Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022

Vitamin D supplementation and total cancer incidence and mortality by daily vs. infrequent large-bolus dosing strategies: a meta-analysis of randomised controlled trials

Br J Cancer . 2022 Jun 8. doi: 10.1038/s41416-022-01850-2 PDF can be rented for $9
N Keum 1 2, Q-Y Chen 3, D H Lee 4, J E Manson 5 6, E Giovannucci 4 6

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Background: Efficacy of vitamin D supplementation may vary by dosing strategies and adiposity. To address such heterogeneity, we performed a meta-analysis of randomised controlled trials of vitamin D supplementation and total cancer outcomes.

Methods: PubMed and Embase were searched through January 2022. Summary relative risk (SRR) and 95% confidence interval (CI) were estimated using the DerSimonian-Laird random-effects model.

Results: For total cancer incidence (12 trials), the SRR for vitamin D supplementation vs. control group was 0.99 (95% CI, 0.94-1.03; P = 0.54; I2 = 0%). No significant association was observed regardless of whether the supplement was given daily or infrequently in a large-bolus. Yet, among trials testing daily supplementation, a significant inverse association was observed among normal-weight individuals (SRR, 0.76; 95% CI, 0.64-0.90; P = 0.001, I2 = 0%), but not among overweight or obese individuals (Pheterogeneity = 0.02). For total cancer mortality (six trials), the SRR was 0.92 (95% CI, 0.82-1.03; P = 0.17; I2 = 33%). A significant inverse association emerged (SRR, 0.87; 95% CI, 0.78-0.96; P = 0.007; I2 = 0%) among studies testing daily supplementations but not among studies that testing infrequent large-bolus supplementations (Pheterogeneity = 0.09).

Conclusions: For vitamin D supplementation, daily dosing, but not infrequent large-bolus dosing, reduced total cancer mortality. For total cancer incidence, bolus dosing did not reduce the risk and the benefits of daily dosing were limited to normal-weight individuals.

