopenia (loss of muscle) 6 X more likely in women with rheumatoid arthritis having low vitamin D – Oct 2021 16 Oct, 2021
Loss of muscle strength –sarcopenia – one of the suspects is vitamin D – Aug 2012 16 Oct, 2021
Less muscle inflammation after exercise if high level of Vitamin D (50 ng) -July 2021 08 Jul, 2021
Low muscle strength predicts low vitamin D level in elderly – March 2021 06 May, 2021
Adding just a little vitamin D does not help (muscle mass in this case) – meta-analysis Jan 2021 06 Feb, 2021
Low muscle mass at least 2X more likely if low Vitamin D (Korea, all ages) – Dec 2020 04 Jan, 2021
4,000 IU of vitamin D for 1 month does not help (muscles in this case) – RCT Jan 2020 21 Sep, 2020
Sarcopenia (muscle loss) is 1.6X more likely if poor Vitamin D receptor – July 2020 23 Jul, 2020
Less muscle loss associated with eating more fish (Omega-3, Vitamin D, Magnesium, etc) – Jan 2020 30 Jan, 2020
2X less muscle soreness after exercise if Omega-3 index higher than 4 – RCT 2014 23 Dec, 2019
Muscles not improved by just Vitamin D weekly (also need exercise) – Dec 2019 17 Dec, 2019
Low vitamin D resulted in reduced genes to make muscles (in rats) – Nov 2019 11 Nov, 2019
Active muscles store vitamin D in the winter - Oct 2019 11 Oct, 2019
Omega-3 helps muscles – Aug 2019 24 Aug, 2019
Muscles of senior women not helped by just vitamin D (also need exercise) – Aug 2019 10 Aug, 2019
8 Signs of Low Vitamin D - sweating, bones ache, muscle pain, poor immune, fatigue, slow healing etc. – YouTube Dec 2018 05 Aug, 2019
Vitamin D stored in muscle via Vitamin D Binding Protein – July 2019 30 Jul, 2019
Mechanisms of vitamin D action in skeletal muscle – June 2019 22 Jun, 2019
Grip strength following wrist fracture increased by 50,000 IU Vitamin D monthly – May 2019 09 May, 2019
Vitamin D supplementation increases strength of lower muscles – Meta-analysis April 2019 01 May, 2019
Vitamin D does not help gain muscle mass (when only use small doses) – March 2019 03 Mar, 2019
Muscle loss (sarcopenia) may be both prevented and treated by Omega-3 – Feb 2019 23 Feb, 2019
Calcium supplements go to muscle, not bone, unless have enough Vitamin K – Feb 2019 12 Feb, 2019
Protein aids muscle gain – meta-analysis March 2018 02 Jan, 2019
Vitamin D and muscle – April 2019 07 Dec, 2018
Exercise plus vitamin D increases elderly muscles (Nordic walking in this case) – RCT Sept 2018 14 Sep, 2018
Postmenopausal women need Vitamin D, protein and exercise to prevent loss of muscle and bone – Aug 2018 21 Aug, 2018
Dietary Protein, Muscle and Physical Function in the Very Old – July 2018 17 Aug, 2018
Disability was 1.9 X more likely if weak muscles and low vitamin D two years before – Aug 2018 06 Aug, 2018
Muscle fatigue 4X less likely in rugby players getting Omega-3 and protein – July 2018 14 Jul, 2018
Seniors can restore lost muscle (Sarcopenia) – first restore vitamin D, then exercise – July 2018 13 Jul, 2018
Muscle problems are both treated and avoided by Vitamin D – April 2018 03 Jul, 2018
Seniors getting Vitamin D (but no exercise) for 3 months failed to increase muscle strength – RCT June 2018 03 Jul, 2018
Muscle, etc. problems if consume little vitamin D (mice) – June 2018 27 Jun, 2018
Poor handgrip strength in 5-year-old girls 3X more likely if low vitamin D – May 2018 24 May, 2018
Vitamin D weekly supplementation (Spinal Cord Injury athletes) increased handgrip strength – May 2018 15 May, 2018
Muscle pain (Low Magnesium) plus Low Vitamin D associated with 10X more Cancer, etc (San Francisco) – Aug 2017 13 Apr, 2018
