Vitamin D Receptor
It appears that 1/3 of everyone with a vitamin D-related disease has a poor VDR
A poor VDR cannot be detected by any standard Vitamin D test (nor Calcitriol nor Calcidiol)
A poor Parathyroid VDR can be detected when high Calcitriol levels fail to decrease PTH levels
- Decreasing PTH shows Vitamin D is getting to Parathyroid - but says nothing about VDRs elsewhere
Many cancers and viruses have learned to protect themselves by deactivating the local VDR
A VDR activation decreases with age
Vitamin D Receptor Overview
studies in Vitamin D Receptor category
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
See also: studies in the Resveratrol category
It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
The Vitamin D Receptor is associated with many health problems
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55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:
| Increasing | Increases |
| 1) Vitamin D supplement Sun Ultraviolet -B |
Vitamin D in the blood and thus in the cells |
| 2) Magnesium | Vitamin D in the blood AND in the cells |
| 3) Omega-3 | Vitamin D in the cells |
| 4) Resveratrol | Vitamin D Receptor |
| 5) Intense exercise | Vitamin D Receptor |
| 6) Get prescription for VDR activator paricalcitol, maxacalcitol? |
Vitamin D Receptor |
| 7) Quercetin (flavonoid) | Vitamin D Receptor |
| 8) Zinc is in the VDR | Vitamin D Receptor |
| 9) Boron | Vitamin D Receptor ?, etc |
| 10) Essential oils e.g. ginger, curcumin | Vitamin D Receptor |
| 11) Progesterone | Vitamin D Receptor |
| 12) Infrequent high concentration Vitamin D Increases the concentration gradient |
Vitamin D Receptor |
| 13) Sulfroaphane and perhaps sulfur | Vitamin D Receptor |
| 14) Butyrate especially gut | Vitamin D Receptor |
| 15) Berberine | Vitamin D Receptor |
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Increased risk of diseases if poor VDR
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Increased risk associated with a poor Vitamin D Receptor
Note: Some diseases reduce VDR activation
those with a * are known to decrease activation
VitaminDWiki - Vitamin D Receptor activation can be increased in 17+ ways
Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, Berberine, intense exercise, Butyrate Sulforaphane Metflormin (Kidney) Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the many VDR activators
Google Scholar has 30,900+ results for many the above VDR activators
Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin - 2016 Mar FREE PDF
Exercise acutely increases vitamin D receptor expression in T lymphocytes in vitamin D-deficient men, independent of age- April 2021 FREE PDF
Quercetin activates vitamin D receptor and ameliorates breast cancer-induced hepatic inflammation and fibrosis - April 2023 FREE PDF
Natural Epigenetic Modulators of Vitamin D Receptor -June 2020 FREE PDF
Did not notice any studies that indicated how much of the activator is needed
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VitaminDWiki - Meta-analyses of the Vitamin D Receptor
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Explosive increase in Quercetin medical publications as of 2022
Epigenetic regulation by quercetin: a comprehensive review focused on its biological mechanisms 2023 Dec doi: 10.1080/10408398.2023.2278760. PDF behind paywall
Research progress of quercetin in cardiovascular disease Nov 2023 10.3389/fcvm.2023.1203713 FREE PDF
Quercetin and metabolic syndrome: A review - Oct 2021 doi: 10.1002/ptr.7144 $15 paywall
Potential Implications of Quercetin in Autoimmune Diseases 2021 Jun doi: 10.3389/fimmu.2021.689044 FREE PDF
Quercetin activates vitamin D receptor and ameliorates breast cancer induced hepatic inflammation and fibrosis 2023 April 10.3389/fnut.2023.1158633 📄 PDF
11+ VitaminDWiki pages with QUERCETIN in the title
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18+ VitaminDWiki pages with CURCUMIN in the title
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Book: Sunlight, UV, Vitamin D and Receptor, Skin and Other Cancers - Dec 2020
Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020
📄 Download the VDR chapter from sci-hub via VitaminDWiki
Has the risk of Breast Cancer due to poor Vitamin D Receptors increased in past decades?
