JMBR https://doi.org/10.1002/jbm4.10581
Glenville Jones,Martin Kaufmann
Ratio of metabolites provides an interesting view
The assay of vitamin D that began in the 1970s with the quantification of one or two metabolites, 25-OH-D or 1,25-(OH)2D, continues to evolve with the emergence of liquid chromatography tandem mass spectrometry (LC-MS/MS) as the technique of choice. This highly accurate, specific, and sensitive technique has been adopted by many fields of endocrinology for the measurement of multiple other components of the metabolome, and its advantage is that it not only makes it feasible to assay 25-OH-D or 1,25-(OH)2D but also other circulating vitamin D metabolites in the vitamin D metabolome. In the process, this broadens the spectrum of vitamin D metabolites, which the clinician can use to evaluate the many complex genetic and acquired diseases of calcium and phosphate homeostasis involving vitamin D. Several examples are provided in this review that additional metabolites (eg, 24,25-(OH)2D3, 25-OH-D3-26,23-lactone, and 1,24,25-(OH)3D3) or their ratios with the main forms offer valuable additional diagnostic information. This approach illustrates that biomarkers of disease can also include metabolites devoid of biological activity. Herein, a case is presented that the decision to switch to a LC-MS/MS technology permits the measurement of a larger number of vitamin D metabolites simultaneously and does not need to lead to a dramatic increase in cost or complexity because the technique uses a highly versatile tandem mass spectrometer with plenty of reserve analytical capacity. Physicians are encouraged to consider adding this rapidly evolving technique aimed at evaluating the wider vitamin D metabolome toward streamlining their approach to calcium– and phosphate-related disease states.
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VitaminDWiki - CYP27B1 category listing contains the following
The CYP27B1 gene activates Vitamin D in the Kidney, Skin, Lungs, Brain, Eyes Breasts etc.
Poor CYP27B1 is assocated with COVID, Miscarriage, Lupus, Alz, Parkinson, MSA, Rickets
CYtochrome P450 family 27 subfamily B member 1 = 25-Hydroxyvitamin D3 1-alpha-hydroxylase
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items in CYP27B1 category
| 343 |
articles in the Genetics
| 530 |
articles in Vitamin D Receptor
| 178 |
articles in Vitamin D Binding Protein
- CYP27B1 and other genes are less activated in seniors
- CYP27B causes many health problems – March 2020
- Every Parkinson’s brain had a poor CYP27B1 gene
What can be done if have a poor CYP27B1
- Larger doses of Vitamin D
- More Bio-available: Gut-friendly form, Topical form, taken with fatty meal, taken with evening meal
- Additional sources: UV
- Increase Vitamin D metabolism: additional Magnesium, Omega-3
- All cytochrome P450 enzymes require Mg++ as a cofactor
- Increase the amount of Vitamin D in the blood that gets to cells: increase activation of VDR
Vitamin D blood test misses CYP27B1 and other genes
VitaminDWiki pages with CYP24A1 in title (27 as of Dec 2021)
This list is automatically updated
Items found: 40
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Vitamin D suppressed by Roundup and Genes - CYP2R1, CYP24A1, CYP450 etc. |
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03 Dec, 2024 |
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Suppression of CYP24A1 gene got more Vitamin D to cells to fight Breast Cancer – March 2023 |
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10 Aug, 2024 |
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Schizophrenia associated with low Vitamin D and CYP2R1, CYP27B1, and CYP24A1 – June 2024 |
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31 Jul, 2024 |
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Acupuncture of scalp activates Vitamin D genes CYP27a1, CYP27b1, and CYP24a (rats with strokes) – May 2024 |
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23 May, 2024 |
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Cancers are sometimes associated with poor CYP24A1 gene (Vitamin D) (Bladder Cancer in this case) – April 2024 |
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23 Apr, 2024 |
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Rare mutation of CYP24A1 gene results in Vitamin D accumulating |
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19 Jul, 2023 |
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CYP24A1 gene and Vitamin D - many studies |
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16 May, 2023 |
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Get Multiple Sclerosis while younger if have a poor CYP24A1 vitamin D gene – May 2023 |
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16 May, 2023 |
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Breast Cancer chemotherapy improved if able to suppress a vitamin D gene (CYP24A1) – May 2023 |
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18 Mar, 2023 |
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No response to vitamin D 7X more likely if poor CYP24A1 or VDBP genes - Feb 2023 |
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11 Feb, 2023 |
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Vitamin D non-responders may have one or more poor genes: GC, LIPC, CYP24A1, and PDE3B – Oct 2022 |
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10 Feb, 2023 |
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Vitamin D resistant genes (CYP24A1, SMRT, SNAIL) – July 2022 |
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13 Dec, 2022 |
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Increased Phosphorus increases Vitamin D getting to cells (CYP24A1, pigs) - Aug 2022 |
