Dementia 4.1 X high risk in those with low Vitamin D, Omega-3, etc.2 decades before (behind paywall) – Nov 2021

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A Biological Index to Screen Multi-Micronutrient Deficiencies Associated with the Risk to Develop Dementia in Older Persons from the Community

J Alzheimers Dis. 2021 Nov 18. doi: 10.3233/JAD-215011
Jeanne Neuffer 1, Marjorie Gourru 1, Aline Thomas 1, Sophie Lefèvre-Arbogast 1, Alexandra Foubert-Samier 2, Catherine Helmer 1, Cécile Delcourt 1, Catherine Féart 1, Cécilia Samieri 1

Background: Low blood status in several nutritional compounds, including long-chain omega-3 fatty acids (LC n-3 PUFA), carotenoids, and vitamin D, have been associated with a higher risk to develop dementia. Nutritional deficiencies may potentiate each other regarding dementia risk; yet the association of multiple nutritional deficiencies with dementia has been little explored.

Objective: To develop an index of micronutritional biological status (MNBS) for the screening of multi-micronutritional deficiencies associated with the risk of dementia in a prospective population-based cohort of older persons.

Methods: We included participants from the Bordeaux Three-City study, who were free of dementia at baseline, had blood measurements of LC n-3 PUFA, carotenoids, and 25(OH)D, and who were followed for up to 18 years for dementia. We used penalized splines in Cox models to model dose-response relationships of each nutritional component with the risk of dementia and construct a risk index.

Results: 629 participants with an average age of 73.1 years were included in the study. Each increase of 1 SD of the MNBS index was associated with a 46%higher risk of dementia (HR = 1.46, 95%CI 1.23; 1.73). Participants with highest index (mean+1SD; max) had a 4-fold increased risk of dementia compared with participants with a low index (min; mean-1SD) (HR = 4.17, 95%CI 2.30; 7.57).

Conclusion: This index of assessment of micronutritional biological status is a practical tool that may help identify populations with inadequate nutritional status, screen eligible individuals for nutritional prevention in primary care, or for supplementation in preventive trials of dementia.

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VitaminDWiki - Cognition and Vitamin D - a few studies

Genes restrict vitamin D from getting to brain cells

• Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues – Sept 2018
• 8 genes associated with both Alzheimer’s and lowish Vitamin D – May 2019
• 2X higher risk of Alzheimer’s if poor Vitamin D Receptor – Meta-analysis June 2021

Getting Vitamin D reduces or halt cognitive decline

• Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
• Schizophrenia reduced by biweekly 50,000 IU Vitamin D and probiotics – RCT Feb 2019
• Cognitive function of adult women improved in 3 months of 50,000 IU weekly Vitamin D – Jan 2019

VitaminDWiki - Cognitive and Omega-3 studies

VitaminDWiki - Cognitive category starts with

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
Dementia page - 50 items

376 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (7 studies), Genetics (9 studies), Vitamin D Receptor (16 studies), Omega-3 (49 studies), Intervention (19 studies), Meta-analyses (22 studies), Depression (23 studies), Parkinson's (22 studies)
Click here for details

Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023

Types of evidence that Vitamin D helps brain problems - 2014

VitaminDWiki - Alzheimers-Cognition - Overview starts with

VitaminDWiki - Overview Schizophrenia and Vitamin D starts with

14 reasons to think that schizophrenia is associated with low vitamin D
1) 97% of patients with schizophrenia are vitamin D deficient
2) Schizophrenia varies with latitude (UVB) by 10X (controversy)
3) Schizophrenia is more common in those with dark skin (when away from the equator)
4) Schizophrenia is associated with low natal vitamin D
5) Schizophrenia has been increasing around the world when vitamin D has been decreasing (controversy)
6) Schizophrenia is associated with low birth rate, which is associated with low vitamin D
7) Schizophrenia is associated with Autism which is associated with low vitamin D
8) Schizophrenia Bulletin Editorial (Jan 2014) speculated that Vitamin D could be a major player
9) Schizophrenia 2X more likely if low vitamin D - meta-analysis
10) Schizophrenia increased 40 % for Spring births after Danes stopped vitamin D fortification
11) Schizophrenia is associated with season of birth
12) Schizophrenia is associated with poor Vitamin D Receptor genes
13) Schizophrenia risk is decreased if give Vitamin D after birth
14) Schizophrenia symptoms reduced when Vitamin D levels are restored

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VitaminDWiki pages with DEMENTIA in title (40 as of May 2022)

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