Genetics category listing contains the following
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VDR items
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See also Vitamin D Binding Protein category listing has items
In addition to inherited poor VDR genes, Herpes downregulates VDR by 8X for a short time
Note: Many people have Herpes but are not aware of it. (example: 48% of black women)
See also web
- Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene Selfhacked Jan 2016 - has lots of linked references
- Includes Exercise, RXR ( and retinol) is needed to produce proteins with the VDR, SIRT1 -potentiates VDR, PGC-1a, Dopamine
- Bile, Omega-3: Omega-6:Curcumin, Resveratrol, Forskolin , Gamma Tocotrienol, Estradiol,
- What Inhibits The Vitamin D Receptor (VDR) or Calcitriol
- Caffeine, Cortisol/Glucocorticoids, Prolactin, Thyroid hormones, Corticosteroids decrease calcitriol, Phosphatonin, Ketoconazole, Heparin and Thiazides decrease
- Pathogens That Inhibit The Vitamin D Receptor include
- P. aeruginosa, H. pylori, Lyme/Borrelia – Live Borrelia reduces VDR by 50 times (in monocytes).
- Tuberculosis – Reduces VDR 3.3-fold.“Gliding” biofilm bacteria, Shigella, Mycobacterium leprase
- Epstein-Barr virus (EBV) – Decreases VDR by a factor of about five, HIV – binds to the VDR (R) and inhibits conversion to active D
- Aspergillus fumigatus – In cystic fibrosis patients,
- Cytomegalovirus – CMV decreases VDR 2.2 fold, Hepatitis C virus – Inhibits CYP24A1|Changes in vitamin D endocrinology during aging in adults] June 2017
Changes in vitamin D endocrinology during aging in adults June 2017
"Aging leads to a decrease in vitamin D receptor number in several organs."
- Interesting, details are behind a paywall
- Bioinformatic approaches to interrogating vitamin D receptor signaling - Sept 2017
- Calcitriol receptor = VDR Wikipedia
- "Glucocorticoids are known to decrease expression of VDR,"
- "Mutations in this gene are associated with type II vitamin D-resistant rickets"
- "The vitamin D receptor plays an important role in regulating the hair cycle."
- Learn more about Calcitriol Receptor Science Direct.COM
- 10 abstracts of book chapters and studies
- Calcitriol ReceptorWikipedia
- "Mutations in this gene are associated with type II vitamin D-resistant rickets"
- "Calcitriol, the active form of vitamin D, binds to the VDR, which then forms a heterodimer with the retinoid-X receptor"
- perhaps this is where Vitamin A is important with Vitamin D
- "Glucocorticoids are known to decrease expression of VDR"
1. Chart: Need more D if poor VDR (ignores VDR activation and loading dose) - Sept 2021
1 minute video description of the chart
1. PubMed - over 300 publications annually
Light activates VDR at conception,etc. - April 2017
Am J Hum Biol. 2017 Apr 22. doi: 10.1002/ajhb.23010
Beckett EL1,2,3, Jones P1, Veysey M2,4, Duesing K3, Martin C1, Furst J5, Yates Z6, Jablonski NG7, Chaplin G7, Lucock M1.
OBJECTIVES:
The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. We examined whether degree of VDR gene methylation acts as a molecular adaptation to light exposure. We explored this in the context of photoperiod at conception, recent UV irradiance at 305 nm, and gene-latitude effects.
METHODS:
Eighty subjects were examined for VDR gene-CpG island methylation density. VDR gene variants were also examined by PCR-RFLP.
RESULTS:
Photoperiod at conception was significantly positively related to VDR methylation density, explaining 17% of the variance in methylation (r2 = 0.17; P = .001). Within this model, photoperiod at conception and plasma 25(OH)D independently predicted methylation density at the VDR-CpG island. Recent UV exposure at 305 nm led to a fivefold increase in mean methylation density (P = .02). Again, UV exposure and plasma 25(OH)D independently predicted methylation density at the VDR-CpG island. In the presence of the BsmI mutant allele, methylation density was increased (P = .01), and in the presence of the TaqI or FokI mutant allele, methylation density was decreased (P = .007 and .04 respectively). Multivariate modeling suggests plasma 25(OH)D, photoperiod at conception, recent solar irradiance, and VDR genotype combine as independent predictors of methylation at the VDR-CpG island, explaining 34% of the variance in methylation (R2 = 0.34, P < .0001).
