The immunomodulatory effects of vitamin D drops in children with recurrent respiratory tract infections
Am J Transl Res. 2021 Mar 15;13(3):1750-1756. eCollection 2021.
Jianqiu Xiao 1, Wei He 1
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Objective: To investigate the effects of vitamin D drops on immune function in children with recurrent respiratory tract infections (RRTI).
Methods: The clinical data of 119 children with RRTI in our hospital were retrospectively retrieved, and they were divided into group A (n=59, receiving routine treatment) and group B (n=60, receiving vitamin D drops) based on their treatment modality. The clinical efficacy, symptom disappearance time, immune function index, insulin-like growth factor (IGF-1), 25-hydroxyvitamin D3 [25-(OH)D3], serum y-interferon (INF-y), and the number of episodes of respiratory tract infections were compared between the two groups.
Results: The total effective rate of treatment in group B was 96.67%, which was significantly higher than 71.19% in group A (P<0.05).
Children in group B had shorter time to disappearance of lung rales, cough, and fever than group A (P<0.05).
Group B had higher IgA, IgG, and IgM levels, higher CD4+, CD3+ levels and lower CD8+ levels as well as higher IGF-1, 25-(OH)D3, INF-y levels, and fewer respiratory infections after treatment than group A (P<0.05).
Conclusion: Vitamin D drops are effective in the treatment of children with RRTI, which is beneficial to the improvement of clinical symptoms and immune function.
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Group A: After admission, patients were given supportive therapy such as supplemental oxygen, cough suppressants, asthma and expectoration treatment according to their condition.
Group B: Vitamin D drops (H20113033, Qingdao Shuangjing Pharmaceutical Co., Ltd. 400 units * 10 tablets * 3 tablets) were taken orally at q.d 800 U. Twenty days of medication and 10 days without in every 30 consecutive days were a course of treatment, and a total of 3 courses were performed.
Appears to be 800 IU
VitaminDWiki RTI studies 26 as of Sept 2021
Infant-Child category has- No consensus on MINIMUM International Units (IU) for healthy infant of normal weight
- 400 IU Vitamin D is no longer enough
Was OK in the past century, but D levels have been dropping for a great many reasons.
FDA doubles the amount of vitamin D permitted in milk – July 2016 - No consensus: range is 600 to 1600 IU – based on many randomized controlled trials
- Review of 400 IU to 2000 IU daily and higher if non-daily
- Fewer pre-infants were vitamin D deficient when they got 800 IU – RCT Feb 2014
- 1600 IU was the conclusion of three JAMA studies
1000 IU recommended in France and Finland – 2013 - appears to be a good level - 5X less mite allergy after add vitamin D
- Child bone fractures with low vitamin D were 55X more likely to need surgery
- 75 % of SIDS had low vitamin D
- Children stayed in ICU 3.5 days longer if low vitamin D – Dec 2015
- 5 out of 6 children who died in pediatric critical care unit had low vitamin D – May 2014
- Infants have gotten free 400 IU of vitamin D in Turkey since 2005, More for longer would be even better – Feb 2022
- Preemies should have vitamin D supplements – reaching an agreement – April 2021
- Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021
Having a good level of vitamin D cuts in half the amount of:
- Asthma, Chronic illness, Doctor visits, Allergies, infection
Respiratory Tract Infection, Growing pains, Bed wetting
Need even more IUs of vitamin D to get a good level if;
- Have little vitamin D: premie, twin, mother did not get much sun access
- Get little vitamin D: dark skin, little access to sun
- Vitamin D is consumed faster than normal due to sickness
- Older (need at least 100 IU/kilogram, far more if obese)
- Not get any vitamin D from formula (breast fed) or (fortified) milk
Note – formula does not even provide 400 IU of vitamin D daily
Infants-Children need Vitamin D
- Sun is great – well known for 1,000’s of years.
US govt (1934) even said infants should be out in the sun - One country recommended 2,000 IU daily for decades – with no known problems
- As with adults, infants and children can have loading doses and rarely need tests
- Daily dose appears to be best, but monthly seems OK
- Vitamin D is typically given to infants in the form of drops
big difference in taste between brands
can also use water-soluable form of vitamin D in milk, food, juice, - Infants have evolved to get a big boost of vitamin D immediately after birth
Colostrum has 3X more vitamin D than breast milk - provided the mother has any vitamin D to spare - 100 IU per kg of infant July 2011, Poland etc.
