Pages tagged with "Loading dose"

229 pages, most important first (overviews, then meta-analyses, then RCTs, then newest). Combine with another topic

• Loading Doses - when you need Vitamin D now, not months from now - video and summary
• Vitamin D: 40-60 ng/mL, Dr. Holick, taking 6,000 IU daily, is at 80ng - video & summary Feb 2025
• Overview Loading of vitamin D
• Vitamin D Deficiency Flowchart for UK Primary Care
• COVID-19 Vitamin D Overview - Sunil video and transcript
• 372 types of vitamin D prescriptions in France, 200,000 IU was the most popular
• Huge gap between vitamin D advice and actual prescriptions
• Grade A recommendations for vitamin D
• NAFLD and Vitamin D - many studies
• ICU patients typically benefit from 300-500,000 IU of Vitamin D - many studies
• Vitamin D is needed before many surgeries – many studies and RCTs
• Infectious Mononucleosis (virus) and Vitamin D - many studies
• Common cause of dizziness (BPPV) reduced 5 X by several doses of 50,000 IU of vitamin D – several studies
• High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis
• Vitamin D before surgery helped again (Thyroid in this case) - meta-analysis
• Low Back Pain not helped by vitamin D if low dose or short duration (loading dose does help however) - meta-analysis
• Vitamin D loading doses quickly and safely raise levels – meta-analysis
• Small amounts of Vitamin D reduce Influenza risk by 22 percent (loading dose is far better) – meta-analysis
• ICU mortality reduced by non-oral vitamin D – meta-analysis
• Fewer days in ICU after 300,000 IU of vitamin D, but not 540,000 – meta-analysis
• Vitamin D loading doses reduce ICU mortality by 30 percent – meta-analysis
• Vitamin D loading doses of up to 400,000 IU OK for adolescents – meta-analysis
• COVID-19 defeated 3x faster by 420,000 IU Vitamin D nanoemulsion – RCT
• Single 600,000 IU dose of nanoemulsion Vitamin D is safe and effective to fight COVID, even if delay until enter ICU – RCT
• Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT
• Severe sepsis may be prevented by 400,000 IU of vitamin D – RCT 2023
• Resistance training 3X weekly in Type 2 Diabetes – 12 weeks - tiny RCT
• 400,000 IU of vitamin D 3 days after COVID symptoms reduced 14 day mortality by 3X – Annweiler RCT
• Vitamin D average level was 33 ng after 400,000 IU in 2 months - RCT
• Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT
• In vitro fertilization NOT helped by 600,000 IU of vitamin D – RCT
• Half as much AFIB after bypass if 600,000 IU of vitamin D before surgery – RCT
• Esophageal Cancer surgery helped by 300,000 IU of Vitamin D – RCT
• Major Depressive Disorder RCTs often use Vitamin D: 50,000 IU weekly or single 300,000 IU - Review
• Birth rates doubled with Vitamin D - 300,000 IU for infertile men – RCT
• ICU patients 6X more likely to die if poor response to 570,000 IU of Vitamin D – RCT
• Surgery complications cut in half by 300,000 IU of vitamin D 2 weeks before (hip and knee) – RCT
• Vitamin D loading doses typically helped critically ill, but never harmed (21 RCTs)
• 44 percent of successful RCTs in VitaminDWiki used non-daily dosing
• Less ultramarathon heart damage if take 150,000 IU of Vitamin D a day earlier – RCT
• Vitamin D loading dose of 30,000 IU twice a week is safe and effective – RCT
• Vitamin D 100,000 IU loading dose and stem cell transplants – RCT
• ICU Vitamin D injection (300,000 IU) helped - RCT
• 3X less Septic Shock in children with sepsis getting 150,000 IU of Vitamin D - RCT
• Half as many problems if take Vitamin D (300,000 IU) before thyroidectomy – RCT
• COVID recovery 1.6X faster after 200,000 IU of Vitamin D RCT
• Taking Vitamin D just before and after surgery helps (open-heart in this case) – RCT
• Loading dose of Vitamin D for patients hospitalized with COVID (140,000 IU) – RCT completed 2021
• Stoss (loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT
• Non-Alcoholic Fatty Liver Disease (NAFLD) treated by Vitamin D (20,000 IU weekly after loading dose) – RCT
• Fewer days in hospital if 300,000 IU of vitamin D before brain surgery - RCT
• Vitamin D supplementation protocols: loading, injection, etc – RCT
• Single 200,000 IU of vitamin D did not benefit the obese in various ways (not a surprise) – RCT
• Hip surgery with multiple doses of 50,000 IU of vitamin D weekly both before and after – RCT 2023
• Inflammation reduced by a single dose of Vitamin D (200,000 IU) – RCT