Widespread pain, arthritis pain and muscle pain are associated with low vitamin D – meta-analysis March 2018 08 Apr, 2018
Fewer Breast Cancer deaths if more muscle (probably due to less fat, more Vitamin D) – April 2018 07 Apr, 2018
Omega-3 helps muscles and reduces inflammation, lipids, and insulin – Nov 2015 03 Mar, 2018
Osteoporosis and low grip strength both associated with low vitamin D – Feb 2018 13 Feb, 2018
Headaches (chronic tension) 3X more likely to have low vitamin D – also muscle weakness and bone tenderness – May 2017 25 Jan, 2018
Weaker hand grip if poor Vitamin D Receptor (15 percent) – Nov 2016 12 Nov, 2017
Seniors gained 0.3 kg of muscle in 6 weeks with 800 IU and Leucine protein – Aug 2017 29 Aug, 2017
Vitamin D improves muscle strength, reduces falling, and reduces frailty – review March 2015 27 Jul, 2017
Muscle strength not increased by Vitamin D - 96 percent were not deficient – RCT April 2017 20 Jul, 2017
Infant muscle development best with 400 IU of vitamin D (not 800) – Sept 2015 13 Jul, 2017
Fast twitch muscles increased by Vitamin D in athletes and seniors (reduce falling) – Oct 2016 08 Jun, 2017
Muscle strength not increased by Vitamin D when 96 percent already had enough – RCT April 2017 30 Apr, 2017
Muscle strength of senior women increased 25 percent with vitamin D, decreased 6 percent with placebo – Oct 2016 08 Mar, 2017
More fast twitch muscles (IIA) are associated with higher levels of Vitamin D – Feb 2017 02 Mar, 2017
Handgrip strength dropped by 20 percent in the last generation (perhaps due to lower vitamin D) - Feb 2017 02 Mar, 2017
Severely burned children recovered muscle capability much faster with daily 1000 IU of vitamin D – RCT March 2017 01 Mar, 2017
Hypothesis: Less severe muscle damage if vitamin D level had been normalized – July 2013 21 Feb, 2017
Large single-dose of Omega-3 reduced expected muscle damage – Feb 2017 21 Feb, 2017
Added 1 lb of muscle to sarcopenia adults in 13 weeks with just 800 IU vitamin D and protein – RCT Jan 2017 31 Jan, 2017
Sarcopenic added 1 lb of muscle in 13 weeks with just 800 IU vitamin D and protein – RCT Jan 2017 31 Jan, 2017
Osteosarcopenic obesity (obese with low bone and muscle mass) twice as likely if low vitamin D – Oct 2016 31 Jan, 2017
More muscle torque associated with higher vitamin D – Jan 2017 05 Jan, 2017
Vitamin D increased muscle strength by 1% to 19% (varied with dose and duration) – review June 2016 22 Nov, 2016
Vitamin D increased muscle strength by 1 to 19 percent – review June 2016 22 Nov, 2016
Vitamin D increasing muscle strength may reduce knee pain – Feb 2016 22 Nov, 2016
Myotonic dystrophy a (rare genetic muscle problem) associated with low vitamin D – Nov 2016 18 Nov, 2016
Myotonic dystrophy (a rare genetic muscle problem) associated with low vitamin D – Nov 2016 18 Nov, 2016
Muscle strength is associated with vitamin D receptor gene variants – March 2016 12 Nov, 2016
Improved muscle function in postmenopausal women with just 1,000 IU of vitamin D daily – RCT May 2015 31 Oct, 2016
Vitamin D supplementation improves muscle strength in healthy adults – meta-analysis of 6 RCT Aug 2014 31 Oct, 2016
Vitamin D improved child muscle mass even without varying dose with weight – RCT Feb 2016 06 May, 2016
Less muscle and insulin resistance for children of vitamin D deficient mothers – Jan 2011 05 May, 2016
Sunshine is a cure for “weak and soft muscles” – 425 BC 22 Apr, 2016
Senior muscles increased somewhat with Omega-3 – RCT July 2015 18 Jan, 2016
