Proof that Vitamin D Works

Created January 2011

Vitamin D prevents or treats 99 health problems

ADHD,  Alcoholic Liver Cirrhosis,  ALS,  Alzheimer's,  Antibiotic Use in Seniors,  Asthma,  Autism,  Autoimmune Diseases,   Back pain,  Blood Cell Cancer,   Breast Cancer,   Cardiovascular,  Cholesterol,  Chronic Hives,  Chronic Kidney Disease,  Cluster Headaches,  Congestive Heart Failure (Infants),  COPD,  Crohn's Disease,  C-Section and Pregnancy Risks,  Cystic Fibrosis,   Dengue Fever,  Depression,   Diabetes,  Diabetic Neuropathy,  Eczema,  Epilepsy,   Falls,  Fatigue,  Fatty Liver (Child),  Fibromyalgia,  Gestational Diabetes,  Gingivitis,  Growing Pains,  Hay Fever,  Heart Attack,  Hemodialysis,  Hepatitis-C,   Hip Fractures,  Hypertension,  ICU survival,  Influenza,  Irritable Bowel Syndrome,  Ischemic Stroke,  Knee Osteoarthritis,  Leg Ulcers,  Long-COVID,   Low Birth Weight,  Lupus,  Male Infertility,   Menstrual Pain,  Metabolic Syndrome,  Middle Ear Infection (Infants),  Mite Allergy,  Multiple Sclerosis,  Non-Alcoholic Fatty Liver Disease,  Osteoarthritis,  Parkinson's Disease,  Perinatal Depression,  Pneumonia (Ventilator-associated),  Poor Sleep,  PreDiabetes,  Preeclampsia,  Pre-term Birth,  Prostate Cancer, Psoriasis,  Quality of Life,   Raynaud's Pain,   Respiratory Tract Infection,  Restless Leg Syndrome,   Rheumatoid Arthritis,   Rickets,  Sarcopenia,  Sepsis,  Short Neonates,  Sickle Cell,  Stronger Senior Muscles,  Survive ICU,  TB,  Tonsillitis,  Trauma Death,  Traumatic Brain Injury,  Tuberculosis,  Ulcerative Colitis,  Urinary Tract Infection,  Vaginosis,  Vertigo,  Warts,  Weight Loss

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Click on ===underlined=== items for details

