One pill every two weeks gives you all the vitamin D most adults need
50,000 IU of Vitamin D once every two weeks proven to prevent/treat:
Diabetes + Heart Failure + Chronic Pain + Depression + Autism + Breast Cancer + Colon Cancer + Prostate Cancer + BPH (prostate) + Preeclampsia + Premature Birth + Falls + Cognitive Decline + Respiratory Tract Infection + Influenza + Tuberculosis + Chronic Obstructive Pulmonary Disease + Lupus + Inflammatory Bowel Syndrome + Urinary Tract Infection + Poor Sleep + Growing Pain + Multiple Sclerosis + PMS + Schizophrenia + Endometriosis + Smoking 27 problems
Note: Once a week also fights: COVID, Headaches, Colds, Fibromyalgia, Asthma, Hives, Colitis etc.
See down this page: Additional health problems fought by 50,000 Vitamin DWEEKLY
33 additional, for a total of 61 health problems fought if take 50,000 IU weekly
Diabetes helped by daily 4,000 IU of Vitamin D – meta-analysis Sept 2017
- which is very close to 50,000 IU every two weeks
Diabetes treated if given enough vitamin D (example: 50,000 IU weekly) – review of RCT - Jan 2017
Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT May 2015
Diabetes (Type 1) 14X more likely in dark skin children with low levels of vitamin D – May 2015
Many Diabetics guts poorly absorb standard vitamin D - need an injection of gut-friendly form
Diabetics helped by vitamin D in 5 ways – meta-analysis June 2018
Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
Chronic Heart Failure reduced by 4,000 IU daily for a year – RCT April 2016
Seniors with Heart Failure helped by daily 4,000 IU of vitamin D (increase 16 ng) – RCT Aug 2014
Congestive heart failure in infants virtually cured by 1000 IU of vitamin D – RCT Feb 2012
Acute Heart Failure length of stay and readmission rates cut in half if high vitamin D – Aug 2017
7X increased chance of death if coronary artery disease and low vitamin D – Oct 2013
Chronic Pain reported 38 percent less often if supplemented with Vitamin D – meta-analysis Sept 2016
- Note - many studies found a variety of types of pain were prevented or relieved by weekly 50,000 IU
Shin pain in elderly men 36 X more likely if low vitamin D – March 2017
Back and leg pain lasts a year longer if low vitamin D – April 2017
Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019
Depression
Depression in adolescent girls reduced somewhat by 50,000 IU weekly for 9 weeks – July 2017
Vitamin D depression RCT canceled: too many were taking Vitamin D supplements, etc. Feb 2018
Autism
Autism treated by Vitamin D (80 – 120 ng) – Cannell update May 2018
Autism risk factors – many are associated with low vitamin D – meta-meta-analysis March 2017
Vitamin D and autism - treat: 300 IU per kg per day, prevent: during pregnancy 5,000 IU – Feb 2017
Autistic children were 3.6 X more likely to have low levels of vitamin D – Nov 2017
Breast cancer
Breast Cancer 80 percent less likely if high level of vitamin D – June 2018
Breast Cancer prevented by Vitamin D (most studies concur) – Dec 2017
Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
Colon Cancer
Colorectal cancer is associated with Vitamin D (17 meta-analyses so far) – July 2018
Colon cancer – how vitamin D prevents and treats it – Nov 2014
45 percent fewer deaths from digestive cancers for 10 ng increase in vitamin D – 2006
Prostate Cancer
Prostate cancer risk increase with Vitamin D (other studies disagree) – meta-analysis Jan 2018
Prostate cancer reduced when 4000 IU vitamin D was added– Hollis RCT April 2015
Prostate cancer in veterans more survivable when have enough vitamin D – Jan 2014
7X increase in stage IV Prostate Cancer survival when vitamin D greater than 32 ng – May 2013
Enlarged prostate
Preeclampsia
Preeclampsia recurrence reduced 2 X by 50,000 IU of vitamin D every two weeks – RCT July 2017
Preeclampsia reduced by Vitamin D (50,000 IU bi-weekly) and Calcium – Oct 2015
