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Anti-inflamatory cytokines increased when vitamin D levels were raised above 30 ng – RCT Feb 2015

Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: A randomized, double blind, placebo-controlled study

Cytokine, Volume 71, Issue 2, February 2015, Pages 132–138 https://doi.org/10.1016/j.cyto.2014.09.012
Tyler Barker a tyler.barker at imail.org , Victoria E. Rogers a, Mark Levy b, Jenna Templeton b, Howard Goldfine b, Erik D. Schneider b, Brian M. Dixon b, Vanessa T. Henriksen a, Lindell K. Weaver c, d, e
a The Physiology Research Laboratory, The Orthopedic Specialty Hospital, Murray, UT 84107, USA
b Research and Development, USANA Health Sciences, Inc., Salt Lake City, UT 84120, USA
c Hyperbaric Medicine, Intermountain Medical Center, Murray, UT 84107, USA
d LDS Hospital, Salt Lake City, UT 84143, USA
e School of Medicine, University of Utah, Salt Lake City, UT 84132, USA



Vitamin D modulates cytokines and muscle performance.
Supplemental vitamin D increased 25(OH)D and 1,25(OH)D without altering work.
Supplemental vitamin D increased IFN-γ and IL-10 in vitamin D insufficient adults.
Wow – a journal just about Cytokines – 71st edition no less!!
4,000 and 8,000 IU doses were both tried
Did not matter dose size, just that blood levels were raised above 30 ng

See also VitaminDWiki

56 studies referenced this study as of Feb 2021

  • The Role of Vitamin D in Suppressing Cytokine Storm in COVID-19 Patients and Associated Mortality - April 2020 FREE PDF
  • Effect of vitamin D supplementation on selected inflammatory biomarkers in older adults: a secondary analysis of data from a randomised, placebo-controlled trial
  • Effects of Vitamin D Supplementation and Seasonality on Circulating Cytokines in Adolescents: Analysis of Data From a Feasibility Trial in Mongolia - Oct 2019   PDF 800 IU to children for 6 months


 Download the PDF from Sci-Hub VitaminDWiki

Chart appears to show that all Cytokines DECREASE with sufficient Vitamin D
The purpose of this study was to determine if vitamin D status before supplementation influences the cytokine response after supplemental vitamin D. Forty-six reportedly healthy adults (mean(SD); age, 32(7) y; body mass index (BMI), 25.3(4.5) kg/m2; serum 25-hydroxyvitamin D (25(OH)D), 34.8(12.2) ng/mL) were randomly assigned (double blind) to one of three groups: (1) placebo (n = 15), or supplemental vitamin D (cholecalciferol) at (2) 4000 (n = 14) or (3) 8000 IU (n = 17). Supplements were taken daily for 35 days. Fasting blood samples were obtained before (Baseline, Bsl) and 35-days after (35-d) supplementation. Serum 25(OH)D, 1,25-dihydroxyvitamin D (1,25(OH)D), cytokines, and intact parathyroid hormone with calcium were measured in each blood sample.
Supplemental vitamin D increased serum 25(OH)D (4000 IU, ≈29%; 8000 IU, ≈57%) and 1,25(OH)D (4000 IU, ≈12%; 8000 IU, ≈38%) without altering intact parathyroid hormone or calcium.
The vitamin D metabolite increases in the supplemental vitamin D groups (n = 31) were dependent on initial levels as serum 25(OH)D (r = −0.63, p < 0.05) and 1,25(OH)D (r = −0.45, p < 0.05) at Bsl correlated with their increases after supplementation.
Supplemental vitamin D increased interferon (IFN)-γ and interleukin (IL)-10 in subjects that were vitamin D insufficient (serum 25(OH)D < 29 ng/mL) compared to sufficient (serum 25(OH)D ⩾ 30 ng/mL) at Bsl.
We conclude that supplemental vitamin D increase a pro- and anti-inflammatory cytokine in those with initially low serum 25(OH)D.

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Attached files

ID Name Comment Uploaded Size Downloads
13544 Mongolia 6 months.jpg admin 26 Feb, 2020 53.58 Kb 920
13543 Cytokine insuff, suff.jpg admin 26 Feb, 2020 38.61 Kb 856
13542 Cytokines 35 days.jpg admin 26 Feb, 2020 73.86 Kb 845
13541 Cytokine Mongolia.pdf admin 26 Feb, 2020 465.03 Kb 527
13540 Cytokine RCT 2015.pdf admin 26 Feb, 2020 444.20 Kb 589