Vitamin D levels massively changed by CYP3A4 gene (drugs such as Ivermectin and anti-epileptics)
Deactivation of CYP3A4 by drugs such as IvermectinINCREASE calcitriol and calcidriol (Vitamin D)
Activation of CYP3A4 by drugs (anti-epileptics. Valium etc DECREASE calcitriol and calcidriol (Vitamin D)
Ivermectin raises levels of vitamin D (by decreasing CYP3A4)
Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022
Changes in CYP3A4 gene affects Vitamin D, health, reactions to some drugs, etc - June 2022
Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities,
targeting CYP3A4*1G allele function. - PDFInterplay between Vitamin D and the Drug Metabolizing Enzyme CYP3A4 - July 2014 - PDF
- "For example, daily administration of rifampin (anti-epileptic) to healthy volunteers lowered the plasma concentration of 25OHD3 by 70% "
CYP3A4 mutation causes vitamin D–dependent rickets type 3 - Feb 2018 - PDF
Role of vitamin D receptor in the regulation of CYP3A gene expression - Nov 2019 - PDF
VDR regulates CYP3A4 2002 PDF
Valium, Xanax change activation of CYP3A4, which decreases calcitriol and calcidriol Perplexity AI PDF July 2025
Large doses of flavanoids might reduce activation of CYP3A4 (increasing Vitamin D getting to cells) - 2024 FREE PDF
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CYP3A4 Wikipedia
CYP3A4metabolizes about half of all drugs: examples include:acetaminophen, codeine, ciclosporin (cyclosporin), diazepam, and erythromycin
grapefruit juice ... is a potent inhibitor of CYP3A4, which can affect the metabolism of a variety of drugs, increasing their bioavailability.