Pages tagged with "Genetics"

352 pages, most important first (overviews, then meta-analyses, then RCTs, then newest). Combine with another topic

• Continuing Medical Education (CME) for Vitamin D includes genes and questions
• Vitamin D levels are strongly associated with genes: overview of twin studies
• Genes and Vitamin D - Malacards
• Pharmacology of vitamin D
• Off topic: Ribosomes also contain genetic information
• PTH and Vitamin D - many studies
• Diabetes and poor Vitamin D genes - many studies
• Response to Vitamin D - many studies
• CYP24A1 gene and Vitamin D - many studies
• Glutathione and Vitamin D synergism - many studies
• Telomeres and Vitamin D - many studies
• CYP2R1 gene reduces response to Vitamin D - many studies
• Ischemic Stroke and Vitamin D - many studies
• Gestational Diabetes and Vitamin D - many studies
• Epigenetics and Vitamin D – many studies
• Fertility is a function of vitamin D around each egg (follicular fluid) – many studies
• Study concluded cognitive problems are not a result of low vitamin D (many studies disagree)
• Multiple Sclerosis 5.1 X more likely if poor sun and poor HLA-DRB1×15:01 - meta-analysis
• Kidney stone risk varies a lot with both genetics and race – meta-analysis
• Hypertension associated with genes which reduce vitamin D – meta-analysis
• Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
• Parkinson’s Disease – no association found with changes in Vitamin D genes – meta-analysis
• Genes may account for some of AA Breast Cancer
• Tuberculosis, Genes, Vitamin D Binding Protein, and RCT – Review
• 430 genes changed when 3,800 IU Vitamin D added in late second trimester – RCT
• 1289 genes changed with higher doses of Vitamin D - RCT
• Response to Vitamin D varies with genes (3,000 IU, weight loss in this RCT)
• Sublingual vitamin D gave similar response as oral for most, and better for some – RCT
• 291 genes improved expression by 2000 IU of vitamin D – RCT
• 24 ng lower response to Vitamin D due to obesity, low initial Vitamin D, and genetics – RCT
• No genetic response to 4,000 IU of Vitamin D (other studies disagree) – RCT
• More than 5X increase in activation of scores of genes for women with Vitamin D (20,000 IU weekly) RCT
• Response to 1000 IU of vitamin D varies by about 4 percent due to gene variants – RCT
• Preeclampsia 3.5 times more likely if low vitamin D (affects 348 Vit. D genes) – RCT
• CYP2R1 gene probably responsible for low vitamin D response – RCT
• Vitamin D and Diseases - many associations
• Changes in CYP3A4 gene affects Vitamin D, health, reactions to some drugs, etc
• How vitamin D helps the lung via vitamin D-binding protein
• Vitamin D - Binding Protein, Receptor, enzymes and health benefits - review
• Breast Cancer far more likely in the sister having poor Vitamin D binding protein or poor CYP2R1 gene
• Diabetes reduces Vitamin D - Mendelian randomization
• Increased occurrence of Graves' and Hashimoto's thyroiditis if poor Vitamin D genes
• Most Autism Risk factors are associated with low vitamin D
• 100 years since the discovery of Vitamin D - 23 studies - 2022, 2023
• Thyroid Cancer 1.9 X more likely if poor gene to generate Vitamin D from the sun (DHCR7)
• Genetics
• Vitamin D regulates 175 genes (in 8 categories)
• Brain may be able to use all forms of Vitamin D (rat brain)
• Why Vitamin D works differently for different people: genetics and epigenetics
• The genetics of vitamin D
• Diseases, Vitamin D Receptor and other genes
• Benefits of Vitamin D often limited by genes
• Glutathione
• Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1
• Vitamin D gene: CYP11A1
• Hypothesis: Circadian Rhythm and Vitamin D are associated via CYP11A1 - Dec 2025
• Genistein, a flavonoid, increases vitamin D getting to cells in two ways
• Early Age-Related Macular Degeneration 2.8 X more likely if low Vitamin D
• 2 Genes make AMD 6X more likely if low vitamin D
• Exosomes provide communication between cells (Vitamin D is needed)
• Vitamin D genes associated with Multiple Sclerosis
• Afib increase by 3X for the 1 in 16 people having poor genes (example of health problem)
• Pregnancy complications cut in half by 4,400 IU of Vitamin D
• Multiple Sclerosis more likely if poor vitamin D genes - 22nd study
• DNA swab tests detect about 1 in 10 of actual gene problems
• Many ways to increase Vitamin D in blood and cells
• Colon Cancer protects itself by changing the VDR and CYP3A4 genes
• Vitamin D levels massively changed by CYP3A4 gene (drugs such as Ivermectin and anti-epileptics)
• SDR42E1 (Vitamin D gene) can greatly reduce Vitamin D from the sun and gut
• Vitamin D Nutrigenomics - High, Medium, and Low Responders
• Suicide attempts by males 3.7 X more likely if poor Vitamin D gene (CYP24A1)
• Vitamin D in Disease Prevention and Cure-Part I - India
• Supplements that improve Vitamin D genes
• Obesity is associated with 1 to 5 poor vitamin D genes (childhood obesity in this case)
• Genes restrict Vitamin D, Vitamin K, Omega-3, Magnesium, etc.
