IBD strongly associated with low Vitamin D – Jan 2022

Gut problems require gut-compatibile Vitamin D, which has been rarely used by trials so far

Vitamin D in Inflammatory Bowel Diseases. Mechanisms of Action and Therapeutic Implications

Nutrients Volume 14 Issue 2 10.3390/nu14020269
by Filippo Vernia ORCID,Marco Valvano ORCID,Salvatore Longo ORCID,Nicola Cesaro,Angelo ViscidoORCID and Giovanni Latella ORCID
Gastroenterology Unit, Department of Life, Health and Environmental Sciences, University of L’Aquila, Piazza S. Tommasi, Coppito, 67100 L’Aquila, Italy

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Background: Vitamin D is an immunoregulatory factor influencing intestinal homeostasis. Recent evidence supports a central role of this micronutrient in the course of Inflammatory Bowel Diseases (IBD). This narrative review aims to provide a general overview of the possible biological mechanisms of action of vitamin D and its therapeutic implications in IBD.

Methods: A systematic electronic search of the English literature up to October 2021 was performed using Medline and the Cochrane Library. Only papers written in English that analyzed the role of vitamin D in IBD were included.

Results: In vitro and animal studies reported that vitamin D signaling improves epithelial barrier integrity regulating the expression of several junctional proteins, defensins, and mucins, modulates the inflammatory response, and affects gut microbiome composition. Recent studies also suggest that vitamin D deficiency is highly prevalent among IBD patients and that low serum levels correlate with disease activity and, less clearly, with disease course.

Conclusions: An increasing body of evidence suggests some role of vitamin D in the pathophysiology of IBD, nonetheless the underlying mechanisms have been so far only partially elucidated. A strong correlation with disease activity has been reported but its implication in the treatment is still undefined. Thus, studies focused on this issue, the definition of vitamin D levels responsible for clinical effects, and the potential role of vitamin D as a therapeutic agent are strongly encouraged.
 Download the PDF from VitaminDWiki

VitaminDWiki - Overview Gut and vitamin D has

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 207 items

VitaminDWiki - Overview Gut and vitamin D contains

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart
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Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
   you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be useful – it is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol		D - Slow
C -Fast		Long
10 Sun/UVBSlowLong
10Topical
(skin patch/cream, vagina)		Slow
Fast nano		Normal
9Nanoemulsion -mucosal
perhaps activates VDR		FastNormal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
4Sublingual/spray
(some goes into gut)		FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