Preeclampsia rate cut in half by high level of vitamin D – meta-analysis March 2014
Preeclampsia 2.7X more frequent if low vitamin D – meta-analysis Sept 2013
Premature Birth
Falls
Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016
Elderly falls reduced 3.6 times by 900 IU of vitamin D and simple exercise – RCT Nov 2016
Hip fracture 58 percent more likely if low vitamin D – meta-analysis March 2017
Free Vitamin D in New Zealand to prevent falls in nursing homes (50,000 IU monthly) – June 2016
Cognitive Decline
Cognition of Alzheimer’s patients improved by daily 4,000 IU of vitamin D – RCT Jan 2015
2,000 IU of vitamin D reduced schizophrenia chance by 77 percent (male infants) - 2004
Severe Alzheimer's delayed by 1 year with vitamin D intervention – March 2014
Mental health intervention trials using enough vitamin D for long enough found benefits – Jan 2017
Respiratory Tract Infection
Vitamin D reduces respiratory tract infections by 40 percent– meta-analysis Dec 2012
Reduced viral respiratory tract infections by half by having more than 38 ng of vitamin D – June 2010 many people get > 38 ng with 50,000 every two weeks
Influenza
Influenza prevented by 40 ng levels or treated with vitamin D hammer (50,000 IU) – June 2015 a single 50,000 IU dose
Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
Tuberculosis
Tuberculosis 4.5X more likely if vitamin D less than 10 nanogram – meta-analysis May 2015
Probability of getting TB reduced 60 percent with just 800 IU of vitamin D – RCT Aug 2012
Tuberculosis risk decreased by 6 percent for each 1 ng increase in Vitamin D – Oct 2014
Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006 which is about 50,000 every week
Tuberculosis recovery speeded up by single 450,000 IU dose of vitamin D – RCT Jan 2017
Chronic Obstructive Pulmonary Disease
Lupus
Lupus flareups cut in half by just 2,000 IU of vitamin D – RCT Dec 2012
Lupus flares totally eliminated by loading dose then 100000 IU of vitamin D each month – Oct 2012
Musculoskeletal pain reduced with 4,000 IU of vitamin D – RCT April 2015 Lupus pain
Lupus helped by Vitamin D supplementation in 3 out of 4 studies – Oct 2017
Lupus is both prevented and treated by Vitamin D – review Dec 2017
Inflammatory Bowel Syndrome
Urinary Tract Infection
UTI associated with low Vitamin D as well as treated - many studies 50,000 IU every 2 weeks should be very similar
Multiple Sclerosis
PMS
PMS in teens reduced 3X by 50,000 IU vitamin D weekly – Jan 2018
PMS reduced by half in girls who had low levels of vitamin D – RCT Dec 2015
Menstrual Pain (PMS) reduced by vitamin D – RCT 2012, 2014, 2016
Single dose of 300,000 IU of vitamin D
Women getting vitamin D needed NO pain relievers, vs 40% of the women without vitamin D
PMS reduced by Vitamin D intervention - meta-analysis May 2019
Schizophrenia
Endometriosis
Smoking
Smoking depression, etc. reduced by Vitamin D (bi-weekly, 50,000 IU) - RCT Dec 2021
Note - Magnesium and Omega-3 supplementation often provide similar benefits for the above health problems
Taking one 50,000 IU capsule of Vitamin D3 every two weeks will result in 80% of adults
bringing their blood levels to above 40 nanograms/ milliliter in 2-6 months, an optimal level for good health.
You can take 50,000 IU pills daily in the first week and feel the benefits by the end of the week
Feeling the benefits quickly greatly increases the likelihood that you will continue with supplementation
**||50,000 IU |To feel benefits in a week|To maintain >40 ng/ml
for 80% of people
Adult|1 per day| 1 every 2 W
Adult - #F00:* high risk |2 per day | 1 every week ||
✻About 20% of adults are at high risk for Vitamin D deficiency: especially those who are obese, pregnant, shut-in, avoid the sun, have dark skin, are elderly, live far from the equator, or need to deal with an illness, injury, or surgery. They need at least 2 times more Vitamin D .