• CYP27A1
• Obese children have poor vitamin D genes (CYP27A1, CYP2R1, CYP27B1)
• Vitamin D, genes, analogues and Immune System
• Many cancers protect themselves by deactivating Vitamin D activated genes ( Pancreatic Cancer and HNF4A in this case)
• Vitamin D Receptor – environment, genetics and epigenetics
• Suppression of CYP24A1 gene got more Vitamin D to cells to fight Breast Cancer
• Vitamin D targets 61 Immune system genes (based on response to 80,000 IU)
• CBD improves the activation of 5 Vitamin D genes (in rats)
• DNA analysis of genes (Polygenic risk) shows increased risk of 9 health problems (all 9 fought by Vitamin D)
• Huge variation in response to vitamin D supplementation – personal vitamin D response index
• Lung Cancer risk increases if low Vitamin D, poor activation of Vitamin D Receptor which affects the CALB1 gene
• Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1
• Acupuncture of scalp activates Vitamin D genes CYP27a1, CYP27b1, and CYP24a (rats with strokes)
• Colon cancer more likely in blacks due to differences in Vitamin D genes (wonder if more Vitamin D would help)
• Obese children had less gene methylation (gene not work as well)
• Hypothesis: Early onset Parkinson's (LRRK2) can be prevented with vitamin D
• COVID virus alters the activation of 100 vitamin D related genes in the lung
• People with Multiple Sclerosis have blunted responses to Vitamin D supplementation
• Does survival of the less fit mean less health (poor genes may be inherited)
• Vitamin D genes – Review
• Many genes can restrict Vitamin D from getting to the cells
• Fructose reduces blood levels of active vitamin D
• Vitamin D is associated with 6 genes, 7 receptors, and a new book
• Molecular Approaches for Optimizing Vitamin D (one size does not fit all) – Carlberg
• Health problems that run in families are often associated with low vitamin D
• Vitamin D and it’s related genes regulate the immune system
• Long-COVID associated with 37 poor genes (no Vitamin D genes)
• Genes make Multiple Sclerosis 2X more likely unless get more vitamin D
• Telomeres in boys were 2.5% longer if 9 ng higher vitamin D
• Telomeres (which extend life) appear to be extended by Vitamin D
• Vitamin D appears to keep telomeres long (longer life)
• Longer telomeres (perhaps live longer) if higher maternal vitamin D
• Parkinson’s Disease, low vitamin D and Vit. D genetics
• Rare mutation of CYP24A1 gene results in Vitamin D accumulating
• Vitamin D accumulation in 1 in 300 people due to gene (CYP24A1) can cause Calcium problems
• Vitamin D non-responders may have one or more poor genes: GC, LIPC, CYP24A1, and PDE3B
• Prostate Cancer – Vitamin D – CYP27B1 – CYP24
• Brain cells can probably activate Vitamin D without liver or kidney (at least in rats)
• 12 Vitamin D genes (Most are not noticed by blood test)
• Get Multiple Sclerosis while younger if have a poor CYP24A1 vitamin D gene
• Vitamin D Health problems can run in families (epigenetics, they miss other reasons) – June 2023)
• Off Topic: DNA data finally being used to identify diseases caused by genes
• Cervical Cancer is prevented by Vitamin D, and treated if caught early (genes are important)
• Vitamin D genes vary with UVB in Europe, Africa, Asia
• Breast Cancer chemotherapy improved if able to suppress a vitamin D gene (CYP24A1)
• Poor CYP2R1 gene reduces blood response to Vitamin D supplementation
• Gene activation by high dose vitamin D - both quick and long term
• Hypertension gene expression reduced by high-dose vitamin D (hypertensive rats)
• High dose vitamin D fights Folate gene changes by COVID, autoimmune, CVD, ALZ
• Vitamin D resistant genes (CYP24A1, SMRT, SNAIL)
• Vitamin D genes may be more important than (25(OH)D) to orthopedics – Review