Health Problem Treat
Prevent		 Reduction by Vit D RCT = Randomized Controlled Trial
   ✻ = link to additional RCT
CT = Clinical Trial
Hypertension T P 149 to 142 mm Hg
HT risk reduced 10X		 RCT ✻  ✻ , 2400 IU.  100,000 IU*
When Vitamin D > 40 ng
Cardiovascular after attack T 32 % fewer deaths CT 1000 IU
[#T1_Diabetes Diabetes Type 1](/pages/diabetes/) P 85 % 12,000 kids, 2000 IU
Diabetes Type 2 T 62 % RCT ✻ CRP reduction, 4000 IU
Injection is far better - #F00:RCT ✻
#F00:RCT 50,000 IU/2weeks + probiotics
#F00:RCT 5,000 IU daily 6 months
Back Pain T [95 %
reduced 50%](/pages/tiki-download-filephp/) 5000/10000 IU
60,000 IU weekly
Influenza P 90 % RCT #F00: *, 2000 IU
Falls P 50% RCT, 100,000 IU monthly
RCT with Meals on Wheels 2016
Hip Fractures P 30 % RCT ✻ 800 IU
Rickets P 98 % Turkey, 400 IU NOT RCT, given to all children
Raynaud's Syndrome T 40 % RCT, visual scale, 20000 IU Avg
Menstrual pain P 76 % RCT, 7000 IU Avg,
70% reduction 2018
PMS reduced by half
Pregnancy risks P 50 % RCT, 4000 IU
C-section, unplanned P 50 % RCT, 4000 IU, small study
Low birth weight P 60 % RCT ✻ 1000 IU of D2
TB P 60 % RCT, 800 IU
Breast Cancer P [Tiki-index. PHP? page_id=931] RCT, 1100 IU (2007)
Rheumatoid Arthritis pain T 40 % RCT, 500 IU, added to prescription
Cystic Fibrosis T 75 %
2nd study improved		 RCT, pilot 4X fewer deaths 250,000 IU
RCT, pilot 8,200 IU
Chronic Kidney T 90 to 70 PTH RCT, 3500 IU,
Respiratory Tract Infection P 63 % 3 RCT, 4000 IU 1 year 2nd 2000/800 IU
20,000 IU weekly
[tiki-browsecategories. PHP? parentId=31&sort;mode=created_desc] T
T 		[Tiki-index. PHP? page_id=3285]
Pain reduced		 Loading then 100,000 IU monthly,
[Tiki-index. PHP? page_id=3619]
Sickle Cell T Less pain
 RCT, up to 100,000 IU/week
Leg ulcer healing T 4X faster RCT, 50,0000 IU/week, small study
Traumatic Brain Injury T [Tiki-index. PHP? page_id=3640] RCT, 20,0000 IU/day with progesterone
Parkinson's Disease T Stabilized RCT, 1200 IU/day
Multiple Sclerosis P
T 		68%
[Tiki-index. PHP? page_id=5279]		 RCT, 7100 IU prevent pre-MS ==> MS
20,000 to 140,000 IU/day
Congestive Heart Failure T [Tiki-index. PHP? page_id=2441] RCT, 1000 IU infants ([Tiki-index. PHP? page_id=4138])
Middle Ear Infection P [Tiki-index. PHP? page_id=4133] RCT, 1000 IU infants
Gingivitis T 88 % RCT, 2000 IU
[Tiki-index. PHP? page_id=28] T [Tiki-index. PHP? page_id=4645] RCT, 4000 IU
Antibiotic use when >70y T [Tiki-index. PHP? page_id=4646] RCT, 60,000 IU monthly
Infants taller Benefit [Tiki-index. PHP? page_id=4668] RCT, 50,000 IU weekly,
for 8 weeks while pregnant
Gestational Diabetes T [Tiki-index. PHP? page_id=4676] RCT, 2 doses of 50,000 IU
After Heart Attack T [Tiki-index. PHP? page_id=4695] RCT, 800,000 IU one time
[tiki-browsecategories. PHP? parentId=43&sort;mode=created_desc] T [Tiki-index. PHP? page_id=2989] RCT, 4000 IU (2012)
Asthma P   T [Tiki-index. PHP? page_id=4745] RCT, 60K IU/month;
RCT 50K IU/week
Need good D at 4 weeks into preg.
[tiki-browsecategories. PHP? parentId=43&sort;mode=created_desc] T [Tiki-index. PHP? page_id=4757] RCT 300,000 IU injection
RCT 1500 IU helped Prozac
RCT 50,000 IU weekly, elderly
[tiki-browsecategories. PHP? parentId=109&sort;mode=created_desc] P [Tiki-index. PHP? page_id=4845] RCT, 5,000 IU
[Tiki-index. PHP? page_id=383] T [Tiki-index. PHP? page_id=5005] RCT, 30-48 ng
RCT 50K IU/week
Hives, Chronic T [Tiki-index. PHP? page_id=5053] RCT, 4000 IU added
Cholesterol T Reduced 4 mg RCT, 400 IU + Ca
Weight Loss T [Tiki-index. PHP? page_id=5166] RCT, 2000 IU +diet +exercise
Gestational Diabetes P 40% RCT ✻ , 5,000 IU
[Tiki-index. PHP? page_id=5151] T [Tiki-index. PHP? page_id=4724] CT, 50,000 IU weekly
#F00:RCT 100,000 IU monthly
[Tiki-index. PHP? page_id=1433] T [Tiki-index. PHP? page_id=5393] RCT >42 mg of vitamin D