VitaminDWiki pages containing IBS or IBD or IRRITABLE BOWEL in title

Items found: 48
Title Modified
IBS - Vitamin D was the only micronutrient under DRV - meta-analysis Oct 2023 16 Dec, 2023
Vitamin D interactions with poor gut (Celiac, IBD, and Bariatric surgery) – several studies 22 Nov, 2023
IBD associated with low vitamin D again (they need to take a gut-friendly form of Vitamin D) – Oct 2023 14 Oct, 2023
IBS reduced by 50,000 IU of Vitamin D (weekly or bi-weekly) – Meta-analysis July 2023 16 Aug, 2023
Irritable Bowel Syndrome and Vitamin D - many studies 30 Jun, 2023
Irritable Bowel Syndrome and Vitamin D - many studies 30 Jun, 2023
IBD treated in children by Vitamin D, especially if use more than 2,000 IU daily for 12 weeks – meta-analysis – Sept 2022 14 Sep, 2022
Vitamin D fights IBD, no consensus yet on dose size and type – Aug 2022 26 Aug, 2022
IBS helped by vitamin D (virtually ignoring dose size, type and duration) – meta-analysis June 2022 09 Jul, 2022
IBD is treated by Vitamin D and other Nutraceuticals – June 2022 23 Jun, 2022
IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 30 May, 2022
IBD in children might be associated with low sun exposure 28 Feb, 2022
IBD strongly associated with low Vitamin D – Jan 2022 09 Jan, 2022
IBS not helped by daily 3,000 IU Vitamin D (but non-daily and gut-friendly help) – RCT July 2021 31 Jul, 2021
IBD and Crohn's patients need Vitamin D, even to increase drug efficacy (Vedolizumab) June 2021 29 Jun, 2021
IBS diarrhea treated by weekly 50,000 IU of Vitamin D – RCT March 2020 25 Mar, 2020
Irritable Bowel Syndrome treated by weekly 50,000 IU Vitamin D – RCT Feb 2019 18 Jan, 2020
IBD and UV dissertation - 2019 10 Sep, 2019
Vitamin D appears to fight Diabetes, MS, RA, Lupus, IBD, Hepatitis, Cancer, Psoriasis, Food allergy, etc – June 2019 17 Jul, 2019
IBD in Finland – 3X increase in 15 years, more prevalent further from equator – Nov 2012 14 May, 2019
Common cold incidence reduced by two thirds (500 IU for IBD with low vitamin D) – RCT Jan 2019 04 Jan, 2019
Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018 09 Dec, 2018
IBS (1 in 5 youths) strongly associated with low vitamin D – Dec 2018 01 Dec, 2018
IBD relapse rate reduced by low Vitamin D - meta-analysis Nov 2018 27 Nov, 2018
IBS quality of life improved by vitamin D (50,000 IU every two weeks) – RCT May 2016 14 Mar, 2018
IBS - many indications that Vitamin D will help - more research needed - March 2018 14 Mar, 2018
Irritable Bowel Syndrome: social media indicates that vitamin D is a good treatment – Oct 2013 05 Feb, 2018
IBS – 6 out of 7 studies shows Vitamin D helps, still want more studies – Jan 2018 25 Jan, 2018
Higher Vitamin D increased the benefit of anti-TNF- α drug used for IBD by 2.6 times – Jan 2017 31 Jan, 2017
IBD in Canadian children increasing 7% per year - Nov 2016 22 Nov, 2016
70 percent of people with IBS had symptoms relieved with high dose vitamin D – 2012 04 Nov, 2016
IBD UC and CD at risk of being vitamin D deficient – May 2011 04 Nov, 2016
IBS – 82 percent had low vitamin D, 3,000 IU spray helped a lot – RCT Dec 2015 25 Aug, 2016
Sleep, Vitamin D, Vitamin B-12, IBS, Fibromyalgia - Gominak March 2015 27 Jul, 2016
IBD deficiencies of Iron and Vitamin D (and new Iron types) – June 2016 20 Jun, 2016
IBS quality of life improved by vitamin D (50,000 IU weekly) – RCT May 2016 17 May, 2016
IBD helped by vitamin D but reluctant to state who helped, in what form, and how much – review Nov 2014 08 Jan, 2016
IBD more likely in areas with low UV ( and thus low vitamin D) – June 2014 05 Dec, 2015
Gut problems more likely if low vitamin D (IBD: 1.6, UC: 2.3) – meta-analysis Aug 2015 31 Oct, 2015
IBD (Collitis, Chron’s) was active 6X more often if low vitamin D – June 2015 03 Oct, 2015
Crohn’s disease deficient in vitamin K – IBD deficient in vitamins K and D – April 2011 17 Feb, 2015
Appears that IBD lowers vitamin D, which increases risk of cancer by 80 percent – Oct 2013 09 Jul, 2014
Irritable Bowel Syndrome - can it be treated by 3000 IU of vitamin D - RCT Feb 2014 28 Feb, 2014
IBD surgery 5X more likely for non-caucasians with low vitamin D – Oct 2012 03 Nov, 2012
IBD and Crohn but not Colitis associated with low vitamin D – May 2011 05 Jun, 2012
IBD colorectal Cancer and vitamin D – Jan 2011 14 Mar, 2012
Dogs – like humans – with IBD were low on vitamin D – July 2011 14 Mar, 2012
IBD less costly when treated with vitamin D3 compared to D2 – Jan 2012 12 Jan, 2012

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