• Ulcerative Colitis significantly reduced by 480,000 IU loading dose of nano Vitamin D – RCT
• Recurrence of child pneumonia delayed by 100000 IU of vitamin D – RCT
• Wisdom tooth (3rd molar) extraction helped by Vitamin D loading dose – RCT
• Severe COVID-19 not fought by vitamin D when given too late - RCT
• Far more Vitamin D in breast milk from a 150,000 IU dose than from daily 5,000 IU – RCT
• Takes a year to restore children and youths to good levels of vitamin D without loading dose - RCT
• Those getting an injection of 300,000 IU Vitamin D got out of the ICU a week sooner – RCT
• 500,000 IU of vitamin D cut in half the hospital days following a lung failure – RCT 2015
• Early Rheumatoid Arthritis helped by 300,000 IU of vitamin D – RCT
• Vitamin D reduced depression – single 300,000 IU – RCT
• Elderly Vitamin D Loading Dose of 500,000 IU is safe and effective – RCT 2009
• Vitamin D injection is far better than oral for diabetics (poor gut) – RCT
• Pregnancies helped a lot by Vitamin D (injection then 50,000 IU monthly) – RCT
• 300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT
• ICU adults getting 540,000 IU of Vitamin D were 2X more likely to be alive 30 days later – RCT
• 5 days of 100,000 IU of Vitamin D increased hemoglobin in critical illness – RCT
• Newborn Vitamin D - single 50,000 IU is better than daily – RCT
• Several Diabetic pains reduced by injection of 300,000 IU of Vitamin D – RCT
• 100,000 IU daily of Vitamin D for 5 days increased Hemoglobin in Mechanically Ventilated adults – RCT
• 2X improved development by severely malnourished children with 2 loading doses of vitamin D – RCT
• Child soccer players who were deficient were helped by a single 200,000 IU vitamin D dose – RCT
• 10 fewer days of ICU Mechanical Ventilation 300,000 IU injection of vitamin D – RCT
• Diabetes (Type II) reduced by single injection of 300,000 IU of vitamin D3 – RCT
• Ulcerative colitis treated by injection of 300,000 IU of vitamin D – RCT
• Vitamin D levels in children optimized with six Vitamin D biscuits – RCT
• Traumatic Brain Injury – 120,000 IU of Vitamin D resulted in 3 fewer days on ventilators – RCT
• Rapidly restore Vitamin D levels with 10,000 IU per kg for children in ICU – RCT 2024
• COPD quality of life improved by 400,000 IU Vitamin D loading dose – RCT
• Biochemical rickets non-existent if breastfeeding mother got 600,000 IU of vitamin D (3 dollars) – RCT
• VITdAL-ICU - AMA RCT
• Spinal Cord injury outcome was better if got Vitamin D and progesterone within 4 hours – RCT 2016
• Loading dose greatly improves subsequent daily Vitamin D if have liver fibrosis – RCT
• Rickets virtually cured by 90,000 IU of Vitamin D along with daily Calcium – RCT
• PMS reduced by half in girls who had low levels of vitamin D – RCT
• Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT
• Vitamin D loading dose of 300,000 IU for children – 3 weeks with capsules, biscuits, injection – RCT
• Bone health not improved in 2 months of Vitamin D (need 6 months or loading dose) – RCT
• Vitamin D loading dose after hip fracture surgery was great – RCT
• Single dose (up to 60,000 IU) vitamin D raised levels in 87 percent of Cystic fibrosis patients – RCT
• Fatigue reduced by a single dose of vitamin D (100,000 IU) – RCT
• Pneumonia in children not stopped for 6 months by single dose of vitamin D (3 months max) – RCT
• Vitamin D in 9 minutes (8,000 IU daily, etc) video - Dec 2025
• First trimester problems 5X more likely if start supplemention with 4,000 of Vitamin D weeks AFTER conception
• Critically ill children – randomized clinical trial to give single doses of up to 400,000 IU of vitamin D – 2019
• 3X more likely to have significant pain after Breast Cancer Surgery if low Vitamin D
• Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection
• Vitamin D injection of 600,000 IU (response by 10 individuals)
• 600,000 IU of vitamin D – 42 ng at 3 months for 1 inj, 3 inj, oral monthly, oral weekly
• Megadose injection of up to 600,000 IU vitamin D3 every three months for adolescents
• 600,000 IU intramuscular D3 helped BMD after pancreatic surgery
• 600000 IU dose raised youth vitamin D level by 60 ng in 3 days
• 600,000 IU of vitamin D2 every 4 months for decades in East Germany – 1987
• 600,000 vitamin D loading doses – good response to both oral and muscular
• Diabetic neuropathy reduced by injection of 600,000 IU of vitamin D
• Neuropathy - 5X more had a good Quality of Life after 600,000 IU of Vitamin D - 2017