The weekly and obese dosing are hiding behind the paywall
References
  1. Gandini S, Boniol M, Haukka J, Byrnes G, Cox B, Sneyd MJ, et al. Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma. Int J Cancer. 2011;128:1414–24. - PubMed - DOI
  2. Li M, Chen P, Li J, Chu R, Xie D, Wang H. Review: the impacts of circulating 25-hydroxyvitamin D levels on cancer patient outcomes: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2014;99:2327–36. - PubMed - DOI
  3. He Y, Timofeeva M, Farrington SM, Vaughan-Shaw P, Svinti V, Walker M, et al. Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study. BMC Med. 2018;16:142. - PubMed - PMC - DOI
  4. Ong JS, Gharahkhani P, An J, Law MH, Whiteman DC, Neale RE, et al. Vitamin D and overall cancer risk and cancer mortality: a Mendelian randomization study. Hum Mol Genet. 2018;27:4315–22. - PubMed
  5. Ong JS, Dixon-Suen SC, Han X, An J, Liyanage U, Dusingize JC, et al. A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization. Nat Commun. 2021;12:246. - PubMed - PMC - DOI
  6. Afzal S, Brøndum-Jacobsen P, Bojesen SE, Nordestgaard BG. Genetically low vitamin D concentrations and increased mortality: Mendelian randomisation analysis in three large cohorts. BMJ. 2014;349:g6330. - PubMed - PMC - DOI
  7. Calderwood AH, Baron JA, Mott LA, Ahnen DJ, Bostick RM, Figueiredo JC, et al. No Evidence for posttreatment effects of vitamin D and calcium supplementation on risk of colorectal adenomas in a randomized trial. Cancer Prev Res. 2019;12:295–304. - DOI
  8. Jorde R, Sollid ST, Svartberg J, Schirmer H, Joakimsen RM, Njølstad I, et al. Vitamin D 20,000 IU per week for five years does not prevent progression from prediabetes to diabetes. J Clin Endocrinol Metab. 2016;101:1647–55. - PubMed - DOI
  9. Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, et al. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. J. Am Med Assoc. 2010;303:1815–22. - DOI
  10. Haykal T, Samji V, Zayed Y, Gakhal I, Dhillon H, Kheiri B, et al. The role of vitamin D supplementation for primary prevention of cancer: meta-analysis of randomized controlled trials. J Community Hosp Intern Med Perspect. 2019;9:480–8. - PubMed - PMC - DOI
  11. Keum N, Lee DH, Greenwood DC, Manson JE, Giovannucci E. Vitamin D supplementation and total cancer incidence and mortality: a meta-analysis of randomized controlled trials. Ann Oncol. 2019;30:733–43. - PubMed - PMC - DOI
  12. Zhang Y, Fang F, Tang J, Jia L, Feng Y, Xu P, et al. Association between vitamin D supplementation and mortality: systematic review and meta-analysis. BMJ. 2019;366:l4673. - PubMed - PMC - DOI
  13. Hollis BW, Wagner CL. Clinical review: The role of the parent compound vitamin D with respect to metabolism and function: why clinical dose intervals can affect clinical outcomes. J Clin Endocrinol Metab. 2013;98:4619–28. - PubMed - PMC - DOI
  14. Mazess RB, Bischoff-Ferrari HA, Dawson-Hughes B. Vitamin D: bolus is bogus—a narrative review. JBMR. 2021;5:e10567.
  15. Pourshahidi LK. Vitamin D and obesity: current perspectives and future directions. Proc Nutr Soc. 2015;74:115–24. - PubMed - DOI
  16. Lotito A, Teramoto M, Cheung M, Becker K, Sukumar D. Serum parathyroid hormone responses to vitamin D supplementation in overweight/obese adults: a systematic review and meta-analysis of randomized clinical trials. Nutrients. 2017;9:241.
  17. Kim H, Chandler P, Ng K, Manson JE, Giovannucci E. Obesity and efficacy of vitamin D(3) supplementation in healthy black adults. Cancer Causes Control. 2020;31:303–7. - PubMed - PMC - DOI
  18. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. - PubMed - PMC
  19. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999;69:842–56. - PubMed - DOI
  20. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88. - PubMed - DOI
  21. Chao YS, Brunel L, Faris P, Veugelers PJ. The importance of dose, frequency and duration of vitamin D supplementation for plasma 25-hydroxyvitamin D. Nutrients. 2013;5:4067–78. - PubMed - PMC - DOI
  22. Dalle Carbonare L, Valenti MT, Del Forno F, Caneva E, Pietrobelli A. Vitamin D: daily vs. monthly use in children and elderly-what is going on? Nutrients. 2017;9:652.
  23. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34. - PubMed - PMC - DOI
  24. LaCroix AZ, Kotchen J, Anderson G, Brzyski R, Cauley JA, Cummings SR, et al. Calcium plus vitamin D supplementation and mortality in postmenopausal women: the Women’s Health Initiative calcium-vitamin D randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2009;64:559–67. - PubMed - DOI
  25. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, et al. Effect of vitamin D and calcium supplementation on cancer incidence in older women: a randomized clinical trial. J Am Med Assoc. 2017;317:1234–43. - DOI