• Neuro problems (AD, PD, MSA) associated with poor vitamin D genes (CYP27A1, CYP27B1)
• Poor or no response to vitamin D was associated with poor genes (cystic fibrosis, 4 genes)
• 10,000 years of gene changes: increasing many health problems, 2 Vitamin D changes,
• Increased Phosphorus increases Vitamin D getting to cells (CYP24A1, pigs)
• Some diseases reduce vitamin D getting to blood or cells
• An ocular disease can be associated with low vitamin D and 1 of 5 poor vitamin D genes
• Health problems can persist through many generations – Epigenetics and Vitamin D
• Epigenetics of Multiple Sclerosis
• Epigenetics and vitamin D – June 2010 clips from the web
• Epigenetics, vitamin D, and Multiple Sclerosis
• Vitamin D metabolism and genes as of
• Hypertension during pregnancy: low Vitamin D, poor Vit. D genes
• Poor vision associated with poor Vitamin D or poor Vit. D genes
• Poor genes (DBP, CYP24A1, CYP2R, etc.) restrict Vitamin D to cells, increasing COVID hospitalization
• Vitamin D levels in cells, not blood, is important (IVF follicular fluid in this case)
• Better handgrip strength if some good vitamin D genes (or if supplement)
• Vitamin D up and down regulates 1,000’s of genes via the Vitamin D Receptor
• Pregnant women need at least 40 ng of Vitamin D (Wagner, genes)
• 179 immune system genes changed activation after Vitamin D added to blood in test tube - Carlberg
• Spontaneous Miscarriage strongly associated with 2 vitamin D genes
• Epigenetics - PDFs and links, with and without Vitamin D
• Vitamin D Metabolite Profiling and genes (CYP24A1, CYP27B1)
• Lower vitamin D associated with several new genes (Korea GWAS)
• COVID-19 cytokine storms perhaps better stopped by the CYP11A1 Vitamin D pathway
• Lung Cancer is up to 7 X more deadly if poor vitamin D genes
• Live longer with lung cancer if have good vitamin D genes (or perhaps lots of vitamin D)
• COVID-19 severity associated with 3 vitamin D genes
• Macular degeneration 4X more likely if low vitamin D and a particular gene
• High-fat diet reduces CYP2R1 gene needed to make semi-activated vitamin D (mice)
• CYP2R1 (vitamin D 25-hydroxylase ) semiactivates vitamin D in many places in the body
• Many Vitamin D metabolites: some help skin aging, reduce Cytokine storms, but are not tested
• Autoimmune risk gene ZMIZ1 is associated with both MS and Vitamin D
• Breast cancer and Vitamin D receptors, CP27B1, and CYP24A1
• Fight Cancer with more than cut, burn, and poison – Nobel prize for T-Cell
• Colorectal Cancer risk increases when genes reduce the vitamin D levels
• COVID-19 5X worse if poor Vitamin D gene (CYP2R1)
• Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues
• Parathyroid increase with age associated with worsening Vitamin D genes
• Human Leukocyte Antigen (HLA) gene problem is associated with Autism, Vitiligo, T1 Diabetes, Celiac, etc
• Obese have 50 percent less of two enzymes in fatty tissue to process vitamin D
• 5839 genes changed during pregnancy (many genes were related to Vitamin D)
• Kidney Stones are related to poor genes – example of CYP24A1 (Vitamin D)
• Higher risk of pulmonary tuberculosis if any of 3 vitamin D genes are poor
• Why Mendelian randomization fails with Vitamin D
• GC, CYP2R1 and DHCR7 genes associated with low vitamin D levels in China – 2012, 2013
• DHCR7 enzyme (gene) synthesizes cholesterol or vitamin D (when UVB is available)
• Oral Cancers - increased risk if low vitamin D or poor vitamin D genes
• 3X higher risk of oral cancer if CYP27B1 and CYP24A1 genes were different
• Increased risk of diabetes if have poor Vitamin D genes
• Low Vitamin D in blood is associated with 69 genes, only 6 of which are reported on