• 600,000 IU of Vitamin D helped 26 out of 28 COVID-19 patients in ICU (Brazil and Bolivia)
• Vitamin D Loading dose (100K IU daily, 14 days) great benefit if severe traumatic lung contusion
• After a TIA, the risk of ischemic stroke reduced 2.4X by a single loading dose of Vitamin D
• Can get 50,000 IU Vitamin D anywhere on the globe
• Cancer Immunotherapy is enhanced by a Vitamin D loading dose
• Vitamin D meets Hill’s Criteria for fighting COVID (adult about 5,000 IU daily)
• Loading dose of 60,000 IU Vitamin D once a week for 5 weeks safely raised deficient to above 30 ng
• Growing pains reduced in 91% of children with a single dose of Vitamin D
• Large dose of vitamin D (200,000 IU) lasts for less than 90 days
• Children in Intensive Care need Vitamin D loading dose of 10000 IU per kg (nearing a consensus)
• Large dose Vitamin D before surgery was found to help by 35 studies
• Loading dose of 300,000 IU Vitamin D got most above 20 ng in a week
• Hospital ICU added high dose vitamin D - malpractice lawsuit costs dropped from 26 million dollars to ZERO
• Residents of a Nursing Home who choose monthly Vitamin D had 4X fewer COVID-19 deaths
• 40 cents of Vitamin D given once during pregnancy reduced respiratory problems by 3%
• Call to action – more Vitamin D for pregnancies, loading doses are OK – Holick
• Breastfeeding Vitamin D loading dose of 300,000 IU is OK - UK govt.
• Childhood cancers – give Vitamin D loading dose if low
• Large Vitamin D loading doses recomended (Italy, goal 40-60 ng) - 2011
• Rickets cured for 3 months with 10,000 IU per kg vitamin D (600,000 IU max)
• Loading Dose of Vitamin D
• Pain relieved by Vitamin D if trial lasted more than 5 months (endometriosis, 50K weekly for 12 months)
• COVID patients not helped by 500K IU of Vitamin D (they already had enough)
• Can You Overdose on Vitamin D - It's Harder Than You Think
• Pediatric trials of high dose vitamin D -163 are in a single online database
• Fast responses to Vitamin D – loading dose, nanoemulsion and Calcifediol
• 3,200 IU of Vitamin D for 3 weeks before colon cancer surgery helped a bit (higher or loading dose would be much better)
• Those getting high dose vitamin D were 7 X less likely to die of COVID-19
• Treat COVID with early high-dose Vitamin D (20th as of June 2022)
• Vitamin D deficiency somewhat treated with weekly 50000 IU Vitamin D2
• Guideline following hip fracture – 50000 IU vitamin D daily for 7 days
• Take lots of Vitamin D at first signs of COVID
• Reasons for Low Vitamin D and what to do
• Better Surgical outcomes if preceded by Vitamin D loading dose
• Inflammatory markers reduced by single 80,000 IU of vitamin D (Saudi)
• Surgeries often deplete Vitamin D - 300,000 IU resulted in little response
• Vitamin D could be restored in 60 days (actually much faster)
• COVID Ventilation 2X less likely if 200,000 IU of Vitamin D when enter hospital
• Vitamin D and COVID, review of evidence, loading dose if less than 50 ng - Masterjohn
• Rapid Vitamin D Delivery May Result in Better COVID Outcomes
• Vitamin D and UV safe and toxic doses - Vieth 1999
• FLCCC COVID guidelines now include vitamin D loading doses
• Vitamin D loading dose (stoss therapy) proven to improve health
• Vitamin D restored in teens by doses totalling 300,000 IU
• French recommended 200,000 IU of Vitamin D to stop COVID-19
• Vitamin D has eliminated ICU COVID-19 in hospital in Dubai since June
• Vitamin D restoration then monthly was the most popular dosing by trials
• COVID-19 mortality reduced 4X (chart looks like 2X) by large, infrequent doses of Vitamin D in France
• French National Academy recommended 100,000 IU of Vitamin D to elderly to fight COVID-19
• Critically ill need vitamin D – how much and which test to use is TBD
• Temporary hair loss (Telogen Effluvium) treated by Vitamin D (200,000 IU, twice a month)
• Traumatic Brain Injury recovery helped by injection of 100,000 IU of Vitamin D
• 400,000 IU of vitamin D reduced adult pain and improved quality of life
• Rheumatoid Arthritis nicely treated by Vitamin D (300,000 IU loading dose)
• Large single dose of more than 300,000 IU of vitamin D works well for 3 months – Review
• Use of Vitamin D in a trauma surgery - Dr. Matthews on Facebook
• ICU patients greatly helped by Vitamin D loading doses – if gut-friendly
• Vitamin D – individual responses to 100,000 IU
• Vitamin D Replentishment (Loading doses are not toxic)