A 50,000 IU capsule costs as little as 20 cents ($20 retail for a bottle of 100 capsules Amazon US )
The very lowest cost source and highest quality of vitamin D3 50,000 IU capsule = Bio-Tech
You can order it from Amazon US (Amazon has the lowest price, but has a policy to not ship any health care products out of a country)
* UK company that ships Bio-Tech products to all the European countries
WLS sells Bio-Tech from the Netherlands to Europe
Many companies on Amazon supply Vitamin D - Sept 2017
Can get 50,000 IU Vitamin D anywhere on the globe
| ** | ||
|---|---|---|
| Dose size | Suppliers | |
| 50,000 IU | 18+ Feb 2024 |
|
| 10,000 IU | 30+ | |
| 5,000 IU | 500+ | |
| 4,000 IU Upper limit specified by IoM |
20+ | ** |
An adult who is not at high risk for vitamin D deficiency can achieve an optimal level with just 8 capsules of 50,000 IU
If at high risk: at least double the number of capsules will be needed for loading and maintenance
Bio-Tech Pharmacal
Bio-Tech makes the only Vitamin D that has ALL of these features:
| Very low cost | 50,000 IU capsule appears to be the lowest-cost source in the world |
| Contains no additives | Nothing to cause an allergy |
| Does not have oil base | Oil is associated with about 20% reduction in response in a clinical trial water-dispersible is better and is not delayed by the Lymph System |
| Tasteless | No unpleasant taste or odor as with some liquids |
| Tiny capsule need not be swallowed |
You can put the capsule powder into the water, milk (animal or plant), juice, food, etc and consume your vitamin D over the period of days. |
| Kosher and Halal certified | Vegi-cap (needed for Kosher) is more expensive |
| Gut friendly | Though some companies have even gut friendlier forms |

Opinion: Founder of VitaminDWiki
95% of people will get full benefit from Bio-Tech Vitamin D
~50% of people will get full benefit from most of the other brands of vitamin D
due to poor gut, allergies, unable to take pills, etc,
Alternately, take 4,000 IU daily (instead of 50,000 bi-weekly
cost is 4X higher, and have 13 more opportunities to forget
Note: The Institute of Medicine says the upper limit is 4,000 IU (average per day)
**||4,000 IU |To feel benefits in a week|To maintain >40 ng/ml
80% of people
Adult|20 per day for 4 days| 1 per day
Adult - #F00:* high risk ** |40 per day for 4 days| 2 per day
Child|10 per day for 4 days|every other day||**
Additional companies that ship internationally include (Note: customs rarely seem concerned about dose size if small quantities, especially via mail)
Can get 50,000 IU Vitamin D anywhere on the globe 16 companies state weekly dosing as of Nov 2023
Swansons, Life Extension Foundation Vitaminshoppe Nutrition Express - can sort by size or type Ebay 35,000 listings in Jan 2024
Cofactors should be adjusted- especially if take for many months
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Reduce Calcium intake to 500 mg/day (dairy products, food, supplements)
Increase Magnesium supplements to 500 mg/day
Additional Vitamin D references
- VitaminDWiki pages containing "50,000" in title 262 as of Aug 2024
- Every 2 weeks 50,000 IU
50,000 IU of Vitamin D once every 2 weeks achieved 40 ng in 3 months – RCT March 2021
50,000 IU of vitamin D every two weeks – Jordan conclusion - RCT July 2017
Vitamin D update – 40-60 ng ideal, 50K biweekly maintenance – Jan 2014
Even taking as much as 4200 IU vitamin D 43 percent had less than 30 ng in blood – RCT Jan 2013 need more?
Vitamin D RCT using 100,000 IU monthly for a variety of health problems – results of ViDA due in 2016{ANAME()}optimal{ANAME}
What is an Optimal Level: 40 ng, 50 ng, 60 ng, 80 ng?
Optimum Vitamin D level: Evidence for 30 and 40 ng – Grant Aug 2013
30 to 50 ng of vitamin D is optimal – Central Europe consensus Sept 2013
Defining normal level of vitamin D (need 4000-5000 IU) - Heaney Spring 2013
40 ng Vitamin D perhaps optimal for reduced mortality – Meta-analysis Jan 2012
Fewer health problems with higher Vitamin D Levels has the following chart

Loading doses of Vitamin D
540000 IU before ICU raised vitamin D by 25 ng in 2 days – March 2011
High Risk of having low vitamin D levels
Obese, Seniors, Pregnant, Shut-in, Dark Skin, very far from the equator, recent surgery/major medical
- avoid the sun, excessive clothing, gut problems, kidney/liver problems, etc.