CONCLUSIONS:
Duration of early-life light exposure and strength of recent irradiance, along with latitudinal genetic factors, influence degree of VDR gene methylation consistent with this epigenetic phenomenon being a molecular adaptation to variation in ambient light exposure. Findings contribute to our understanding of human biology.
More and more PubMed papers on Vitamin D Receptor
- Vitamin D and VDR in Gynecological Cancers—A Systematic Review - Dec 2017
- Heart failure and vitamin D receptor gene Nov 2016
- 10.1016/j.clnu.2016.11.010 📄 Download the PDF from Sci-hub via VitaminDWiki
- The frequency distribution of vitamin D Receptor fok I gene polymorphism among Ugandan pulmonary TB patients
- July 2016 - free PDF online
- Vitamin D receptor-targeted treatment to prevent pathological dedifferentiation of pancreatic β cells under hyperglycaemic stress
- https://doi.org/10.1016/j.diabet.2017.07.006 Sept 2017 - details are behind a paywall
1. Ways to increase the VDR - Selfhacked
Vitamin D Receptor Gene: Ways to Activate it, Calcitriol, Benefits Self-hacked.com Aug 2018
A list of ways to Increase EITHER active Vitamin D or Vitamin D Receptor
Following subset list May include some non-VDR items by mistake
See self-hacked article for hyperlinks and details
RXR (and retinol) is needed to produce proteins with the VDR. 1,25D3 binds to the VDR, which then combines with RXR to activate gene expression. (Not all VDR-dependent genes need RXR.)
SIRT1 -potentiates VDR [R, R] – acetylation of VDR lessens 1,25D/VDR signaling. SIRT1 increased the ability of VDR to associate with RXR.
PGC-1a [R]– potentiates VDR. It is a coactivator of the VDR, but it still needs 1,25D3.
Dopamine [R]
The VDR evolved from its ancient role as a detoxification nuclear receptor. LCA is produced from the gut bacteria (metabolizing liver-derived chenodeoxycholic acid). LCA travels to the colon, where the VDR binds to LCA or 1,25 D and activates the CYP3A4 and SULT2A genes facilitate disposal from the cell via the ABC efflux transporter [R].
Omega-3: DHA, EPA [R], – Fish oil/DHA
Omega-6: γ-Linolenic acid, Arachidonic acid [R],
Curcumin[R]– Curcumin is more active than LCA/Bile in driving VDR-mediated transcription and that it binds to VDR with approximately the same affinity as LCA.
Resveratrol[R] – Potentiates VDR by: (1) potentiating 1,25D binding to VDR; (2) activating RXR; (3) stimulating SIRT1.
Gamma Tocotrienol [R]- Tocotrienols or Tocopherols (IHERB)
Estradiol increases VDR expression [R, R] and calcitriol levels [R].
1. Many VDR test kits can be used ELISA and other testers
Examples**
1. # <span style="color:#F06;">89+</span> VitaminDWiki Vitamin D Receptor pages have CANCER etc. in the title
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1. VDR category is associated with these <span style="color:#F06;">49</span> other VitaminDWiki categories
Genetics 74, Binding Protein 46, Virus 33, CYP27B1 32, Pregnancy 24, Breathing 24, Diabetes 23, Cancer 22, Infant-Child 21, Cancer - Breast 19, Autoimmune 18, Resveratrol 18, Cognitive 16, Obesity 16, Osteoporosis 13, Cancer - Colon 13, Gut 13, Immunity 12, Parkinson 11, Cancer - Other 11, Seniors 10, Rheumatoid Arthritis 10, Cancer - Skin 10, Multiple Sclerosis 10, Hypertension 9, Vision 8, Tuberculosis 8, Skin 7, Thyroid 7, Skin - Dark 7, Cancer - Prostate 7, Back pain 7, Fertility and sperm 6, Dental 6, Women 6, Cancer - Ovarian 6, Bone - Health 6, Sports 6, Cardiovascular 6, Lupus 6, Cancer - after diagnosis 5, UV 5, Liver 5, Intervention 4, Autism 4, Deficiency 4, Books & videos 4, Mortality 4, Stroke 4, Middle East 4, Kidney 4, Cancer - Lung 4, Cancer - Bladder 4
1. Details of associations with the VDR category
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