The controversial role of vitamin D as an antioxidant: results from randomised controlled trials
Nutrition Research Reviews https://doi.org/10.1017/S0954422418000197
Sara Tagliaferri (a1), Debora Porri (a2), Rachele De Giuseppe (a2), Matteo Manuelli (a2) matteo.manuelli@unimi.it
VitaminDWiki
- Oxidative stress to DNA prevented by Vitamin D (H2O2, rats) – Jan 2019
- Hypothesis – less vitamin D results in faster aging – Nov 2017 has the following graphic
Vitamin D and Omega-3 both reduce Inflammation
Inflammation Intervention trials using Vitamin D:
- A small amount of Vitamin D for a short time does not help (2800 IU, 8 weeks) – RCT Oct 2021
- COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021
- Diabetic inflammation reduced by Vitamin D (30,000 IU weekly) – RCT July 2020
- Type 2 Diabetes inflammation reduced by 50,000 IU of Vitamin D bi-weekly and resistance training – RCT – June 2019
- Urinary sepsis – a single Vitamin D injection reduced hospital days by 40 percent – RCT April 2018
- Can burn pain be relieved by 4 g of Omega-3 and 2,000 IU of vitamin D – RCT due 2021
- Eczema (Atopic Dermatitis) treated by 1600 IU of vitamin D – meta-analysis Dec 2016
- UTI associated with low Vitamin D as well as treated - many studies
- Inflammation reduced by a single dose of Vitamin D (200,000 IU) – RCT Jan 2016
- Anti-inflamatory cytokines increased when vitamin D levels were raised above 30 ng – RCT Feb 2015
- Diabetic inflammation reduced by Calcium and 50,000 IU of vitamin D in 8 weeks – RCT 2014
- Malaria in mice brains, and associated inflammation, prevented by Vitamin D intervention – July 2014
- Inflammation in African Americans not reduced with 3 months of 4000 IU of vitamin D – RCT Dec 2013
- Gingivitis inflammation (retracted) -Jan 2013
- 4000 IU vitamin D daily for just 5 days reduced inflammation after heart attack – RCT Jan 2013
- Atopic dermatitis dramatically reduced in Iran with 1600 IU of vitamin D – RCT March 2012
- Sepsis is both prevented and treated by Vitamin D - many studies
Pages listed in BOTH the categories Omega-3 and Inflammation
- Opioid addiction reduced by Omega-3 (gut inflammation in mice) – Aug 2019
- Treat wounds, stop inflammation with nanoemulsion textile of Omega-3 and Resveratrol - Sept 2019
- Inflammation is reduced by each of the following: Vitamin D, Omega-3, Diet
- Sepsis reduced the Omega-3 response and half life – April 2019
- Pollutants increase Respiratory problems, Vitamin D, Omega-3, etc. decrease them – May 2018
- Severe acute pancreatitis treated in 11 ways by Omega-3 in just 7 days – RCT April 2018
- Omega-3 treats animal inflammation better than human (those studies use higher doses and different ratios than for humans) - March 2018
- Omega-3 helps muscles and reduces inflammation, lipids, and insulin – Nov 2015
- Omega-3 improves gut bacteria, reduces inflammation and depression – Dec 2017
- Can burn pain be relieved by 4 g of Omega-3 and 2,000 IU of vitamin D – RCT due 2021
- 2.7 fewer days in hospital after surgery if had taken Omega-3 (19 RCT) – meta-analysis – June 2017
- Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017
- Omega-3 reduces many psychiatric disorders – 2 reviews 2016
- Depression due to inflammation reduced by Omega-3 (children and pregnant) – Nov 2015
- Omega-7 - in addition to Omega-3
- Inflammation reduction through diet: Omega-3 etc. Feb 2014
- Traumatic brain injury treated by Vitamin D Progesterone Omega-3 and glutamine – May 2013
- Omega-3 reduced vitamin D3 inflammation for obese – RCT Jan 2013
Some studies published after the current study was submitted
- The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress in Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials June 2018 doi: 10.1055/a-0630-1303 Free PDF "Overall, this meta-analysis shows that in diabetic patients, taking vitamin D had significant effects on hs-CRP and MDA levels, and significantly increased NO, TAC and GSH levels."
- Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter Aug 2018 Free PDF https://doi.org/10.1371/journal.pone.0200040
Vitamin D: Oxidative Stress, Immunity, and Aging - 2016 Book
Table of Contents
Vitamin D: An Overview
Vitamin D: A Fountain of Youth in Gene Regulation; Peter W. Jurutka, G. Kerr Whitfield, Ryan Forster...
Vitamin D Receptor: Genomic and Epigenomic Effects; Prashant K. Singh and Moray J. Campbell
Vitamin D Analogs and Their Clinical Uses; Glenville Jones
Extrarenal CYP27B1 and Vitamin D Physiology; Martin Hewison
Oxidative Stress
Vitamin D and Oxidative Stress; Huei-Ju Ting and Yi-Fen Lee
Vitamin D3 Upregulated Protein 1 (VDUP1): Roles in Redox Signaling and Stress-Mediated Diseases; ...
Vitamin D and Its Role in Photoprotection of the Skin; Clare Gordon-Thomson, Wannit Tongkao-on, and Rebecca S. Mason
Vitamin D and Adipose Tissue: 1α, 25-Dihydroxyvitamin D3 (Calcitriol) Modulation of Energy Metabolism, Reactive Oxygen Species, and Inflammatory Stress; Antje Bruckbauer and Michael B. Zemel
Membrane Receptors for Vitamin D Metabolites and the Role of Reactive Oxygen Species; Ramesh C. Khanal and Ilka Nemere
Immunity and Disease
Vitamin D and Human Innate Immunity; Eun-Kyeong Jo, Dong-Min Shin, and Robert L. Modlin
Vitamin D and Autoimmune Disease; Colleen E. Hayes, Corwin D. Nelson, and Justin A. Spanier
Vitamin D: Anti-Inflammatory Actions to Prevent and Treat Diseases; Jun Sun
Vitamin D and Infection; Jim Bartley and Carlos A. Camargo, Jr.
Aging
Potential Role of Vitamin D and Fibroblast Growth Factor 23–Klotho System in Aging; Nasimul Ahsan, Syed K. Rafi, ...
Vitamin D and Cardiovascular Disease; Jared P. Reis and Pamela L. Lutsey
Vitamin D, Aging, and Chronic Diseases; Pentti Tuohimaa
Vitamin D: Defending the Aging Nervous System; Cédric Annweiler
VitaminDWiki pages with ANTIOXIDANTS in title
This list is automatically updated
Items found: 6
Increased oxidative stress has been implicated as a potential causal factor in the development of several diseases. In the last decade, an extensive literature has been produced on vitamin D, not limited to its well-known function like a steroid hormone on skeletal tissue, but for its potential pleiotropic role in human health. Several researchers have suggested relationships between vitamin D intake and health outcomes such as cancer prevention and increased immunity, or possible role in preventing diabetes, and in inflammation. Little is known about its antioxidant effect. The aim of the present review was to explore major evidence regarding the potential scavenger capacity of vitamin D in high-evidence human studies. Studies considered by the present review suggest that the potential role of vitamin D as an antioxidant could not be confirmed. Current literature showed controversial effects about the ability of cholecalciferol to prevent or ameliorate oxidative stress biomarkers, and there is need of further and high-quality studies testing the antioxidant effect of vitamin D supplementation.
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