High Risk of little Vitamin D category overview with associated searches
Obese need 2.5 IU of vitamin D per kg to increase 1 ng (about 3.4 X more) – RCT Sept 2013 example of a high-risk group
50,000 IU vitamin D weekly increased levels by 52 ng normally, but only 28 ng if obese – Oct 2013
Extremely low Toxicity Note: 50,000 IU is not even toxic if taken daily for 30 days
Millions of people have taken single dose of 500,000 IU of vitamin D without any problem
10,000 IU daily can be taken for years and years. (The body naturally removes any excess)
Some indication that too much vitamin D causes problems in hospitals
100,000 IU monthly vs placebo RCT Aug 2018
- adverse events in 16% of both Vitamin D and placebo groups: 10.1016/j.clnu.2018.07.034
Use the same 50,000 IU pill monthly for children
Children no longer get much vitamin D from milk - fortify at home
Other Vitamin D information
Does Less Sun mean More Disease video tells you WHY vitamin D is needed
258+ Randomized Clinical Trials with non-daily dosing
- Note: very little difference if Vitamin D is taken every day or with 16 X a dose taken every 16 days
Vitamin D deficiency is a major global public health problem – Maps Nov 2013
Would you be opposed to my getting more vitamin D
- How to ask your doctor if you should take more vitamin D
Overview Rare Allergic reaction to vitamin D
- Magnesium, wool, oil, etc. About 1 in 300 people, typically due to low level of Magnesium
Vitamin D3 for Vegans - many studies Vegan D3 surprisingly does not cost much more
Low Cost vitamin D - including liquid and bulk typically 5 cents per 5000 IU
Overviews at VitaminDWiki
Proof that Vitamin D Works 99 proofs as of Jan 2025
Even taking as much as 4200 IU vitamin D 43 percent had less than 30 ng in blood – RCT Jan 2013
30 percent of vitamin D sold now has more than 2000 IU - Dec 2012 vs US govt says 600 IU is enough
85% achieved 20 ng with avg of 3300 IU of vitamin D - oral and injection Aug 2012
Breastfeeding with daily or monthly doses of vitamin D virtually the same – RCT Dec 2013
It is OK to miss getting your vitamin D supplement by even a week - just take it when you remember to do so.
If you have gut problems or poor absorption , you should probably take Vitamin D3 in a more easily absorbable form such as BioMulsion gel
If you just have a maintenance dosing without loading dose it will take 6-9 months to feel the benefits
No need to test your vitamin D blood level - But, a test will confirm when you are getting enough Vitamin D
Oil-based Vitamin D3 has the worst bioavailability – April 2014
There are many near-term benefits to be felt by having an optimum level of vitamin D
There is a 4X variability in response between individuals
- The dose sizes on this page may be two times higher or 2 times lower than what you need
- About 5% of the population should not supplement with vitamin D
- generally because Vitamin D increases or decreases the effect of their medications ( Contra-indications )
- When in a hospital, you must make them aware that you have a higher level of vitamin D than most of the population. Virtually all drug doses assume low levels of vitamin D, and high levels can increase/decrease potency by 3X. A Chemo dose, for example, might be decreased by 3X for people with optimal vitamin D, giving you much less trauma, but if not reduced, you might die.
- Review of vitamin D interaction with drugs – Jan 2014
Let your calendar remind you when to take your supplement - Not have to remember: Which SUNday is this?
Healthy in Seven Days - Loading dose of Vitamin D – book 2014
- Restocking vitamin D quickly gets you to a good level in less than a week instead of less than a year
Vitamin D once every two weeks is OK, daily is nice but not required – Aug 2014
Breastfeeding with daily or monthly doses of vitamin D virtually the same – RCT Dec 2013
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33 additional Health Problems fought when taking 50,000 IU Vitamin D weekly
See also
Take 50,000 IU of Vitamin D weekly for 2-4 months, then get a test - Dec 2021
Vitamin D supplementation guidelines (adults – 50,000 IU per week) – Feb 2017
Health problems fought by 50,000 IU weekly: or bi-weekly
ADHD, Anxiety, Asthma, Autism, Back Pain, BPH (prostate), Cancer - Breast, Cancer - Colon, Cancer - Prostate, Cardiovascular, Chronic Obstructive Pulmonary Disease, Cognitive Decline, Colds, COVID, Depression, Diabetes, Endometriosis, Falls, Fibromyalgia, Hashimoto's Thyroiditis, Hay Fever, Heart Failure, Hives, Hypertension – Pulmonary, Immune System, Infant, Inflammatory Bowel Syndrome, Influenza, Kidney Disease, Knee-Pain, Lupus, Migraine, Multiple Sclerosis, Muscles - women, Obesity, Pain - Chronic, Pain - Growing, PMS, Preeclampsia, Premature Birth, Respiratory Tract Infection, Schizophrenia, Sleep-Poor, Sleep Apnea, Smoking, Sports Performance, Stroke, Surgery, Tonsilitis, Tuberculosis, Ulcerative Colitis, Ulcers – Venous, Urinary Tract Infection click here for proof
50,000 IU of Vitamin D - many studies 160+
short URL = is.gd/vitdweek