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25 Aug, 2022 |
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Poor genes (DBP, CYP24A1, CYP2R, etc.) restrict Vitamin D to cells, increasing COVID hospitalization – May 2022 |
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18 May, 2022 |
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Suicide attempts by males 3.7 X more likely if poor Vitamin D gene (CYP24A1) – Oct 2021 |
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08 May, 2022 |
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Vitamin D Metabolite Profiling and genes (CYP24A1, CYP27B1)– Nov 2021 |
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08 Dec, 2021 |
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3X higher risk of oral cancer if CYP27B1 and CYP24A1 genes were different – May 2012 |
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22 Jan, 2021 |
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Hypertension 2X more likely if poor CYP24A1 vitamin D gene (China) – Jan 2020 |
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10 Jan, 2020 |
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Eye vitamin D may not be associated with blood VitD, but is associated with CYP27B1 and CYP24A1 – Nov 2019 |
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18 Nov, 2019 |
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Kidney Stones are related to poor genes – example of CYP24A1 (Vitamin D) – Nov 2019 |
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16 Nov, 2019 |
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Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019 |
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15 Nov, 2019 |
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Acute Coronary Syndrome is associated with poor Vitamin D genes (CYP27B1, CYP24A1) – Nov 2019 |
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15 Nov, 2019 |
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Increased risk of weight gain when gene restricts Vitamin D getting to tissues (CYP24A1 in this case) – Nov 2019 |
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07 Nov, 2019 |
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CYP24A1 gene in cancer cells may actually remove vitamin D from the blood – Oct 2012 |
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16 May, 2019 |
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Hepatitis C 1.4X more likely if poor CYP24A1 gene – May 2019 |
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08 May, 2019 |
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Natural pregnancy 4X more likely if sperm had a lot of CYP24A1 – April 2019 |
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10 Apr, 2019 |
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Vitamin D accumulation in 1 in 300 people due to gene (CYP24A1) can cause Calcium problems – June 2018 |
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31 Dec, 2018 |
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CYP24A1 gene mutation is a cause of rare infant vitamin D toxicity – Aug 2011 |
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31 Dec, 2018 |
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Maternal diabetes with poor Vitamin D gene (CYP24A1) increases risk of diabetes in female offspring by 40 percent – Jan 2018 |
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24 Jan, 2018 |
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Vitamin D gene (CYP24A1) changes decrease breast and pancreatic cancers – meta-analysis Nov 2017 |
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20 Dec, 2017 |
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Calcium problems associated with CYP24A1 (a Vitamin D gene) – Oct 2017 |
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08 Nov, 2017 |
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If Lupus in family – 5 times more likely to get Lupus if low vitamin D and poor CYP24A1 – June 2016 |
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07 Jun, 2017 |
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Breast Cancer rate reduced 72 percent by vitamin D gene polymorphism CYP24A1 – Nov 2014 |
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30 Mar, 2016 |
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Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1 – Nov 2015 |
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16 Nov, 2015 |
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Prostate Cancer – Vitamin D – CYP27B1 – CYP24 – June 2011 |
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16 Nov, 2015 |
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Genes such as CYP27B1, CYP24A1 and Vitamin D – JAMA Nov 2012 |
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16 Nov, 2015 |
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Mutations in CYP24A1 gene (vitamin D) associated with kidney problems – Jan 2013 |
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16 Nov, 2015 |
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Activation (methylation) of CYP2R1 and CYP24A1 predict response to dose of vitamin D – Oct 2013 |
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24 Feb, 2015 |
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Breast cancer and Vitamin D receptors, CP27B1, and CYP24A1 – Sept 2010 |
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26 Nov, 2014 |
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CYP24A1 gene, kidney disease, and vitamin D - May 2011 |
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02 Nov, 2012 |