• Vitamin D injections of a total of 1,800,000 IU reduced shinbone tenderness
• Lupus flares totally eliminated by loading dose then 100000 IU of vitamin D each month
• Intensive Care (ICU) helped by Vitamin D – review of past and on-going studies
• Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing
• Loading dose for Vitamin D
• Healthy in Seven Days - Loading dose of Vitamin D – book 2014
• Vitamin D during pregnancy – single 200,000 IU similar to daily 5,000 IU
• Cerebral malaria deaths prevented by loading dose of vitamin D (mice)
• Sickle cell Vitamin D deficiency corrected with 160 K IU loading dose
• 600,000 IU vitamin D normalized virtually all seniors in 3 months (Injection better than oral)
• Variety of vitamin D loading dose recommendations in the UK - 2011
• ICU survival increased with vitamin D single 540K IU loading dose - JAMA
• Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome
• Rheumatoid arthritis reduced by 440,000 IU of Vitamin D over 4 months
• Treating Vitamin D deficiency in senior women – such as 50,000 IU daily for 15 days then twice a month – Review
• Vitamin D3 loading dose of 500,000 IU for elderly
• Infant Vitamin D doubles 6 months after birth (can double in 2 weeks)
• 100,000 IU Vitamin D weekly for 4 weeks is safe and effective for children
• Vitamin D levels of seniors restored with 50,000 IU weekly for 8 weeks
• Bio-available Vitamin D following mega-doses (up to 500,000 IU) – Clinical trial due 2018
• Congenital Heart problems - vitamin D levels drop even lower after surgery, loading dose probably required - thesis 2015
• Restore Vitamin D levels with 200,000–400,000 IU over 2 months, followed by on-going
• Clinical trials using a LOT of vitamin D intervention
• Weekly dosing of vitamin D is far better than single large dose (chronic liver, children)
• Loading dose of 300,000 IU of vitamin D does not last long
• Just 2 doses of Vitamin D resulted in many benefits (Chronic Kidney Disease)
• Vitamin D injection helped migrants a bit, but some had poor or even negative responses
• Vitamin D injection lasts longer and has bigger response than weekly oral
• 200,000 IU restored levels in HIV children having low vitamin D
• Turkey prescribed 400 IU for all infants, with loading dose for those with rickets – 2005
• Canadian grant funding lost for prescribing 50,000 IU of vitamin D
• Vitamin D loading dose then weekly 50,000 IU not help (COPD) if very deficient
• Long time between large vitamin D injections resulted in 6X increase in health complaints
• Injection of 300,000 IU of vitamin D3 similar to 10 months of oral 25,000 IU
• 300000 IU injection of vitamin D3
• Review of Vitamin D (including free, frequency, injection, how much.)
• Quick restoration of vitamin D in children – 10,000 IU per kg loading dose was not enough
• 80,000 IU monthly winter vitamin D got all healthy people above 20 ng (need more)
• 300,000 IU loading dose of vitamin D does not help the obese much
• Single 300,000 IU Vitamin D dose lasts about 2 months
• Neonate loading dose of 30,000 IU vitamin D helped a lot
• Vitamin D Loading dose - 20,000 IU daily is not enough if obese, etc. (Cancer) great table and chart
• Normalize vitamin D safely within 1-2 weeks
• Loading dose of Vitamin D2 REDUCED vitamin D blood in a third of the patients
• 100,000 IU single dose of vitamin D - 2010
• Osteoporosis Society UK: 20 ng vitamin D is sufficient, loading dose 300,000 IU
• Will vitamin D loading dose and 50,000 IU monthly will help after melanoma surgery
• 300000 IU vitamin D monthly may treat MS
• 540000 IU before ICU raised vitamin D by 25 ng in 2 days
• Barefoot on mega doses of vitamin D and his book on Cancer
• Vitamin D for Italians – Senior 2300 IU, if deficient loading dose of at least 300,000 IU– Med Society 2011
• 300,000 IU every 3 months helped raise vitamin D levels in half of RA patients
• Hip surgery followed by 100000 IU then 1000 IU of vitamin D daily
• Loading dose of 300,000 IU vitamin D every 6 months
• France attempts to restock vitamin D levels with 7000 or 14000 IU daily
• Half of the seniors needed more than 1700 IU vitamin D3 (50000 monthly)
• Vitamin D2 loading doses did not increase, and may have decreased blood levels
• 300,000 IU vitamin D helped seniors in many ways
• Critical reappraisal of vitamin D deficiency – 800 IU and some megadose
• 300000 IU of vitamin D every 3 months may not have been enough