• Response to Vitamin D varied by 12 ng due to gene variants (CYP2R1)
• Vitamin D effects on over 300 genes varies with genetics and levels
• Mucosal membranes (mouth, lungs, nose, intestines, etc) can activate Vitamin D
• Vitamin D genes are important, update
• Glucocorticoid treatment reduces Vitamin D getting to cells via 3 or 4 genes
• Diabetes changes liver genes so as to destroy (catabolize) Vitamin D
• Hypothesis: Obesity reduces Vitamin D production by repressing CYP2R1 gene in liver and fat tissue
• Vitamin D restricted in getting to cells by genes, obesity, etc
• Multiple Sclerosis and obesity share some gene problems (as well as low vitamin D)
• Vitamin D roles in obesity: genetics and cell signaling
• Genes indicate that Obesity causes vitamin D deficiency
• Eye vitamin D may not be associated with blood VitD, but is associated with CYP27B1 and CYP24A1
• Some Rickets is due to poor genes - Vitamin D needed lifelong
• Vitamin D deficiency is associated with 35 genes, only 7 of are commercially tested
• CYP2R1 mutations also cause vitamin D-deficient rickets
• CYP2R1 gene problem increases Multiple Sclerosis risk by 1.4X
• Vitamins regulate some human genes
• Many Ashkenazi Jewish diseases associated with low vitamin D or poor Vit D genes
• Hypertension 2X more likely if poor CYP24A1 vitamin D gene (China)
• Vitamin D may be a magic bullet for the cells (not based on Vitamin D blood tests)
• Race changes the risk of various health problems, but many questions remain
• Lung disease, vitamin D, and epigenetics
• Epigenetics identified Cervical Cancer 100 percent of time – 2019
• Gene problem discovered by taking Vitamin D, sibling had same gene problem
• GC and CYP2R1 genes associated with higher summer vitamin D levels
• Genes (CYP2R1 and GC) which restrict the amount of Vitamin D which gets into bloodstream
• CYP2R1 and GC variations decrease vitamin D response – PHD thesis
• 8 genes associated with both Alzheimer’s and lowish Vitamin D
• Lower vitamin D in blood causes Alzheimer's Disease (Mendelian gene analysis)
• Strong Vitamin D deficiency associations in Asthma patients
• 98 pcnt of genes that Vitamin D activates to reduce MS are also activated by Interferon
• Live longer if have more than 40 ng of Vitamin D (gene analysis of 10,500 people)
• Fasting and Diabetes both reduce Vitamin D activation (CYP2R1 in rodents)
• Acute Coronary Syndrome is associated with poor Vitamin D genes (CYP27B1, CYP24A1)
• Increased risk of weight gain when gene restricts Vitamin D getting to tissues (CYP24A1 in this case)
• The story of the Human Body -excellent book by Daniel Lieberman
• Lung Cancer (NSLC) more lethal if poor Vitamin D gene ( CYP2R1)
• Might be able to predict who will benefit from vitamin D by just 2 genes
• Some people need more vitamin D to get the same response – perhaps due to genes
• Gestational Diabetes Mellitus associated with 4 Vitamin D genes
• Genes such as CYP27B1, CYP24A1 and Vitamin D – JAMA
• Review of 11 Vitamin D genes
• Vitamin D gene expression varies with Epileptic age
• Obesity might be related to Vitamin D genes
• Cancer treatment by Vitamin D sometimes is restricted by genes
• Body may change gene activation if more Vitamin D is needed (Schizophrenia in this case)
• Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1
• UVB effects on genes of those with and without Psoriasis
• UVB increases vitamin D even if poor kidney by changing CYP27B1 genes in skin
• Obesity associated with poor Vitamin D genes (VDR in this study)
• U.S. healthcare system (and its investors) are really good at monetizing illness, but not wellness
• Gut genes related to important disease changed in Obese with 2,000 IU for 12 weeks
• Food allergies are associated with Vitamin D thru genes, etc.