More than 100 IU/kg is probably better 829 items in the category Infant/Child See also - 34 pages in VitaminDWiki had BREASTFE*in title as of Jan 2022
- "BIRTH DEFECTS" 172 items as of July 2016
- Stunting OR “low birth weight” OR LBW OR preemie OR preemies OR preterm 1940 items as of Oct 2018
- 96 VitaminDWiki pages contained PRETERM or PREEMIE in title as of Aug 2021
- "SUDDEN INFANT DEATH" OR SIDS 214 items as of Dec 2020
- Overview of Rickets and Vitamin D
- Youth category listing has
174 items along with related searches - Down syndrome and low vitamin D - several studies
- Rett syndrome associated with low vitamin D, treated by Omega-3
Items in both categories Breathing and Infant-Child:
- Vitamin D levels are low during Recurrent Wheezing - Feb 2024
- Obese asthmatic children Vitamin D - 50,000 IU then 8,000 IU daily - RCT Jan 2024
- France has injected 200,000 infants with RSV vaccine, based on no long-term data - Here we go again - Dec 2023
- Respiratory infections in children 6 X more likely if low Vitamin D (avg of 2 studies) - Aug 2023
- Prevention of allergies, eczema, asthma, in children – Vitamin D during pregnancy is a principal solution – July 2023
- Respiratory infection, children and Vitamin D - many studies
- Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023
- 3% fewer respiratory problems in children if single 100K vitamin D in 3rd trimester – May 2023
- Chronic tonsillitis virtually eliminated in children by Vitamin D (50,000 IU weekly) – RCT May 2023
- RSV kills 100,000 children annually around the world (Vitamin D can help)– May 2022
- Small doses of Vitamin D do not reduce childhood breathing allergies – meta-analysis Oct 2022
- Vitamin D reduces childhood allergic airway diseases (confirmed by metabolomics this time) – May 2022
- Wheezing and asthmatic children have weaker Vitamin D responses - May 2022
- Croup (due to viruses) has surged with Omicron - March 2022
- Allergy medications may be improved by Vitamin D (6X for birch pollen in this case) – Aug 2021
- Infant Respiratory Infections not reduced by mothers taking small amount of vitamin D (28,000 weekly)– RCT July 2021
- Recurrent RTI treatment success: Conventional 71 pcnt, Vitamin D 96 pcnt – March 2021
- The 6 percent of infants hospitalized for ARI are 2.2 X more likely to be Vitamin D deficient – April 2021
- Acute pneumonia in children 3X less likely if greater than 30 ng of vitamin D – Jan 2021
- Preemie Respiratory Distress Syndrome is 5X more likely if low vitamin D – Dec 2020
- Recurrent Wheezing in children is associated with low Vitamin D – several studies
- Respiratory viral infection (RSV) and low vitamin D - many studies
- Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020
- Gene which predicts wheezing is associated with low vitamin D – Oct 2019
- Bronchiolitis in children associated with both pollution and low solar – July 2019
- Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019
- Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019
- Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
- Childhood Asthma somewhat reduced by 2400 IU vitamin D late in pregnancy (néed more, earlier) March 2019
- Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019
- Black infant recurrent wheezing rate dropped from 42 percent to 31 percent with just 400 IU of vitamin D – RCT Dec 2018
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
- Immature lungs in immature newborns – Vitamin D helps – Sept 2018
- Bronchiolitis had 1.3 X longer hospitalization if low Vitamin D (1016 infants) – Sept 2018
- Pneumonia in Egyptian Children 3.6 X more likely if poor Vitamin D Receptor – Aug 2018
- Childhood pneumonia not treated by 100,000 IU of vitamin D – Cochrane (need more, inhaled) – July 2018
- Pneumonia is increasing (now 1 in 6 child deaths), more vitamin D studies needed – June 2018
- Childhood Respiratory Health hardly improved with 600 IU of vitamin D (need much more) – May 2018
- Indoor pollution is a problem with obese black asthmatic children – May 2018
- Both parents smoke – child’s vitamin D level was 30 percent lower and worse asthma – May 2018
- Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Rapid newborn breathing (transient tachypnea) associated with low vitamin D – Dec 2017
- Preemies with poor lungs (Respiratory distress syndrome) have low levels of vitamin D – Nov 2017
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Respiratory infection in infant was 7 X more likely if low cord Vitamin D – March 2017
- Viral Pneumonia in children 52 X more-likely if very low vitamin D (trend) – June 2017
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Childhood allergy, asthma and eczema associated with repeated low vitamin D tests – Oct 2016
- Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016
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