  26. Wactawski-Wende J, Kotchen JM, Anderson GL, Assaf AR, Brunner RL, O’Sullivan MJ, et al. Calcium plus vitamin D supplementation and the risk of colorectal cancer. N. Engl J Med. 2006;354:684–96. - PubMed - DOI
  27. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539–58. - PubMed - DOI
  28. Cashman KD, van den Heuvel EG, Schoemaker RJ, Prévéraud DP, Macdonald HM, Arcot J. 25-Hydroxyvitamin D as a biomarker of vitamin D status and its modeling to inform strategies for prevention of vitamin D deficiency within the population. Adv Nutr. 2017;8:947–57.
  29. Chandler PD, Chen WY, Ajala ON, Hazra A, Cook N, Bubes V, et al. Effect of vitamin D3 supplements on development of advanced cancer: a secondary analysis of the VITAL randomized clinical trial. JAMA Netw Open. 2020;3:e2025850. - PubMed - PMC - DOI
  30. Chatterjee R, Fuss P, Vickery EM, LeBlanc ES, Sheehan PR, Lewis MR, et al. Vitamin D supplementation for prevention of cancer: the D2d cancer outcomes (D2dCA) ancillary study. J Clin Endocrinol Metab. 2021;106:2767–78. - PubMed - PMC - DOI
  31. Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, et al. Vitamin D supplements and prevention of cancer and cardiovascular disease. N. Engl J Med. 2019;380:33–44. - PubMed - DOI
  32. Neale RE, Baxter C, Romero BD, McLeod DSA, English DR, Armstrong BK, et al. The D-Health trial: a randomised controlled trial of the effect of vitamin D on mortality. Lancet Diabetes Endocrinol. 2022;10:120–8. - PubMed - DOI
  33. Virtanen JK, Nurmi T, Aro A, Bertone-Johnson ER, Hyppönen E, Kröger H, et al. Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial-a randomized controlled trial. Am J Clin Nutr. 2022;115:1300–10.
  34. Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr. 2007;85:1586–91. - PubMed - DOI
  35. Avenell A, MacLennan GS, Jenkinson DJ, McPherson GC, McDonald AM, Pant PR, et al. Long-term follow-up for mortality and cancer in a randomized placebo-controlled trial of vitamin D(3) and/or calcium (RECORD trial). J Clin Endocrinol Metab. 2012;97:614–22. - PubMed - DOI
  36. Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ. 2003;326:469. - PubMed - PMC - DOI
  37. Scragg R, Khaw KT, Toop L, Sluyter J, Lawes CMM, Waayer D, et al. Monthly high-dose vitamin D supplementation and cancer risk: a post hoc analysis of the vitamin d assessment randomized clinical trial. JAMA Oncol. 2018;4:e182178. - PubMed - PMC - DOI
  38. Dusso AS. Kidney disease and vitamin D levels: 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and VDR activation. Kidney Int Suppl. 2011;1:136–41. - DOI
  39. Pittas AG, Dawson-Hughes B, Sheehan P, Ware JH, Knowler WC, Aroda VR, et al. Vitamin D supplementation and prevention of type 2 diabetes. N. Engl J Med. 2019;381:520–30. - PubMed - PMC - DOI
  40. Barbarawi M, Zayed Y, Barbarawi O, Bala A, Alabdouh A, Gakhal I, et al. Effect of Vitamin D supplementation on the incidence of diabetes mellitus. J Clin Endocrinol Metab. 2020;105:2857–68.
  41. Hahn J, Cook NR, Alexander EK, Friedman S, Walter J, Bubes V, et al. Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial. BMJ. 2022;376:e066452-e. - DOI
  42. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000;72:690–3. - PubMed - DOI
  43. Mendes MM, Hart KH, Lanham-New SA, Botelho PB. Suppression of parathyroid hormone as a proxy for optimal vitamin D status: further analysis of two parallel studies in opposite latitudes. Nutrients. 2020;12:942.
  44. Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology. 2007;132:2169–80. - PubMed - DOI
  45. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140:883–99. - PubMed - PMC - DOI
  46. Han J, Guo X, Yu X, Liu S, Cui X, Zhang B, et al. 25-Hydroxyvitamin D and total cancer incidence and mortality: a meta-analysis of prospective cohort studies. Nutrients. 2019;11:2295. - PMC - DOI
  47. Grant WB, Al Anouti F, Boucher BJ, Dursun E, Gezen-Ak D, Jude EB, et al. A narrative review of the evidence for variations in serum 25-hydroxyvitamin D concentration thresholds for optimal health. Nutrients. 2022;14:639.
  48. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–30. - PubMed - DOI
  49. Sempos CT, Binkley N. 25-Hydroxyvitamin D assay standardisation and vitamin D guidelines paralysis. Public Health Nutr. 2020;23:1153–64. - PubMed - PMC - DOI
  50. Tawfik GM, Giang HTN, Ghozy S, Altibi AM, Kandil H, Le H-H, et al. Protocol registration issues of systematic review and meta-analysis studies: a survey of global researchers. BMC Med Res Methodol. 2020;20:213. - PubMed - PMC - DOI
  51. Niedermaier T, Gredner T, Kuznia S, Schöttker B, Mons U, Brenner H. Vitamin D supplementation to the older adult population in Germany has the cost-saving potential of preventing almost 30 000 cancer deaths per year. Mol Oncol. 2021;15:1986–94. - PubMed - PMC - DOI