• Genes evolve to adapt to excess or low vitamin D (Eskimo, Reindeer, etc.)
• Obesity cut semi-activation of Vitamin D in half (mice)
• Gene differences can result in 14 ng difference in vitamin D levels
• Hypertension 3.1 X more likely in males with poor CPY24A1 gene (but 2.5 X less likely for females)
• CYP24A1 gene in cancer cells may actually remove vitamin D from the blood
• Less vitamin D generated from sunlight by schizophrenia patients – 2016
• Hepatitis C 1.4X more likely if poor CYP24A1 gene
• Natural pregnancy 4X more likely if sperm had a lot of CYP24A1
• Neurofibromatosis – 1 in 3500 have it, associated with low vitamin D
• Schizophrenia and vitamin D have latitude-related genes
• The more the African Ancestry, the lower the vitamin D level
• CYP24A1 gene mutation is a cause of rare infant vitamin D toxicity
• Mutations in CYP24A1 gene (vitamin D) associated with kidney problems
• Vitamin D insufficiency was 3.7 X more likely if CYP2R1 gene variation
• Hypothesis - Autism can be different between twins due to HPV differences in placenta
• Micronutrients, methylation, epigenetics, longevity podcast by Rhonda Patrick and Tim Ferriss
• Vitamin D Heritability: twin studies – 20 percent to 85 percent, GWAS 5 percent
• 5.8 X more likely to die in 15 year followup if low vitamin D and poor methylation
• Vitamin D and the epigenome
• Epigenetics meets endocrinology – 2011
• Low vitamin D in pregnancy – epigenetic pancreas problems in offspring (mice)
• Low frequency hearing loss (Otosclerosis) associated with vitamin D genes
• Activation (methylation) of CYP2R1 and CYP24A1 predict response to dose of vitamin D
• Blacks may not need as much Vitamin D (for their bones)
• Vitamin D affects at least 3,023 DNA locations
• The Anti-cancer Actions of Vitamin D
• Vitamin D effects on lung immunity and respiratory diseases – 2011
• Low vitamin D in mother rat altered 426 genes in newborn rat
• Surprise:Three different types of vitamin D can activate the vitamin D receptor
• Vitamin D (also B9, B12, C, E, and K) can be limited by genes
• 600 mg of Calcium and a gene increases probability of Prostate Cancer by 50 pcnt
• Calcium problems associated with CYP24A1 (a Vitamin D gene)
• Genes and Vitamin D – literature review
• Common Vitamin D gene variants and resulting diseases
• Type 1 diabetes, genes and vitamin D
• Vitamin D during pregnancy – dramatic changes in both metabolism and genes
• How Vitamin D prevents many cancers (c-MYC)
• Genes which reduce blood-level vitamin D increase the risk of Alzheimer’s disease
• Mendelian proof that low vitamin D (due to 3 genes) increase risk of MS by 20 percent
• Multiple Sclerosis, gene expression, and vitamin D: Venn diagrams
• Multiple Sclerosis relapse in children is twice as likely having a Vitamin D Gene score of 6
• Vitamin D dose size needed – VitD testing tells only a portion of the story
• 2,776 vitamin D receptor binding sites
• Rickets-vitamin D deficiency and dependency
• Rickets: Calcium, Genes, etc
• Infections, vitamin D and genes – detailed review
• Macular Degeneration decreased with UV and perhaps Vitamin D genetics
• Breast Cancer rate reduced 72 percent by vitamin D gene polymorphism CYP24A1
• Genes May Play a Role in Vitamin D Deficiency
• Osteoporosis is associated with more than vitamin D genes
• Vitamin D and its active metabolites – DeLuca
• Genes associated with low vitamin D also associated with childhood tooth decay
• Genome-wide view on the physiology of vitamin D – ebook
• Genome-wide view on the physiology of vitamin D
• Vitamin D targets 4 MS genes
• Increased risk of multiple sclerosis risk in African Americans due to genes
• Poorly functioning Vitamin D Receptor (VDR) was 5X more likely in children with low vitamin D levels
• Immune modulation by Vitamin D, food allergy, chart of genes
• Magnesium level can also be low due to genetics and drugs
• No apparent genetic association between vitamin D and obesity
• Genes in the blood are not static, 20 percent change with the seasons - such as Vitamin D Receptor
• Skin damaged by sun helped by vitamin D supplementation - pilot study
• Genes account for less than 18 percent of variation in vitamin D levels
• Vitamin D level can be high, but little benefit: due to kidney, genes, low Magnesium etc.
