Table of contents
- Association of Vitamin D Deficiency With Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis
- Overview Tuberculosis and Vitamin D has the following summary
- A few vitamin D and TB in VitaminDwiki
- TB Meta-analysis
- A Poor Vitamin D Receptor prevents Vitamin D in blood from getting to the cells
- Vitamin D Receptor activation can be increased by:
- TB and Vitamin D Receptor:
Association of Vitamin D Deficiency With Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis
Cureus 13(9): e17883. doi:10.7759/cureus.17883
Sunam Kafle, Anjan Kumar Basnet, Kumar Karki, Manusha Thapa Magar, Shumneva Shrestha, Randhir S. Yadav
Pulmonary tuberculosis, caused by Mycobacterium tuberculosis, is a significant public health issue, especially in developing countries, affecting millions of people every year. Despite the development of many antitubercular antibiotics and increased awareness of preventive methods, it is still a major cause of mortality worldwide. Vitamin D, a micronutrient known to have a major role in bone and calcium metabolism, has also shown its immunomodulatory effects to suppress mycobacterial growth. We conducted a systematic review and meta-analysis of the available evidence to explore the association between vitamin D levels and tuberculosis. We performed a systematic search for articles from inception to May 2021 in multiple databases.
We included 26 studies in our qualitative synthesis and 12 studies in meta-analysis or quantitative synthesis. In our meta-analysis, we used a random-effect model to calculate the odds ratio (OR) of vitamin D deficiency in tuberculosis patients compared to the healthy controls. On pooled analysis, we found that the odds of the participants having vitamin D deficiency was 3.23 times more in tuberculosis patients compared to the healthy group (OR=3.23, CI = 1.91-5.45, p<0.0001). Thus, we concluded that there is an association between low levels of vitamin D and tuberculosis infections. We suggest conducting long-term prospective cohort studies in tuberculosis endemic countries to better understand the causal relationship between vitamin D deficiency and tuberculosis.
Download the PDF from VitaminDWiki
Overview Tuberculosis and Vitamin D has the following summary
Many studies have found that Vitamin D both PREVENTS and TREATS TB
- As with many other diseases, we expect that there will be at least a 4X range of vitamin D due to:
- 4X range in the response in the vitamin D blood level for the same IU dose - for healthy, non-obese, people
- Poor Vitamin D Receptor activation results in far less vitamin D getting to cells
- However, a VDR restriction is not noticed by Vitamin D blood tests
- UV appears to be as powerful or perhaps more powerful than vitamin D in TREATING TB
- Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006
- TB 10X less likely to catch if have sufficient vitamin D – Dec 2011
- Trials using small vitamin D doses neither prevent nor treat TB 2023 2022 2020
- No tuberculosis if more than 80 ng of vitamin D (cattle) - Jan 2022
- Humans need a lot of Vitamin D as well
A few vitamin D and TB in VitaminDwiki
- Tuberculosis recovery speeded up by single 450,000 IU dose of vitamin D – RCT Jan 2017
- Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006
- Every TB patient benefited from 2 doses of 600,000 IU of vitamin D – RCT Jan 2013
- TB arrested by cod-liver oil (containing vitamin D) in 1848 3X better than other treatments at the time
TB Meta-analysis
- Latent Tuberculosis 44 percent less likely if Vitamin D more than 30 ng - 14th meta-analysis Jan 2022
- Those with TB were 3.2 X more likely to have low vitamin D – 13th meta-analysis Sept 2021
- Tuberculosis still associated with low vitamin D – 12th meta-analysis June 2021
- Tuberculosis 3X more likely if less than 12 ng of Vitamin D - meta-analysis Sept 2019
- Tuberculosis increased risk if poor Vitamin D receptor varies by race – meta-analysis Feb 2019
- Tuberculosis (multi-drug resistant) was 13.4 X more likely to be quickly cleared with Vitamin D - Meta-analysis Feb 2019
- Catching Tuberculosis from family member 2 X more likely if low vitamin D – meta-analysis Dec 2018
- Tuberculosis in children 1.7 X more likely if low vitamin D – meta-analysis Aug 2018
- Low vitamin D is a risk factor for tuberculosis – meta-analysis Dec 2016
- Tuberculosis 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Oct 2016
- Tuberculosis 4.5X more likely if vitamin D less than 10 nanogram – meta-analysis May 2015
- Tuberculosis, genes and vitamin D – Meta-Analysis Dec 2013
- TB associated with low vitamin D in a review and meta-analysis – 2008
- TB and vitamin D updated review and meta-analysis – plays a role Jan 2010
A Poor Vitamin D Receptor prevents Vitamin D in blood from getting to the cells
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by:
(Resveratrol)), Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc
TB and Vitamin D Receptor:
- TB patients had low Vitamin D and poor Vitamin D receptor – June 2019
- TB and Leprosy are easily confused and associated with Vitamin D Receptor
- Certain types of Tuberculosis are 2X more likely with a poor Vitamin D Receptor – April 2019
- Tuberculosis increased risk if poor Vitamin D receptor varies by race – meta-analysis Feb 2019
- Pulmonary Tuberculosis 2X more likely if poor Vitamin D Receptor (Mexico) – April 2018
- TB risk in Blacks increased 20 percent having poor Vitamin D Receptors – Sept 2017
- Tuberculosis 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Oct 2016
- Tuberculosis, genes and vitamin D – Meta-Analysis Dec 2013
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