VitaminDWiki - Vitamin D: not one size, type, form, route for all - Jan 2022

2X to 3X more Vitamin D is needed if obese

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  • Normal weight     Obese     (50 ng = 125 nanomole)

Click here for 2014 study

VitaminDWiki Mortality pages with CANCER in title (34 as of July 2022)

This list is automatically updated

Items found: 36
Title Modified
People with Cancer having more than 30 ng of Vitamin D are 40% less likely to die (of any cause) – Nov 2023 23 Nov, 2023
Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013 31 Jul, 2023
Cancer incidence or mortality not changed by small Vitamin D doses: 2021-2023 01 May, 2023
Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018 30 Apr, 2023
Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022 03 Jul, 2022
Cancer incidence and death reduced by both Vitamin D and UVB – Grant Oct 2021 15 Oct, 2021
Cancer mortality not reduced by small vitamin D doses - Sept 2021 21 Sep, 2021
Cancer death (non-skin) 2.3 X more likely if low Vitamin D – Aug 2021 17 Aug, 2021
Deaths after Cancer Surgery higher in blacks (probably low vitamin D) – Dec 2020 10 Jan, 2021
Cancer patients in ICU with low vitamin D were 3.4 X more likely to die within a year – Dec 2020 31 Dec, 2020
Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020 09 Nov, 2020
Cancer is leading cause of death - Vitamin D and Receptor activators help 09 Nov, 2019
Mortality increased: 4X Cancer, 5X Diabetes if eat a lot of meat protein – March 2014 08 Nov, 2019
Vitamin D Supplements Reduce Cancer Mortality – Greger Sept 2019 10 Sep, 2019
Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019 05 Jul, 2019
People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019 05 Jul, 2019
Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019 07 May, 2019
Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019 13 Apr, 2019
Cancer patients 64% less likely to die if have high level of vitamin D – Dec 2011 26 Nov, 2018
Vitamin D reduces the risk of Breast Cancer, improves treatment, and improves survival 10 Sep, 2018
The “Deadly Breast Cancer Gene” Is A Myth, Lancet Study Confirms – Jan 2018 13 Jan, 2018
Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017 29 Dec, 2017
Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017 13 Jun, 2017
Death after Breast Cancer 2 times less likely if take lots of Magnesium – Dec 2015 15 Jun, 2016
Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013 09 Nov, 2014
Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014 30 Sep, 2014
Cancer incidence not reduced by 1100 IU of vitamin D (proven again) but mortality decreased – June 2014 17 Jun, 2014
Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 12 May, 2014
More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014 08 May, 2014
Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014 08 Apr, 2014
Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 06 Mar, 2014
Vitamin D and Cancer Mortality – review Jan 2013 17 Sep, 2013
Mortality and Cancer varies with latitude in France too – 2010 26 Oct, 2012
More US deaths due to cancer than heart if dark skinned – Sept 2012 18 Sep, 2012
Lack of solar UVB in US is associated with some Cancers - 2006 28 Dec, 2011
Solar radiation, vitamin D and cancer incidence and mortality in Norway 13 Apr, 2010

VitaminDWiki Meta-analysis pages with CANCER in title (72 as of July 2022)