[Tiki-index. PHP? page_id=3924] T [Tiki-index. PHP? page_id=5387] CT, 4,000 IU in daily bread
Death of Critically Ill
Patients		 T 20% increase in survivability RCT 540 K IU loading than 90K monthly
Restless Leg Syndrome T Score 26 ==> 10 CT, Vitamin D dose size
not stated in abstract
Hepatitis-C T Aided normal drugs RCT 2.000 IU
Crohn's disease T improved when > 30 ng
2nd study fewer relapses		 RCT 2,000 IU
10,000 IU RCT
Pre-term birth P 2.5X decrease, also: fewer
c-section & better Apgar		 RCT 2,000 IU India
Cluster headaches T CH eliminated in 60% 10,000 IU, Mg, Omega-3, etc
Autism T 80% improved CT 300 IU/kg/day for 3 months
PreDiabetes T ~20% reduced RCT 60,000 IU/month
Weight loss:%%%Overweight and Obese T 12 lbs in 6 months RCT 100,000 IU/month
Sarcopenia = muscle loss T 27% increase RCT 1,000 IU
Growing Pains T 60% decrease ~100,000 IU/month - NOT RCT
2nd study, similar results
Osteoarthritis pain T 60% decrease 50,000 IU/weekly - NOT RCT
ALS T helped 2,000 IU - NOT RCT, given to all
Vertigo T 3X reduction if raised > 10ng 600,000 IU load, then maint.
NOT RCT, given to all
Warts T 80% eliminated injection NOT RCT
60,000 IU/injection
Metabolic Syndrome P reduced 44% when VitD
increased by 30 ng		 NOT RCT, given to all
Hay fever P reduced 48% RCT   1,000 IU for 30 days
Preeclampsia P Recurrance cut in half
#F00:_ 3 RCT_ 3.6 X less likely if > 30 ng		 50,000 IU every 2 weeks
4,000 IU daily
Blood cell cancer
Multiple Myeloma		 T Survival 90% vs 50% 10,000 IU/week
NOT RCT, given to all
Irritable Bowel Syndrome T Reduced 3,000 IU spray RCT
Urinary Tract Infection P 50% reduction RCT 20,000 IU weekly
Mite Allergy P 5X reduction RCT 2,000 IU preg, 800 IU child
Perinatal depression
(depression near birth)		 T 50% reduction RCT 2,000 IU for just a few weeks
Vaginosis T 10X reduction RCT 2,000 IU
Eczema T Reduced 2 RCT 1,600 IU
Non-Alcoholic %%%Fatty Liver Disease T Reduced RCT 20,000 IU weekly
Knee Osteoartiritis T Pain Reduced RCT 60,000 IU monthly after loading dose
Tuberculosis T Faster Recovery RCT single 450,000 IU dose
Stroke - Ischemic T Faster Recovery RCT single 600,000 IU injection
~~#F00:_ RCT_ ~~ single 300,000 IU injection
Sepsis T Reduce ICU and Hospital
length of stay by 7 days each		 RCT 400,000 IU
Trauma deaths T 50% fewer deaths Vitamin D & Glutamine
NOT RCT, given to all
Hemodialysis patients T helped 50,000 IU weekly NOT RCT, given to all
Fatty liver - child T 2 X reduction RCT  Vitamin D & DHA
Fatigue T Reduced 100,000 IU single dose
NOT RCT, given to all
Sleep Disorders T Nicely treated RCT  50.000 IU bi-weekly
Pneumonia
(Ventilator-associated)		 T ~~#F00:_ RCT_ ~~ ~hs~ Death rate cut in half 300,000 IU injection
Infertile males T birth rate doubled RCT   300,000 IU + maint
Waist size T Waist size reduced 3 cm 100,000 IU loading + maint for 6 months
for those with Metabolic Syndrome
NOT RCT, given to all
Attention Deficient%%% Hyperactivity Disorder T Reduced
Reduced		 RCT  3,000 IU for 12 weeks
RCT  50,000 IU weekly
Alcoholic liver cirrhosis T improved survival 1,000 IU of vitamin D NOT RCT
Diabetic nephropathy T Reduced HOMA-IR, FRS RCT 50,000 IU weekly
Ulcerative Colitis T Reduced 60% RCT 50,000 IU nano daily for a week
Obese weight loss T Lost 3X more pounds $10 of Vitamin D added to
  calorie restriction & walking
Endometriosis T Nicely treated RCT  50.000 IU bi-weekly
Diabetic Wounds T 4X more likely to heal RCT  6,400 daily
Alzheimer's T Often reverse Each person gets a different amount of
Vit D, Omega-3, B12, Iron, etc
Autoimmune P Decrease 30% RCT  Vit D + Omega-3
Smoking T reduce problems RCT  50,000 bi-weekly
Tonsillitis T Virtually eliminated RCT  50,000 weekly
Epilepsy T Helped 6 ways NOT RCT, given to children & adults
Dengue Fever T P
Psoriasis T cured 30,000 to 60,000 IU
ICU Survival T 2X longer 500,000 IU
Long-COVID T 60,000 IU weekly

