Decrement of Serum Vitamin D Level After Stroke
Ann Rehabil Med. 2017 Dec;41(6):944-950, https://doi.org/10.5535/arm.2017.41.6.944
Kiyoung Kim, MD, Kye Hee Cho, MD, Sang Hee Im, MD, PhD, Jaewoo Choi, MD, Junghoon Yu, MD and MinYoung Kim, MD, PhD kmin@cha.ac.kr
Department of Rehabilitation Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Vitamin D levels drop in first 30 days
Vitamin D levels < 30 days, > 30 days
Objective: To investigate the serum vitamin D level and its determinant factors in stroke patients.
Methods
Fifty-one stroke patients who had documented serum level of 25-hydroxyvitamin D(25(OH)D) were included. Patients were divided into subacute (n=23) and chronic groups (n=28). The mean levels of 25(OH)D of the two groups were compared. Correlations between each 25(OH)D level and post-stroke duration were also analyzed. To assess other possible influencing factors, patients were subdivided by ambulation ability and feeding methods for comparison of 25(OH)D level.
Results
The mean level of 25(OH)D was significantly lower in the chronic group than in the subacute group (12.3 vs. 16.3 ng/mL; p<0.05). The serum 25(OH)D level decreased according to the duration after stroke (r=−0.52, p=0.01). Patients with a history of total parenteral nutrition had lower 25(OH)D levels than subjects who had enteral nutrition in the subacute group (7.3 vs. 18.8 ng/mL; p<0.01). However, the levels of 25(OH)D were not different between the oral feeding and tube feeding groups. Among the chronic group subjects, patients who could walk without assistance had higher 25(OH)D levels than non-ambulatory patients (ambulatory vs. non-ambulatory group; 18.3 vs. 11.3 ng/mL; p<0.05).
Conclusion
After stroke onset, serum vitamin D level decreases with time regardless of feeding methods, and total parenteral nutrition may aggravate its deficiency. In terms of long-term care, non-ambulatory patients might be at a higher risk of vitamin D deficiency. Supplementation of vitamin D should be considered especially for stroke patients who are non-ambulatory and on total parenteral nutrition.
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VitaminDWiki – Stroke category contains
Overview Hypertension and Vitamin D Overview Cardiovascular and vitamin D
Stroke more likely if low Vitamin D
- Stroke 74% less likely if high vitamin D (7,295 women 20-50 years old) – July 2017
- Stroke is 13.5 X more likely if low vitamin D and high blood pressure – March 2015
- Ischemic stroke 17 X more likely if low vitamin D – April 2017
- Stroke is strongly associated with Calcification of cerebral arteries (perhaps low Vitamin D, Vitamin K, Mg…) – March 2018
- Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014
Post-Stroke worse if low Vitamin D
- Poor Acute Ischemic Stroke 4X more likely if low Vitamin D - Nov 2023
- Stroke risks increased if low Vitamin D: Death 3.6 X, recurrence 5.5 X – Meta-analysis Nov 2019
- Stroke outcome at 3 months was 3X worse if bad stroke and low vitamin D – Jan 2020
- Death after Ischemic Stroke 2.5 X more likely if less than 10 ng of Vitamin D – May 2019
- Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015
- Depression following a stroke is 2.7 X more likely if low vitamin D – Sept 2018
- Stroke incidence not associated with low Vitamin D (but stroke outcome is) – Aug 2019
Post-Stroke better if add Vitamin D
- Post-stroke Vitamin D supplementation helped in 11 ways – May 2023
- Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT June 2018
- Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017
- Ischaemic stroke – Vitamin D doubled survival (Injection followed by monthly 60,000 IU) – RCT Aug 2016
- Stroke patients need more than 2,000 IU of vitamin D (found this time in Japan) – RCT June 2019
Post-Stroke better if Vitamin D actually gets to cells
- Resveratrol fights Parkinson, Alzheimers, Diabetes, Cardiovascular, ALS, Stroke, etc.– Nov 2018
- Stroke rehabilitation (and prevention) requires Vitamin D actually getting to cells – March 2020
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- Nerve cells and Vitamin D – many studies
- Water-soluble form of vitamins are needed for some health problems
- Post-stroke depression not reduced by 2,000 IU of vitamin D (not a surprise) – Nov 2021
- Depression is associated with stroke if low vitamin D or winter – Nov 2018
- Depression following a stroke is 2.7 X more likely if low vitamin D – Sept 2018
- Omega-3 and Vitamin D each treat many mental health problems - April 2018
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- No longer depressed, but risk of stroke is still 1.7X higher (did not consider low vitamin D) – May 2015
- ALL of the top 10 health problems of women are associated with low vitamin D
- Post stroke depression 9X more likely if low vitamin D – Dec 2014
- Stroke patients with low vitamin D were 10X more likely to become depressed – Aug 2014
23+ VitaminDWiki Stroke pages have ISCHEMIC OR ISCHAEMIC in the title
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