This list is automatically updated

Items found: 82
Title Modified
1.5X more likely to die of Prostate Cancer if low vitamin D when initially diagnosed – meta-analysis March 2024 13 Mar, 2024
Pancreatic Cancer survival 2.3 X more likely if good level of Vitamin D – meta-analysis Sept 2023 15 Sep, 2023
Thyroid Cancer 1.4 X higher risk if low vitamin D– meta-analysis Feb 2018 29 Aug, 2023
Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013 31 Jul, 2023
16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis May 2023 22 May, 2023
Breast Cancer not prevented by vitamin D when use small doses or for just a short time – Meta-analysis April 2023 11 May, 2023
Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018 30 Apr, 2023
Breast Cancer risk - meta-analysis of 50 studies - Dec 2019 25 Mar, 2023
Ovarian Cancer 37 percent less likely if high vitamin D – meta-analysis March 2023 20 Mar, 2023
Colorectal Cancer 10 percent more likely if poor Vitamin D Receptor – meta-analysis Jan 2023 08 Jan, 2023
Colorectal cancer 14 percent less likely if 10 ng more Vitamin D – 22nd meta-analysis – Sept 2022 13 Sep, 2022
USPSTF says no evidence that Vitamins prevent CVD or Cancer (data disagrees) Aug 2022 05 Sep, 2022
Even after a Cancer diagnosis Vitamin D improves survival – meta-analysis Aug 2022 19 Aug, 2022
Colorectal cancer 40 percent less likely if 1000 IU more Vitamin D – 21st meta-analysis – Oct 2021 29 Oct, 2021
Colorectal cancer 25 percent less likely if good level of Vitamin D – 20th meta-analysis – June 2021 02 Jul, 2021
Lung Cancer death 40 percent less likely if high level of Vitamin D – meta-analysis Nov 2020 24 Nov, 2020
Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020 09 Nov, 2020
Vitamin D fights 13 cancers – review of 35 meta-analyses – Oct 2020 06 Oct, 2020
Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020 02 Oct, 2020
Colorectal cancer treated by Vitamin D – 19th meta-analysis – Sept 2020 17 Sep, 2020
3X less risk of Liver cancer if more than 30 ng of vitamin D – meta-analysis July 2020 28 Jul, 2020
Liver Cancer 8 percent less likely for every 4 ng higher level of vitamin D – Meta-analysis April 2020 02 Apr, 2020
Breast Cancer risk reduced 17 percent by 1 hour of daily summer sun – meta-analysis Jan 2020 07 Jan, 2020
Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019 14 Dec, 2019
Colon cancer both prevented and treated by Vitamin D – meta-analysis Dec 2019 04 Dec, 2019
Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016 09 Nov, 2019
Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019 05 Jul, 2019
People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019 05 Jul, 2019
Breast Cancer rate reduced by 40 percent with Omega-3 – meta-analysis June 2013 16 Jun, 2019
Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019 13 Jun, 2019
Variety of Vitamin D forms treat Prostate Cancer – RCT Review April 2019 01 May, 2019
Pancreatic cancer risk of death reduced 19 percent by Vitamin D – meta-analysis June 2017 20 Mar, 2019
Breast Cancer reduced 20 percent by fish (Omega-3) – meta-analysis Feb 2019 05 Mar, 2019
16 percent less Prostate Cancer sometimes for each 10 ng vitamin D increase - meta-analysis Jan 2011 13 Oct, 2018
Lung Cancer risk decreased 2.4 percent with every 100 IU Vitamin D extra intake – meta-analysis Sept 2018 15 Sep, 2018
Colorectal cancer is associated with Vitamin D (17 meta-analyses so far) – July 2018 18 Jul, 2018
Thyroid Cancer 1.3X higher risk if low vitamin D (yet again) – meta-analysis June 2018 02 Jun, 2018
Cancer not treated by Vitamin D when ignore dose size, type, and length of trial – meta-analysis April 2018 09 Apr, 2018
Pancreatic cancer risk reduced 25 percent by just 10 micrograms of Vitamin D or Vitamin B12 – meta-analysis March 2018 30 Mar, 2018
Prostate cancer risk increase with Vitamin D (other studies disagree) – meta-analysis Jan 2018 11 Jan, 2018
Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017 29 Dec, 2017
Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017 14 Dec, 2017
Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017 27 Jul, 2017
Lung Cancer less likely if vitamin D (higher level or supplement) – meta-analysis May 2015 06 Jul, 2017
Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017 13 Jun, 2017
Lung Cancer risk decreases 5 percent for every 2.5 nanogram increase in Vitamin D – meta-analysis Sept 2015 22 Feb, 2017
Colorectal cancer 60 percent less likely: high vs low Vitamin D level – meta-analysis Dec 2016 22 Dec, 2016
Colorectal Cancer recurrence not prevented by 1,000 IU of vitamin D – meta-analysis Dec 2016 09 Dec, 2016
Bladder cancer modifiable risk factors include low vitamin D – meta-analysis March 2016 08 Dec, 2016
Bladder cancer 60 percent less likely if have high vitamin D – meta-analysis Dec 2015 08 Dec, 2016
Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014 12 Nov, 2016
10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012 23 Sep, 2016
Kidney cancer 22 percent less likely if high vitamin D – meta-analysis Nov 2015 30 Mar, 2016
Bladder cancer 25 percent less likely if have high vitamin D – meta-analysis April 2015 24 Dec, 2015
Bladder cancer 25 percent less likely if have high vitamin D – meta-analysis Oct 2014 24 Dec, 2015
Non-cancer colon growths 7 percent less likely with each 10 ng increase in vitamin D – Oct 2011 31 Oct, 2015
Cancer risk weakly associated with vitamin D-binding protein – meta-analysis Sept 2015 15 Oct, 2015
Meta-graphs of vitamin D and Cancer – Dec 2011 20 Sep, 2015
Colon cancer 30 percent more likely if low vitamin D – 12th meta-analysis Aug 2015 14 Aug, 2015
Obesity causes 20 percent of all cancer, low vitamin D may be the connection – meta-analysis - Sept 2014 31 May, 2015
Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015 03 May, 2015
Colon cancer risk reduced by many vitamins – 13 percent reduction by Vitamin D – meta-analysis Jan 2015 11 Dec, 2014
Breast Cancer – review of 2 RCT did not find association with 1000 IU of Vitamin D – July 2013 16 Nov, 2014
Cancer (colon, breast, lymph) survival about 2X better with high level vitamin D – meta-analysis July 2014 30 Sep, 2014
Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014 30 Sep, 2014
Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 12 May, 2014
More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014 08 May, 2014
Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014 08 Apr, 2014
Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 06 Mar, 2014
Breast Cancer post menopause down 12 percent for every 5 ng of vitamin D – meta-analysis May 2013 28 Oct, 2013
Probably need more than 1000 IU of vitamin D to prevent cancer – meta-analysis Aug 2013 20 Aug, 2013
3.2 percent less Breast Cancer for 2.4 ng more vitamin D – meta-analysis June 2013 08 Jul, 2013
Colorectal cancer 26 percent less likely for every 10 ng of vitamin D – meta-analysis Aug 2011 10 Nov, 2012
Breast cancer association with low vitamin D suggested by Meta-analysis -April 2010 19 Jul, 2012
Colon cancer probability increases with decreased vitamin D – Meta-analysis July 2011 23 Jun, 2012
Vitamin D has a complex relationship with Cancer – meta-analysis July 2011 30 Sep, 2011
Meta-analysis of 3 cancers - 10 ng more vitamin D decrease colorectal by 15 percent– May 2010 31 Aug, 2011
Risk of Prostate Cancer weakly associated with vitamin D - meta-analysis March 2011 11 Aug, 2011
Meta-analysis found vitamin D association with colon but not prostate nor breast cancer May 2010 17 Jan, 2011
Meta-analysis not find low vitamin D years before breast cancer – Aug 2010 10 Sep, 2010
Meta-analysis confirmed that vitamin D and calcium prevents breast cancer – June 2010 30 Aug, 2010
Meta-analysis did not find strong association between vitamin D and breast cancer risk -April 2010 12 May, 2010
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