Muscle strength of Judo athletes increased 13 percent following single dose of 150,000 IU vitamin D – RCT Nov 2015 05 Nov, 2015
More muscle response when have adequate vitamin D 27 Jul, 2015
Pelvic floor muscle strength is low after giving birth if vitamin D deficient – March 2015 20 Mar, 2015
Weight loss includes muscle loss unless add vitamin D, whey and leucine – RCT Feb 2015 07 Feb, 2015
Elderly lost extra half pound of leg and arm muscle mass if low vitamin D (6 years) – Oct 2014 27 Jan, 2015
Vitamin D and bicarbonate perhaps synergistically reduce muscle loss – June 2013 27 Jan, 2015
Muscle increased 17 percent in vitamin D insufficient elderly getting 4,000 IU for 4 months – RCT Oct 2013 27 Jan, 2015
Low Vitamin D breaks down muscle by interferring with protein - Editorial Nov 2013 27 Jan, 2015
People with old burns improved muscle strength with 2200 IU average vitamin D – RCT Sept 2014 20 Dec, 2014
Vitamin D supplementation help muscles of seniors who are vitamin D deficient – meta-analysis July 2014 18 Jul, 2014
Muscle fatigue reduced with 10,000 IU of vitamin D – March 2013 05 May, 2014
MRI of elderly skeletal muscle lacking vitamin D – April 2014 30 Apr, 2014
Muscle cells differentiate into fat cells if there is low vitamin D in petrie dish – April 2013 30 Apr, 2014
Skeletal muscles helped by vitamin D – Review Feb 2014 08 Feb, 2014
Higher vitamin D during pregnancy associated with stronger hand grip at age 4 – Oct 2013 03 Jan, 2014
Elderly lower limb muscle strength improved with Vitamin D supplementation - Meta-analysis Oct 2013 23 Dec, 2013
Vitamin D improves muscle strength if deficient – meta-analysis - Oct 2010 19 Dec, 2013
Muscle strength not increased by raising vitamin D to only 30 ng – RCT Aug 2012 19 Dec, 2013
Vitamin D provides faster recovery after muscle overuse – April 2013 18 Dec, 2013
Type 2 muscles, not all muscles, get benefit from Vitamin D - Dec 2012 23 Oct, 2013
Evidence that vitamin D is also stored in muscle cells – Sept 2013 26 Sep, 2013
Muscle strength in youth increased with 60,000 IU vitamin D per week and 1 g Calcium – April 2010 10 Aug, 2013
Hypothesis: Low vitamin D is one of the causes of muscle weakness in alcoholics – Dec 2012 31 Jul, 2013
More muscle injuries in NFL players who were low on vitamin D – July 2011 13 Jul, 2013
Muscle inflammation 17X more probable if vitamin D deficient – Feb 2013 13 Jul, 2013
Muscle improved by increasing vitamin D if previously less than 24 ng – June 2013 02 Jul, 2013
Most immigrant women in Sweden had little vitamin D and lots of muscle pain – May 2013 22 May, 2013
Deadly amount of vitamin D speeds up recovery of crushed muscles in rats – Dec 2012 19 Apr, 2013
Relevance of Vitamin D in Bone and Muscle Health of Cancer Patients - Jan 2013 06 Dec, 2012
Vitamin D2 intervention increased elderly muscle strength – Nov 2010 10 Nov, 2012
Higher vitamin D helps regain muscle strength after knee surgery – July 2011 01 Sep, 2011
Meta-analysis of RCT – vitamin D might increase senior muscle function – Sept 2010 14 Sep, 2010
Skeletal Muscle weakness from lack of vitamin D fixed by adding Calcium and phosphorus – Aug 2010 11 Aug, 2010
Vitamin D, Muscle Function, and Exercise Performance in kids – June 2010 09 Jun, 2010
Vitamin D improving muscles may be due to improving phosphate levels – June 2010 03 Jun, 2010
Vit D associated with less muscle fat 11 Apr, 2010
Reduced muscle function in mice lacking Vitamin D Receptors in muscles – June 2019 No value for &#039;modification_date_major&#039;



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