• Increased mortality associated with low vitamin D genes
• Multiple Sclerosis is connected to Vitamin D by gene to gene interactions
• Parkinson's disease and LRRK2 gene
• Asthma related to vitamin D by 4 plausible genes
• Asthma strongly associated with modification in vitamin D genes
• Possible ways that vitamin D does its magic
• Impact of vitamin D on immune function: lessons learned from genome-wide analysis
• Vitamin D Genes varied seasonally with European but not Asian ancestors – VDBP
• Colorectal cancer – need more vitamin D if you have certain genes
• Response to vitamin D related to DBP and CYP2RI genes
• Genes breast cancer and vitamin D receptor
• Melanoma risk 2X to 4X higher if Vitamin D receptor genes had morphed
• Melanoma and Vitamin D genes - multiple papers
• Vitamin D and microRNAs in bone
• Diabetics with 8ng less vitamin D had a 50 percent increase chance of DHCR7 gene variation
• Vitamin D may block the obesity gene (FTO)
• New approaches to bones, genes, and vitamin D
• Mice lacking CYP2R1 enzyme activate about half of much vitamin D
• 40 percent less likely to get adequate vitamin D response if have certain genes
• RXRA gene activity at birth weakly associated with bone density at age 4
• Pancreatic Cancer association with PRKCA gene and the active form of vitamin D
• Race vs vitamin D level - Veith
• Response to Vitamin D3 varied with rs4588, D2 less response than D3 and did not change
• Migration to Northern Latitudes enabled by mutation of gene: DHCR7 resulting in more vitamin D
• Epigenetics of prostate cancer and vitamin D
• Trying to understand the effect of genetics vitamin D levels in the blood
• Lupus in blacks associated with low vitamin D AND short telomeres
• Telomeres longer for dialysis patients having higher levels of vitamin D
• Melanoma reduces by half the amount of vitamin D activated by the skin
• Genes in white blood cells of blacks associated with vitamin D deficiency
• Genes and different vitamin D related substances in the skin
• Vitamin D - Health panacea or false prophet (Klotho gene)
• Vitamin D gene expression associated with diseases
• Difference in Fok gene reduced response to vitamin D by 35 percent
• Genetic influence on Vitamin D is small compared to environmental influence
• Learning about MS and vitamin D in offspring from mice
• Unsure of association of vitamin D and prostate Cancer - 2011
• Twins reduction in vitamin D in the winter or summer
• CYP24A1 gene, kidney disease, and vitamin D
• Genetic differences explain some of vitamin D variation in African-Americans
• Vitamin D insufficiency 2.5X more likely with three genes – Lancet
• Vitamin D Shows Promise in Curing Baldness
• Hypothesis: Stem cells need vitamin D too
• Metabolites and genes may predict responses to Calcium and Vitamin D
• Food allergy 80 percent more likely if have certain genes and vitamin D deficient
• Vitamin D, Allergy, and genetics
• Novel vitamin D gene regulation – CYP21A2
• People 2 cm taller had different Calcium and Vitamin D genotypes
• MS and vitamin D may be related by HLA gene
• MS due to low level of vitamin D may be due to a specific gene
• Genes affect vitamin D processing in many places - 2010
• Genetics and colon cancer with only 400 IU of vitamin D – Dissertation
• Vitamin D genes and insulin resistance – MS
• Genome-wide association study of circulating vitamin D levels
• Unable to find a gene linking vitamin D and MS
• People with TB and one geneotype benefited more from 10000 IU of vitamin D
• Hypothesis of Diet disease and pigment variation in humans
• UVB Psoriasis and Genes
• Gene variations were not associated with risk of colorectal cancer in Czech