Most proofs are RCT (Randomized Controlled Trials), where not even the doctor knows who gets it vitamin D

  • 2 are meta-analyses of multiple RCTs

  • Vitamin D was given to ALL infants in the entire country (Rickets) - not an RCT

  • In several studies, researchers felt that it was unethical not to give vitamin D to everyone

  • In some studies, the dose size varied with the needs of the person (overweight, etc)

  • In some studies, the COFACTORS were adjusted to the needs of the patients

    • Curing requires the dose size and cofactors to be adjusted to the needs of each patient.

Many Clinical Trials have not found a benefit because of one or more of the following failures:

  1. Fails to use a [Tiki-index. PHP? pageid=766] (often < 1,100 IU)
    • The Even larger dose needed if: 1) obese, 2) [Tiki-index. PHP? pageid=745], 3) sick (many diseases consume lots of vitamin D)

  2. Fails to have given vitamin D for a long enough time (a few RCT lasted less than 5 weeks)

  3. Fails to have given Vitamin D frequently enough. [Tiki-index. PHP? page_id=2475] - and at least weekly for D2

    • Note: Infrequent dosing also causes unbalancing of the body's chemistry

  4. Fails to provide a [Tiki-index. PHP? page_id=326], or had too short a duration to restore the vitamin D levels

  5. Fails to use D3 form, instead uses the [Tiki-index. PHP? page_id=2138]

  6. Fails to have a healthy range of [Tiki-index. PHP? pageid=1446] or other important [Tiki-index. PHP? pageid=1270] (especially for bone-related trials

    • Also, differences in Magnesium can result in 30% change in response to vitamin D
    • Magnesium is dependent on water, food, supplements

  7. Fails to notice the pre-existing vitamin D levels - only those who are low will likely show a benefit

  8. Fails to notice how/when the vitamin D was taken (which can change the response by as much as 2X)

  9. Fails to report on compliance (in one case 40% of the participants did not take the supplements consistently)

    Many Meta-Analyses also do not find a benefit because one or more of the above failures

In addition, many [tiki-browsecategories. PHP? parentId=82&sort;mode=created_desc] average together ALL of the trials

Imagine a story about a meta-analysis of aspirin (which has never been done)

     There would be scores of RCT for aspirin not working with 3 mg doses

     There would be a many RCT of aspirin not working with 30 mg doses

     There would be a few studies of aspirin WORKING with 300+ mg doses

     There would be many studies of small amounts of Willow bark (Vitamin D2 instead of Vitamin D3)

     Then there would be a meta-analysis of aspirin and Willow Bark

     - That meta-analysis would conclude that aspirin and Willow bark do not work.

See also VitaminDWiki: Random Controlled Trials with vitamin D intervention

More intervention trials for Vitamin D than for the TOTAL of Vitamins A + C + K combined

Vitamin D = 2199 , Others = 1803 Vitamin A 702 + Vitamin C 768 + Vitamin K 333      as of Aug 2020

See also VitaminDWiki

image

CLICK ON chart for more information and translation

Vitamin D is especially needed during pregnancy

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Also, The Vitamin D Receptor limits the amount of Vitamin D in the blood actually gets to the tissue

The risk of 48+ diseases at least double with poor Vitamin D Receptor

Short URL = is.gd/dproof

Tags: Intervention Intervention - non daily Overview